Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1984881453', 'doi': 'https://doi.org/10.1097/00003246-200002000-00027', 'title': 'Coagulation system and platelets are fully activated in uncomplicated sepsis', 'display_name': 'Coagulation system and platelets are fully activated in uncomplicated sepsis', 'publication_year': 2000, 'publication_date': '2000-02-01', 'ids': {'openalex': 'https://openalex.org/W1984881453', 'doi': 'https://doi.org/10.1097/00003246-200002000-00027', 'mag': '1984881453', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10708182'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/00003246-200002000-00027', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S108732581', 'display_name': 'Critical Care Medicine', 'issn_l': '0090-3493', 'issn': ['0090-3493', '1530-0293'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054071885', 'display_name': 'Antonis Mavrommatis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200777214', 'display_name': 'National and Kapodistrian University of Athens', 'ror': 'https://ror.org/04gnjpq42', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I200777214']}, {'id': 'https://openalex.org/I4210166445', 'display_name': 'Evangelismos Hospital', 'ror': 'https://ror.org/05q4veh78', 'country_code': 'GR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166445']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Antonis C. Mavrommatis', 'raw_affiliation_strings': ['the Department of Critical Care and Pulmonary Services (Drs. Mavrommatis, Roussos, Zakynthinos), University of Athens Medical School, and the Hematology Laboratory (Drs. Theodoridis, Orfanidou, Christopoulou-Kokkinou), Evangelismos Hospital, Athens, Greece.'], 'affiliations': [{'raw_affiliation_string': 'the Department of Critical Care and Pulmonary Services (Drs. Mavrommatis, Roussos, Zakynthinos), University of Athens Medical School, and the Hematology Laboratory (Drs. Theodoridis, Orfanidou, Christopoulou-Kokkinou), Evangelismos Hospital, Athens, Greece.', 'institution_ids': ['https://openalex.org/I200777214', 'https://openalex.org/I4210166445']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047140890', 'display_name': 'Thodoris Theodoridis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200777214', 'display_name': 'National and Kapodistrian University of Athens', 'ror': 'https://ror.org/04gnjpq42', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I200777214']}, {'id': 'https://openalex.org/I4210166445', 'display_name': 'Evangelismos Hospital', 'ror': 'https://ror.org/05q4veh78', 'country_code': 'GR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166445']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Thodoris Theodoridis', 'raw_affiliation_strings': ['the Department of Critical Care and Pulmonary Services (Drs. Mavrommatis, Roussos, Zakynthinos), University of Athens Medical School, and the Hematology Laboratory (Drs. Theodoridis, Orfanidou, Christopoulou-Kokkinou), Evangelismos Hospital, Athens, Greece.'], 'affiliations': [{'raw_affiliation_string': 'the Department of Critical Care and Pulmonary Services (Drs. Mavrommatis, Roussos, Zakynthinos), University of Athens Medical School, and the Hematology Laboratory (Drs. Theodoridis, Orfanidou, Christopoulou-Kokkinou), Evangelismos Hospital, Athens, Greece.', 'institution_ids': ['https://openalex.org/I200777214', 'https://openalex.org/I4210166445']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068205813', 'display_name': 'Androula Orfanidou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200777214', 'display_name': 'National and Kapodistrian University of Athens', 'ror': 'https://ror.org/04gnjpq42', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I200777214']}, {'id': 'https://openalex.org/I4210166445', 'display_name': 'Evangelismos Hospital', 'ror': 'https://ror.org/05q4veh78', 'country_code': 'GR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166445']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Androula Orfanidou', 'raw_affiliation_strings': ['the Department of Critical Care and Pulmonary Services (Drs. Mavrommatis, Roussos, Zakynthinos), University of Athens Medical School, and the Hematology