Publication Information

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'https://openalex.org/W2142574099', 'https://openalex.org/W2147895004', 'https://openalex.org/W2151512427', 'https://openalex.org/W2165808595', 'https://openalex.org/W2194582812', 'https://openalex.org/W4246647258'], 'related_works': ['https://openalex.org/W4391429808', 'https://openalex.org/W4387958448', 'https://openalex.org/W4387957980', 'https://openalex.org/W4386446287', 'https://openalex.org/W4286449000', 'https://openalex.org/W2082776945', 'https://openalex.org/W2048915739', 'https://openalex.org/W1986029666', 'https://openalex.org/W1972685619', 'https://openalex.org/W12212036'], 'abstract_inverted_index': {'The': [0, 127, 343, 499, 738, 800, 1071, 1289, 1558, 2383, 3003, 3185, 3582, 3674], 'protein': [1, 46, 128, 173, 277, 565, 568, 583, 779, 801, 2452, 2483, 2711, 3135, 3152, 3208, 3326, 3362, 3401, 3419, 3504, 3522, 3636, 3996, 4039, 4086, 4135, 4158, 4271, 4290], 'tyrosine': [2, 32, 129, 159, 278, 280, 409, 566, 569, 584, 595, 635, 780, 802, 1813, 3100, 3692, 3770, 3805, 3813, 3875, 4026, 4069, 4173, 4194, 4338, 4372, 4399], 'phosphatase': [3, 130, 803, 1746], 'SHP-2': [4, 30, 59, 73, 100, 114, 131, 157, 186, 200, 227, 241, 627, 742, 1690, 1722, 1739, 1750, 1780, 1859, 1953, 3742, 3937], 'is': [5, 101, 132, 228, 288, 628, 640, 747, 794, 1247, 1294, 1416, 1433, 2051, 2694, 3197, 3210, 3338, 3737, 3863, 3872, 3932], 'an': [6, 133, 766, 1160, 1883, 2497, 2729, 3322, 3555, 3595, 3657, 4074], 'important': [7, 134, 767, 1161, 4075], 'regulator': [8, 118, 135, 245], 'of': [9, 17, 22, 34, 48, 58, 72, 97, 119, 136, 144, 149, 161, 175, 185, 199, 224, 246, 267, 269, 286, 298, 359, 397, 480, 521, 551, 554, 576, 593, 636, 644, 648, 741, 748, 759, 769, 771, 797, 1023, 1036, 1045, 1073, 1164, 1250, 1254, 1271, 1292, 1383, 1396, 1401, 1405, 1431, 1560, 1695, 1703, 1716, 1725, 1734, 1749, 1765, 1777, 1806, 1858, 1920, 1970, 2032, 2145, 2156, 2296, 2313, 2334, 2482, 2500, 2668, 2690, 2709, 2716, 2735, 2740, 2779, 2874, 2890, 2920, 2922, 2944, 2986, 2995, 3092, 3102, 3150, 3170, 3187, 3308, 3383, 3399, 3458, 3514, 3565, 3577, 3600, 3628, 3642, 3662, 3672, 3677, 3683, 3693, 3703, 3767, 3771, 3799, 3808, 3834, 3998, 4008, 4029, 4041, 4057, 4070, 4144, 4174, 4180, 4195, 4211, 4236, 4245, 4284, 4321, 4335, 4339, 4358, 4369, 4373, 4393, 4401], 'the': [10, 23, 42, 95, 137, 150, 169, 222, 353, 360, 389, 398, 475, 603, 633, 637, 649, 1021, 1034, 1042, 1046, 1251, 1272, 1287, 1299, 1318, 1393, 1402, 1436, 1567, 1641, 1687, 1696, 1701, 1712, 1726, 1735, 1763, 1773, 1803, 1807, 1810, 1854, 1861, 1997, 2142, 2293, 2297, 2315, 2408, 2448, 2508, 2524, 2576, 2607, 2640, 2666, 2674, 2714, 2732, 2776, 2871, 2888, 2984, 2991, 3025, 3054, 3151, 3162, 3172, 3180, 3188, 3193, 3204, 3214, 3271, 3295, 3330, 3407, 3434, 3456, 3484, 3499, 3512, 3549, 3563, 3566, 3570, 3578, 3588, 3598, 3604, 3612, 3620, 3624, 3639, 3660, 3678, 3681, 3690, 3694, 3701, 3765, 3768, 3772, 3781, 3794, 3800, 3803, 3809, 3831, 3835, 3868, 3873, 3995, 4004, 4014, 4024, 4030, 4038, 4067, 4071, 4106, 4129, 4141, 4148, 4167, 4171, 4175, 4178, 4192, 4196, 4199, 4207, 4285, 4300, 4310, 4336, 4340, 4367, 4370, 4374, 4388, 4394, 4397, 4402], 'Janus': [11, 138, 401, 545], 'kinase-2': [12, 139, 402, 546], '(Jak2)/signal': [13, 140], 'transducer': [14, 141, 264, 477, 548], 'and': [15, 86, 142, 213, 265, 318, 407, 478, 549, 599, 639, 646, 751, 782, 886, 1015, 1025, 1225, 1263, 1640, 1669, 1708, 1714, 1761, 1775, 1799, 1809, 1860, 1882, 1905, 1927, 1940, 1952, 1964, 1988, 2041, 2096, 2118, 2179, 2201, 2229, 2244, 2248, 2282, 2306, 2323, 2374, 2451, 2475, 2494, 2606, 2631, 2659, 2687, 2707, 2737, 2942, 2993, 3019, 3036, 3048, 3056, 3068, 3107, 3142, 3182, 3218, 3253, 3278, 3306, 3334, 3406, 3472, 3488, 3539, 3542, 3670, 3736, 3826, 3866, 3931, 3973, 3976, 4047, 4092, 4119, 4203, 4224, 4257, 4344, 4415], 'activator': [16, 143, 266, 479, 550], 'transcription': [18, 145, 552, 2924], '(Stat)': [19, 146], 'pathway': [20, 147, 501, 1168, 1698, 3706], 'downstream': [21, 148, 592, 796, 1724, 4334], 'cytokine/prolactin': [24, 151], 'receptor': [25, 121, 152, 248, 355, 364, 392, 408, 542, 594, 773, 1018, 3810, 3880], 'family.': [26, 153], 'We': [27, 154, 1718, 2978, 3264, 3828, 4080, 4188], 'report': [28, 155], 'that': [29, 93, 156, 220, 293, 778, 1030, 1256, 1301, 1428, 1689, 1720, 2424, 3095, 3127, 3280, 3287, 3298, 3689, 3860, 3867, 4094, 4162, 4170, 4330], 'dephosphorylates': [31, 158], '(Tyr-1007)': [33, 160], 'Jak2': [35, 55, 80, 82, 162, 182, 207, 209, 406, 791, 1014, 1037, 1308, 1397, 1645, 1678, 1707, 1757, 1822, 1909, 1921, 2307, 2725, 2741, 2780, 2996, 3044, 3093, 3103, 3125, 3134, 3166, 3177, 3196, 3207, 3268, 3333, 3450, 3519, 3601, 3629, 3684, 3776, 3825, 3999, 4042, 4064, 4078, 4132, 4181, 4202, 4296, 4317, 4322, 4343, 4377], 'kinase,': [36, 163], 'a': [37, 68, 76, 110, 116, 164, 195, 203, 237, 243, 289, 295, 357, 463, 579, 587, 1248, 1276, 1282, 1311, 1704, 1731, 1745, 1753, 1766, 2154, 2160, 2688, 3040, 3049, 3060, 3071, 3080, 3086, 3121, 3130, 3221, 3237, 3247, 3259, 3283, 3303, 3343, 3357, 3370, 3376, 3396, 3413, 3446, 3452, 3459, 3491, 3649, 3667, 3697, 3738, 3933, 3985, 4034, 4156, 4252, 4263, 4313, 4331, 4348], 'critical': [38, 165, 464, 641, 1409], 'recruitment': [39, 166, 1740, 1788, 3739, 3934], 'site': [40, 167, 1789, 2144, 3740, 3877, 3935], 'for': [41, 103, 113, 168, 230, 240, 642, 1411, 2030, 2053, 2099, 2159, 2216, 2331, 2338, 2393, 2430, 2441, 2511, 2571, 3016, 3024, 3379, 3554, 3741, 3824, 3936, 3959, 3965, 3982, 4093, 4117, 4131, 4164, 4221, 4228, 4387, 4410], 'ubiquitin': [43, 170, 1931], 'ligase-associated': [44, 