Publication Information

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2302, 2377, 2391, 2409, 2424, 2477, 2488, 2495, 2517, 2638, 2712, 2739, 2808, 2862, 2914, 2980, 3074, 3115, 3158, 3285, 3291, 3301, 3359, 3368, 3382, 3390, 3475, 3547, 3549, 3564, 3572, 3590, 3605, 3620, 3674, 3842, 3903, 3921, 3940, 3984, 3994, 4036, 4082, 4159, 4260, 4271, 4286, 4299, 4327, 4348, 4364, 4385, 4405], 'modification': [9, 190, 473, 552, 1499, 3264, 3861], 'by': [10, 16, 191, 197, 1167, 1601, 1755, 1815, 2112, 2328, 2576, 2722, 2792, 2826, 2898, 2963, 3080, 3096, 3275, 3297, 3413, 3442, 3445, 3524, 3634, 3651, 3687, 3694, 3760, 3923, 3960, 4011, 4014, 4027, 4381, 4388], '(ISGylation)': [12, 193, 553], 'are': [13, 24, 148, 194, 205, 329, 509, 704, 951, 1004, 2228, 2244, 2253, 2429, 2498, 2519, 2566], 'strongly': [14, 25, 195, 206, 3394, 4379], 'activated': [15, 26, 196, 207], 'interferons.': [17, 198], 'Accordingly,': [18, 199], 'ISGylation': [23, 78, 99, 106, 119, 204, 259, 280, 287, 300, 640, 772, 835, 1107, 1148, 1520, 2304, 2322, 2411, 2466, 2497, 2511, 3535, 3574, 3835, 3850, 4069, 4183, 4191, 4211, 4262, 4301, 4317], 'upon': [27, 114, 208, 295, 2419, 2501, 3653], 'viral': [28, 209], 'bacterial': [30, 211], 'infections': [31, 212], 'during': [33, 214], 'other': [34, 72, 215, 253, 4076], 'stress': [35, 216], 'conditions,': [36, 217], 'suggesting': [37, 218], 'important': [38, 219], 'roles': [39, 220, 4073], 'for': [40, 68, 137, 221, 249, 318, 511, 614, 771, 834, 1104, 1440, 1533, 1981, 2204, 2215, 2221, 2226, 2242, 2251, 2960, 3453, 3875, 4030, 4178, 4269], 'system': [43, 79, 107, 224, 260, 288, 2512, 3825, 3882], 'in': [44, 102, 111, 139, 151, 174, 178, 225, 283, 292, 320, 332, 355, 359, 711, 891, 953, 1108, 1473, 1496, 1504, 1508, 1546, 1559, 1709, 1734, 1750, 1795, 1826, 1952, 2002, 2029, 2073, 2279, 2323, 2346, 2384, 2706, 2754, 3022, 3089, 3098, 3119, 3261, 3309, 3318, 3353, 3417, 3579, 3656, 3706, 3730, 3736, 3746, 3767, 3778, 3784, 3799, 3809, 3821, 3827, 3838, 3895, 3907, 4000, 4066, 4142, 4162, 4173, 4192, 4203, 4209, 4212, 4265, 4302, 4355, 4371, 4392], 'innate': [45, 226], 'immune': [46, 227], 'responses.': [47, 228], 'Here,': [48, 229, 1483], 'we': [49, 230, 1484, 1549, 2325, 2644, 3277, 3668, 4197, 4248], 'report': [50, 231, 1485], 'identification': [52, 233, 1074, 1542], 'ubiquitin-protein': [55, 236, 430, 728], 'isopeptide': [56, 237, 431, 657, 729], 'ligase': [57, 67, 136, 238, 248, 317, 730, 1532, 3110, 3874], '(E3)': [58, 239], 'EFP': [59, 85, 93, 123, 131, 147, 240, 266, 274, 304, 312, 328, 1490, 1510, 1527, 1553, 1614, 2088, 2229, 2277, 2301, 2317, 2408, 2416, 2699, 2717, 2745, 2787, 2803, 2841, 3031, 3068, 3076, 3087, 3148, 3260, 3586, 3848, 3867, 3888, 3985, 4042, 4065, 4149, 4172, 4179, 4188, 4201, 4218, 4259, 4290, 4297, 4313, 4363, 4375, 4402, 4407], '(estrogen-responsive': [60, 241, 1491], 'finger': [61, 242, 1492, 1515, 3156], 'protein)': [62, 243], 'as': [63, 108, 110, 244, 289, 291, 883, 1082, 1115, 1181, 1221, 1435, 1456, 1759, 2171, 2829, 3198, 3553, 3577, 3609, 3870], 'E3': [66, 135, 247, 316, 1003, 1012, 1168, 1214, 1452, 1459, 1531, 1545, 2489, 2564, 2569, 3109, 3873, 4079], '14-3-3σ': [69, 101, 138, 250, 282, 319, 1501, 1642, 2092, 2306, 2321, 2413, 3092, 3113, 3117, 3167, 3266, 3271, 3321, 3345, 3358, 3400, 3409, 3428, 3438, 3450, 3511, 3594, 3647, 3662, 3717, 3818, 3837, 3855, 3890, 3930, 3956, 3973, 4007, 4190, 4210, 4264, 4300], 'protein.': [70, 90, 251, 271, 3267], 'Like': [71, 252], 'known': [73, 254, 367, 563, 2506, 3468], 'components': [74, 150, 255, 331, 2507], '(ISG15,': [80, 261], 'UBE1L,': [81, 262, 2515, 2912, 3283, 3902, 3939], 'UBP43,': [82, 263, 993, 2516, 2913], 'UBC8),': [84, 265], 'is': [86, 132, 267, 313, 363, 498, 598, 641, 832, 888, 932, 995, 1098, 1165, 1528, 1536, 1555, 2467, 2478, 2700, 2719, 2842, 2958, 3078, 3104, 3467, 3480, 3507, 3663, 3856], 'also': [87, 268, 1005, 1113, 2573, 2824, 2896, 3059, 3521, 3758, 3832, 3976, 4331], 'an': [88, 133, 269, 314, 656, 1083, 1529, 1635, 2751, 3061, 3199, 3773, 3871], 'interferon-inducible': [89, 270], 'Expression': [91, 272, 3365], 'small': [94, 275, 434, 446, 1088, 2217], 'interfering': [95, 276, 435, 1089], 'RNA': [96, 277, 1090, 1891, 1912, 2202, 2219, 2732], 'decreased': [97, 278], '293T': [104, 285, 1705, 2283, 2341, 3100, 3288, 3539, 3596, 3823, 3881, 3896, 4193, 4266, 4276], 'cell': [105, 286, 1785, 1972, 2387, 2393, 2709, 3354, 4022, 4194, 4358], 'well': [109, 290], 'MCF-7': [112, 293, 1782, 1895, 2343, 2389, 2740, 2755, 2863, 3657, 3680, 4321], 'cells': [113, 294, 818, 1706, 1731, 1747, 1812, 1896, 1943, 2026, 2284, 2344, 2363, 2371, 2380, 2390, 2738, 2756, 2861, 3540, 3597, 3681, 3841, 3844, 3897, 4277, 4322, 4342, 4351], 'interferon': [115, 296, 414, 4396], 'treatment.': [116, 297, 2900], 'Furthermore,': [117, 298, 2504], 'enzyme': [120, 301, 722, 770, 784, 1079, 1103, 1119, 1439, 3202], 'activity': [121, 302, 2483], 'was': [124, 305, 1620, 1646, 1659, 1668, 1793, 1886, 1897, 1917, 1968, 2109, 2164, 2169, 2213, 2728, 2852, 2895, 3307, 3347, 3351, 3459, 3520, 3632, 3728, 3743, 3776, 3893, 3931, 3935, 3957, 3975, 3980, 4378, 4403, 4409], 'RING': [125, 306, 1514, 3106, 3155], 'domain-dependent.': [126, 307], 'These': [127, 308, 1523, 3253], 'findings': [128, 309], 'indicate': [129, 