Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1984907812', 'doi': 'https://doi.org/10.1158/1538-7445.am2013-4084', 'title': 'Abstract 4084: Resveratrol attenuates prostate cancer growth by inhibiting insulin-like growth factor-1 receptor signaling.', 'display_name': 'Abstract 4084: Resveratrol attenuates prostate cancer growth by inhibiting insulin-like growth factor-1 receptor signaling.', 'publication_year': 2013, 'publication_date': '2013-04-01', 'ids': {'openalex': 'https://openalex.org/W1984907812', 'doi': 'https://doi.org/10.1158/1538-7445.am2013-4084', 'mag': '1984907812'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2013-4084', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5038145358', 'display_name': 'Sandeep Sheth', 'orcid': 'https://orcid.org/0000-0001-6570-8120'}, 'institutions': [{'id': 'https://openalex.org/I196729704', 'display_name': 'Southern Illinois University School of Medicine', 'ror': 'https://ror.org/0232r4451', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196729704', 'https://openalex.org/I2801502357']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sandeep Sheth', 'raw_affiliation_strings': ['Southern Illinois Univ. School of Medicine, Springfield, IL.'], 'affiliations': [{'raw_affiliation_string': 'Southern Illinois Univ. School of Medicine, Springfield, IL.', 'institution_ids': ['https://openalex.org/I196729704']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018100467', 'display_name': 'Sarvesh Jajoo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196729704', 'display_name': 'Southern Illinois University School of Medicine', 'ror': 'https://ror.org/0232r4451', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196729704', 'https://openalex.org/I2801502357']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sarvesh Jajoo', 'raw_affiliation_strings': ['Southern Illinois Univ. School of Medicine, Springfield, IL.'], 'affiliations': [{'raw_affiliation_string': 'Southern Illinois Univ. School of Medicine, Springfield, IL.', 'institution_ids': ['https://openalex.org/I196729704']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041281654', 'display_name': 'Debashree Mukherjea', 'orcid': 'https://orcid.org/0000-0001-5092-9860'}, 'institutions': [{'id': 'https://openalex.org/I196729704', 'display_name': 'Southern Illinois University School of Medicine', 'ror': 'https://ror.org/0232r4451', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196729704', 'https://openalex.org/I2801502357']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Debashree Mukherjea', 'raw_affiliation_strings': ['Southern Illinois Univ. School of Medicine, Springfield, IL.'], 'affiliations': [{'raw_affiliation_string': 'Southern Illinois Univ. School of Medicine, Springfield, IL.', 'institution_ids': ['https://openalex.org/I196729704']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063716997', 'display_name': 'Kelly Sheehan', 'orcid': 'https://orcid.org/0000-0001-8131-2820'}, 'institutions': [{'id': 'https://openalex.org/I196729704', 'display_name': 'Southern Illinois University School of Medicine', 'ror': 'https://ror.org/0232r4451', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196729704', 'https://openalex.org/I2801502357']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kelly Sheehan', 'raw_affiliation_strings': ['Southern Illinois Univ. School of Medicine, Springfield, IL.'], 'affiliations': [{'raw_affiliation_string': 'Southern Illinois Univ. School of Medicine, Springfield, IL.', 'institution_ids': ['https://openalex.org/I196729704']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052036878', 'display_name': 'Leonard P. Rybak', 'orcid': 'https://orcid.org/0000-0002-9365-5924'}, 'institutions': [{'id': 'https://openalex.org/I196729704', 'display_name': 'Southern Illinois University School of Medicine', 'ror': 'https://ror.org/0232r4451', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196729704', 'https://openalex.org/I2801502357']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Leonard P. Rybak', 'raw_affiliation_strings': ['Southern Illinois Univ. School of Medicine, Springfield, IL.'], 'affiliations': [{'raw_affiliation_string': 'Southern Illinois Univ. School of Medicine, Springfield, IL.', 'institution_ids': ['https://openalex.org/I196729704']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5059572673', 'display_name': 'Vickram Ramkumar', 'orcid': 