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[45, 274, 1614, 1854, 3284, 3977, 4074], 'its': [46, 275, 711, 1124, 1604, 4055], 'ligands': [47, 276, 534, 1125, 1280], 'accumulate.': [48, 277], 'To': [49, 278, 1593, 2997, 3634, 3669, 3896, 4072, 4319], 'understand': [50, 279], 'factors': [51, 280, 4052], 'underlying': [52, 281], 'expression,': [54, 283, 4388, 4546], 'we': [55, 284, 1247, 1272, 1410, 1620, 1689, 4327], 'cloned': [56, 285, 3212, 4149], '5′-flanking': [58, 287, 1974, 2034, 2571, 2609, 2643, 2662, 2681, 2866, 3160, 3196, 3687, 4141], 'region': [59, 74, 107, 122, 288, 303, 336, 351, 1975, 2035, 2572, 2610, 2636, 2655, 2674, 2867, 3161, 3197, 3624, 3688, 4427], 'gene': [63, 126, 292, 355, 1979, 2039, 2577, 2615, 2871, 3201, 3693, 3740, 4147, 4154, 4334, 4452], 'and': [64, 82, 92, 114, 133, 155, 170, 175, 186, 192, 218, 293, 311, 321, 343, 362, 384, 399, 404, 415, 421, 447, 520, 687, 730, 1014, 1021, 1118, 1148, 1197, 1304, 1308, 1424, 1543, 1603, 1666, 1706, 1724, 1822, 1838, 1909, 1958, 2042, 2088, 2151, 2176, 2228, 2261, 2265, 2293, 2322, 2346, 2354, 2421, 2426, 2433, 2464, 2478, 2499, 2529, 2622, 2758, 2764, 2819, 2835, 2860, 2901, 2921, 2927, 2929, 2935, 2981, 3007, 3055, 3118, 3129, 3204, 3211, 3225, 3233, 3279, 3303, 3318, 3343, 3384, 3394, 3463, 3492, 3541, 3600, 3619, 3694, 3854, 3871, 3889, 3934, 3952, 4013, 4017, 4113, 4180, 4198, 4249, 4287, 4299, 4356, 4377, 4414, 4442, 4511, 4525, 4530], 'characterized': [65, 294, 521], 'putative': [66, 72, 129, 295, 301, 358, 2565, 3834, 3903], 'regulatory': [67, 296, 4462], 'motifs.': [68, 297], 'Analysis': [69, 298, 1106], 'promoter': [73, 190, 302, 419, 1598, 1693, 3808, 4078, 4197, 4240, 4310, 4325, 4409, 4438], 'revealed': [75, 104, 160, 304, 333, 389, 1843, 2579, 3832], 'presence': [77, 306, 1713, 3433, 4491], 'three': [79, 128, 165, 308, 357, 394, 2564, 3833, 4329], 'potential': [80, 309, 3672, 3800, 4056], 'NF-κB-like': [81, 130, 166, 183, 310, 359, 395, 412, 1715, 2566, 2630, 2649, 2668, 2909, 3835, 3904, 3929, 3942, 3975], 'two': [83, 162, 312, 391, 2022, 2908, 3675, 3928], 'SP1': [84, 313], 'binding': [85, 131, 167, 314, 360, 396, 1122, 1716, 2560, 2567, 2631, 2650, 2669, 2910, 3004, 3108, 3803, 3827, 3905, 3930, 3943], 'sites.': [86, 315], 'Transient': [87, 316], 'transfection': [88, 317, 3143, 3312, 3607, 4206, 4212, 4257], 'vascular': [90, 319, 486, 1008, 1149, 1667, 1707, 2230], 'endothelial': [91, 142, 320, 371, 475, 1006, 1633, 1704, 1722, 2184], 'smooth': [93, 144, 322, 373, 487, 1009, 1150, 1668, 1708, 1725, 2231], 'muscle': [94, 145, 323, 374, 488, 1010, 1151, 1669, 1709, 1726], 'cells': [95, 146, 324, 375, 1634, 1670, 1705, 1723, 1727, 2185, 2232, 3018], 'using': [96, 325, 1816, 2144, 2544, 2872, 3094, 3169, 3380, 3519, 3715, 3727], 'chimeric': [97, 326, 4091, 4331], '5′-deletion': [98, 327, 4092, 4332], 'constructs': [99, 328, 3140, 3584, 3644, 4095, 4289, 4371, 4472, 4506], 'linked': [100, 329, 725, 3493], 'to': [101, 111, 177, 194, 210, 225, 330, 340, 406, 423, 439, 454, 688, 726, 1099, 1123, 1128, 1302, 1586, 1698, 1769, 1772, 1829, 1866, 1868, 1963, 2015, 2028, 2030, 2045, 2047, 2090, 2111, 2128, 2178, 2276, 2308, 2310, 2557, 2639, 2658, 2677, 2690, 2726, 2905, 3073, 3102, 3191, 3243, 3267, 3290, 3298, 3326, 3358, 3360, 3368, 3374, 3423, 3470, 3484, 3560, 3573, 3575, 3602, 3606, 3615, 3626, 3663, 3681, 3683, 3697, 3699, 3798, 3841, 3844, 3848, 3851, 3856, 3859, 3885, 3971, 4020, 4294, 4306, 4477], 'luciferase': [102, 138, 202, 331, 367, 431, 3639, 4153, 4184, 4191, 4226, 4267, 4387, 4391, 4502], 'reporter': [103, 332, 4094], 'that': [105, 161, 334, 390, 996, 1113, 1209, 1249, 1270, 1274, 1282, 1286, 