310, 1525], 'that': [130, 143, 311, 324, 647, 655, 830, 999, 1096, 1432, 1448, 1486, 1526, 1552, 2473, 2562, 2571, 2650, 2698, 2786, 2873, 3066, 3075, 3111, 3336, 3469, 3476, 3509, 3814, 3854, 4187, 4330], 'vivo.': [140, 321, 1509], 'fact': [142, 323, 1431], 'both': [144, 325, 1093, 1173, 1441, 1503, 2492], 'UBC8': [145, 326, 1080, 1097, 1112, 1203, 1433, 1465, 1479, 1606, 3152, 3165, 3194, 3369, 3391, 3904, 3941], 'common': [149, 330, 952, 1557], 'ubiquitin': [153, 334, 426, 472, 546, 610, 724, 1009, 1077, 1117, 1153, 1158, 1213, 1444, 1451, 1561, 2434, 2568, 3108, 3163, 4078], 'conjugation': [156, 337, 1564, 3742, 4039], 'pathways': [157, 338], 'suggests': [158, 339], 'a': [159, 162, 340, 343, 468, 705, 884, 933, 1099, 1116, 1182, 1210, 1436, 1487, 1556, 1669, 1920, 2055, 2799, 2830, 2882, 2890, 3105, 3120, 3334, 3342, 3709, 3720, 3857, 4207, 4225, 4282, 4303], 'mechanism': [160, 341, 505, 2464], 'whereby': [161, 342, 506], 'limited': [163, 344], 'set': [164, 345, 3420], 'enzymes': [166, 347, 709, 1161], 'accomplishes': [167, 348], 'diverse': [168, 349], 'post-translational': [169, 350], 'modifications': [170, 351], 'their': [172, 353, 903], 'substrates': [173, 354], 'response': [175, 356, 451, 2919], 'to': [176, 357, 471, 501, 609, 643, 646, 781, 997, 1162, 1207, 1216, 1480, 1517, 1904, 1971, 2431, 2469, 2472, 2480, 2749, 2907, 3166, 3313, 3560, 3582, 3616, 3665, 3794, 3813, 3864, 3883], 'changes': [177, 358], 'environmental': [179, 360], 'stimulations.': [180, 361], 'one': [364, 2646, 2701], 'several': [366], 'Ubl': [368], 'modifiers': [370], '(1.Haas': [371, 477], 'A.L.': [372, 478, 2444], 'Ahrens': [373, 479], 'P.': [374, 480, 571, 797, 1379], 'Bright': [375, 481], 'P.M.': [376, 482, 1125, 1236], 'Ankel': [377, 483], 'H.': [378, 484], 'J.': [379, 485, 688, 841, 915, 972, 1126, 1237, 1269, 1291, 1311, 1328, 1385, 1399, 1414, 1871, 2186, 2436, 2447, 2550, 2626, 2685, 3011, 4102, 4124], 'Biol.': [380, 486, 530, 588, 743, 916, 977, 1028, 1127, 1194, 1238, 1270, 1292, 1312, 1415, 1587, 1772, 2187, 2448, 2529, 2929, 2948, 3213, 4103, 4125], 'Chem.': [381, 487, 917, 1128, 1239, 1271, 1293, 1313, 1416, 2188, 2449, 4104, 4126], '1987;': [382, 488], '262:': [383, 489], '11315-11323Abstract': [384, 490], 'Full': [385, 401, 403, 491, 534, 536, 758, 760, 921, 923, 1132, 1134, 1243, 1245, 1275, 1277, 1297, 1299, 1317, 1319, 1420, 1422, 2192, 2194, 2453, 2455, 4108, 4110, 4130, 4132], 'Text': [386, 402, 404, 492, 535, 537, 759, 761, 922, 924, 1133, 1135, 1244, 1246, 1276, 1278, 1298, 1300, 1318, 1320, 1421, 1423, 2193, 2195, 2454, 2456, 4109, 4111, 4131, 4133], 'PDF': [387, 405, 493, 538, 762, 925, 1136, 1247, 1279, 1301, 1321, 1424, 2196, 2457, 4112, 4134], 'PubMed': [388, 406, 494, 521, 539, 576, 592, 632, 698, 747, 763, 812, 845, 873, 926, 981, 1032, 1067, 1137, 1198, 1248, 1280, 1302, 1322, 1346, 1371, 1403, 1425, 1591, 1776, 1878, 2154, 2197, 2458, 2533, 2555, 2603, 2633, 2692, 2778, 2933, 2952, 2993, 3015, 3054, 3143, 3188, 3217, 3248, 3501, 4113, 4135, 4242], 'Google': [389, 409, 495, 524, 542, 579, 595, 635, 701, 750, 766, 815, 848, 876, 929, 984, 1035, 1070, 1140, 1201, 1251, 1283, 1305, 1325, 1349, 1374, 1406, 1428, 1594, 1779, 1881, 2157, 2200, 2461, 2536, 2558, 2606, 2636, 2695, 2781, 2936, 2955, 2996, 3018, 3057, 3146, 3191, 3220, 3251, 3504, 4116, 4138, 4245], 'Scholar,': [390, 525, 580, 751, 849, 1252, 1284, 1306, 1326, 1350, 1375, 1407, 2537, 2607, 2937, 2997, 3221, 4117], '2.Schwartz': [391], 'D.C.': [392], 'Hochstrasser': [393], 'M.': [394, 853, 1191, 1266, 1288, 1332, 1358, 1362, 1383, 1397, 1856, 2134, 2438, 2545, 2590, 2594, 2611, 2670, 2764, 2770, 3003, 3040, 3046, 3130, 3134, 3175, 3179, 4099, 4121], 'Trends': [395, 528], 'Biochem.': [396, 517, 625, 691, 1339, 2771, 3047], 'Sci.': [397, 805, 1060, 3241], '2003;': [398, 629, 870, 1314, 1400, 1875, 2151, 2189, 2630, 2689], '28:': [399], '321-328Abstract': [400], 'Scopus': [407, 522, 540, 577, 593, 633, 699, 748, 764, 813, 846, 874, 927, 982, 1033, 1068, 1138, 1199, 1249, 1281, 1303, 1323, 1347, 1372, 1404, 1426, 1592, 1777, 1879, 2155, 2198, 2459, 2534, 2556, 2604, 2634, 2693, 2779, 2934, 2953, 2994, 3016, 3055, 3144, 3189, 3218, 3249, 3502, 4114, 4136, 4243], '(318)': [408], 'Scholar).': [410, 496, 543, 596, 636, 702, 767, 816, 877, 930, 985, 1202, 1429, 1595, 1780, 1882, 2158, 2201, 2559, 2782, 3019, 3147, 3192, 3252, 3505, 4139, 4246], 'Upon': [411], 'type': [412, 2964], 'I': [413, 2965], '(IFN)': [415], '3The': [416], 'abbreviations': [417], 'used': [418, 2214, 3308, 3879], 'are:': [419], 'IFN,': [420], 'interferon;': [421], 'E1,': [422, 2486], 'ubiquitin-activating': [423, 721], 'enzyme;': [424], 'E2,': [425, 2487], 'carrier': [427, 725], 'protein;': [428], 'E3,': [429], 'ligase;': [432], 'siRNA,': [433], 'RNA;': [436, 448], 'HA,': [437], 'hemagglutinin;': [438], 'Ni-NTA,': [439], 'nickel-nitrilotriacetic': [440], 'acid;': [441], 'PBS,': [442, 2376, 4347], 'phosphate-buffered': [443, 1947], 'saline;': [444], 'shRNA,': [445], 'hairpin': [447, 2218], 'ISRE,': [449], 'IFN-stimulated': [450, 2704, 2918, 2972, 3090], 'element;': [452], 'Stat,': [453], 'signal': [454, 3974, 3989], 'transducer': [455], 'activator': [457], 'transcription.': [459], 'treatment,': [460, 2724, 4397], 'forms': [462], 'covalent': [463], 