171], 'inhibitory': [45, 172, 1290, 1320], 'suppressor': [47, 174, 553, 1072], 'cytokine': [49, 120, 176, 247, 270, 363, 555, 600, 772, 798, 1017, 1074, 2718], 'signaling-1': [50, 177, 556, 1075], '(SOCS-1),': [51, 178], 'thereby': [52, 179], 'contributing': [53, 180], 'to': [54, 75, 181, 202, 388, 395, 505, 513, 632, 754, 1012, 1079, 1261, 1268, 1298, 1307, 1389, 1399, 1421, 1435, 1564, 1667, 1692, 1772, 1814, 1866, 1902, 1908, 1917, 1930, 1950, 1962, 1967, 1980, 1996, 2070, 2133, 2140, 2189, 2211, 2399, 2638, 2705, 2723, 2775, 2868, 2887, 2981, 2990, 3000, 3010, 3043, 3070, 3083, 3089, 3110, 3124, 3144, 3165, 3176, 3195, 3212, 3224, 3258, 3286, 3302, 3321, 3340, 3356, 3373, 3422, 3449, 3494, 3532, 3552, 3666, 3708, 3817, 3988, 4083, 4090, 4185, 4206, 4255, 4266, 4279, 4293, 4316, 4346, 4352], 'stability.': [56, 183, 3777, 4079], 'Inactivation': [57, 184], 'function': [60, 112, 187, 239, 740, 1430], 'by': [61, 66, 99, 123, 188, 193, 226, 250, 322, 350, 469, 789, 1281, 1699, 1728, 1743, 1785, 1892, 2001, 2012, 2057, 2213, 2250, 2320, 2326, 2387, 3013, 3113, 3153, 3192, 3250, 3366, 3442, 3656], 'blocking': [62, 189, 2127, 3634], 'receptor/SHP-2': [63, 190], 'association': [64, 191, 2985, 3466, 3661], 'or': [65, 192, 1742, 2421, 2490, 3085, 3546, 3802, 3970, 4109, 4230, 4396], 'using': [67, 194, 1730, 1744, 2407, 2447, 2507, 2517, 2673, 3039, 3078, 3120, 3369, 3445, 3529, 4251], 'catalytically': [69, 196, 571, 1862], 'inactive': [70, 197, 282, 572, 1747, 1863], 'mutant': [71, 198, 284, 574, 1732, 1748, 1816, 1868, 1886, 3806, 4027, 4112, 4400], 'led': [74, 201, 3355, 4278], 'marked': [77, 204], 'increase': [78, 205, 1755, 3323, 3359, 3435, 3454, 3501, 3571, 3596, 3651, 3658], 'in': [79, 206, 313, 405, 466, 508, 590, 743, 1170, 1295, 1392, 1413, 1738, 1752, 1756, 1762, 1769, 2072, 2102, 2191, 2219, 2236, 2264, 2345, 2617, 2876, 2998, 3029, 3133, 3179, 3206, 3228, 3270, 3289, 3324, 3342, 3348, 3360, 3436, 3455, 3502, 3518, 3526, 3560, 3572, 3597, 3608, 3626, 3652, 3659, 3700, 3774, 3811, 3878, 3992, 4011, 4021, 4037, 4077, 4123, 4147, 4183, 4282, 4297, 4350, 4376], 'ubiquitination/degradation,': [81, 208], 'phosphorylation': [83, 210, 410, 1679, 1758, 3101, 3876], 'on': [84, 211, 301, 1677, 1680, 1759, 2414, 2438, 2477, 2496, 3066], 'Tyr-1007,': [85, 212], 'Jak2/SOCS-1': [87, 98, 214, 225, 1302, 1767, 2702, 2917, 2987, 3460, 3465, 4280], 'association.': [88, 215], 'Furthermore,': [89, 216], 'functional': [90, 217], 'studies': [91, 218, 1425], 'indicate': [92, 219, 3297, 4169, 4329], 'modulating': [94, 221, 1700], 'interaction': [96, 223, 1303, 2730, 3331, 4200, 4281], 'essential': [102, 229], 'prolactin/Stat5-mediated': [104, 231], 'signaling.': [105, 232, 774, 1019], 'Together': [106, 233], 'our': [107, 234], 'results': [108, 235, 4168], 'provide': [109, 236], 'novel': [111, 238], 'as': [115, 242, 310, 474, 518, 765, 1080, 1159, 1317, 1819, 1821, 2336, 2428, 2533, 2569, 2696, 2883, 3059, 3236, 3336, 3364, 3388, 4161, 4216], 'positive': [117, 244, 3377], 'signaling': [122, 249, 460, 591, 745, 1167, 1415, 1784, 2715, 2878, 3705], 'regulating': [124, 251, 3775], 'ubiquitination/degradation': [125, 252, 3269], 'pathways.': [126, 253], 'Prolactin': [254, 2700], '(PRL)': [255], '1The': [256], 'abbreviations': [257], 'used': [258, 2029, 3387, 3830], 'are:': [259], 'PRLprolactinPRLRPRL': [260], 'receptorWTwild': [261], 'typeJak2Janus': [262], 'kinase-2Statsignal': [263], 'transcriptionSOCS-1suppressor': [268], 'signaling-1SH2Src': [271], 'homology': [272, 558], '2FBSfetal': [273], 'bovine': [274, 561, 2081], 'serumSHP-2SH2': [275], 'domain-containing': [276, 564], 'phosphatase-2PTP1Bprotein': [279], 'phosphatase-1BCAcatalytically': [281], 'C463A': [283, 573], 'form': [285, 575, 1733, 1805, 1857, 2295, 3798, 3807, 3833, 3862, 3881, 4028, 4347, 4392], 'SHP-2.': [287, 577], 'polypeptide': [290], 'neuroendocrine': [291], 'hormone': [292, 344], 'exerts': [294], 'broad': [296], 'range': [297], 'biological': [299, 348], 'effects': [300], 'diverse': [302], 'target': [303, 1565], 'tissues.': [304], 'PRL': [305, 354, 510, 541, 2028, 2122, 2252, 2327, 2877, 3001, 3023, 3097, 3299, 3317, 3353, 3429, 3463, 3964, 4009, 4058, 4145, 4186, 4227, 4276, 4353, 4418], 'regulates': [306, 1782, 2713, 4177, 4198, 4342], 'different': [307, 2332, 2692, 3605, 4149], 'processes': [308], 'such': [309, 473, 517], 'those': [311], 'involved': [312], 'mammary': [314, 522, 2167, 3274], 'gland': [315], 'development,': [316], 'reproduction,': [317], 'immune': [319, 4258], 'regulation': [320, 770, 3702], '(reviewed': [321, 1169], 'Ref.': [323], '1Goffin': [324], 'V.': [325, 369, 438, 658, 1831, 2541, 3716, 3887], 'Binart': [326, 372], 'N.': [327, 373, 866, 889, 982, 1136, 2928], 'Touraine': [328], 'P.': [329, 870, 872, 1649, 2849], 'Kelly': [330, 374, 419, 441, 661, 688, 1834, 2003, 2544, 2594, 2897, 3719, 3841, 3890, 3919], 'P.A.': [331, 375, 420, 442, 662, 689, 1835, 2545, 2595, 2898, 3720, 3842, 3891, 3920], 'Annu.': [332], 'Rev.': [333, 377], 'Physiol.': [334], '2002;': [335, 966, 997, 1233, 1659, 2859], '64:': [336], '47-67Crossref': [337], 'PubMed': [338, 381, 430, 453, 494, 535, 619, 673, 697, 715, 735, 819, 839, 881, 903, 937, 974, 1005, 1066, 1108, 1151, 1220, 1241, 1345, 1377, 1484, 1514, 1553, 1591, 1635, 1662, 1846, 2556, 2601, 2769, 2797, 2841, 2862, 2912, 2937, 2973, 3731, 3756, 3852, 3902, 3926, 3951], 'Scopus': [339, 382, 454, 495, 536, 620, 674, 698, 716, 840, 882, 904, 938, 975, 1006, 1067, 1109, 1152, 1221, 1242, 1346, 1378, 1485, 1515, 1554, 1592, 1636, 1663, 1847, 2557, 2602, 2770, 2798, 2842, 2863, 2913, 2938, 2974, 3732, 3757, 3903, 3927, 