1305, 1413, 1579, 1691, 1844, 2300, 2896, 3350, 3736, 4028, 4050, 4060, 4284, 4292, 4397, 4425, 4443], '−1543/−587': [108, 337, 4457], 'contributed': [109, 338, 4293], 'importantly': [110, 339], 'both': [112, 188, 341, 417, 1145, 1306, 1631, 1703, 1721, 3220, 4247, 4255, 4270, 4285, 4417, 4495, 4523, 4542], 'basal': [113, 189, 342, 418, 1162, 4084, 4239, 4295, 4324, 4408, 4447, 4517, 4536, 4545], 'stimulated': [115, 148, 344, 377, 3090], 'expression': [116, 191, 215, 345, 420, 444, 997, 1114, 1251, 1470, 1581, 1616, 4085, 4192, 4296, 4448, 4503], 'gene.': [120, 349, 4219], 'This': [121, 350, 1905], 'contained': [127, 356, 1849, 4115, 4129, 4290, 4435, 4466], 'sites': [132, 168, 184, 361, 397, 413, 1717, 1750, 2568, 2899, 3172, 3804, 3906, 3931, 4011], 'was': [134, 363, 517, 1204, 1252, 1267, 1584, 1601, 1617, 1758, 1812, 1907, 1928, 1988, 2126, 2153, 2302, 2384, 2398, 2440, 2462, 2468, 2517, 2539, 2555, 2687, 2786, 2879, 2946, 3084, 3235, 3272, 3316, 3352, 3366, 3378, 3421, 3457, 3468, 3482, 3501, 3558, 3569, 3656, 3661, 3712, 3724, 3796, 3916, 3936, 4063, 4096, 4207, 4393], 'responsible': [135, 364], 'increased': [137, 366, 1472, 4501], 'activity': [139, 368, 3377, 3640, 4227, 4268, 4311, 4392, 4410, 4439], 'observed': [140, 369, 3937, 4398], 'when': [141, 370], 'or': [143, 372, 532, 547, 2247, 2286, 3076, 3092, 3173, 3336, 3429, 3434, 3442, 3511, 4059, 4170, 4260, 4383, 4401, 4483, 4488], 'were': [147, 172, 204, 376, 401, 433, 1820, 1836, 1916, 1961, 2084, 2168, 2240, 2288, 2324, 2339, 2357, 2449, 2605, 2724, 2798, 2832, 2848, 2903, 2914, 2965, 3037, 3112, 3145, 3188, 3217, 3223, 3251, 3296, 3338, 3585, 3593, 3649, 3677, 3873, 4015, 4079, 4148, 4165, 4178, 4372, 4475], 'with': [149, 196, 378, 425, 845, 1158, 1161, 1194, 1278, 1417, 1465, 1700, 1762, 1814, 1856, 1911, 1949, 2086, 2290, 2326, 2342, 2471, 2511, 2618, 2766, 2827, 2937, 2948, 2968, 2984, 3010, 3039, 3058, 3086, 3120, 3179, 3237, 3340, 3438, 3504, 3517, 3534, 3549, 3629, 3823, 4001, 4037, 4213, 4258, 4274, 4399, 4412, 4516, 4535], 'lipopolysaccharide.': [150, 379], 'DNase': [151, 380, 2551, 2683, 2713, 2782, 2891, 3912], 'I': [152, 381, 2552, 2684, 2714, 2783, 2892, 3913], 'footprinting': [153, 382, 2553, 2685, 2893, 3914], 'assays': [154, 383, 2894], 'electrophoretic': [156, 385, 478, 3473], 'mobility': [157, 386, 479], 'shift': [158, 387, 480, 2769, 3995], 'assay': [159, 388, 2554, 2686], '(1': [169, 398, 2476], '2)': [171, 400, 3853, 3935, 3961], 'likely': [173, 402, 724, 1127, 2904, 4465], 'functional': [174, 403, 1606, 3899, 4057, 4066], 'responsive': [176, 405, 1697], 'stimuli.': [178, 407, 2313, 3361], 'Upon': [179, 408], 'simultaneous': [180, 409, 4211], 'mutation': [181, 410], '1': [185, 414, 2792, 2900, 2926, 3006, 3264, 3933, 4012], '2,': [187, 416, 2652], 'response': [193, 422], 'stimulation': [195, 424, 1699, 3437, 4499], 'LPS,': [197, 426, 482], 'as': [198, 427, 522, 539, 696, 707, 852, 951, 953, 1017, 1289, 1534, 1858, 1860, 1990, 2148, 2156, 2297, 2359, 2474, 2578, 2877, 2882, 2995, 3067, 3098, 3227, 3286, 3347, 3392, 3445, 3450, 3571, 3752, 3845, 3852, 3860, 3867, 4126, 4133, 4201, 4224, 4473], 'measured': [199, 428, 3385], 'by': [200, 429, 1019, 1530, 1741, 1760, 1930, 2236, 2580, 2616, 2800, 2916, 3147, 3168, 3174, 3459, 3494, 3581, 3587, 3714, 3726, 3760, 3809, 3983, 4209], 'relative': [201, 430, 4390], 'activity,': [203, 432, 4326], 'significantly': [205, 434, 4394, 4500], 'diminished.': [206, 435], 'These': [207, 436, 1576, 3733, 4140, 4281, 4370, 4422], 'results': [208, 437, 1419, 2889, 3395, 3734, 4282], 'point': [209, 438], 'NF-κB-dependent': [211, 440], 'regulating': [213, 442], 'suggest': [219, 