Publication Information

{'id': 'https://openalex.org/W1985206692', 'doi': 'https://doi.org/10.3109/00365528909091237', 'title': 'Omeprazole: Mode of Action and Effect on Acid Secretion in Animals', 'display_name': 'Omeprazole: Mode of Action and Effect on Acid Secretion in Animals', 'publication_year': 1989, 'publication_date': '1989-01-01', 'ids': {'openalex': 'https://openalex.org/W1985206692', 'doi': 'https://doi.org/10.3109/00365528909091237', 'mag': '1985206692', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2557668'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.3109/00365528909091237', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S55592950', 'display_name': 'Scandinavian Journal of Gastroenterology', 'issn_l': '0036-5521', 'issn': ['0036-5521', '1502-7708'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110223870', 'display_name': 'Björn Wallmark', 'orcid': None}, 'institutions': [], 'countries': ['SE'], 'is_corresponding': True, 'raw_author_name': 'B. Wallmark', 'raw_affiliation_strings': ['Dept. of Biology, AB Hässle, Mölndal, Sweden.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Biology, AB Hässle, Mölndal, Sweden.', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5110223870'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.804, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 39, 'citation_normalized_percentile': {'value': 0.711409, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '24', 'issue': 'sup166', 'first_page': '12', 'last_page': '18'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10276', 'display_name': 'Helicobacter pylori-related gastroenterology studies', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10276', 'display_name': 'Helicobacter pylori-related gastroenterology studies', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/parietal-cell', 'display_name': 'Parietal cell', 'score': 0.96518123}, {'id': 'https://openalex.org/keywords/h', 'display_name': 'H(+)-K(+)-Exchanging ATPase', 'score': 0.64158773}, {'id': 'https://openalex.org/keywords/gastric-glands', 'display_name': 'Gastric glands', 'score': 0.4838356}], 'concepts': [{'id': 'https://openalex.org/C2779743957', 'wikidata': 'https://www.wikidata.org/wiki/Q1640093', 'display_name': 'Parietal cell', 'level': 4, 'score': 0.96518123}, {'id': 'https://openalex.org/C2777498785', 'wikidata': 'https://www.wikidata.org/wiki/Q422210', 'display_name': 'Omeprazole', 'level': 2, 'score': 0.89913046}, {'id': 'https://openalex.org/C2777504413', 'wikidata': 'https://www.wikidata.org/wiki/Q846270', 'display_name': 'Gastric acid', 'level': 3, 'score': 0.8110804}, {'id': 'https://openalex.org/C49039625', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretion', 'level': 2, 'score': 0.7806783}, {'id': 'https://openalex.org/C2911069308', 'wikidata': 'https://www.wikidata.org/wiki/Q415784', 'display_name': 'H(+)-K(+)-Exchanging ATPase', 'level': 4, 'score': 0.64158773}, {'id': 'https://openalex.org/C23265538', 'wikidata': 'https://www.wikidata.org/wiki/Q300033', 'display_name': 'ATPase', 'level': 3, 'score': 0.6181751}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.48759192}, {'id': 'https://openalex.org/C2778052355', 'wikidata': 'https://www.wikidata.org/wiki/Q5526783', 'display_name': 'Gastric glands', 'level': 4, 'score': 0.4838356}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46753713}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.45979732}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.454728}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.43669876}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37891126}, {'id': 'https://openalex.org/C2781443798', 'wikidata': 'https://www.wikidata.org/wiki/Q383249', 'display_name': 'Gastric mucosa', 'level': 3, 'score': 0.3738102}, {'id': 'https://openalex.org/C2779422922', 'wikidata': 'https://www.wikidata.org/wiki/Q1029907', 'display_name': 'Stomach', 'level': 2, 'score': 0.2555987}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1511221}], 'mesh': [{'descriptor_ui': 'D005744', 'descriptor_name': 'Gastric Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009853', 'descriptor_name': 'Omeprazole', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000251', 'descriptor_name': 'Adenosine Triphosphatases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D000251', 'descriptor_name': 'Adenosine Triphosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005744', 'descriptor_name': 