Laboratory (Drs. Theodoridis, Orfanidou, Christopoulou-Kokkinou), Evangelismos Hospital, Athens, Greece.'], 'affiliations': [{'raw_affiliation_string': 'the Department of Critical Care and Pulmonary Services (Drs. Mavrommatis, Roussos, Zakynthinos), University of Athens Medical School, and the Hematology Laboratory (Drs. Theodoridis, Orfanidou, Christopoulou-Kokkinou), Evangelismos Hospital, Athens, Greece.', 'institution_ids': ['https://openalex.org/I200777214', 'https://openalex.org/I4210166445']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059236085', 'display_name': 'Charis Roussos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210166445', 'display_name': 'Evangelismos Hospital', 'ror': 'https://ror.org/05q4veh78', 'country_code': 'GR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166445']}, {'id': 'https://openalex.org/I200777214', 'display_name': 'National and Kapodistrian University of Athens', 'ror': 'https://ror.org/04gnjpq42', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I200777214']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Charis Roussos', 'raw_affiliation_strings': ['the Department of Critical Care and Pulmonary Services (Drs. Mavrommatis, Roussos, Zakynthinos), University of Athens Medical School, and the Hematology Laboratory (Drs. Theodoridis, Orfanidou, Christopoulou-Kokkinou), Evangelismos Hospital, Athens, Greece.'], 'affiliations': [{'raw_affiliation_string': 'the Department of Critical Care and Pulmonary Services (Drs. Mavrommatis, Roussos, Zakynthinos), University of Athens Medical School, and the Hematology Laboratory (Drs. Theodoridis, Orfanidou, Christopoulou-Kokkinou), Evangelismos Hospital, Athens, Greece.', 'institution_ids': ['https://openalex.org/I4210166445', 'https://openalex.org/I200777214']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001230595', 'display_name': 'Vana Christopoulou-Kokkinou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210166445', 'display_name': 'Evangelismos Hospital', 'ror': 'https://ror.org/05q4veh78', 'country_code': 'GR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166445']}, {'id': 'https://openalex.org/I200777214', 'display_name': 'National and Kapodistrian University of Athens', 'ror': 'https://ror.org/04gnjpq42', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I200777214']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Vana Christopoulou-Kokkinou', 'raw_affiliation_strings': ['the Department of Critical Care and Pulmonary Services (Drs. Mavrommatis, Roussos, Zakynthinos), University of Athens Medical School, and the Hematology Laboratory (Drs. Theodoridis, Orfanidou, Christopoulou-Kokkinou), Evangelismos Hospital, Athens, Greece.'], 'affiliations': [{'raw_affiliation_string': 'the Department of Critical Care and Pulmonary Services (Drs. Mavrommatis, Roussos, Zakynthinos), University of Athens Medical School, and the Hematology Laboratory (Drs. Theodoridis, Orfanidou, Christopoulou-Kokkinou), Evangelismos Hospital, Athens, Greece.', 'institution_ids': ['https://openalex.org/I4210166445', 'https://openalex.org/I200777214']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5015585526', 'display_name': 'Spyros Zakynthinos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210166445', 'display_name': 'Evangelismos Hospital', 'ror': 'https://ror.org/05q4veh78', 'country_code': 'GR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166445']}, {'id': 'https://openalex.org/I200777214', 'display_name': 'National and Kapodistrian University of Athens', 'ror': 'https://ror.org/04gnjpq42', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I200777214']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Spyros Zakynthinos', 'raw_affiliation_strings': ['Spyros Zakynthinos, MD, Critical Care Department, Evangelismos Hospital, 45-47 Ipsilandou St, GR-10675 Athens, Greece.', 'the Department of Critical Care and Pulmonary Services (Drs. Mavrommatis, Roussos, Zakynthinos), University of Athens Medical School, and the Hematology Laboratory (Drs. Theodoridis, Orfanidou, Christopoulou-Kokkinou), Evangelismos Hospital, Athens, Greece.'], 'affiliations': [{'raw_affiliation_string': 'Spyros Zakynthinos, MD, Critical