448], 'means': [221, 450], 'linking': [223, 452], 'inflammatory': [227, 456, 728], 'response.': [228, 457, 1731], '1The': [459], 'abbreviations': [460], 'used': [461, 1962, 3184, 3422, 3570, 3662, 4125, 4476], 'are:': [462], 'RAGE,receptor': [463], 'glycationend': [466], 'products;': [467], 'AGE,': [468], 'advancedglycation': [469], 'product;': [471], 'BAEC,': [472], 'bovine': [473, 2255, 2755], 'aortic': [474, 2183], 'cell;': [476, 489], 'EMSA,': [477], 'assay;': [481], 'lipopolysaccharide;': [483], 'RSMC,': [484], 'rat': [485, 1318, 2229], 'PCR,': [490], 'polymerase': [491], 'chain': [492], 'reaction;': [493], 'bp,': [494], 'base': [495], 'pair(s);': [496], 'ANOVA,': [497], 'analysis': [498, 1842, 1987, 2582, 3604, 3652, 3660, 3774, 3915], 'variance.': [500], '(for': [501], 'foradvanced': [503], 'products),': [506], 'molecules,': [516], 'initially': [518], 'identified': [519, 1018, 1602, 3819, 3875], 'interaction': [525, 1416], 'site': [526, 2632, 2651, 2670, 2911, 2925, 2933, 3005, 3109, 3757, 3822, 3944, 3950, 3960, 4032, 4048, 4062, 4067, 4112, 4434], 'products': [531, 2162], 'AGEs,': [533], 'formed': [535], 'diverse': [537, 1611], 'circumstances': [538, 1612], 'consequence': [541, 716], 'irreversible': [543], 'glycation/oxidation': [544], 'proteins': [546], 'lipids': [548], '(1Ruderman': [549], 'N.': [550, 599, 746, 773, 775, 779, 1996], 'Williamson': [551], 'J.': [552, 556, 566, 601, 618, 620, 622, 639, 656, 669, 753, 784, 825, 878, 923, 962, 1026, 1048, 1062, 1066, 1086, 1232, 1325, 1331, 1343, 1348, 1368, 1381, 1385, 1387, 1390, 1432, 1444, 1484, 1496, 1556, 1640, 1644, 1646, 1652, 1655, 1672, 1785, 1798, 1880, 1893, 2006, 2059, 2072, 2195, 2197, 2199, 2216, 2587, 3028, 3405, 3780], 'Brownlee': [553], 'M.': [554, 594, 614, 616, 630, 652, 744, 860, 886, 1038, 1064, 1335, 1434, 1442, 1486, 1494, 1539, 1682, 1781, 1876, 2055, 2191, 2193, 2207, 2366], 'FASEB': [555], '1992;': [557, 642, 672, 787, 1801, 1896, 2075, 2219], '6:': [558], '2905-2914Crossref': [559], 'PubMed': [560, 571, 588, 606, 648, 678, 759, 831, 911, 946, 985, 1187, 1238, 1359, 1377, 1399, 1459, 1511, 1661, 1807, 1902, 1944, 2010, 2081, 2225, 2375, 2598, 2708, 3032, 3416, 3791], 'Scopus': [561, 572, 589, 607, 760, 790, 832, 912, 947, 986, 1188, 1239, 1360, 1460, 1512, 1662, 1945, 2011, 2376, 2599, 3033, 3417, 3792], '(350)': [562], 'Google': [563, 574, 591, 609, 649, 679, 762, 792, 834, 883, 914, 949, 988, 1053, 1091, 1190, 1241, 1362, 1378, 1400, 1462, 1514, 1664, 1808, 1903, 1947, 2013, 2082, 2226, 2378, 2601, 2709, 3035, 3419, 3794], 'Scholar,': [564, 575, 592, 610, 650, 763, 793, 808, 884, 915, 1054, 1363, 1379], '2Baynes': [565], 'Diabetes.': [567], '1991;': [568, 1393], '40:': [569], '405-412Crossref': [570], '(0)': [573], '3Sugaya': [576], 'K.': [577, 664, 750, 781, 972, 1793, 1888, 2067], 'Gukagawa': [578], 'T.': [579, 583, 738, 765, 783, 803, 810, 931, 1217, 1327, 1440, 1492], 'Inoko': [580], 'H.': [581, 598, 626, 752, 968, 1070, 1365, 1389, 1436, 1488, 2203], 'Ikemura': [582], 'Genomics.': [584], '1994;': [585, 756, 805, 880, 908, 943, 982, 1684], '23:': [586], '408-419Crossref': [587], '(211)': [590], '4Brownlee': [593], 'Cerami': [595, 973], 'A.': [596, 668, 907, 942, 974, 981, 1042, 1044, 1072, 1438, 1446, 1490, 1498, 1797, 1892, 2071, 3407], 'Vlassara': [597, 967], 'Engl.': [600], 'Med.': [602, 1183], '1988;': [603], '318:': [604], '1315-1320Crossref': [605], '(2407)': [608], '5Schmidt': [611, 2188], 'A.M.': [612, 654, 795, 824, 921, 1028, 1076, 1177, 1231, 1347, 1454, 1506, 1570, 1678, 1783, 1878, 1936, 2057, 2189], 'Vianna': [613, 2190], 'Gerlach': [615, 2192], 'Brett': [617, 655, 922, 1324, 1651, 1784, 1879, 2058, 2194], 'Ryan': [619, 2196], 'Kao': [621, 2198], 'Esposito': [623, 2200], 'C.': [624, 929, 1040, 2201], 'Hegarty': [625, 2202], 'Hurley': [627, 2204], 'W.': [628, 1938, 2205, 2368, 3411], 'Clauss': [629, 2206], 'Wang': [631, 659, 1788, 1883, 2062, 2208], 'F.': [632, 660, 1789, 1884, 2063, 2209], 'Pan': [633, 661, 1790, 1885, 2064, 2210], 'Y.