3952], '(345)': [340], 'Google': [341, 384, 431, 456, 497, 538, 622, 676, 700, 718, 736, 820, 842, 884, 906, 940, 977, 1008, 1069, 1111, 1154, 1223, 1244, 1348, 1380, 1487, 1517, 1556, 1594, 1638, 1665, 1849, 2559, 2604, 2772, 2800, 2844, 2865, 2915, 2940, 2976, 3734, 3759, 3853, 3905, 3929, 3954], 'Scholar).': [342, 385, 457, 498, 539, 623, 737, 1070, 1245, 1381, 1557, 1850, 2560, 2866, 2977, 3760, 3955], 'generates': [345], 'its': [346, 1386], 'multiple': [347], 'functions': [349], 'interacting': [351], 'with': [352, 2120, 2151, 2289, 2459, 2566, 2575, 2645, 3022, 3161, 3220, 3416, 3433, 3490, 3548, 3594, 3611, 3790, 3821, 3963, 3984, 4101, 4114, 4226, 4262, 4295, 4303, 4312, 4384, 4407, 4417], '(PRLR),': [356], 'member': [358, 1249], 'class': [361], 'I': [362], 'superfamily': [365], '(2Bole-Feysot': [366], 'C.': [367, 608, 860], 'Goffin': [368, 437, 657, 1830, 2540, 3715, 3886], 'Edery': [370, 2584, 2899, 3909], 'M.': [371, 606, 727, 854, 1116, 1118, 1130, 1185, 1191, 1229, 1335, 1357, 1473, 1500, 1526, 1607, 1613, 2585, 2749, 2813, 2819, 2900, 2955, 3910], 'Endocr.': [376], '1998;': [378, 616, 732], '19:': [379], '225-268Crossref': [380], '(1602)': [383], 'Ligand': [386], 'binding': [387], 'PRLR': [390, 604, 625, 744, 1727, 1783, 1808, 1998, 2884, 3646, 3679, 3695, 3773, 3801, 3836, 4072, 4108, 4176, 4197, 4341, 4375, 4395], 'induces': [391, 3098, 3648], 'dimerization': [393], 'leading': [394, 512, 1771, 2774, 3664, 3707, 4205], 'activation': [396, 643, 1035, 1043, 1394, 1694, 2885, 2921, 3710], 'constitutively': [399], 'associated': [400, 1419, 4359], '(Jak2),': [403], 'resulting': [404], '(3Lebrun': [411], 'J.J.': [412, 434, 654, 683, 1227, 1827, 2537, 3712, 3883], 'Ali': [413, 435, 655, 1828, 2538, 2929, 3713, 3884], 'S.': [414, 436, 448, 656, 668, 679, 703, 721, 723, 1128, 1144, 1201, 1205, 1329, 1363, 1479, 1524, 1548, 1597, 1603, 1611, 1615, 1829, 1841, 2539, 2551, 2583, 2755, 2803, 2809, 2817, 2821, 2926, 2930, 2949, 3714, 3726, 3744, 3838, 3885, 3897, 3908, 3939], 'Sofer': [415], 'L.': [416, 528, 1207, 2589, 3914], 'Ullrich': [417, 439, 609, 659, 690, 1832, 1874, 2542, 3717, 3888], 'A.': [418, 440, 449, 610, 660, 669, 687, 691, 852, 913, 921, 947, 980, 988, 1126, 1146, 1181, 1323, 1327, 1339, 1359, 1371, 1443, 1480, 1494, 1549, 1623, 1833, 1842, 2543, 2552, 2751, 2763, 2829, 2894, 3718, 3727, 3889, 3898], 'J.': [421, 490, 612, 693, 704, 846, 892, 926, 1049, 1203, 1214, 1373, 1510, 1576, 1578, 1582, 1624, 2591, 2593, 2765, 2782, 2784, 2788, 2830, 2901, 2967, 3745, 3843, 3916, 3918, 3940], 'Biol.': [422, 615, 705, 815, 893, 927, 1062, 1216, 1587, 1625, 1658, 2793, 2831, 2858, 2902, 3746, 3844, 3941], 'Chem.': [423, 706, 894, 928, 1626, 2832, 2903, 3747, 3845, 3942], '1994;': [424], '269:': [425], '14021-14026Abstract': [426], 'Full': [427, 710, 712, 836, 898, 900, 932, 934, 969, 971, 1000, 1002, 1236, 1238, 1630, 1632, 2836, 2838, 2907, 2909, 3751, 3753, 3849, 3946, 3948], 'Text': [428, 711, 713, 837, 899, 901, 933, 935, 970, 972, 1001, 1003, 1237, 1239, 1631, 1633, 2837, 2839, 2908, 2910, 3752, 3754, 3850, 3947, 3949], 'PDF': [429, 714, 838, 902, 936, 973, 1004, 1240, 1634, 2840, 2911, 3755, 3851, 3950], 'Scholar,': [432, 677, 701, 719, 821, 907, 941, 978, 1112, 1349, 1488, 1518, 1595, 2801, 2845, 3906], '4Lebrun': [433], 'Proc.': [443, 663, 1474, 1543, 1836, 2546, 3721, 3892], 'Natl.': [444, 664, 1475, 1544, 1837, 2547, 3722, 3893], 'Acad.': [445, 665, 1476, 1545, 1838, 2548, 3723, 3894], 'Sci.': [446, 666, 1477, 1546, 1839, 2549, 3724, 3895], 'U.': [447, 667, 823, 825, 1478, 1547, 1840, 2550, 3725, 3896], '1995;': [450, 491, 670, 833, 1843, 2553, 3728, 3899], '92:': [451, 671, 1844, 2554, 3729, 3900], '4031-4035Crossref': [452, 672, 1845, 2555, 3730, 3901], '(114)': [455, 675, 1848, 2558, 3733, 3904], 'These': [458, 2067, 4233, 4327], 'membrane-proximal': [459], 'events': [461], 'play': [462], 'role': [465, 589, 1291, 1410, 3699, 3766, 4076, 4368], 'signal': [467, 476, 547, 1794], 'propagation': [468], 'recruiting': [470], 'effector': [471], 'molecules': [472], 'transcription-5': [481], '(Stat-5)': [482], '(5Wakao': [483], 'H.': [484, 1122, 1132, 1325, 1351, 1353, 1355, 1601, 1619, 2743, 2745, 2747, 2807, 2825, 2896, 2951], 'Gouilleux': [485], 'F.': [486, 949, 1055], 'Groner': [487, 728, 2181], 'B.': [488, 526, 729], 'EMBO': [489, 692, 1372, 1509, 2764], '14:': [492], '854-855Crossref': [493], '(48)': [496], 'Jak2/Stat-5': [500, 3704], 'has': [502, 752, 763, 1156, 2879], 'been': [503, 1157, 2880], 'shown': [504, 1011, 1563, 2722, 3227, 3347, 3559, 3859, 3991, 4122], 'be': [506, 755, 3240], 'indispensable': [507], 'mediating': [509], 'signals,': [511], 'various': [514, 2717], 'physiological': [515], 'responses': [516], 'terminal': [519], 'differentiation': [520], 'epithelial': [523, 2168, 3275], 'cells': [524, 2033, 2152, 2261, 2279, 2316, 2423, 2562, 3007, 3277, 3291, 3528, 3536, 3786, 4097, 4380], '(6Groner': [525], 'Hennighausen': [527], 'Breast': [529], 'Cancer': [530, 2061], 'Res.': [531], '2000;': [532, 707, 895, 3748, 3943], '2:': [533, 967, 998], '149-153Crossref': [534], '(35)': [537], 'prolactin': [540], 'wild': [543, 1643, 1855, 3795, 4016, 4306, 4389], 'type': [544, 1644, 1856, 3796, 4017, 4307, 4390], 'Src': [557], '2': [559], 'fetal': [560, 2080], 'serum': [562, 2082, 2321, 3014], 'SH2': [563, 1278, 1387, 1884, 2733], 'phosphatase-2': [567], 'phosphatase-1B': [570], 'SHP-2,': [578], 'ubiquitously': [580], 'expressed': [581], 'cytoplasmic': [582], 'phosphatase,': [585], 'plays': [586, 3696, 4073], 'central': [588, 1277], 'kinases,': [596], 'G-protein-coupled': [597], 'receptors,': [598], 'receptors': [601], 