Care Department, Evangelismos Hospital, 45-47 Ipsilandou St, GR-10675 Athens, Greece.', 'institution_ids': ['https://openalex.org/I4210166445']}, {'raw_affiliation_string': 'the Department of Critical Care and Pulmonary Services (Drs. Mavrommatis, Roussos, Zakynthinos), University of Athens Medical School, and the Hematology Laboratory (Drs. Theodoridis, Orfanidou, Christopoulou-Kokkinou), Evangelismos Hospital, Athens, Greece.', 'institution_ids': ['https://openalex.org/I4210166445', 'https://openalex.org/I200777214']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.931, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 264, 'citation_normalized_percentile': {'value': 0.999928, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '28', 'issue': '2', 'first_page': '451', 'last_page': '457'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10218', 'display_name': 'Epidemiology and Management of Sepsis and Septic Shock', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10218', 'display_name': 'Epidemiology and Management of Sepsis and Septic Shock', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11721', 'display_name': 'Blood Rheology and Coagulation Mechanisms', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10881', 'display_name': 'Thrombosis and Coagulation Disorders', 'score': 0.9928, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/prothrombin-time', 'display_name': 'Prothrombin time', 'score': 0.59994}, {'id': 'https://openalex.org/keywords/coagulation', 'display_name': 'Coagulation', 'score': 0.559742}, {'id': 'https://openalex.org/keywords/sepsis', 'display_name': 'Sepsis', 'score': 0.518804}, {'id': 'https://openalex.org/keywords/beta-thromboglobulin', 'display_name': 'Beta-thromboglobulin', 'score': 0.4817343}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.83225846}, {'id': 'https://openalex.org/C2778261982', 'wikidata': 'https://www.wikidata.org/wiki/Q1755136', 'display_name': 'Partial thromboplastin time', 'level': 3, 'score': 0.7557766}, {'id': 'https://openalex.org/C2778384902', 'wikidata': 'https://www.wikidata.org/wiki/Q183134', 'display_name': 'Sepsis', 'level': 2, 'score': 0.7477581}, {'id': 'https://openalex.org/C2777628635', 'wikidata': 'https://www.wikidata.org/wiki/Q1765564', 'display_name': 'Septic shock', 'level': 3, 'score': 0.631251}, {'id': 'https://openalex.org/C2780434524', 'wikidata': 'https://www.wikidata.org/wiki/Q1144385', 'display_name': 'Prothrombin time', 'level': 2, 'score': 0.59994}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.5902513}, {'id': 'https://openalex.org/C2779026020', 'wikidata': 'https://www.wikidata.org/wiki/Q416336', 'display_name': 'Antithrombin', 'level': 3, 'score': 0.5543022}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5418762}, {'id': 'https://openalex.org/C2778382381', 'wikidata': 'https://www.wikidata.org/wiki/Q179217', 'display_name': 'Coagulation', 'level': 2, 'score': 0.5358618}, {'id': 'https://openalex.org/C159973064', 'wikidata': 'https://www.wikidata.org/wiki/Q3740205', 'display_name': 'Platelet factor 4', 'level': 3, 'score': 0.5269464}, {'id': 'https://openalex.org/C3018697912', 'wikidata': 'https://www.wikidata.org/wiki/Q179217', 'display_name': 'Platelet activation', 'level': 3, 'score': 0.52004004}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.4869948}, {'id': 'https://openalex.org/C2781318281', 'wikidata': 'https://www.wikidata.org/wiki/Q3639099', 'display_name': 'Beta-thromboglobulin', 'level': 4, 'score': 0.4817343}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.38928622}, {'id': 'https://openalex.org/C2777557582', 'wikidata': 'https://www.wikidata.org/wiki/Q190016', 'display_name': 'Heparin', 'level': 2, 'score': 0.093755424}], 'mesh': [{'descriptor_ui': 'D001778', 'descriptor_name': 'Blood Coagulation Disorders', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D001778', 'descriptor_name': 'Blood Coagulation Disorders', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': True}, {'descriptor_ui': 'D015539', 'descriptor_name': 'Platelet Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': True}, {'descriptor_ui': 'D012772', 'descriptor_name': 