-C.E.': [634, 662, 1791, 1886, 2065, 2211], 'Tsang': [635, 2212], 'T.C.': [636, 2213], 'Stern': [637, 665, 800, 821, 867, 895, 934, 1045, 1081, 1180, 1228, 1344, 1451, 1503, 1567, 1653, 1675, 1794, 1889, 2068, 2214], 'D.': [638, 666, 801, 822, 868, 896, 935, 1036, 1046, 1082, 1181, 1229, 1341, 1345, 1452, 1504, 1568, 1654, 1676, 1795, 1890, 2069, 2215], 'Biol.': [640, 670, 1349, 1369, 1391, 1799, 1894, 2073, 2217, 2704], 'Chem.': [641, 671, 1350, 1370, 1392, 1800, 1895, 2074, 2218], '267:': [643, 673, 1802, 1897, 2076, 2220], '14987-14997Abstract': [644, 2221], 'Full': [645, 675, 1354, 1356, 1374, 1396, 1804, 1899, 2078, 2222], 'Text': [646, 676, 1355, 1357, 1375, 1397, 1805, 1900, 2079, 2223], 'PDF': [647, 677, 1358, 1376, 1398, 1806, 1901, 2080, 2224], '6Neeper': [651], 'Schmidt': [653, 823, 920, 1027, 1075, 1230, 1346, 1453, 1505, 1569, 1677, 1782, 1877, 2056], 'Yan': [657, 796, 815, 865, 893, 1031, 1178, 1222, 1551, 1649, 1786, 1881, 2060], 'S.D.': [658, 797, 816, 866, 894, 917, 1032, 1179, 1223, 1428, 1480, 1552, 1650, 1787, 1882, 2061], 'Elliston': [663, 1792, 1887, 2066], 'Shaw': [667, 1041, 1796, 1891, 2070], '14998-15004Abstract': [674, 1803, 1898, 2077], 'Scholar).': [680, 835, 1191, 1242, 1401, 1463, 1515, 1575, 1687, 1809, 1904, 2379, 2602, 2710], 'AGE': [681, 836], 'formation': [682, 720, 837], 'occurs': [683, 706], 'during': [684], 'normal': [685], 'aging,': [686], 'an': [689, 2545, 3287], 'accelerated': [690], 'degree': [691], 'hyperglycemic': [693], 'conditions': [694, 3097], 'such': [695, 851, 1533, 3866], 'diabetes': [697], 'mellitus.': [698], 'In': [699, 1192, 1243, 1402, 3964, 4459, 4494], 'renal': [700, 1153, 1170, 1195], 'failure,': [701], 'enhanced': [702, 1141, 1200, 1253, 1421, 1523], 'β2-microglobulin': [705], 'result': [709], 'markedly': [712], 'delayed': [713], 'clearance,': [714], 'one': [715, 1845, 3743], 'which,': [718], 'AGE-β2-microglobulin,': [722], 'bone': [729], 'joint': [731], 'destruction': [732], 'characteristic': [733, 990], 'dialysis-related': [735, 1198], 'amyloidosis': [736], '(7Miyata': [737], 'Inagi': [739, 768], 'R.': [740, 769, 862, 874, 970, 1074, 1078, 1329, 1367, 1383, 1648, 1674, 1680, 3409], 'Iida': [741, 770, 819, 1226], 'Y.': [742, 771, 820, 1058, 1060, 1227], 'Sato': [743], 'Yamada': [745, 774], 'Oda': [747, 766], 'O.': [748, 767, 799, 812, 1219, 1323, 1550, 1638, 2591, 3784], 'Maeda': [749, 780], 'Seo': [751], 'Clin.': [754, 785, 826, 1233, 1656], 'Invest.': [755, 786, 827, 1234, 1657], '93:': [757], '521-528Crossref': [758], '(352)': [761], '8Miyata': [764], 'Araki': [772], 'Horiuchi': [776], 'S.': [777, 888, 892, 906, 941, 980, 1339, 1566, 1952], 'Taniguchi': [778], 'Kinoshita': [782], '92:': [788], '1243-1252Crossref': [789], '(413)': [791], '9Schmidt': [794], 'Hori': [798, 811, 1218, 1549, 1637], 'Miyata': [802, 891], 'Circulation.': [804, 1571, 1683], '90:': [806, 1685], '1251Google': [807], '10Miyata': [809], 'Zhang': [813, 1059, 1220, 1330, 1645], 'J.H.': [814, 1221, 3024], 'Ferran': [817, 1224], 'L.': [818, 1225, 1548], '1996;': [828, 1235, 1456, 1508, 1572], '98:': [829, 1236], '1088-1094Crossref': [830, 1237], '(277)': [833, 1240], 'also': [839, 3874], 'favored': [840], 'other': [842, 1244, 1279, 4051], 'settings': [843, 1404], 'associated': [844], 'accumulation': [847], 