'including': [602], '(7Stein-Gerlach': [605], 'Wallasch': [607], 'Int.': [611], 'Biochem.': [613], 'Cell': [614, 814, 1061, 1586, 1657, 2039, 2164, 2341, 2792, 2857], '30:': [617], '559-566Crossref': [618], '(71)': [621], 'Following': [624], 'activation,': [626], 'tyrosine-phosphorylated,': [629], 'physically': [630], 'associates': [631], 'carboxyl-terminal': [634, 1284], 'PRLR,': [638, 1736, 2298], 'Stat5': [645, 1951, 1971, 4134, 4152], 'induction': [647, 2889], 'β-casein': [650, 2577], 'gene': [651, 1573, 2578, 2923, 3709], 'promoter': [652], '(4Lebrun': [653, 1826, 2536, 3711, 3882], '8Ali': [678], 'Chen': [680], 'Z.': [681], 'Lebrun': [682], 'Vogel': [684], 'W.': [685, 850, 1536], 'Kharitonenkov': [686], '1996;': [694], '15:': [695, 2971], '135-142Crossref': [696], '(128)': [699], '9Ali': [702], '275:': [708, 896, 3749, 3944], '39073-39080Abstract': [709, 3750, 3945], '(32)': [717, 3758, 3953], '10Berchtold': [720], 'Volarevic': [722], 'Moriggl': [724], 'R.': [725, 1083, 1120, 1175, 1189, 1457, 1496, 1532, 1605, 2811, 2959], 'Mercep': [726], 'Mol.': [730, 813, 1060, 1585, 1656, 2596, 2791, 2856, 2931, 3921], 'Endocrinol.': [731, 2597, 2933, 3922], '12:': [733], '556-567Crossref': [734], 'precise': [739], 'thus': [746, 1710], 'vital': [749, 3698], 'importance': [750], 'yet': [753, 3199], 'fully': [756], 'characterized.': [757], 'Modulation': [758], 'Jak': [760], 'kinase': [761, 792, 1047, 1309, 1319, 2726, 2997, 4182], 'activity': [762, 793, 1404, 1713, 1723, 2727], 'appeared': [764], 'mechanism': [768], 'Studies': [775], 'have': [776, 1426, 3686, 3857], 'indicated': [777, 1427, 2337, 2429, 3028, 3094], 'phosphatases': [781, 1032], 'adaptor/proteasomal': [783], 'degradation': [784, 1673, 1776, 2778, 2994, 3307, 3627, 3641, 3671, 4087, 4159, 4244, 4357], 'machinery': [785], 'are': [786], 'two': [787, 3168], 'means': [788], 'which': [790, 2050, 3171, 3812], 'regulated': [795], 'receptors.': [799, 2719], 'SHP-1': [804], '(11Yi': [805], 'T.': [806, 848, 891, 1053, 1134, 1138, 1140, 1331, 1361, 1365, 1367, 1599, 1617, 2753, 2757, 2759, 2805, 2823], 'Mui': [807], 'A.L.': [808], 'Krystal': [809], 'G.': [810, 856, 868, 1459], 'Ihle': [811, 1058, 1368, 2760], 'J.N.': [812, 911, 1059, 1369, 2761], '1993;': [816], '13:': [817], '7577-7586Crossref': [818], '12Klingmuller': [822], 'Lorenz': [824], 'Cantley': [826], 'L.C.': [827], 'Neel': [828, 962], 'B.G.': [829, 963], 'Lodish': [830], 'H.F.': [831], 'Cell.': [832, 965, 996, 1232, 2932], '80:': [834], '729-738Abstract': [835], '(842)': [841], 'Scholar),': [843, 885, 2773, 2916, 2941], 'CD45': [844, 1024], '(13Irie-Sasaki': [845], 'Sasaki': [847, 1334, 1358, 2750], 'Matsumoto': [849, 1125], 'Opavsky': [851], 'Cheng': [853, 912], 'Welstead': [855], 'Griffiths': [857], 'E.': [858], 'Krawczyk': [859], 'Richardson': [861, 1188, 1456], 'C.D.': [862], 'Aitken': [863], 'K.': [864, 1124, 1609, 1621, 2815, 2827], 'Iscove': [865], 'Koretzky': [867], 'Johnson': [869], 'Liu': [871], 'Rothstein': [873], 'D.M.': [874], 'Penninger': [875], 'J.M.': [876, 943], 'Nature.': [877, 1104, 1147], '2001;': [878, 929, 1550, 1588, 1627, 2794, 2833, 2970], '409:': [879], '349-354Crossref': [880], '(455)': [883], 'PTP1B': [887], '(14Aoki': [888], 'Matsuda': [890, 1052, 1366, 2758], '39718-39726Abstract': [897], '(155)': [905], '15Myers': [908], 'M.P.': [909], 'Andersen': [910], 'Tremblay': [914, 993], 'M.L.': [915, 994], 'Horvath': [916], 'C.M.': [917], 'Parisien': [918], 'J.P.': [919], 'Salmeen': [920], 'Barford': [922], 'D.': [923, 1099, 1177, 1209, 1455, 1467, 1504, 1522, 1647, 2847], 'Tonks': [924], 'N.K.': [925], '276:': [930, 1628, 2834], '47771-47774Abstract': [931], '(378)': [939], '16Zabolotny': [942], 'Bence-Hanulec': [944], 'K.K.': [945], 'Stricker-Krongrad': [946], 'Haj': [948], 'Wang': [950], 'Y.': [951, 953, 1142], 'Minokoshi': [952], 'Kim': [954], 'Y.B.': [955], 'Elmquist': [956], 'J.K.': [957], 'Tartaglia': [958], 'L.A.': [959], 'Kahn': [960], 'B.B.': [961], 'Dev.': [964, 995, 2969], '489-495Abstract': [968], '(686)': [976], '17Cheng': [979], 'Uetani': [981], 'Simoncic': [983], 'P.D.': [984], 'Chaubey': [985], 'V.P.': [986], 'Lee-Loy': [987], 'McGlade': [989], 'C.J.': [990, 1528, 2965], 'Kennedy': [991], 'B.P.': [992], '497-503Abstract': [999], '(464)': [1007], 'Scholar)': [1009, 1155, 1639, 1666, 2605, 3735, 3854, 3930], 'were': [1010, 1823, 1870, 1889, 1910, 1932, 1954, 1972, 1982, 2010, 2022, 2055, 2068, 2138, 2149, 2187, 2208, 2234, 2262, 2280, 2317, 2343, 2385, 2405, 2412, 2425, 2435, 2456, 2492, 2515, 2563, 2615, 2643, 2682, 3008, 3033, 3045, 3064, 3386, 3537, 3787, 3957, 3980, 4098, 4219, 4238, 4248, 4260, 4381, 4413], 'dephosphorylate': [1013], 'block': [1016], 'In': [1020, 1682, 3431, 4019], 'case': [1022], 'PTP1B,': [1026], 'it': [1027, 3281, 3496], 'was': [1028, 1562, 1675, 1922, 1999, 2034, 2505, 2530, 2662, 2721, 3051, 3129, 3216, 3395, 3411, 3467, 3486, 3524, 3584, 3630, 3815, 4033, 4061, 4088, 4242, 4291], 'demonstrated': [1029], 'these': [1031, 3779], 'inhibit': [1033, 2724], 'through': [1038, 1310, 1385, 1417, 2728, 4362], 'dephosphorylating': [1039, 1786], 'Tyr-1007': [1040, 1391, 1760, 2739], 'within': [1041, 1790], 'loop': [1044, 1395, 2873], '(18Feng': [1048], 'Witthuhn': [1050], 'B.A.': [1051], 'Kohlhuber': [1054], 'Kerr': [1056], 'I.M.': [1057], '1997;': [1063, 1105, 1148], '17:': [1064], '2497-2501Crossref': [1065], '(277)': [1068], '(SOCS-1,': [1076], 'also': [1077, 3265], 'referred': [1078], 'JAB)': [1081], '(19Starr': [1082], 'Willson': [1084, 1194, 1446, 1491, 1529], 'T.A.': [1085, 1114, 1195, 1447, 1492, 1530], 'Viney': [1086, 1196], 'E.M.': [1087, 1197], 'Murray': [1088], 'L.J.': [1089], 