'Shock, Septic', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D012772', 'descriptor_name': 'Shock, Septic', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000990', 'descriptor_name': 'Antithrombin III', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000990', 'descriptor_name': 'Antithrombin III', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D001778', 'descriptor_name': 'Blood Coagulation Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001780', 'descriptor_name': 'Blood Coagulation Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016022', 'descriptor_name': 'Case-Control Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005344', 'descriptor_name': 'Fibrinopeptide A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005344', 'descriptor_name': 'Fibrinopeptide A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010447', 'descriptor_name': 'Peptide Hydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010447', 'descriptor_name': 'Peptide Hydrolases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010976', 'descriptor_name': 'Platelet Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011446', 'descriptor_name': 'Prospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011498', 'descriptor_name': 'Protein Precursors', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D011498', 'descriptor_name': 'Protein Precursors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011498', 'descriptor_name': 'Protein Precursors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011516', 'descriptor_name': 'Prothrombin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011516', 'descriptor_name': 'Prothrombin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012720', 'descriptor_name': 'Severity of Illness Index', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012772', 'descriptor_name': 'Shock, Septic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012772', 'descriptor_name': 'Shock, Septic', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/00003246-200002000-00027', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S108732581', 'display_name': 'Critical Care Medicine', 'issn_l': '0090-3493', 'issn': ['0090-3493', '1530-0293'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10708182', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.73, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1558653051', 'https://openalex.org/W1567817045', 'https://openalex.org/W1818048824', 'https://openalex.org/W1872858710', 'https://openalex.org/W1970932627', 'https://openalex.org/W1972671359', 'https://openalex.org/W1992644897', 'https://openalex.org/W2002008524', 'https://openalex.org/W2007063402', 'https://openalex.org/W2012022490', 'https://openalex.org/W2018745526', 'https://openalex.org/W2030145547', 'https://openalex.org/W2044331400', 'https://openalex.org/W2045010042', 'https://openalex.org/W2052792411', 'https://openalex.org/W2061235805', 'https://openalex.org/W2067230470', 'https://openalex.org/W2071637551', 'https://openalex.org/W2079008038', 'https://openalex.org/W2079319233', 'https://openalex.org/W2085311523', 'https://openalex.org/W2088870170', 'https://openalex.org/W2104631810', 'https://openalex.org/W2121044470', 'https://openalex.org/W2121779915', 'https://openalex.org/W2151962457', 'https://openalex.org/W2163604359', 'https://openalex.org/W2292173227', 'https://openalex.org/W2315524066', 'https://openalex.org/W2336770370', 'https://openalex.org/W2396849003', 'https://openalex.org/W244306418', 'https://openalex.org/W2915946847', 'https://openalex.org/W4230071474', 'https://openalex.org/W4293242440', 'https://openalex.org/W4324113851', 'https://openalex.org/W45316589'], 'related_works': ['https://openalex.org/W4211117411', 'https://openalex.org/W2811413127', 'https://openalex.org/W2359135438', 'https://openalex.org/W2356362309', 'https://openalex.org/W2110223924', 'https://openalex.org/W2074772071', 'https://openalex.org/W2035952571', 'https://openalex.org/W2029341269', 'https://openalex.org/W1857288271', 'https://openalex.org/W107393773'], 'abstract_inverted_index': {'Objective:': [0], 'To': [1], 'test': [2], 'the': [3, 6, 15, 22, 28, 201, 231, 283, 317], 'hypothesis': [4], 'that': [5], 