'amyloid': [849, 1212], 'proteins,': [850], 'components': [854], 'intracellular': [856], 'neurofibrillary': [857], 'tangles': [858], '(11Smith': [859], 'Kutty': [861], 'Richey': [863, 889], 'P.': [864, 890, 1080, 1084, 1448, 1500, 2364, 2589, 3782], 'Chader': [869], 'G.': [870, 876, 900, 925, 1068, 1450, 1502], 'Wiggert': [871], 'B.': [872], 'Petersen': [873], 'Perry': [875, 899], 'Am.': [877, 1047, 1085], 'Pathol.': [879, 1049, 1087], '145:': [881], '42-47PubMed': [882], '12Smith': [885], 'Taneda': [887], 'Monnier': [897], 'V.': [898], 'Proc.': [901, 936, 975], 'Natl.': [902, 937, 976], 'Acad.': [903, 938, 977], 'Sci.': [904, 939, 978], 'U.': [905, 940, 979, 1056], '91:': [909, 944, 983], '5710-5714Crossref': [910], '(744)': [913], '13Yan': [916], 'Chen': [918, 1332, 1429, 1433, 1481, 1485, 1639], 'X.': [919, 1430, 1482], 'Godman': [924, 1449, 1501], 'Scott': [926], 'C.W.': [927], 'Caputo': [928], 'Frappier': [930], 'Yen': [932], 'S.H.': [933], '7787-7791Crossref': [945], '(541)': [948], 'Scholar),': [950, 1092, 2083], 'well': [952, 1859], 'extracellular': [955], 'amyloid-β': [956, 1414], 'peptide': [957, 1415], 'accumulations': [958], '(14Vitek': [959], 'M': [960], 'Bhattacharya': [961], 'Glendening': [963], 'J.M.': [964], 'Stopa': [965], 'E.': [966, 1034, 2362], 'Bucala': [969], 'Manogue': [971], '4766-4770Crossref': [984], '(766)': [987], 'Scholar)': [989, 1665, 1948, 2014, 2227, 3036, 3420, 3795], "Alzheimer's": [992, 1477], 'disease.': [993], 'We': [994, 1284], 'hypothesized': [995, 1273], 'cells,': [1004, 1007, 1011], 'including': [1005], 'mononuclear': [1012], 'phagocytes,': [1013], 'certain': [1015], 'neurons,': [1016], 'immunohistochemistry': [1020], 'situhybridization': [1023], 'studies': [1024, 1135, 2277, 3327, 3648], '(15Brett': [1025], 'Zou': [1029, 1553], 'Y.S.': [1030, 1554], 'Weidman': [1033], 'Pinsky': [1035], 'Neeper': [1037], 'Przysiecki': [1039], 'Migheli': [1043, 1445, 1497], '1993;': [1050, 2007, 2705], '143:': [1051], '1699-1712PubMed': [1052], '16Ritthaler': [1055], 'Deng': [1057], 'Greten': [1061], 'Abel': [1063], 'Allenberg': [1065], 'Otto': [1067], 'Roth': [1069], 'Bierhaus': [1071], 'Ziegler': [1073], 'Waldherr': [1077], 'Wahl': [1079], 'Nawroth': [1083, 1447, 1499], '1995;': [1088, 1184, 1351, 1658], '146:': [1089], '688-694PubMed': [1090], 'places': [1093], 'this': [1094, 1595, 1730, 3186, 4047, 4061], 'molecule': [1095], 'prime': [1097], 'position': [1098], 'mediate': [1100], 'pathogenic': [1102], 'effects': [1103, 1299, 1623], 'AGEs.': [1105], 'tissues': [1110], 'has': [1111, 3741], 'suggested': [1112, 1522, 1578], 'consequences': [1119], 'are': [1126, 4222, 4464], 'be': [1129, 1311, 2906], 'regulated': [1130], 'at': [1131, 2103, 2131, 2317, 2334, 2389, 2392, 2454, 2457, 2508, 2520, 2526, 2541, 2794, 2954, 2978, 3052, 3133, 3529, 3546, 3563, 3839, 3892, 4010, 4046], 'multiple': [1132, 3671], 'levels.': [1133], 'Immunohistochemical': [1134], 'diabetic,': [1137], 'AGE-rich': [1138], 'vasculature': [1139, 1171, 1528], 'demonstrated': [1140, 1248, 1412, 4034, 4237, 4405], 'immunoreactivity': [1143], 'endothelium': [1147], 'from': [1152, 1156, 1518, 2607, 2637, 2656, 2675, 3001, 3016, 3089, 3158, 3208, 3427], 'arteries': [1154], 'obtained': [1155, 1971, 3015, 3713], 'patients': [1157, 1193], 'diabetes,': [1159], 'compared': [1160, 4273, 4411, 4515, 4534], 'levels': [1163], 'staining': [1165, 1201], 'age-matched': [1173], 'control': [1174, 3289, 3572, 4187], 'individuals': [1175], '(17Schmidt': [1176], 'Nat.': [1182], '1:': [1185], '1002-1004Crossref': [1186], '(126)': [1189], 'failure': [1196], 'amyloidosis,': [1199], 'noted': [1205], 'macrophages': [1208], 