'Rayner': [1090], 'J.R.': [1091], 'Jenkins': [1092], 'B.J.': [1093, 1461], 'Gonda': [1094], 'T.J.': [1095], 'Alexander': [1096, 1464, 1501, 1537, 2962], 'W.S.': [1097, 1173, 1465, 1502, 1538, 2963], 'Metcalf': [1098, 1176, 1466, 1503, 1521], 'Nicola': [1100, 1210, 1470, 1507, 1541], 'N.A.': [1101, 1211, 1471, 1508, 1542], 'Hilton': [1102, 1212, 1468, 1505, 1539, 1652, 2852, 2960], 'D.J.': [1103, 1213, 1469, 1506, 1540, 1653, 2853, 2961], '387:': [1106, 1149], '917-921Crossref': [1107], '(1805)': [1110], '20Endo': [1113], 'Masuhara': [1115, 1356, 2748], 'Yokouchi': [1117], 'Suzuki': [1119, 1326], 'Sakamoto': [1121, 1354, 2746], 'Mitsui': [1123], 'Tanimura': [1127], 'Ohtsubo': [1129], 'Misawa': [1131, 1352, 2744], 'Miyazaki': [1133], 'Leonor': [1135], 'Taniguchi': [1137], 'Fujita': [1139], 'Kanakura': [1141], 'Komiya': [1143], 'Yoshimura': [1145, 1338, 1370, 1622, 1894, 2762, 2828], '921-924Crossref': [1150], '(1230)': [1153], 'established': [1158, 2882], 'negative-feedback': [1162, 2872, 3344], 'inhibitor': [1163], 'cytokine-activated': [1165], 'Jak/Stat': [1166], 'Refs.': [1171], '21Alexander': [1172], 'Starr': [1174, 1495, 1531, 2958], 'Nicholson': [1178, 1444, 1533], 'S.E.': [1179, 1445, 1490, 1534], 'Farley': [1180, 1442, 1493], 'Elefanty': [1182], 'A.G.': [1183], 'Brysha': [1184], 'Kile': [1186, 1460], 'B.T.': [1187], 'Baca': [1190, 1472, 1499], 'Zhang': [1192, 1497, 2956], 'J.G.': [1193, 1441, 1498, 1520, 2957], 'Sprigg': [1198], 'N.S.': [1199], 'Rakar': [1200, 1523], 'Corbin': [1202], 'Mifsud': [1204], 'DiRago': [1206], 'Cary': [1208, 1454], 'Leukocyte': [1215], '1999;': [1217, 1342, 1374, 1481, 1511, 2766, 2904, 2934], '66:': [1218], '588-592Crossref': [1219], '(99)': [1222], 'Scholar': [1224], "22O'Shea": [1226], 'Gadina': [1228], 'Schreiber': [1230], 'R.D.': [1231], '109:': [1234], 'S121-S131Abstract': [1235], '(947)': [1243], 'SOCS-1': [1246, 1260, 1274, 1293, 1384, 1412, 1432, 1561, 1787, 1963, 2007, 2042, 2128, 2134, 2146, 2736, 2875, 2891, 3325, 3335, 3337, 3361, 3380, 3400, 3418, 3437, 3439, 3503, 3516, 3521, 3533, 3553, 3573, 3635, 3653, 4118, 4270, 4289, 4345], 'SOCS': [1252], 'family': [1253], 'proteins': [1255, 1420, 4360], 'includes': [1257], 'eight': [1258], 'members,': [1259], 'SOCS-7': [1262], 'cytokine-inducible': [1264], 'SH2-containing': [1265], 'protein.': [1266, 2147], 'Similar': [1267, 2867], 'other': [1269, 2869], 'members': [1270], 'family,': [1273], 'contains': [1275], 'domain': [1279, 1388, 2734], 'followed': [1280, 3282, 3441], 'conserved': [1283, 1438], 'region': [1285, 1321], 'called': [1286], 'SOCS-box.': [1288], 'part': [1296], 'due': [1297, 3211], 'fact': [1300], 'blocks': [1304], 'substrate': [1305, 2670], 'access': [1306], '24': [1312], 'amino': [1313], 'acid': [1314], 'segment': [1315], 'denoted': [1316], '(23Sasaki': [1322], 'Yasukawa': [1324, 1600, 2806], 'Kamizono': [1328], 'Syoda': [1330], 'Kinjyo': [1332], 'I.': [1333, 1651, 2587, 2851, 3840, 3912], 'Johnston': [1336], 'J.A.': [1337], 'Genes': [1340, 2968], 'Cells.': [1341], '4:': [1343], '339-351Crossref': [1344], '(306)': [1347], '24Yasukawa': [1350], 'Wakioka': [1360, 2752], 'Ohtsuka': [1362, 2754], 'Imaizumi': [1364, 2756], '18:': [1375, 1512, 2767], '1309-1320Crossref': [1376, 2768], '(602)': [1379, 2771], 'Recruitment': [1382], 'phosphorylated': [1390, 1918, 1968, 2738, 3090], 'leads': [1398, 2886, 3301], 'inhibition': [1400, 2919], 'catalytic': [1403], 'Jak2.': [1406, 1717, 1778, 3309, 3643, 3673, 3989, 4165, 4212, 4246], 'A': [1407], 'second': [1408], 'down-regulating': [1414], 'targeting': [1418], 'proteasomal': [1422, 1670, 2777], 'degradation.': [1423, 1671], 'Various': [1424], 'this': [1429, 1683, 3861, 3879], 'attributed': [1434], 'highly': [1437], 'SOCS-box': [1439, 1559], '(25Zhang': [1440], 'Zugaro': [1448], 'L.M.': [1449], 'Simpson': [1450], 'R.J.': [1451], 'Moritz': [1452], 'R.L.': [1453], 'Hausmann': [1458], 'Kent': [1462], 'S.B.': [1463], '96:': [1482], '2071-2076Crossref': [1483], '(527)': [1486], '26Nicholson': [1489], '375-385Crossref': [1513], '(370)': [1516], '27Zhang': [1519], 'Asimakis': [1525], 'Greenhalgh': [1527], 'Carter': [1535], '98:': [1551], '13261-13265Crossref': [1552], '(139)': [1555], 'both': [1566], 'fusion': [1568], 'product': [1569], 'TEL': [1570], '(the': [1571], 'Ets-variant': [1572], '6)-Jak2': [1574], '(28Frantsve': [1575, 2781], 'Schwaller': [1577, 2783], 'Sternberg': [1579, 2785], 'D.W.': [1580, 2786], 'Kutok': [1581, 2787], 'Gilliland': [1583, 2789], 'D.G.': [1584, 2790], '21:': [1589, 2795], '3547-3557Crossref': [1590, 2796], '(143)': [1593, 2799], '29Kamizono': [1596, 2802], 'Hanada': [1598, 2804], 'Minoguchi': [1602, 1606, 2808, 2812], 'Kato': [1604, 1618, 2810, 2824], 'Hattori': [1608, 2814], 'Hatakeyama': [1610, 2816], 'Yada': [1612, 2818], 'Morita': [1614, 2820], 'Kitamura': [1616, 2822], 'Nakayama': [1620, 2826], '12530-12538Abstract': [1629, 2835], '(273)': [1637, 2843], 'full-length': [1642], '(30Ungureanu': [1646], 'Saharinen': [1648, 2848], 'Junttila': [1650, 2850], 'Silvennoinen': [1654, 2854], 'O.': [1655, 2855], '22:': [1660, 2860], '3316-3326Crossref': [1661, 2861], '(213)': [1664, 2864], 'ubiquitination': [1668, 1774, 2992, 3305, 3669], 'This': [1672, 3592], 'process': [1674], 'dependent': [1676], 'Tyr-1007.': [1681], 'study,': [1684], 'we': [1685, 3313, 3762, 3856, 4364], 'investigated': [1686, 3315], 'hypothesis': [1688], 'contributes': [1691], 'PRL-mediated': [1693, 3267], 'Jak2/Stat5': [1697], 'formation': [1702, 1764, 3457], 'complex': [1705, 3461, 4349], 'between': [1706, 2731, 3332, 4201], 'SOCS-1,': [1709, 2302, 3495, 4204], 'maintaining': [1711], 'stability': [1715, 