'conjugates': [464, 904], 'with': [465, 1172, 1209, 1715, 1801, 1843, 1934, 1946, 1989, 2054, 2067, 2262, 2287, 2333, 2351, 2366, 2375, 2397, 2730, 2854, 2970, 3151, 3323, 3357, 3384, 3516, 3530, 3543, 3567, 3600, 3622, 3671, 3683, 3711, 3719, 3899, 3919, 3937, 3967, 3982, 4278, 4325, 4346], 'cellular': [466, 507, 4217], 'proteins,': [467], 'process': [469, 638, 713], 'similar': [470, 645, 2430, 2471], '(ubiquitination': [474], 'or': [475, 2356, 3684, 3702, 3910, 4155, 4230], 'ubiquitylation)': [476], 'Ubiquitylation': [497], 'now': [499], 'understood': [500], 'be': [502, 644, 660, 2470, 2574, 2750, 2790, 3273], 'dominant': [504], 'proteins': [508, 1164, 1178, 1470, 2521, 3294, 3471, 3629, 3916, 4366], 'marked': [510], 'degradation': [512], '(3.Pickart': [513], 'C.M.': [514], 'Annu.': [515], 'Rev.': [516, 740], '2001;': [518, 744, 842, 1343], '70:': [519], '503-533Crossref': [520], '(2922)': [523], '4.Hicke': [526], 'L.': [527, 1413], 'Cell': [529, 586, 1193, 1699, 2527, 2927], '1999;': [531, 978, 1272, 3012, 4105], '9:': [532], '107-112Abstract': [533], '(386)': [541], 'However,': [544], 'unlike': [545], 'modification,': [547, 2909, 3667], 'role': [549, 3258], 'has': [554, 561, 774, 880, 1204, 2127, 2746, 3195], 'not': [555, 825, 895, 3588, 3735, 3744, 3783, 3846, 3997, 4052, 4153], 'been': [556, 562, 775, 881, 1205, 1574, 2128, 2747, 3196], 'clearly': [557], 'defined,': [558], 'although': [559], 'since': [564], '1979': [565], '(5.Farrell': [566], 'P.J.': [567], 'Broeze': [568], 'R.J.': [569], 'Lengyel': [570], 'Nature.': [572, 1367, 2599, 3139, 3184, 3497], '1979;': [573], '279:': [574], '523-525Crossref': [575], '(200)': [578], '6.Ritchie': [581], 'K.J.': [582, 859, 912, 2140, 2523, 2923], 'Zhang': [583, 623, 689, 866, 913, 973, 1024, 1583, 2147, 2184, 2524, 2548, 2924, 2944, 3209], 'D.-E.': [584, 624, 690, 867, 914, 974, 1025, 1584, 1763, 2148, 2185, 2525, 2549, 2925, 2945, 3210], 'Semin.': [585, 2526, 2926], 'Dev.': [587, 869, 2150, 2528, 2928], '2004;': [589, 755, 1029, 1064, 1588, 2530, 2930, 2949, 3214, 3245], '15:': [590, 2531, 2931], '237-246Crossref': [591, 2532, 2932], '(119)': [594, 2535, 2935], 'composed': [599], 'two': [601, 4075], 'domains,': [602, 619, 949], 'each': [603, 1914], 'which': [605, 950, 1170, 1831, 2957, 3519], 'bears': [606], 'sequence': [607, 3073], 'identity': [608], '(33': [611], '32%': [613], 'N-': [616], 'C-terminal': [618], 'respectively)': [620], '(7.Kim': [621], 'K.I.': [622, 684, 861, 910, 1019, 1578, 2142, 2177, 2539, 2939, 3204], 'Biophys.': [626, 692, 1340, 2772, 3048], 'Res.': [627, 693, 1341, 1874, 2629, 2688, 2773, 3049], 'Commun.': [628, 694, 1342, 2774, 3050], '307:': [630], '431-434Crossref': [631], '(63)': [634], 'expected': [642, 2468], 'ubiquitylation.': [650, 1150], 'Mass': [651], 'spectrometry': [652], 'analysis': [653, 2727, 2851, 3312], 'confirmed': [654], 'bond': [658], 'can': [659, 1454, 1494, 3149, 3472, 3512, 3592, 3868], 'formed': [661], 'between': [662, 1184, 1464], 'C': [664], 'terminus': [665], 'lysine': [670], 'ϵ-amino': [671], 'group': [672], 'target': [675, 1163, 1177, 1188, 1469, 1481, 3858], '(8.Zou': [677], 'W.': [678, 837, 1050, 3231], 'Papov': [679], 'V.': [680], 'Malakhova': [681, 907, 2178, 2540], 'O.': [682], 'Kim': [683, 860, 909, 1015, 2141, 2176, 2445], 'Dao': [685], 'C.': [686, 1042, 3223], 'Li': [687, 1412], '2005;': [695, 2450, 2552], '336:': [696], '61-68Crossref': [697], '(66)': [700], 'There': [703], 'series': [706], 'distinct': [708], 'involved': [710], 'ubiquitylation': [716, 2476], 'deubiquitylation,': [718], 'viz.': [719], '(E1),': [723], '(E2),': [727], '(E3),': [731], 'Dub': [734], 'deubiquitining': [735], 'proteases': [736, 942], '(9.Weissman': [737], 'A.M.': [738], 'Nat.': [739, 1192], 'Mol.': [741, 975, 1026, 1585, 1770, 2946, 3211], 'Cell.': [742, 754, 976, 1027, 1586, 1771, 2947, 3212], '2:': [745, 1196], '169-178Crossref': [746], '(1257)': [749], '10.Wilkinson': [752], 'K.D.': [753], '119:': [756], '741-745Abstract': [757], '(27)': [765], 'An': [768], 'E1': [769, 783], '(UBE1L)': [773], 'cloned': [776], 'shows': [778], 'high': [779], 'homology': [780], 'UBE1': [785], '(11.Kok': [786], 'K.': [787, 865, 1336, 1860, 2146, 2543, 2615, 2674, 2758, 2768, 3034, 3044], 'Hofstra': [788], 'R.': [789, 963, 1290, 4123, 4235, 4237], 'Pilz': [790], 'A.': [791, 795, 808, 967, 1063, 1864, 2619, 2678, 2762, 3038, 3244, 3494], 'van': [792, 968], 'den': [793], 'Berg': [794], 'Terpstra': [796], 'Buys': [798], 'C.H.': [799], 'Carritt': [800], 'B.': [801, 1389, 1391, 1858, 2547, 2613, 2672, 3484], 'Proc.': [802, 1057, 3238], 'Natl.': [803, 1058, 3239], 'Acad.': [804, 1059, 3240], 'U.': [806, 1061, 1258, 3242, 4091], 'S.': [807, 1062, 1121, 1232, 1308, 1330, 1366, 2598, 2760, 3036, 3138, 3183, 3243], '1993;': [809], '90:': [810], '6071-6075Crossref': [811], '(88)': [814], 'UBE1L-deficient': [817], 'express': [819, 4332], 'only': [820, 4148], 'free': [821], 'do': [824], 'show': [826], 'conjugation,': [828], 'indicating': [829, 1142], 'UBE1L': [831, 991, 1608, 3367, 3389, 3546], 'necessary': [833], '(12.Yuan': [836], 'Krug': [838, 1055, 3236], 'R.M.': [839, 1056, 3237], 'EMBO': [840, 1398, 3010], '20:': [843], '362-371Crossref': [844], '(420)': [847], '13.Malakhova': [850], 'O.A.': [851, 908, 2132, 2179, 2541], 'Yan': [852, 