'pervaded': [1210], 'inflamed': [1211], 'deposits': [1213], 'containing': [1214, 2253, 2272, 2629, 2648, 2667, 2737, 2808, 2844, 2856, 3122, 3538, 3553, 4194, 4216], 'AGE-β2-microglobulin': [1215], '(10Miyata': [1216], 'tissue': [1245, 3258], 'studies,': [1246], 'developing': [1255, 1317], 'neurons': [1256, 1314, 1475], 'central': [1259, 1319, 1407], 'nervous': [1260, 1320, 1408], 'system.': [1261], 'As': [1262, 4100], 'generation': [1264], 'AGEs': [1266], 'unlikely': [1268], 'environment,': [1271], 'might': [1276], 'interact': [1277], 'setting.': [1283], 'found': [1285, 3725], 'served': [1288, 3285, 4200], 'neuronal': [1291, 1468], 'amphoterin,': [1294, 1303], 'mediating': [1295, 1729], 'neurite-outgrowth': [1297], 'promoting': [1298], 'previously': [1300, 2691], 'attributed': [1301], 'amphoterin': [1309], 'could': [1310], 'co-localized': [1312], 'system': [1321], '(18Hori': [1322], 'Slattery': [1326, 1439, 1491], 'Cao': [1328, 1647], 'J.X.': [1333], 'Nagashima': [1334, 1441, 1493], 'Lundh': [1336], 'E.R.': [1337], 'Vijay': [1338], 'Nitecki': [1340], 'Morser': [1342, 1443, 1495], '270:': [1352], '25752-25761Abstract': [1353], '(1044)': [1361], '19Rauvala': [1364], 'Pihlaskari': [1366, 1382], '1987;': [1371], '262:': [1372], '16625-16635Abstract': [1373], '20Merenmies': [1380], 'Laitinen': [1384], 'Wartiovaara': [1386], 'Rauvala': [1388], '266:': [1394], '16722-16729Abstract': [1395], 'system,': [1409], 'have': [1411, 1521, 4307], 'neural': [1422], 'toxicity': [1423], 'microglial': [1425], 'activation/migration': [1426], '(21Yan': [1427, 1479], 'Fu': [1431, 1483], 'Zhu': [1435, 1487], 'Roher': [1437, 1489], 'Nature.': [1455, 1507], '382:': [1457, 1509], '685-691Crossref': [1458, 1510], '(1848)': [1461, 1513], 'Consistent': [1464, 4000], 'these': [1466, 3647, 4002], 'findings,': [1467], 'affected': [1474, 1529], 'brain': [1478], 'Recent': [1516], 'observations': [1517, 1577], 'our': [1519], 'laboratory': [1520], 'immunostaining': [1524], 'autoimmune/inflammatory': [1531], 'disorders,': [1532], 'systemic': [1535], 'lupus': [1536], 'erythematosus': [1537], '2A.': [1538], 'Schmidt,': [1540], 'unpublished': [1541], 'observations.': [1542], 'murine': [1544, 2118], 'atherosclerotic': [1545], 'plaques': [1546, 1835, 1848], '(22Park': [1547], 'Verstuyft': [1555], 'Rubin': [1557], 'E.M.': [1558], 'Liu': [1559], 'J.K.': [1560], 'Yeo': [1561], 'H.C.': [1562], 'Ames': [1563], 'B.N.': [1564], 'Andaz': [1565], '94:': [1573], '200Google': [1574], 'subject': [1585], 'cell-specific': [1587], 'regulation': [1588, 4082], 'based': [1589, 4228], 'microenvironmental': [1591], 'cues.': [1592], 'test': [1594, 2998, 3275], 'hypothesis,': [1596], 'initial': [1605, 1965], 'characterization': [1607], 'undertaken.': [1608], 'Given': [1609], 'under': [1613, 2991, 4315], 'apparently': [1618], 'altered,': [1619], 'studied': [1621], 'prototypic': [1626], 'stimulus,': [1627], 'lipopolysaccharide': [1628], '(LPS),': [1629], 'cultured': [1632], '(23Schmidt': [1635], 'A.-M.': [1636], 'Li': [1641], 'J.F.': [1642], 'Crandall': [1643], '96:': [1659], '1395-1403Crossref': [1660], '(829)': [1663], '(24Fredman': [1671], 'Pauly': [1673], 'Monticone': [1679], 'Crow': [1681], '1567Google': [1686], 'Here': [1688], 'demonstrate': [1690], 'LPS': [1701, 2327, 3439, 4498], 'cells.': [1710], 'Furthermore,': [1711, 4403], 'appears': [1718], 'essential': [1719, 4322], 'A': [1732, 2407, 2473, 2542], 'bacteriophage': [1733], 'library': [1734], '(2.0': [1735], '×': [1736, 3249], '106': [1737], 'plaque-forming': [1738], 'units)': [1739], 'constructed': [1740], 'cloning': [1742, 3148], 'human': [1743, 1776, 1872, 2051, 2095, 2575, 2613, 2773, 