3599, 4179, 4210], 'determined': [1719], 'abrogating': [1721], 'either': [1729, 2486, 3079, 3543, 4105], 'deficient': [1737], 'site,': [1741], 'resulted': [1751], 'significant': [1754], 'complex,': [1768], 'turn': [1770], 'Therefore,': [1779, 4066, 4151], 'critically': [1781], 'Jak2,': [1791, 3234, 4091, 4256], 'consequently': [1792], 'allowing': [1793], 'propagation/maintenance.': [1795], 'Materials,': [1796], 'Plasmid': [1797], 'Constructs,': [1798], 'Antibodies—Expression': [1800], 'plasmids': [1801, 1852, 1879, 2291], 'encoding': [1802, 1853, 1880, 2292, 2612, 3793, 4104], 'Nb2': [1804, 2038, 2046, 2294, 3006, 3290, 3311, 3527, 3535, 3797, 3832, 4015, 4107, 4110, 4391, 4403], 'corresponding': [1811], 'COOH-terminal': [1812, 3691, 3769, 3804, 3869, 4025, 4068, 4172, 4193, 4337, 4371, 4398], 'phenylalanine': [1815], 'form,': [1817, 1887, 4404], 'Nb2PRLRY382F,': [1818], 'well': [1820], 'described': [1824, 2534, 2570, 3389], 'previously': [1825, 2535, 2881, 3687, 3858], 'Expression': [1851, 1878], 'cysteine': [1864], '463': [1865], 'alanine': [1867], 'SHP-2CA': [1869], 'obtained': [1871, 1955, 2035, 2170, 2417, 2484], 'from': [1872, 1912, 1923, 1933, 1956, 1974, 1984, 2024, 2036, 2171, 2418, 2485], 'Axel': [1873], '(Max-Plank': [1875], 'Institute,': [1876, 1897, 2176], 'Germany).': [1877], 'Myc-SOCS-1': [1881], 'domain-inactivating': [1885], 'Myc-SOCS-1R105E,': [1888], 'kindly': [1890], 'provided': [1891, 2000, 2056], 'Akihiko': [1893], '(Life': [1895], 'Sciences': [1896], 'Kurume,': [1898], 'Japan).': [1899], 'Monoclonal': [1900, 1926, 1948, 1978, 1993], 'antibody': [1901, 1907, 1916, 1961, 1994, 3042, 3055, 3082, 3088, 3123, 3164, 3194, 3223, 3372, 3448, 3493, 3987, 4254, 4265, 4315], 'phosphotyrosine': [1903, 3084, 3181], '(4G10)': [1904], 'polyclonal': [1906, 1928, 3041, 3087, 3122, 3163, 3222, 3371, 3447, 3492, 3986, 4253, 4314], 'purchased': [1911, 1973, 1983, 2023], 'Upstate': [1913], 'Biotechnology.': [1914], 'Polyclonal': [1915, 1960], 'Tyr-1007/Tyr-1008': [1919, 3091], 'BIOSOURCE': [1924], 'International.': [1925], 'antibodies': [1929, 1949, 1966, 1979, 2450, 2510], 'Santa': [1934, 1985], 'Cruz': [1935, 1986], 'Biotechnology': [1936, 1987], '(Santa': [1937], 'Cruz,': [1938], 'CA)': [1939], 'Novocastra': [1941], 'Laboratories': [1942, 1976], 'Ltd.': [1943], '(Newcastle,': [1944], 'United': [1945], 'Kingdom),': [1946], 'respectively.': [1947, 1992], 'BD': [1957], 'Transduction': [1958], 'Laboratories.': [1959], 'monoclonal': [1965, 3081, 4264], 'Tyr-694': [1969], 'Zymed': [1975], 'Inc.': [1977, 2015], 'Myc': [1981], 'Roche': [1989, 2521], 'Applied': [1990], 'Science,': [1991], '(U6)': [1995], 'Paul': [2002], '(Paris,': [2004], 'France).': [2005], 'Phosphothiolated': [2006], 'antisense': [2008, 2131, 3530, 3550, 3567, 3613], 'oligonucleotides': [2009, 2132, 3531, 3551, 3568, 3614], 'synthesized': [2011], 'Alpha': [2013], 'DNA': [2014], '(Sherbrooke,': [2016], 'Quebec,': [2017], 'Canada).': [2018, 2066], 'Protein': [2019, 2403], 'A-Sepharose': [2020, 2453], 'beads': [2021], 'Amersham': [2025], 'Biosciences.': [2026], 'Ovine': [2027], 'treatment': [2031, 3478], 'Sigma.': [2037], 'Culture': [2040], 'Antisense': [2043], 'Oligonucleotide': [2044], 'Treatments—The': [2045], 'rat': [2047], 'pre-T': [2048, 3004], 'lymphoma,': [2049], 'PRL-dependent': [2052], 'growth,': [2054], 'Peter': [2058], 'Gout': [2059], '(BC': [2060], 'Agency,': [2062], 'Vancouver,': [2063], 'British': [2064], 'Columbia,': [2065], 'grown': [2069, 2188, 2263, 3009, 3538], 'confluence': [2071, 2190], 'growth': [2073, 2203], 'media': [2074, 2077, 2104, 2107, 2194, 2222, 2239], '(RPMI': [2075, 2105], '1640': [2076, 2106, 2193, 2221, 2238], 'containing': [2078, 2108, 2195, 2223, 2240, 2272, 3053], '10%': [2079, 2084, 2109, 2196, 2224, 2273, 2473], '(FBS),': [2083], 'horse': [2085, 2110], 'serum,': [2086, 2111], '7.5%': [2087, 2112], 'sodium': [2088, 2113, 2358, 2378], 'bicarbonate,': [2089, 2114], '5': [2090, 2276], 'mm': [2091, 2094, 2116, 2350, 2361, 2364, 2367, 2377, 2381, 2463, 2468, 2624, 2629, 2649, 2652, 2657], 'β-mercaptoethanol,': [2092], '200': [2093, 2115], 'glutamine)': [2095, 2117], 'then': [2097, 2209, 2283, 2324, 2457, 2632, 3020, 3034, 3540, 3974], 'starved': [2098, 2235, 2318, 3012, 3541, 3958, 4220, 4414], '18': [2100, 2311, 3017, 3960, 4222], 'h': [2101, 2312, 2443, 3115, 3140, 3155, 3252, 3427, 3476, 4052, 4056, 4223], 'starvation': [2103], 'stimulated': [2119, 2249, 2325, 3021, 3962, 4225, 4416], 'ovine': [2121, 2251], 'at': [2123, 2153, 2253, 2328, 2389, 2396, 2444, 2634, 3104, 3138, 3243, 3412, 3425, 3469, 3474, 3575, 3587, 3603, 4044, 4050], '1': [2124, 2254, 2329, 2363, 2366, 2370, 2376, 2380, 2628, 3244, 3968, 4051], 'μg/ml.': [2125, 2255], 'For': [2126, 3778], 'expression,': [2129, 2314], 'phosphothiolated': [2130], 'mRNA': [2135, 2892], '(sequence:': [2136], '5′-CACCTGGTTGTGTGCTACCAT-3′)': [2137], 'designed': [2139], 'recognize': [2141], 'initiation': [2143], 'Oligonucleotides': [2148], 'incubated': [2150], 'concentration': [2155, 2499], '15': [2157, 2623, 2651, 2656], 'μm': [2158], '16-h': [2161], 'period.': [2162, 3557], 'HC11': [2163, 3276], 'Culture—HC11,': [2165], 'mouse': [2166, 3273, 3384], 'cells,': [2169, 3312], 'Nancy': [2172], 'Hynes': [2173], '(Friedrich': [2174], 'Miescher': [2175], 'Basel,': [2177], 'Switzerland)': [2178], 'Bernd': [2180], '(Georg': [2182], 'Speyer': [2183], 'Haus,': [2184], 'Frankfurt,': [2185], 'Germany)': [2186], 'RPMI': [2192, 2220, 2237], 'FBS,': [2197, 2225], 'insulin': [2198, 2226, 2241], '(5': [2199, 2227, 2242], 'μg/ml),': [2200, 2228], 'epidermal': [2202], 'factor': [2204], '(10': [2205], 'ng/ml).': [2206], 