2133, 2544], 'Malakhov': [854, 2135], 'M.P.': [855, 906, 2136, 2175], 'Yuan': [856, 1049, 2137, 3230], 'Y.': [857, 1286, 1364, 1862, 2138, 2596, 2617, 2676, 2999, 3005, 3136, 3181, 3492, 4119], 'Ritchie': [858, 911, 2139], 'Peterson': [862, 2143], 'L.F.': [863, 2144], 'Shuai': [864, 2145], 'Genes': [868, 2149], '17:': [871, 2152], '455-460Crossref': [872, 2153], '(265)': [875, 2156], 'UBP43': [878, 931], '(USP18)': [879], 'identified': [882, 2645, 3197], 'de-ISGylating': [885], 'isopeptidase': [886], 'highly': [889, 2499], 'specific': [890], 'removing': [892], 'ISG15,': [893, 2514, 2911, 3276], 'but': [894, 3734, 3782, 4152], 'Nedd8': [896], 'SUMO': [898], '(small': [899], 'modifier)': [901], 'from': [902, 1159, 1478, 1672, 1688, 1887, 1892, 1913, 2098, 2165, 2641, 2734, 2857, 3164], '(14.Malakhov': [905], '2002;': [918, 1368, 1417, 2600, 3140, 3185, 4239], '277:': [919, 1418], '9976-9981Abstract': [920], '(382)': [928], 'member': [934], 'UBP': [937], '(USP)': [938], 'family': [939, 958], 'ubiquitin-specific': [941], 'contains': [944, 1832, 3060, 3070], 'conserved': [945], 'Cys': [946], 'His': [948], 'all': [954, 2505], 'members': [955, 1006], 'this': [957, 3374, 3791, 3988], '(15.Liu': [959], 'L.Q.': [960], 'Ilaria': [961], 'Jr.,': [962, 2983], 'Kingsley': [964], 'P.D.': [965], 'Iwama': [966], 'Etten': [969], 'R.A.': [970], 'Palis': [971], '19:': [979], '3029-3038Crossref': [980], '(132)': [983], 'Based': [986, 2579], 'on': [987, 990, 1512, 1919, 2319, 2580, 3889, 4315], 'information': [989, 2640], 'it': [994, 3934, 4050], 'logical': [996], 'hypothesize': [998], 'E2': [1001, 1010, 1078, 1102, 1118, 1160, 1174, 1185, 1438], 'families.': [1013], 'Recently,': [1014, 3193], 'et': [1016, 1039, 2665], 'al.': [1017, 1040, 2666], '(16.Kim': [1018, 1577, 3203], 'Giannakopoulos': [1020, 1579, 2940, 3205], 'N.V.': [1021, 1580, 2941, 3206], 'Virgin': [1022, 1581, 2942, 3207], 'H.W.': [1023, 1582, 2943, 3208], '24:': [1030, 1589, 2950, 3215], '9592-9600Crossref': [1031, 1590, 2951, 3216], '(185)': [1034, 1593, 2954, 3219], 'Scholar)': [1036, 1071, 2637, 2696, 3058], 'Zhao': [1038], '(17.Zhao': [1041], 'Beaudenon': [1043, 3224], 'S.L.': [1044, 3225], 'Kelley': [1045, 3226], 'M.L.': [1046, 3227], 'Waddell': [1047, 3228], 'M.B.': [1048, 3229], 'Schulman': [1051, 3232], 'B.A.': [1052, 3233], 'Huibregtse': [1053, 3234], 'J.M.': [1054, 2442, 3235], '101:': [1065, 3246], '7578-7582Crossref': [1066, 3247], '(248)': [1069, 3250], 'reported': [1072, 2748], '(UBCH8/UbcM8)': [1081], 'ISG15-conjugating': [1084, 3824], 'enzyme.': [1085], 'Using': [1086], '(siRNA)': [1091], 'approach,': [1092], 'groups': [1094], 'indicated': [1095, 2100], 'predominant': [1100, 3817], 'IFN-induced': [1105, 2320, 4182, 4316], 'HeLa': [1109, 3840], 'cells.': [1110, 2342, 2744, 2867, 3289, 4214, 4267, 4394], 'Interestingly,': [1111], 'functions': [1114, 1434], '(18.Kumar': [1120, 1231], 'Kao': [1122, 1233], 'W.H.': [1123, 1234], 'Howley': [1124, 1235], '1997;': [1129, 1240, 2775, 3051], '272:': [1130, 1241], '13548-13554Abstract': [1131, 1242], '(133)': [1139, 1250], 'Scholar),': [1141, 2462, 2956], 'possible': [1144, 3257], 'cross-talk': [1145], 'In': [1151, 2656], 'system,': [1154], 'transfer': [1156, 1475, 3161], 'mediated': [1166], 'enzymes,': [1169], 'interact': [1171, 1208, 3150], 'its': [1176, 1513, 2968, 3154], 'function': [1180, 1455, 3869], 'bridge': [1183], '(19.Hochstrasser': [1190], '2000;': [1195, 1294, 4127], 'E153-E157Crossref': [1197], '(368)': [1200], 'shown': [1206, 3021, 3317, 3705, 3766, 4141, 4370], 'number': [1211], 'ligases': [1215, 1453, 2565, 2570], 'mediate': [1217], 'ubiquitylation,': [1219], 'such': [1220], 'E6AP,': [1222], 'HHARI,': [1223, 4083], 'Parkin,': [1224], 'cIAP,': [1225], 'Dorfin,': [1226], 'EFP,': [1227, 2880], 'RLIM,': [1228], 'Staring': [1230], '20.Moynihan': [1253], 'T.P.': [1254, 4087], 'Ardley': [1255, 4088], 'H.C.': [1256, 4089], 'Nuber': [1257, 4090], 'Rose': [1259, 4092], 'S.A.': [1260, 4093], 'Jones': [1261, 3487, 4094], 'P.F.': [1262, 4095], 'Markham': [1263, 4096], 'A.F.': [1264, 4097], 'Scheffner': [1265, 4098], 'Robinson': [1267, 4100], 'P.A.': [1268, 4101], '274:': [1273, 4106], '30963-30968Abstract': [1274, 4107], '(107)': [1282, 4115], '21.Imai': [1285, 4118], 'Soda': [1287, 4120], 'Takahashi': [1289, 4122], '275:': [1295, 4128], '35661-35664Abstract': [1296, 4129], '(657)': [1304, 4137], '22.Hu': [1307], 'Yang': [1309], 'X.': [1310], '278:': [1315, 2190], '10055-10060Abstract': [1316], '(197)': [1324], '23.Niwa': [1327], 'Ishigaki': [1329], 'Doyu': [1331], 'Suzuki': [1333], 'T.': [1334, 1352, 1354, 1356, 1360, 1395, 1866, 2584, 2586, 2588, 2592, 2621, 2680, 2766, 3001, 3007, 3009, 3042, 3124, 3126, 3128, 3132, 3169, 3171, 3173, 3177], 'Tanaka': [1335], 'Sobue': [1337], 'G.': [1338], '281:': [1344], '706-713Crossref': [1345], '(71)': [1348], '24.Urano': [1351], 'Saito': [1353, 2585, 3125, 3170], 'Tsukui': [1355, 2587, 3127, 3172], 'Fujita': [1357, 2589, 3129, 3174], 'Hosoi': [1359, 2591, 3131, 3176], 'Muramatsu': [1361, 2593, 2769, 3045, 3133, 3178], 'Ouchi': [1363, 2595, 3135, 3180], 'Inoue': [1365, 2597, 2759, 3035, 3137, 3182], '417:': [1369, 2601, 3141, 3186], '871-875Crossref': [1370, 2602, 3142, 3187], '(308)': [1373, 2605, 3145, 3190], '25.Kramer': [1376], 'O.H.': [1377], 