3164, 3507, 3691, 3703, 3738, 3920, 4145], 'lung': [1744, 2096], 'genomic': [1745, 2142, 3813], 'DNA': [1746, 1924, 1926, 1969, 2157, 2165, 2722, 2883, 3157, 3270, 3814], 'into': [1747, 1918, 2348, 3149, 3213, 3253, 3596, 4168, 4375], 'BamHI': [1749, 1852], 'λDASH': [1752], '11': [1753], '(Stratagene,': [1754], 'La': [1755], 'Jolla,': [1756], 'CA)': [1757, 2102, 3083], 'screened': [1759], 'hybridization': [1761, 1826, 3488], 'synthetic': [1764, 2023], 'oligonucleotide': [1765, 1862, 1956, 2024, 2912], 'probe': [1766, 1811, 1863, 3063, 3510, 3515], '(Ps-1)': [1767], 'corresponding': [1768, 1865, 2027, 2044, 3680, 3696], 'nucleotides': [1770, 3711, 4007, 4029], '+17': [1771], '+101': [1773], 'cDNA': [1778, 1874, 2053, 3509, 3514], 'sequence': [1779, 1966, 1970, 2158, 2166, 2884, 3193, 3603, 3815, 3883], '(6Neeper': [1780, 1875, 2054], '5′-end-labeled': [1813, 2721], '[γ-32P]ATP': [1815, 2087], 'T4-polynucleotide': [1817], 'kinase.': [1818], 'Lifts': [1819], 'prepared': [1821, 2358, 4179, 4328], 'hybridized': [1823, 1855, 3503], 'QuikHyb': [1825], 'solution': [1827], 'according': [1828, 2689, 3190, 3242], "manufacturer's": [1831, 3245], 'instructions': [1832], '(Stratagene).': [1833, 3498, 3525], 'Positive': [1834], 'selected': [1837], 'purified.': [1839], 'Southern': [1840], 'blot': [1841], '3.5-kilobase': [1851], 'insert,': [1853], 'Ps-1': [1857], 'another': [1861, 2791, 4214], '(Ps-2)': [1864], '+19': [1867], '+43': [1869], 'insert': [1906, 4132], 'isolated': [1908, 3224], 'digested': [1910], 'HindIII.': [1912], 'resulting': [1914, 3590, 4163], 'fragments': [1915, 2723, 3155, 3592], 'subcloned': [1917, 3595], 'plasmid': [1919, 3276, 3304, 4215], 'pBluescript': [1920], 'II': [1921], 'SK(+)': [1922], 'sequencing.': [1925], 'sequencing': [1927, 2138, 2863], 'performed': [1929, 1989, 2688, 3236], 'dideoxy': [1932], 'chain-termination': [1933], 'method': [1934], '(25Maxam': [1935], 'Gilbert': [1937], 'Methods': [1939], 'Enzymol.': [1940], '1980;': [1941], '65:': [1942], '499-560Crossref': [1943], '(9556)': [1946], 'Sequenase': [1950], '(U.': [1951], 'Biochemical': [1953], 'Corp.).': [1954], 'Vector-specific': [1955], 'T3': [1957], 'T7': [1959], 'primers': [1960, 2130, 2147, 2876, 3183, 3676], 'obtain': [1964], 'information.': [1967], 'shown': [1981], 'Fig.': [1983], '1.': [1984], 'Primer': [1985, 3522, 3658], 'extension': [1986, 2161, 3659], 'described': [1991, 2360, 3099, 3228], '(26Perkins': [1992], 'N.D.': [1993], 'Lawrence': [1994], 'Edwards': [1995], 'Duckett': [1997], 'C.S.': [1998], 'Agranlff': [1999], 'A.B.': [2000], 'Schmid': [2001], 'R.M.': [2002], 'Nabel': [2003], 'G.J.': [2004], 'EMBO': [2005, 3027], '12:': [2008, 2596, 3789], '3551-3558Crossref': [2009], '(407)': [2012], 'map': [2016, 3664], 'transcriptional': [2018, 4121, 4343, 4353, 4364], 'initiation': [2019], 'site.': [2020, 3668, 4123], 'Briefly,': [2021, 2380, 3247], 'primers,': [2025], 'Pe-5': [2026, 3679, 3729], '−104': [2029, 3682], '−83': [2031, 3684], '(Fig.': [2040, 3202, 3718, 3771, 3876, 3938, 3962, 4159, 4367, 4480], '1)': [2041], 'Pe-6': [2043, 3695, 3717], '+18': [2046, 3698], '+41': [2048, 3700], 'end-labeled': [2085, 2936, 2986, 3060], 'annealed': [2089], '5': [2091, 2387, 3306, 4481], 'μg': [2092, 2950], 'poly(A)+': [2097], 'RNA': [2098, 3426, 3456, 3465, 3481], '(CLONTECH,': [2099], 'Palo': [2100], 'Alto,': [2101], '58': [2104], '°C': [2105, 2133, 2510, 3548], '20': [2107, 2759, 2949], 'min.': [2108, 2136, 2959], 'After': [2109, 2331, 2442, 2788, 2825, 3472, 3526], 'cooling': [2110], 'room': [2112, 2795, 2955, 2979, 3053, 3530], 'temperature': [2113, 2956, 2980, 3531], '10': [2115, 2524, 2778, 3134, 3993], 