'coagulation': [7, 104, 127, 132, 244, 247, 264, 270, 318, 327], 'system': [8, 289], 'and': [9, 17, 25, 39, 51, 54, 79, 94, 108, 114, 118, 122, 135, 140, 151, 157, 176, 196, 200, 214, 225, 239, 249, 259, 274, 290, 310, 325, 338], 'platelets': [10, 120, 291], 'are': [11, 292, 320, 329], 'activated': [12, 136, 294], 'in': [13, 31, 36, 62, 236, 242, 254, 261, 295, 307, 312], 'sepsis,': [14, 48, 50, 74, 78, 147], 'uncomplicated': [16], 'usually': [18], 'earliest': [19], 'stage': [20], 'of': [21, 103, 116, 119, 131, 159, 233, 282, 316, 333, 344], 'septic': [23, 40, 52, 70, 82, 262, 313], 'process,': [24], 'to': [26, 163, 209], 'compare': [27], 'findings': [29], 'detected': [30], 'sepsis': [32, 38, 258, 309], 'with': [33, 47, 73, 76, 81, 181, 219], 'those': [34], 'found': [35], 'severe': [37, 49, 77, 257, 308], 'shock.': [41], 'Design:': [42], 'Prospective': [43], 'study': [44], 'comparing': [45], 'patients': [46, 71], 'shock,': [53, 263, 314], 'healthy': [55, 85], 'volunteers.': [56], 'Setting:': [57], 'General': [58], 'intensive': [59], 'care': [60], 'unit': [61], 'a': [63, 234], 'tertiary': [64], 'university': [65], 'hospital.': [66], 'Patients:': [67], 'Seventy-four': [68], 'consecutive': [69], '(45': [72], '15': [75], '14': [80], 'shock).': [83], 'Fourteen': [84], 'volunteers': [86], 'served': [87], 'as': [88], 'control': [89, 182], 'subjects.': [90], 'Intervention:': [91], 'None.': [92], 'Measurements': [93], 'Main': [95], 'Results:': [96], 'After': [97], 'blood': [98], 'sampling,': [99], 'molecular': [100], 'activation': [101], 'markers': [102], '(prothrombin': [105, 133], 'fragments': [106, 149], '1': [107, 150], '2,': [109, 152], 'fibrinopeptide': [110, 153], 'A,': [111, 154], 'thrombin-antithrombin': [112], 'complexes,': [113, 156], 'monomers': [115, 158], 'fibrin)': [117], '(β-thromboglobulin': [121], 'platelet': [123, 141], 'factor': [124, 203, 237, 301], '4),': [125], 'several': [126], 'factors,': [128, 245], 'global': [129, 246, 269, 326], 'tests': [130, 271, 328], 'time': [134], 'partial': [137], 'thromboplastin': [138], 'time),': [139], 'count': [142], '(PTL)': [143], 'were': [144, 161, 206, 251, 266, 272, 280], 'measured.': [145], 'In': [146, 256, 297, 305], 'prothrombin': [148], 'thrombin-anti-thrombin': [155], 'fibrin': [160], 'increased': [162, 208], '2.52': [164, 170], '±': [165, 169, 173, 185, 189, 193, 211, 216, 222, 227], '0.21': [166], 'nmol/L,': [167, 187], '20.88': [168], 'ng/mL,': [171, 191], '33.8': [172], '2.9': [174], 'μg/L,': [175, 195], '69%': [177], 'positive,': [178], 'respectively,': [179], 'compared': [180, 218], 'subjects': [183], '(0.86': [184], '063': [186], '1.14': [188], '0.15': [190], '16.07': [192], '1.01': [194], '0%,': [197], 'respectively).': [198, 229], 'β-Thromboglobulin': [199], 'β-thromboglobulin-to-platelet': [202], '4': [204], 'ratio': [205], 'also': [207], '107.87': [210], '11.87': [212], 'IU/mL': [213, 224], '8.86': [215], '1.06,': [217], 'controls': [220], '(18.36': [221], '2.99': [223], '2.67': [226], '0.52,': [228], 'With': [230], 'exception': [232], 'decrease': [235], 'XII': [238, 302], 'an': [240], 'increase': [241], 'fibrinogen,': [243], 'tests,': [248], 'PTL': [250, 275, 322], 'not': [252], 'changed': [253], 'sepsis.': [255, 296], 'mainly': [260, 311], 'factors': [265, 319], 'markedly': [267], 'decreased,': [268, 324], 'prolonged,': [273, 330], 'was': [276], 'reduced.': [277], 'All': [278], 'changes': [279], 'independent': [281], 'causative': [284], 'infectious': [285], 'pathogen.': [286], 'Conclusion:': [287], 'Coagulation': [288], 'strongly': [293], 'this': [298], 'stage,': [299], 'only': [300], 'is': [303, 323], 'decreased.': [304], 'contrast,': [306], 'most': [315], 'depleted,': [321], 'indicating': [331], 'exhaustion': [332], 'hemostasis.': [334], 'Finally,': [335], 'Gram-positive,': [336], 'Gram-negative,': [337], 'other': [339], 'microorganisms': [340], 'produce': [341], 'identical': [342], 'impairment': [343], 'coagulation.': [345]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1984881453', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 19}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-09-11T12:49:45.574762', 'created_date': '2016-06-24'}