'Zhu': [1378], 'Ostendorff': [1380], 'H.P.': [1381], 'Golebiewski': [1382], 'Tiefenbach': [1384], 'Peters': [1386], 'M.A.': [1387], 'Brill': [1388], 'Groner': [1390], 'Bach': [1392], 'I.': [1393], 'Heinzel': [1394], 'Gottlicher': [1396], '22:': [1401], '3411-3420Crossref': [1402], '(441)': [1405], '26.Chin': [1408], 'L.S.': [1409], 'Vavalle': [1410], 'J.P.': [1411], '35071-35079Abstract': [1419], '(100)': [1427], 'dual': [1437], 'raises': [1445], 'possibility': [1447], 'some': [1449], 'UBC8-interacting': [1450, 1488, 2567, 4077], 'ligase,': [1460], 'mediating': [1461], 'interaction': [1463, 2969, 3529], 'helping': [1472], 'proteins.': [1482], 'protein,': [1489], 'protein),': [1493], 'help': [1495], 'transfection': [1505, 3631, 4195], 'experiments': [1506], 'depends': [1511], 'domain': [1516, 3157], 'support': [1518, 3083, 3255, 3593], '14-3-3σ.': [1522, 1534, 3315, 3537, 3703, 3876, 4019], 'data': [1524], 'This': [1535, 3349], 'first': [1538, 3878], 'study': [1539], 'reporting': [1540], 'vivo,': [1547, 2324], 'provide': [1550], 'evidence': [1551], 'component': [1558], 'pathways.': [1565], 'Plasmid': [1566], 'Construction—Plasmids': [1567], 'pCAGGS-mISG15,': [1568], 'pCAGGS-His6-mISG15,': [1569], 'pFLAG-CMV2-UBC8,': [1570], 'pCAGGS-HA-UBE1L': [1572], 'have': [1573], 'described': [1575, 1760, 2129, 2172, 3578, 3826, 3927], 'previously': [1576, 1761, 2130, 2173], 'pcDNA3-UBC8': [1596], 'pcDNA3-UBE1L': [1598], 'were': [1599, 1687, 1707, 1732, 1748, 1824, 1944, 1985, 2027, 2052, 2063, 2096, 2260, 2285, 2307, 2349, 2364, 2372, 2381, 2395, 2414, 2811, 2823, 3295, 3411, 3430, 3439, 3541, 3558, 3575, 3598, 3614, 3692, 3757, 3917, 4008, 4024, 4084, 4273, 4323, 4343, 4352, 4367], 'constructed': [1600], 'subcloning': [1602], 'cDNAs': [1604], 'into': [1609, 1622, 1630, 1648, 1661, 2268, 2340, 3287, 4275], 'pcDNA3.1(+)': [1611], 'vector.': [1612, 2271], 'Human': [1613, 1654, 1883], 'cDNA': [1615, 1643, 1656, 2230], '(Open': [1616, 1644, 1657], 'Biosystems,': [1617], 'Huntsville,': [1618], 'AL)': [1619], 'subcloned': [1621, 1647, 1660], 'pFLAG-CMV2': [1624, 1650, 1663], 'vector': [1625, 1633, 2208, 2338, 2354, 4228], '(Sigma),': [1626, 2080, 2087], 'generating': [1627, 1640, 1652, 1665], 'pFLAG-CMV2-EFP,': [1628], 'pcDNA3': [1632], 'containing': [1634, 1954, 1991, 2976], 'N-terminal': [1636], 'hemagglutinin': [1637], '(HA)': [1638], 'tag,': [1639], 'pcDNA3-HA-EFP.': [1641], 'Biosystems)': [1645, 1658], 'vector,': [1651, 1664], 'pFLAG-CMV2–14-3-3σ.': [1653], 'HHARI': [1655, 4156], 'pFLAG-CMV2-HHARI.': [1666], 'pcDNA3.1(+)-FLAG-Parkin': [1667], 'kind': [1670], 'gift': [1671], 'Dr.': [1673, 1689, 1816, 2113], 'Jian': [1674], 'Feng': [1675], '(State': [1676], 'University': [1677, 1693], 'New': [1679], 'York,': [1680], 'Buffalo,': [1681], 'NY).': [1682], 'Mammalian': [1683], 'HA-14-3-3σ-expressing': [1684], 'pRRS-103': [1685], 'constructs': [1686, 3552, 3608, 3906, 4253, 4292], 'Haian': [1690], 'Fu': [1691, 2439], '(Emory': [1692], 'School': [1694], 'Medicine,': [1696], 'Atlanta,': [1697], 'GA).': [1698], 'Culture': [1700, 1789], 'Transfection—Human': [1702], 'embryonic': [1703], 'kidney': [1704], 'cultured': [1708, 1794, 1825], "Dulbecco's": [1710, 1796], 'modified': [1711, 1797, 2030, 3274, 3718], "Eagle's": [1712, 1798], 'medium': [1713, 1799, 1840], '(Invitrogen)': [1714], '10%': [1716, 1802, 2013], 'fetal': [1717, 1803, 1845], 'bovine': [1718, 1804, 1846], 'serum': [1719, 1805, 1847], '(Hyclone,': [1720], 'Logan,': [1721], 'UT),': [1722], '2': [1724, 1807, 2796, 3993], 'mm': [1725, 1808, 1960, 1997, 2007, 2017, 2036, 2041], 'l-glutamine': [1726], '(Invitrogen).': [1727], 'For': [1728, 1744], 'small-scale': [1729], 'transfection,': [1730, 1746], 'grown': [1733], '6-well': [1735, 2347], 'plates': [1736, 2348], 'transfected': [1738, 1754, 2286, 3542, 3599, 4274], 'using': [1739, 1899, 2661, 2869, 3679, 3697, 4224], 'PolyFect': [1740], 'reagent': [1741, 1901], '(Qiagen': [1742], 'Inc.).': [1743], 'large-scale': [1745], 'plated': [1749], '10-cm': [1751], 'dishes': [1752], 'calcium': [1756], 'phosphate': [1757], 'precipitation': [1758, 2032], '(27.Zhang': [1762], 'Hetherington': [1764], 'C.J.': [1765], 'Chen': [1766], 'H.M.': [1767], 'Tenen': [1768], 'D.G.': [1769], '1994;': [1773, 2990], '14:': [1774], '373-381Crossref': [1775], '(53)': [1778], 'breast': [1783, 2742, 2865], 'cancer': [1784, 2743, 2866], 'line': [1786], '(American': [1787], 'Type': [1788], 'Collection,': [1790], 'Manassas,': [1791], 'VA)': [1792], 'supplemented': [1800], 'l-glutamine.': [1809], 'WM9': [1810, 1893, 2711, 2735, 2858], 'melanoma': [1811, 2708, 2737, 2860], '(kindly': [1813], 'provided': [1814, 2111], 'Meenhard': [1817], 'Herlyn,': [1818], 'Wistar': [1820], 'Institute,': [1821], 'Philadelphia,': [1822], 'PA)': [1823], '2%': [1828, 1844, 2011], 'tumor': [1829], 'medium,': [1830], 'MCDB': [1833], '153': [1834], '(80%;': [1835], 'Sigma)': [1836], 'Leibovitz': [1838], 'L-15': [1839], '(20%;': [1841], 'Invitrogen)': [1842], '1': [1849], 'μg/ml': [1850, 2368], 'insulin': [1851], '(Sigma)': [1852], '(28.Leaman': [1853, 2667], 'D.W.': [1854, 2609, 2668], 'Chawla-Sarkar': [1855, 2610, 2669], 'Jacobs': [1857, 2180, 2612, 2671], 'Vyas': [1859, 2614, 2673], 'Sun': [1861, 2616, 2675], 'Ozdemir': [1863, 2618, 2677], 'Yi': [1865, 