'Cells': [2207, 2233, 2614, 3032, 3956, 4213, 4412], 'induced': [2210], 'differentiate': [2212], 'incubating': [2214], 'them': [2215], '3': [2217, 2442, 3114, 3139, 3251, 3971, 4055], 'days': [2218], 'hydrocortisone': [2230, 2245], '(1': [2231, 2246, 2648], 'μm).': [2232], 'μg/ml)': [2243], 'μm)': [2247], 'Transient': [2256], 'Transfection—The': [2257], 'human': [2258, 3782], 'embryonic': [2259, 3783], '293': [2260, 2422, 2561, 3785, 4096, 4379], "Dulbecco's": [2265], 'modified': [2266], "Eagle's": [2267], 'medium': [2268], '(4.5': [2269], 'g/liter': [2270], 'glucose)': [2271], 'FBS.': [2274], 'Approximately': [2275], '×': [2277, 2391, 2636], '105': [2278], 'plated': [2281], 'co-transfected': [2284, 2565, 3789, 4100, 4215, 4383], '(by': [2285], 'calcium': [2286], 'phosphate': [2287], 'method)': [2288], 'expression': [2290, 2567, 2610, 3517, 3523, 3574, 3637, 3654, 3791, 3822, 4102, 4115, 4385, 4408], 'PRLRY382F,': [2299, 3819, 4405], 'SHP-2WT,': [2300], 'SHP-2CA,': [2301], 'ubiquitin,': [2303], 'SOCS-1R105E,': [2304], 'Stat-5,': [2305], '(0.1–1.0': [2308], 'μg).': [2309], 'After': [2310, 4054], 'overnight': [2319, 3556], 'deprivation': [2322, 3015], 'μg/ml': [2330, 2371], 'periods': [2333], 'time': [2335, 3026, 3261, 3579, 3590, 3606, 3622, 4006, 4142, 4234], 'each': [2339, 2431, 2512, 2572], 'experiment.': [2340, 2433, 2513], 'Lysis—Cells': [2342], 'lysed': [2344, 2616], 'RIPA': [2346], 'lysis': [2347, 2618, 3057], 'buffer': [2348, 2461, 2619, 2647, 3058], '(50': [2349], 'Tris-HCl,': [2351], 'pH': [2352, 2465, 2654], '7.4,': [2353], '1%': [2354], 'Nonidet': [2355], 'P-40,': [2356], '0.25%': [2357], 'deoxycholate,': [2359], '150': [2360, 2467], 'NaCl,': [2362, 2469], 'EDTA,': [2365], 'phenylmethylsulfonyl': [2368], 'fluoride,': [2369], '(aprotinin,': [2372], 'leupeptin,': [2373], 'pepstatin),': [2375], 'orthovanadate,': [2379], 'NaF).': [2382], 'lysates': [2384, 2416, 2440, 2489, 3979], 'cleared': [2386], 'centrifugation': [2388], '12,000': [2390, 2635], 'g': [2392, 2637], '10': [2394, 4229], 'min': [2395, 3471, 4046], '4': [2397, 2445], '°C': [2398, 2446], 'remove': [2400], 'insoluble': [2401], 'material.': [2402], 'concentrations': [2404], 'measured': [2406], 'Bradford': [2409], 'technique.': [2410], 'Immunoprecipitation—Immunoprecipitations': [2411], 'performed': [2413, 2506], 'cellular': [2415], 'Nb2,': [2419], 'HC11,': [2420], 'transiently': [2426, 2564, 3788, 4099, 4214, 4382], 'transfected': [2427], 'specific': [2432, 4089], 'Immunoprecipitations': [2434, 4247], 'carried': [2436, 2531, 2663, 3046, 4249], 'out': [2437, 2532, 2664, 4250], 'cell': [2439, 2488], 'specified': [2449, 2509], 'beads.': [2454], 'Immunoprecipitates': [2455], 'washed': [2458], 'HNTG': [2460], '(20': [2462], 'HEPES,': [2464], '7.5,': [2466], '0.1%': [2470], 'Triton': [2471, 2621], 'X-100,': [2472, 2622], 'glycerol)': [2474], 'separated': [2476, 2495, 3065], 'SDS-PAGE.': [2478, 2501], 'Western': [2479, 2502, 3075, 3117, 3367, 3443], 'Blotting—Standardized': [2480], 'amounts': [2481], 'whole': [2487], 'immunoprecipitations': [2491, 3038, 3440, 4320], 'loaded': [2493], 'appropriate': [2498], 'blotting': [2503, 3076, 3118, 3368, 3444], 'analysis': [2504, 3077, 3119], 'Proteins': [2514, 3063], 'revealed': [2516, 3126, 3167, 3451, 3497], 'chemiluminescence': [2518], '(Lumi-Light': [2519], 'Plus,': [2520], 'Diagnostics)': [2522], 'following': [2523, 2665, 3428, 3462, 3477], "manufacturer's": [2525], 'instructions.': [2526], 'Luciferase': [2527], 'Assay—The': [2528], 'assay': [2529, 2661], 'vectors': [2568, 3792, 3823, 4103, 4116, 4386], 'experiment': [2573], 'along': [2574, 3820, 4113, 4406], 'promoter/luciferase': [2579], 'reporter': [2580], 'construct': [2581], '(31Ali': [2582], 'Pellegrini': [2586, 3839, 3911], 'Lesueur': [2588, 3913], 'Paly': [2590, 3915], 'Djiane': [2592, 3917], '1992;': [2598, 3923], '6:': [2599, 3924], '1242-1248Crossref': [2600, 3925], '(0)': [2603, 3928], 'internal': [2608], 'control': [2609, 3378], 'vector': [2611, 4409], 'β-galactosidase.': [2613], '(1%': [2620], 'MgSO4,': [2625], '4mm': [2626], 'EGTA,': [2627], 'dithiothreitol)': [2630], 'centrifuged': [2633], 'clear': [2639], 'lysates.': [2641], 'Lysates': [2642], 'mixed': [2644], 'ATP': [2646], 'ATP,': [2650], 'KH2PO4,': [2653], '7.8,': [2655], 'MgCl2),': [2658], 'luciferase': [2660, 2680], 'addition': [2667], 'luciferin': [2669], '(Roche': [2671], 'Diagnostic)': [2672], 'Dynex': [2675], 'luminometer': [2676], '(Chantilly,': [2677], 'VA).': [2678], 'Relative': [2679], 'units': [2681], 'normalized': [2683], 'against': [2684], 'β-galactosidase': [2685], 'values,': [2686], 'representative': [2689], 'five': [2691], 'experiments': [2693], 'presented': [2695], 'relative': [2697], 'light': [2698], 'units.': [2699], 'Dependent': [2701], 'Association': [2703], 'Leads': [2704], 'Ubiquitination': [2706], 'Degradation': [2708], 'Jak2—SOCS-1': [2710], 'negatively': [2712], 'It': [2720], '(24Yasukawa': [2742], '30Ungureanu': [2846], 'cytokines,': [2870], '(32Pezet': [2893], 'Favre': [2895], '274:': [2905], '24497-24502Abstract': [2906], '(163)': [2914], 'interaction,': [2918], '(33Tomic': [2925], 'Chughtai': [2927], '158:': [2935], '45-54Crossref': [2936], '(58)': [2939], 'prevention': [2943], 'lactation': [2945], '(34Lindeman': [2946], 'G.J.': [2947], 'Wittlin': [2948], 'Lada': [2950], 'Naylor': [2952], 'M.J.': [2953], 'Santamaria': [2954], 'Ormandy': [2964], 'Visvader': [2966], '1631-1636Crossref': [2972], '(89)': [2975], 'initially': [2979, 3764], 'intended': [2980], 'determine': [2982, 3202, 3511, 4084], 'whether': [2983, 3203, 3316, 4085, 4191], 'would': [2988, 3319], 'lead': [2989, 