'https://orcid.org/0000-0001-6852-5303'}, 'institutions': [{'id': 'https://openalex.org/I196729704', 'display_name': 'Southern Illinois University School of Medicine', 'ror': 'https://ror.org/0232r4451', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196729704', 'https://openalex.org/I2801502357']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vickram Ramkumar', 'raw_affiliation_strings': ['Southern Illinois Univ. School of Medicine, Springfield, IL.'], 'affiliations': [{'raw_affiliation_string': 'Southern Illinois Univ. School of Medicine, Springfield, IL.', 'institution_ids': ['https://openalex.org/I196729704']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 65}, 'biblio': {'volume': '73', 'issue': '8_Supplement', 'first_page': '4084', 'last_page': '4084'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.7908, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.7908, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.6959, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2776816829', 'wikidata': 'https://www.wikidata.org/wiki/Q407329', 'display_name': 'Resveratrol', 'level': 2, 'score': 0.8294205}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.8011049}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.6437979}, {'id': 'https://openalex.org/C2780689927', 'wikidata': 'https://www.wikidata.org/wiki/Q24766801', 'display_name': 'Insulin-like growth factor', 'level': 4, 'score': 0.63843626}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.55605024}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.5535159}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5350581}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.48055318}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.4792509}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.45659694}, {'id': 'https://openalex.org/C88634738', 'wikidata': 'https://www.wikidata.org/wiki/Q24769543', 'display_name': 'Annexin', 'level': 3, 'score': 0.43981737}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42805198}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.38337457}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.37657523}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23696876}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.23628592}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.1603916}, {'id': 'https://openalex.org/C74864618', 'wikidata': 'https://www.wikidata.org/wiki/Q2332446', 'display_name': 'Staining', 'level': 2, 'score': 0.06799132}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.04732907}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2013-4084', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.8, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2982823661', 'https://openalex.org/W2800670286', 'https://openalex.org/W2590769241', 'https://openalex.org/W2189320406', 'https://openalex.org/W2130733926', 'https://openalex.org/W2121592873', 'https://openalex.org/W2099817208', 'https://openalex.org/W2058160713', 'https://openalex.org/W2044196034', 'https://openalex.org/W2014231481'], 'abstract_inverted_index': {'Abstract': [0], 'Introduction:': [1], 'Prostate': [2], 'cancer': [3, 9, 18, 117, 169, 368, 420], 'is': [4, 22, 38, 60], 'the': [5, 11, 42, 95, 146, 192, 207, 214, 223, 233, 240, 289, 298, 334, 347, 356, 386, 433, 438], 'most': [6], 'commonly': [7], 'diagnosed': [8], 'in': [10, 153, 163, 170, 181, 270, 309, 338, 353, 355, 370, 375], 'United': [12], 'States.': [13], 'The': [14], 'etiology': [15], 'of': [16, 33, 44, 98, 148, 159, 167, 194, 216, 225, 228, 235, 242, 254, 258, 268, 274, 291, 300, 307, 330, 336, 343, 349, 392, 432, 437], 'prostate': [17, 45, 101, 116, 168, 367, 400, 419], 'development': [19], 'and': [20, 133, 138, 150, 184, 202, 221, 238, 251, 266, 297, 302, 327, 332, 351], 'progression': [21], 'not': [23], 'very': [24], 'clear.': [25], 'Accumulating': [26], 'evidence': [27], 'suggests': [28], 'that': [29, 312, 363, 385], 'an': [30], 'elevated': [31], 'level': [32], 'insulin-like': [34, 424], 'growth': [35, 43, 369, 421, 425], 'factor-1': [36, 426], '(IGF-1)': [37], 'positively': [39], 'associated': [40, 261], 'with': [41, 262, 276, 316, 346], 'cancer.': [46, 102, 401], 'IGF-1': [47, 149, 217, 331], 'exerts': [48], 'its': [49, 55, 90, 396], 'mitogenic': [50], 'effect': [51], 'by': [52, 93, 124, 131, 188, 230, 377, 422], 'binding': [53], 'to': [54, 72, 144], 'receptor,': [56], 'IGF-1R,': [57], 