2620, 2679], 'Williams': [1867, 2622, 2681], 'B.R.': [1868, 2623, 2682], 'Borden': [1869, 2115, 2182, 2624, 2683], 'E.C.': [1870, 2183, 2625, 2684], 'Interferon': [1872, 2627, 2686, 3654], 'Cytokine': [1873, 2628, 2687], '23:': [1876, 2631, 2690], '745-756Crossref': [1877, 2632, 2691], '(112)': [1880, 2635, 2694], 'IFN-α': [1884], '(Roferon-A)': [1885], 'Roche.': [1888], 'Northern': [1889, 2725, 2783, 2827], 'Blotting—Total': [1890], 'isolated': [1898], 'RNA-Bee': [1900], '(Tel-Test)': [1902], 'according': [1903], "manufacturer's": [1906], 'instructions.': [1907], 'Ten': [1908], 'micrograms': [1909], 'total': [1911, 2731, 3406, 3425, 4033, 4037, 4055], 'time': [1915], 'point': [1916], 'separated': [1918], 'formaldehyde-agarose': [1921], 'gel': [1922], '(0.22': [1923], 'm),': [1924], 'blotted': [1925], 'onto': [1926], 'Hybond': [1927], 'N+': [1928], 'membrane': [1929], '(Amersham': [1930, 2060], 'Biosciences),': [1931, 2090], 'probed': [1933], '32P-labeled': [1935], 'cDNAs.': [1936], 'Nickel-Nitrilotriacetic': [1937], 'Acid': [1938], '(Ni-NTA)-Agarose': [1939], 'Purification—Forty-eight': [1940], 'hours': [1941, 2024, 2361], 'post-transfection,': [1942, 2025], 'washed': [1945, 1986, 2064, 2373, 4344], 'saline': [1948], '(PBS)': [1949], 'lysed': [1951, 2028], 'PBS': [1953, 1990], '1%': [1955, 1992, 2043], 'Nonidet': [1956, 1993, 2044], 'P-40': [1957, 1994], '10': [1959], 'imidazole.': [1961], 'Ni-NTA-agarose': [1962, 3920], 'beads': [1963], '(20': [1964], 'μl;': [1965], 'Qiagen': [1966], 'Inc.)': [1967], 'then': [1969, 2000], 'added': [1970], 'extracts': [1973, 3355, 3682], '(500': [1974, 3556, 3612], 'μg)': [1975, 3557, 3613], 'rotated': [1977], 'at': [1978, 2795, 2801, 2806, 2843, 2884], 'room': [1979], 'temperature': [1980], '4': [1982, 3381], 'h.': [1983], 'Precipitates': [1984], 'three': [1987, 2065], 'times': [1988, 2066], '20': [1996], 'imidazole': [1998], 'boiled': [2001, 2072], 'SDS-PAGE': [2003, 2074], 'sample': [2004, 2075], 'buffer': [2005, 2034, 2070], '(62.5': [2006], 'Tris-HCl': [2008, 2037], '(pH': [2009, 2038], '6.8),': [2010], 'SDS,': [2012], 'glycerol,': [2014], '100': [2016], 'dithiothreitol).': [2018], 'Immunoprecipitation': [2019], 'Western': [2021, 2167, 2849, 3310, 3415, 3635, 3695, 3924, 4028], 'Blot': [2022], 'Analyses—Forty-eight': [2023], 'radioimmune': [2031], 'assay': [2033], '(50': [2035], '7.6),': [2039], '150': [2040], 'NaCl,': [2042], 'P-40,': [2045], '0.25%': [2046], 'deoxycholate,': [2047], '0.1%': [2049], 'SDS).': [2050], 'Immunocomplexes': [2051], 'precipitated': [2053], 'mixture': [2056, 4283], 'A/G-agarose': [2059], 'Biosciences).': [2061], 'Immunoprecipitates': [2062], 'same': [2069, 3332, 3419], 'buffer.': [2076], 'Antibodies': [2077], 'against': [2078, 3303, 3699], 'FLAG': [2079, 3305], 'HA': [2081], '(Covance': [2082], 'Inc.,': [2083], 'Denver,': [2084], 'PA),': [2085], 'Myc': [2086], '(BD': [2089], '(Upstate,': [2093], 'Chicago,': [2094], 'IL)': [2095], 'purchased': [2097], 'manufacturers.': [2101], 'Mouse': [2102], 'anti-human': [2103], 'monoclonal': [2105], 'antibody': [2106, 2126, 2161, 2871, 3302, 3673, 3678, 3698, 3762], '(clone': [2107, 2162], '5.1)': [2108], 'kindly': [2110], 'Ernest': [2114], '(The': [2116], 'Cleveland': [2117], 'Clinic': [2118], 'Foundation,': [2119], 'Cleveland,': [2120], 'OH).': [2121], 'Rabbit': [2122], 'anti-mouse': [2123, 3675, 3751], 'polyclonal': [2125], '(13.Malakhova': [2131], 'Anti-mouse': [2159], 'IgG1κ': [2160], 'MOPC-21)': [2163], 'Sigma.': [2166], 'blotting': [2168, 2784, 2828, 3416, 3696, 4029], 'performed': [2170, 2729, 2853, 3669], '(29.Malakhov': [2174], 'B.S.': [2181], '16608-16613Abstract': [2191], '(213)': [2199], 'Interference': [2203], 'EFP—The': [2205], 'mammalian': [2206, 2291], 'pSUPER.retro.puro': [2209, 2270, 2353], '(OligoEngine,': [2210], 'Seattle,': [2211], 'WA)': [2212], 'constructing': [2216], '(shRNA)': [2220], 'EFP.': [2222], 'targeted': [2224], 'sequences': [2225], 'siRNA': [2227, 4177, 4222, 4252, 4291, 4314], 'regions': [2231, 2903], '1158–1176': [2232], '(ggaaaagaaatccaagaaa;': [2233], 'siRNA1)': [2234], '711–729': [2236], '(ggtggagcagctacaacaa;': [2237], 'siRNA2).': [2238], 'synthesized': [2240, 2249], 'oligonucleotides': [2241, 2250, 2259], 'siRNA1': [2243], '5′-Gatccccggaaaagaaatccaagaaattcaagagatttcttggatttcttttccttttta-3′': [2245], '5′-Agcttaaaaaggaaaagaaatccaagaaatctcttgaatttcttggatttcttttccggg-3′;': [2247], 'siRNA2': [2252], '5′-Gatccccggtggagcagctacaacaattcaagagattgttgtagctgctccaccttttta-3′': [2254], '5′-Agcttaaaaaggtggagcagctacaacaatctcttgaattgttgtagctgctccaccggg-3′.': [2256], 'annealed': [2258], 'digested': [2261], 'BglII': [2263], 'HindIII': [2265], 'inserted': [2267], 'To': [2272, 2312, 2714, 2835, 3268, 4060, 4308], 'test': [2273, 2313], 'efficiency': [2275], 'shRNA': [2278, 2289, 2318, 2358, 4383, 4390], 'cotransfection': [2281, 2329], 'experiments,': [2282], 'pSUPER-EFP': [2288, 2331, 2357], 'plasmids': [2293, 3393], 'encoding': [2294], 'FLAG-14-3-3σ': [2295, 3286, 3892, 3979, 4034, 4272], 'His-ISG15.': [2297], 'analyzed': [2308, 2825, 3576, 3693, 4025], '48': [2309, 2403], 'h': [2310, 2810, 2886], 'post-transfection.': [2311], 'effect': [2315, 3886], 'packaged': [2326], 'retrovirus': [2327, 2355], 'shRNAs': [2332], 'amphotropic': [2335], 'retroviral': [2336, 4226], 