3320], 'response': [2999, 4184, 4351], 'stimulation.': [3002, 3430, 3464, 4187, 4354], 'lymphoma': [3005], 'confluence,': [3011], 'h,': [3018, 3245, 3961, 3969, 3972], 'points': [3027, 3580, 3607, 4235], 'Fig.': [3030, 3229, 3349, 3561, 3993, 4124], '1A.': [3031], 'collected': [3035, 3975], 'lysed,': [3037], 'out,': [3047], 'sample': [3050], 'included': [3052], 'negative': [3061], 'control.': [3062], 'SDS-PAGE': [3067], 'transferred': [3069], 'nitrocellulose': [3072], 'membrane.': [3073], 'Initially,': [3074], 'indeed': [3096], 'transient': [3099], 'tyrosines': [3105], '1007': [3106], '1008,': [3108], 'returning': [3109], 'basal': [3111, 3404, 3423], 'level': [3112, 3136, 3209, 3249, 3327, 3363, 3409, 3420, 3997, 4040, 4136], 'post-treatment.': [3116, 4053], 'there': [3128, 3394, 4032, 4060, 4241], 'time-dependent': [3131, 3304, 3358, 3453, 3500, 3640, 3650, 3668], 'decrease': [3132, 3205, 4036], 'starting': [3137, 3242, 4043], 'post-treatment': [3141], 'continued': [3143], 'decrease,': [3145], 'reaching': [3146, 3246], 'stable': [3147], 'low': [3148], 'levels': [3149, 3424, 3505], '6': [3154], '(Fig.': [3156, 3292, 3479, 3506, 3615, 4272, 4323], '1A,': [3157, 3230], 'middle': [3158, 3481], 'panel).': [3159, 3482, 3509, 3618, 4326], 'Blotting': [3160], 'bands': [3169], 'upper': [3173, 3351], 'one': [3174], 'corresponded': [3175], 'observed': [3178, 3279, 3602, 4163, 4208], 'phospho-Jak2': [3183], 'immunoblots.': [3184], 'nature': [3186], 'lower': [3189, 3231, 3508, 3617, 4126, 4325], 'band': [3190], 'detected': [3191, 3241, 3365, 3410, 3468], 'not': [3198, 4138, 4154], 'clear.': [3200], 'To': [3201, 3510], 'ubiquitination,': [3213, 4363], 'membrane': [3215, 3485, 4311], 'stripped': [3217, 3487], 'reprobed': [3219, 3489], 'ubiquitin.': [3225], 'As': [3226, 3346, 3375, 3558, 3990, 4121, 4274], 'panel,': [3232, 3352, 4127], 'ubiquitinated': [3233], 'migrating': [3235], 'smear,': [3238], 'could': [3239], 'maximum': [3248], 'gradually': [3254], 'decreasing': [3255], 'thereafter': [3256], 'up': [3257], '24-h': [3260], 'point': [3262], 'examined.': [3263, 3581], 'examined': [3266, 3763, 4190, 4366], 'PRL-responsive': [3272], 'pattern': [3284, 4130, 4160], 'similar': [3285, 4157], 'seen': [3288], '1B).': [3293], 'Together,': [3294, 4166], 'data': [3296, 4328], 'stimulation': [3300, 3318, 3354, 3415, 3647, 4010, 4146, 4237, 4277], 'Using': [3310], 'next': [3314, 4081, 4189, 4365], 'and,': [3328], 'consequently,': [3329], 'known': [3339], 'act': [3341], 'loop.': [3345], '1C,': [3350, 3480, 3507], 'SOCS-1.': [3374, 3827, 4411], 'detection,': [3381], 'extracts': [3382], 'thymus': [3385], 'under': [3390, 3403], '"Experimental': [3391], 'Procedures."': [3392], 'Interestingly,': [3393, 4287], 'detectable': [3397, 4063], 'amount': [3398], 'present': [3402], 'conditions': [3405], 'highest': [3408], '3–6-h': [3414], 'PRL.': [3417], 'returned': [3421], '16–24': [3426], 'agreement': [3432], 'protein,': [3438], '30': [3470, 3966, 4045, 4231], 'peaked': [3473], '3–6': [3475], 'When': [3483], 'again': [3498], 'contribution': [3513], 'PRL-induced': [3515], 'degradation,': [3520, 4133], 'blocked': [3525], 'mRNA.': [3534], 'left': [3544], 'untreated': [3545], 'treated': [3547], '1D,': [3562, 3616], 'presence': [3564], 'prevented': [3569], 'all': [3576, 4283], 'effect': [3583], 'particularly': [3585], 'obvious': [3586], '6-h': [3589, 3621], 'point.': [3591], 'correlated': [3593], 'samples': [3609, 4012, 4022, 4298, 4304], 'pretreated': [3610], 'At': [3619], 'point,': [3623], 'attenuation': [3625], 'most': [3631], 'apparent.': [3632], 'Thus,': [3633], 'impedes': [3638], 'Taken': [3644], 'together,': [3645], 'accompanied': [3655], 'Jak2/SOCS-1,': [3663], 'ultimately': [3665], 'Carboxyl-terminal': [3675], 'Tyrosine': [3676], 'Regulates': [3680], 'Kinetics': [3682], 'Ubiquitination/Degradation—We': [3685], 'reported': [3688], '(9Ali': [3743, 3938], 'Here': [3761], 'studies,': [3780], 'kidney': [3784], '382': [3814], 'mutated': [3816], 'phenylalanine,': [3818], 'specifically': [3829], '(35Ali': [3837], '1991;': [3846], '266:': [3847], '20110-20117Abstract': [3848], 'because': [3855, 4240], 'biologically': [3864], 'active': [3865], 'tyrosine,': [3870], 'Tyr-382,': [3871], 'major': [3874], '31Ali': [3907], 'min,': [3967], 'lysed.': [3977], 'Cellular': [3978], 'prepared': [3981], 'immunodetection': [3983], '2A,': [3994, 4125], 'remained': [4000], 'relatively': [4001], 'constant': [4002], 'over': [4003, 4140], '3-h': [4005], 'course': [4007, 4143], 'overexpressing': [4013, 4023, 4299, 4305], 'receptor.': [4018], 'contrast,': [4020], 'receptor,': [4031], 'rapid': [4035], 'clearly': [4048], 'visible': [4049], 'stimulation,': [4059], 'little': [4062], 'present.': [4065], 'sought': [4082], 'reason,': [4095], 'PRLRY382F': [4111, 4301], 'Stat5.': [4120], 'unlike': [4128], 'did': [4137], 'change': [4139], 'samples.': [4150, 4286], 'does': [4153], 'undergo': [4155], 'differential': [4209], 'noted': [4217], 'above': [4218], 'min.': [4232], 'selected': [4239], 'minimal': [4243], 'complexes': [4259], 'blotted': [4261], 'Myc,': [4267], 'recognizing': [4268], 'Myc-tagged': [4269], '2B).': [4273], 'expected,': [4275], 'more': [4288], 'found': [4292], 'co-immunoprecipitate': [4294], 'compared': [4302], 'PRLR.': [4308], 'Reprobing': [4309], 'showed': [4318], 'equal': [4319], '2B,': [4324], 'mechanism(s)': [4332], 'operating': [4333], 'Because': [4355], 'SOCS-1-mediated': [4356], 'occurs': [4361], 'ubiquitination.': [4378]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1984848300', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-24T15:53:57.462656', 'created_date': '2016-06-24'}