'Gastric Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017506', 'descriptor_name': 'H(+)-K(+)-Exchanging ATPase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009853', 'descriptor_name': 'Omeprazole', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010295', 'descriptor_name': 'Parietal Cells, Gastric', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010295', 'descriptor_name': 'Parietal Cells, Gastric', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.3109/00365528909091237', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S55592950', 'display_name': 'Scandinavian Journal of Gastroenterology', 'issn_l': '0036-5521', 'issn': ['0036-5521', '1502-7708'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2557668', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 26, 'referenced_works': ['https://openalex.org/W1519058182', 'https://openalex.org/W1542845577', 'https://openalex.org/W1721323399', 'https://openalex.org/W1965415217', 'https://openalex.org/W1975963600', 'https://openalex.org/W1979087886', 'https://openalex.org/W1982249220', 'https://openalex.org/W1995779830', 'https://openalex.org/W2017472773', 'https://openalex.org/W2022260319', 'https://openalex.org/W2036636126', 'https://openalex.org/W2044483565', 'https://openalex.org/W2046075488', 'https://openalex.org/W2057001748', 'https://openalex.org/W2063653971', 'https://openalex.org/W2064194125', 'https://openalex.org/W2084639611', 'https://openalex.org/W2088623127', 'https://openalex.org/W2110331159', 'https://openalex.org/W2123431776', 'https://openalex.org/W2158909322', 'https://openalex.org/W2163743158', 'https://openalex.org/W2168234648', 'https://openalex.org/W2413442204', 'https://openalex.org/W301735020', 'https://openalex.org/W613972312'], 'related_works': ['https://openalex.org/W28676792', 'https://openalex.org/W2427385174', 'https://openalex.org/W2343699089', 'https://openalex.org/W2135261276', 'https://openalex.org/W2112214672', 'https://openalex.org/W2103414797', 'https://openalex.org/W2103337844', 'https://openalex.org/W2064603938', 'https://openalex.org/W2032844690', 'https://openalex.org/W1985206692'], 'abstract_inverted_index': {'AbstractH+,K+-ATPase': [0], 'constitutes': [1], 'the': [2, 6, 14, 38, 43, 53, 57, 68, 71, 75, 98, 103, 111, 146, 149], 'final': [3], 'step': [4], 'in': [5, 13, 37, 70, 91, 110, 140, 158], 'acid': [7, 30, 54, 72, 119, 134, 168], 'secretory': [8], 'process': [9], 'that': [10], 'takes': [11], 'place': [12], 'parietal': [15, 44, 58, 76, 177], 'cell,': [16], 'and': [17, 60, 94, 116, 132, 157], 'this': [18], 'enzyme': [19], 'has': [20], 'recently': [21], 'been': [22], 'recognized': [23], 'as': [24], 'a': [25, 47, 141, 153, 171], 'target': [26, 85], 'for': [27, 164], 'inhibitors': [28], 'of': [29, 42, 56, 67, 74, 113, 118, 126, 145, 148], 'secretion.': [31], 'The': [32], 'gastric': [33, 99, 127], 'H+,K+-ATPase': [34, 69, 105, 128], 'is': [35, 50, 61, 79, 89, 102, 121], 'located': [36], 'uniquely': [39], 'acidic': [40], 'environment': [41], 'cell.': [45, 77], 'Omeprazole,': [46], 'weak': [48], 'base,': [49], 'concentrated': [51], 'within': [52], 'canaliculus': [55], 'cell': [59], 'rapidly': [62], 'converted': [63], 'to': [64, 83, 97, 107, 124, 166], 'an': [65], 'inhibitor': [66, 106], 'compartments': [73], 'Omeprazole': [78, 101, 151], 'thus': [80], 'activated': [81], 'close': [82], 'its': [84], 'enzyme,': [86], 'where': [87], 'it': [88], 'present': [90], 'high': [92], 'concentrations,': [93], 'binds': [95], 'selectively': [96], 'H+,K+-ATPase.': [100], 'first': [104], 'be': [108], 'used': [109], 'treatment': [112], 'acid-related': [114], 'diseases,': [115], 'inhibition': [117, 125], 'secretion': [120, 135, 169], 'closely': [122], 'correlated': [123], 'activity.': [129], 'Both': [130], 'basal': [131], 'stimulated': [133], 'are': [136, 162], 'inhibited': [137], 'by': [138], 'omeprazole': [139], 'dose-dependent': [142], 'manner,': [143], 'irrespective': [144], 'nature': [147], 'stimulus.': [150], 'exerts': [152], 'prolonged': [154], 'antisecretory': [155], 'effect,': [156], 'dogs,': [159], '4': [160], 'days': [161], 'required': [163], 'return': [165], 'normal': [167], 'following': [170], 'maximal': [172], 'inhibitory': [173], 'dose.Key': [174], 'Words:': [175], 'Gastric': [176], 'cellH+,K+-ATPaseomeprazole': [178]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1985206692', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2025-01-18T22:02:52.750922', 'created_date': '2016-06-24'}