'packaging': [2337], 'pCL-10A1': [2339], 'seeded': [2345], 'infected': [2350, 4324], 'control': [2352, 2832, 3677, 3753], 'retrovirus.': [2359], 'Twenty-four': [2360], 'post-infection,': [2362], 'selected': [2365], '6': [2367, 3383, 4158], 'puromycin.': [2369], 'Dead': [2370], 'out': [2374, 4345], 'attached': [2378, 4349], 'live': [2379, 4350], 'amplified,': [2382, 4353], 'resulting': [2383, 4354], 'stable': [2385, 3482, 4356], 'shRNA-expressing': [2386, 4357], 'pools.': [2388, 4359], 'different': [2392], 'pools': [2394], 'treated': [2396], '1000': [2398], 'units/ml': [2399], 'human': [2400, 2707, 2736, 2741, 2859, 2864, 3030, 3688, 3700], 'IFN-α.': [2401, 3689], 'After': [2402, 4337, 4395], 'h,': [2404, 2797], 'analyzed.': [2415], 'Is': [2417], 'Up-regulated': [2418], 'IFN': [2420, 2502, 2723, 2793, 2874, 2899, 2966, 3081], 'Treatment—Because': [2421], 'primary': [2423], 'tertiary': [2425], 'structures': [2426], 'those': [2432], '(30.Narasimhan': [2435], 'Wang': [2437], 'Z.': [2440], 'Klein': [2441], 'Haas': [2443], 'J.-J.P.': [2446], '280:': [2451], '27356-27365Abstract': [2452], '(155)': [2460], 'predicted': [2479, 3713], 'involve': [2481], 'enzymes.': [2490], 'Notably,': [2491, 3740], 'induced': [2500, 2897, 3079], 'stimulation.': [2503], '(i.e.': [2513], 'UBC8)': [2518], 'IFN-inducible': [2520, 2577], '(6.Ritchie': [2522, 2922], '31.Kim': [2538], 'Hoebe': [2542], 'Beutler': [2546], 'Immunol.': [2551], '175:': [2553], '847-854Crossref': [2554], '(77)': [2557], 'We': [2560, 3830, 3877, 4215], 'hypothesized': [2561, 2654], 'may': [2572], 'encoded': [2575], 'genes.': [2578], 'published': [2581], 'reports': [2582], '(24.Urano': [2583, 3123, 3168], '28.Leaman': [2608], 'available': [2639], 'Web': [2642], 'sites,': [2643], 'candidate': [2647], '(EFP)': [2649], 'fully': [2651], 'matched': [2652, 3337], 'criteria.': [2655], 'gene': [2657, 2753, 2973, 3032], 'profiling': [2659], 'studies': [2660], 'oligonucleotide': [2662], 'array,': [2663], 'Leaman': [2664], 'showed': [2697, 2785, 2872], 'genes': [2705, 2905], 'lines': [2710], 'WM35.': [2713], 'determine': [2715, 2836, 3269, 3659], 'whether': [2716, 2837, 3270, 3660, 3866, 4200, 4250], 'mRNA': [2718, 2788, 2804, 2821], 'truly': [2720], 'up-regulated': [2721, 2791], 'blot': [2726, 2850, 3311], 'prepared': [2733, 2856], 'estrogen-inducible': [2752], '(32.Ikeda': [2757, 3033], 'Orimo': [2761, 3037], 'Sano': [2763, 3039], 'Watanabe': [2765, 3041], 'Tsutsumi': [2767, 3043], '236:': [2776, 3052], '765-771Crossref': [2777, 3053], '(16)': [2780, 3056], 'could': [2789, 3272, 3831, 4254], 'treatment': [2794, 3082], 'reaching': [2798, 2881], 'maximum': [2800, 2883], '∼5h.': [2802], 'levels': [2805, 2822, 3407, 3426, 3435, 3447, 4004, 4016, 4035, 4295, 4361], '8': [2807], '24': [2809], 'still': [2812, 3513], 'higher': [2813, 3434, 3446, 4003, 4015], 'than': [2814], 'basal': [2816], 'level': [2817, 2845, 2878, 4046, 4377, 4400], '(Fig.': [2818, 2833, 2887, 3361, 3377, 3401, 3451, 3763, 3947, 3990, 4306], '1A).': [2819, 2834], 'positive': [2831, 2891], 'induction': [2839], 'expression,': [2848], 'lysates': [2855, 4023], 'Immunodetection': [2868], 'EFP-specific': [2870], 'increased': [2875, 3370, 3395, 3959, 3987, 4044, 4163], '∼8': [2885], '1B).': [2888], 'As': [2889, 3020, 3316, 3704, 3765, 3926, 3999, 4140, 4369], 'control,': [2892], 'promoter': [2902, 2961, 3069], 'related': [2906], 'including': [2910], 'UBC8,': [2915, 3548], 'contain': [2916], 'element': [2920], '(ISRE)': [2921], '16.Kim': [2938], 'responsible': [2959], 'activation': [2962], 'via': [2967, 3153, 3630], 'factor-3': [2974], 'complex': [2975], 'phosphorylated': [2977], 'Stat1,': [2978], 'Stat2,': [2979], 'IRF9': [2981], '(33.Darnell': [2982], 'J.E.': [2984], 'Kerr': [2985], 'I.M.': [2986], 'Stark': [2987], 'G.R.': [2988], 'Science.': [2989, 4238], '264:': [2991], '1415-1421Crossref': [2992], '(5028)': [2995], '34.Fujii': [2998], 'Shimizu': [3000], 'Kusumoto': [3002], 'Kyogoku': [3004], 'Taniguchi': [3006], 'Hakoshima': [3008], '18:': [3013], '5028-5041Crossref': [3014], '(175)': [3017], 'Fig.': [3023, 3319, 3464, 3583, 3707, 3768, 3800, 3810, 3828, 4001, 4143, 4372], '1C,': [3024], '5′-flanking': [3026], 'region': [3027], 'ISRE': [3062, 3072], 'sequence.': [3063], 'facts': [3065, 3254], 'involvement': [3085], 'ISGylation.': [3091, 3595, 3891, 4059, 4176], 'Can': [3093, 3648], 'Be': [3094, 3649], 'Modified': [3095, 3650], 'Transfection': [3101], 'System—EFP': [3102], 'finger-type': [3107], 'directs': [3112], 'ubiquitination': [3114], 'promotes': [3116], 'proteolysis': [3118], 'proteasome-dependent': [3121], 'manner': [3122, 4305], 'mediates': [3159], 'E2-conjugating': [3201], '17.Zhao': [3222], 'cotransfected': [3278, 3356], 'plasmid': [3279], 'DNA': [3280], 'expressing': [3281], 'His-ISG15,': [3282, 3901, 3938, 3983], 'UbcM8,': [3284], 'His-ISG15': [3290, 3550, 3606, 4270], 'covalently': [3292], 'linked': [3293], 'enriched': [3296, 3918], 'Ni-NTA': [3298, 3324, 3443, 3525, 3561, 3617, 4012], 'pull': [3299, 3562, 3618], 'down,': [3300], 'epitope': [3306], 'detect': [3314, 3833], '2,': [3320, 3362, 3378, 3402, 3452, 4002], 'associated': [3322], 'resin': [3325, 3526], 'independently': [3326], 'modification.': [3329], 'At': [3330], 'time,': [3333], 'band': [3335, 3350, 3376, 3775, 3792, 