'whose': [58], 'expression': [59, 241, 299], 'also': [61, 324], 'increased': [62, 239], 'during': [63], 'tumor': [64, 195, 208, 321, 328, 357], 'growth.': [65, 196, 322], 'Resveratrol,': [66], 'a': [67, 164, 248, 252, 389], 'phytoalexin,': [68], 'has': [69], 'been': [70], 'shown': [71], 'possess': [73], 'anti-cancer': [74], 'action': [75], 'against': [76, 281, 399], 'various': [77], 'cancers': [78], 'through': [79], 'unknown': [80], 'mechanism/s.': [81], 'In': [82, 104, 156], 'this': [83], 'study,': [84], 'we': [85], 'examined': [86], 'whether': [87], 'resveratrol': [88, 160, 185, 231, 259, 292, 308, 364, 393], 'mediates': [89], 'anti-tumor': [91, 397], 'effects': [92, 257], 'inhibiting': [94, 423], 'trophic': [96], 'actions': [97, 398], 'IGF-1/IGF-1R': [99, 344, 379], 'on': [100, 109, 206, 293], 'Methods:': [103], 'vitro': [105, 371], 'studies': [106], 'were': [107, 142, 178, 199, 260, 313], 'performed': [108, 143, 205], 'highly': [110], 'aggressive': [111], 'androgen': [112], 'receptor': [113, 427], 'negative': [114], 'human': [115], 'cells,': [118], 'PC-3M-MM2.': [119], 'Cell': [120], 'viability': [121, 265], 'was': [122, 129, 161, 186, 204], 'assessed': [123], 'MTS': [125], 'assays,': [126], 'while': [127], 'apoptosis': [128, 269, 296], 'determined': [130], 'Annexin-FITC': [132], 'PI': [134], 'staining.': [135], 'Additionally,': [136], 'ELISA': [137], 'western': [139], 'blotting': [140], 'techniques': [141], 'examine': [145], 'levels': [147, 329], 'protein': [151, 250], 'involved': [152], 'IGF-axis,': [154], 'respectively.': [155], 'vivo': [157, 376], 'efficacy': [158], 'tested': [162], 'xenograft': [165], 'model': [166], 'severe': [171], 'combined': [172], 'immunodeficient': [173], '(SCID)': [174], 'mice.': [175], 'PC-3M-MM2': [176, 219, 271, 317], 'cells': [177, 220, 275, 318], 'subcutaneously': [179, 314], 'injected': [180, 315], 'these': [182, 339], 'mice': [183, 311], 'administered': [187], 'oral': [189, 305], 'gavage': [190], 'for': [191, 394, 441], 'assessment': [193], 'Primary': [197], 'tumors': [198], 'then': [200], 'excised': [201], 'immunohistochemistry': [203], 'sections.': [209], 'Results:': [210], 'Resveratrol': [211, 323, 417], 'significantly': [212], 'inhibited': [213, 333], 'release': [215], 'from': [218], 'reduced': [222, 263, 325], 'activation': [224, 234, 335], 'IGF-1R.': [226], 'Inhibition': [227], 'IGF-1R': [229, 282, 337], 'suppressed': [232, 319, 366], 'Akt': [236], '(pAkt)': [237], 'programmed': [243], 'cell': [244, 264, 294], 'death': [245], '4': [246], '(PDCD4),': [247], 'pro-apoptotic': [249], 'target': [253, 391], 'Akt.': [255], 'These': [256, 382], 'induction': [267], 'cells.': [272], 'Treatment': [273], 'short': [277], 'interfering': [278], '(si)': [279], 'RNA': [280], 'or': [283], 'PI3': [284], 'kinase': [285], 'inhibitor': [286], '(LY294002)': [287], 'mimicked': [288], 'response': [290], 'viability,': [295], 'pAkt': [301, 350], 'PDCD4.': [303], 'Furthermore,': [304], 'administration': [306], 'SCID': [310], 'subsequent': [320], 'serum': [326], 'tumors.': [340], 'This': [341], 'modulation': [342], 'coincided': [345], 'inhibition': [348], 'increase': [352], 'PDCD4': [354], 'tissue.': [358], 'Conclusion:': [359], 'Our': [360], 'results': [361], 'indicate': [362], 'effectively': [365], 'as': [372, 374], 'well': [373], 'attenuating': [378], 'signaling': [380], 'pathway.': [381], 'data': [383], 'demonstrate': [384], 'IGF/IGF-1R': [387], 'represent': [388], 'relevant': [390], 'mediating': [395], 'Citation': [402], 'Format:': [403], 'Sandeep': [404], 'Sheth,': [405], 'Sarvesh': [406], 'Jajoo,': [407], 'Debashree': [408], 'Mukherjea,': [409], 'Kelly': [410], 'Sheehan,': [411], 'Leonard': [412], 'P.': [413], 'Rybak,': [414], 'Vickram': [415], 'Ramkumar.': [416], 'attenuates': [418], 'signaling.': [428], '[abstract].': [429], 'In:': [430], 'Proceedings': [431], '104th': [434], 'Annual': [435], 'Meeting': [436], 'American': [439], 'Association': [440], 'Cancer': [442, 452], 'Research;': [443], '2013': [444], 'Apr': [445], '6-10;': [446], 'Washington,': [447], 'DC.': [448], 'Philadelphia': [449], '(PA):': [450], 'AACR;': [451], 'Res': [453], '2013;73(8': [454], 'Suppl):Abstract': [455], 'nr': [456], '4084.': [457], 'doi:10.1158/1538-7445.AM2013-4084': [458]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1984907812', 'counts_by_year': [], 'updated_date': '2024-12-08T13:08:41.338247', 'created_date': '2016-06-24'}