3797], 'molecular': [3339, 3714, 3803], 'mass': [3340, 3715, 3804], 'single': [3343, 3721], 'ISG15-conjugated': [3344], 'detected.': [3348], 'observed': [3352, 3745], 'lane': [3363, 3385, 3403, 3455, 3949], '2).': [3364, 3386], 'intensity': [3372], 'additional': [3375, 3774], 'compare': [3379], 'lanes': [3380, 3992], 'Cotransfection': [3387, 4288], 'ISG15-modified': [3397], 'form': [3398, 3473, 3514], '8).': [3404, 3456], 'determined': [3412], 'direct': [3414], 'experiments.': [3422], 'Although': [3423, 4041], 'quite': [3431], 'equal,': [3432], 'significantly': [3433, 4043], 'unmodified': [3437, 3517, 3771, 4006], 'pulled': [3440, 3522, 4009], 'down': [3441, 3523, 3563, 3619, 4010], 'accompanied': [3444, 4013], 'ISGylated': [3449, 3510, 3915, 3929, 3955, 4018, 4048, 4166], 'example,': [3454], 'result': [3458], 'very': [3460, 3481], 'repeatable': [3461], '(also': [3462], 'see': [3463], '4).': [3465], 'It': [3466, 3506], '14-3-3': [3470, 3477, 4365], 'dimers': [3474, 3515], 'dimeric': [3478], 'structure': [3479], '(35.Xiao': [3483], 'Smerdon': [3485], 'S.J.': [3486, 3496], 'D.H.': [3488], 'Dodson': [3489], 'G.G.': [3490], 'Soneji': [3491], 'Aitken': [3493], 'Gamblin': [3495], '1995;': [3498], '376:': [3499], '188-191Crossref': [3500], '(400)': [3503], 'likely': [3508], '14-3-3σ,': [3518, 3772, 4049, 4071, 4167, 4320], 'through': [3527, 4220], 'His-ISG15/14-3-3σ.FIGURE': [3531], '4EFP': [3532], 'enhances': [3533], 'A,': [3538], 'FLAG-14-3-3σ,': [3544], 'HA-EFP,': [3545], 'indicated.': [3554, 3610], 'Proteins': [3555, 3611], 'subjected': [3559, 3615, 3664], 'Western-blotted': [3565, 3621], '(WB)': [3566], 'anti-FLAG': [3568], 'antibody.': [3569, 3624, 3754], 'Protein': [3570], 'legend': [3581], '4.': [3584], 'B,': [3585], '(but': [3587], 'Parkin': [3589, 4081, 4154], 'HHARI)': [3591], 'HA-14-3-3σ,': [3601], 'FLAG-EFP,': [3602], 'FLAG-Parkin,': [3603], 'FLAG-HHARI,': [3604], 'anti-HA': [3623], 'these': [3628, 4251], 'examined': [3633, 4085], 'blotting.': [3636, 3925], 'Conj.,': [3637], 'conjugate.View': [3638], 'Large': [3639], 'Image': [3640], 'Figure': [3641], 'ViewerDownload': [3642], 'Hi-res': [3643], 'image': [3644], 'Download': [3645], '(PPT)': [3646], 'Treatment': [3655], 'Cells—To': [3658], 'endogenous': [3661, 4319], 'immunoprecipitation': [3670], 'anti-14-3-3σ': [3672, 3761], 'IgG1': [3676, 3752], 'without': [3685, 3942], 'stimulation': [3686], 'immunoprecipitates': [3691, 3748, 3756], '3A,': [3708], 'species': [3710, 3819], 'moiety': [3723], '(28': [3724], '+': [3725], '17': [3726], 'kDa)': [3727], 'detected': [3729, 3759, 3777, 3798, 3820, 3922, 3932, 3977], 'IFN-treated': [3732, 3780, 3839, 4213], 'sample,': [3733], 'untreated': [3738, 3786, 4393], 'one.': [3739, 3787], '14-3-3σ/ISG15': [3741, 3807], '3B).': [3764], '3B,': [3769], 'besides': [3770], 'samples,': [3781], 'size': [3789], 'corresponds': [3793, 3812], '3A.': [3801], 'conjugate': [3808], '3': [3811], '2.': [3829], 'A549': [3843], '(data': [3845, 3996], 'shown).': [3847, 3998], 'Promotes': [3849], '14-3-3σ—The': [3852], 'observation': [3853], 'prompted': [3862], 'us': [3863], 'investigate': [3865, 4309], 'examine': [3884, 4061], 'expressed': [3894], 'along': [3898], 'absence': [3909], 'presence': [3911], 'HA-EFP.': [3913], 'above,': [3928], 'when': [3933, 3978], 'coexpressed': [3936, 3981], 'addition': [3944], 'HA-EFP': [3946, 3961], '4A,': [3948, 3991], '4);': [3950], 'however,': [3951], 'amount': [3953, 4056], 'dramatically': [3958], '(lane': [3963, 4150], '5).': [3964], 'On': [3965], 'film': [3966], 'longer': [3968], 'exposure': [3969], 'times,': [3970], 'ISGy-lated': [3972], '3)': [3995], 'whole': [4021], 'directly': [4026], 'determination': [4031], 'levels.': [4040], 'did': [4051], 'enhance': [4053], 'specificity': [4063, 4170], 'supporting': [4067, 4174], 'ligases,': [4080], '(20.Moynihan': [4086], '4B,': [4144], '4),': [4151], '(lanes': [4157], '8),': [4160], 'resulted': [4161], 'accumulation': [4164], 'demonstrating': [4168], '14–3-4σ': [4175], 'Decreases': [4180], '14-3-3σ—After': [4185], 'showing': [4186], 'supports': [4189], 'assays,': [4196], 'further': [4198], 'tested': [4199, 4249], 'depletion': [4202], 'vivo': [4204], 'would': [4205], 'cause': [4206], 'decrease': [4208, 4255], 'reduced': [4216, 4293], 'approach': [4223], '(pSUPER-EFP1': [4229], 'pSUPER-EFP2)': [4231], '(36.Brummelkamp': [4232], 'T.R.': [4233], 'Bernards': [4234], 'Agami': [4236], '296:': [4240], '550-553Crossref': [4241], '(3968)': [4244], 'First,': [4247], 'Plasmids': [4268], 'increasing': [4279], 'amounts': [4280], 'pSUPER-EFP1': [4285, 4326, 4389], 'pSUPER-EFP2.': [4287], 'dose-dependent': [4304], '5A).': [4307], 'effects': [4311], 'pSUPER-EFP2': [4328, 4382], 'retroviruses': [4329], 'puromycin': [4334, 4338], 'selection': [4335], 'marker.': [4336], 'selection,': [4339], 'dead': [4341], 'examined.': [4368], '5B,': [4373], 'inhibited': [4380, 4387], 'weakly': [4386], 'up-regulated,': [4404]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1985146373', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 18}, {'year': 2022, 'cited_by_count': 20}, {'year': 2021, 'cited_by_count': 19}, {'year': 2020, 'cited_by_count': 21}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2024-12-10T03:05:43.808902', 'created_date': '2016-06-24'}