'min,': [2116, 2432], 'Moloney': [2117], 'leukemia': [2119], 'virus': [2120], 'reverse': [2121], 'transcriptase': [2122], '(Promega,': [2123], 'Madison,': [2124], 'WI)': [2125], 'added': [2127, 3317, 3367], 'extend': [2129], '42': [2132], '30': [2135, 2452, 2958, 2989, 3065, 3544], 'Dideoxy': [2137, 2862], 'clone': [2143], 'same': [2146, 2874, 2993, 3096, 4131], 'above': [2149, 2475, 2878, 3764, 4474], '(Pe-5': [2150], 'Pe-6)': [2152], 'carried': [2154, 2880], 'out': [2155, 2881], 'ladders.': [2159, 2885], 'alongside': [2163], 'ladders': [2167], 'analyzed': [2169], 'denatured': [2172], 'polyacrylamide': [2173, 2853, 3116], 'gel': [2174, 2768, 2854, 3478, 3994], '(8%)': [2175, 2855], 'exposed': [2177, 3297], 'autoradiographic': [2179], 'film': [2180], 'overnight.': [2181], 'Bovine': [2182], '(BAECs,': [2186], 'Ref.': [2187, 3020, 3778], '(RSMCs,': [2233], 'generously': [2234], 'provided': [2235], 'Dr.': [2237], 'Abraham': [2238], 'Rothman),': [2239], 'maintained': [2241], "Dulbecco's": [2243], 'modified': [2244], "Eagle's": [2245], 'medium': [2246, 2296, 3315, 3346, 3370], 'M199': [2248], '(Life': [2249, 3239], 'Technologies,': [2250, 2259, 3240], 'Inc.),': [2251], 'respectively,': [2252], 'fetal': [2254], 'serum': [2256, 2301, 2756, 3351, 3448], '(10%,': [2257, 2437], 'Life': [2258], 'Inc.)': [2260, 3241], 'penicillin': [2262], '(100': [2263, 2267], 'units/ml)': [2264], 'streptomycin': [2266], 'μg/ml),': [2268], 'humidified': [2270], 'incubators': [2271], 'CO2': [2273], '(5%).': [2274], 'Prior': [2275, 3325], 'basal/stimulated': [2279, 3329], 'function': [2280, 3330, 4241], 'promoter,': [2284, 3334, 3911], 'BAECs': [2285, 2315, 3091, 3232, 3335, 3428, 4169, 4248, 4298, 4376, 4479, 4510, 4529], 'RSMCs': [2287, 2323, 3093, 3234, 3337, 3430, 4250, 4484, 4514, 4533], 'washed': [2289, 2340, 2469, 3339], 'phosphate-buffered': [2291, 2344, 2350, 3341], 'saline': [2292, 2345, 2351, 3342], 'placed': [2294, 3344], 'above,': [2298, 3100, 3348], 'except': [2299, 3349], 'omitted': [2303, 3353], '8': [2305, 2332, 3355, 3371, 3441], 'h': [2306, 2333, 3356, 3372, 3444, 4173], 'prior': [2307, 3101, 3266, 3357, 3373, 3605], 'exposure': [2309, 3359], 'indicated': [2312, 3041, 3446, 3632, 3735, 3759, 4283, 4424], 'Both': [2314], '(utilized': [2316], 'passage': [2318], '1–3': [2319], 'experiments)': [2321], 'treated': [2325], '(10': [2328], 'ng/ml,': [2329], 'Difco).': [2330], '37': [2335], '°C,': [2336, 2459, 2528], 'monolayers': [2338], 'twice': [2341, 3528], 'cold': [2343, 2349, 2405], 'scraped': [2347], '(1.0': [2352], 'ml)': [2353, 2439, 2736, 2807], 'nuclear': [2355, 2466, 2515, 2531, 2537, 2952, 2963, 3013, 3087], 'extracts': [2356, 2953, 2964, 3014], '(27Schrieber': [2361], 'Matthias': [2363], 'Muller': [2365], 'Schaffner': [2367], 'Nucleic': [2369, 2592, 3785], 'Acids': [2370, 2593, 3786], 'Res.': [2371, 2594, 3787], '1989;': [2372, 3029], '17:': [2373], '6419Crossref': [2374], '(4013)': [2377], 'suspension': [2383], 'centrifuged': [2385, 2450, 2519], 'min': [2388, 2453, 2507, 2525, 2779, 2793, 2977, 2990, 3051, 3066, 3545], '3,500': [2390], 'rpm': [2391, 2456, 2522], '4': [2393, 2458, 2509, 2527, 3137, 4160, 4368], '°C.': [2394, 3565], 'pellet': [2397, 2467], 'then': [2399, 2434, 2518, 2849, 2982, 3056, 3113, 3502, 3594, 4166, 4373], 'resuspended': [2400, 2479], '0.4': [2402], 'ml': [2403, 2482, 2839], 'buffer': [2406, 2472, 2485, 2734, 3121], '(0.010': [2408], 'm': [2409, 2414, 2419, 2488, 2495, 2501, 2743, 2746, 2749, 2810, 3124, 3131], '(pH': [2410, 2489, 2740, 2812, 3127], '7.9)': [2411, 2490], 'HEPES,': [2412, 2491], '0.010': [2413], 'KCl,': [2415, 2752], '0.0001m': [2416], 'EDTA,': [2417, 2496, 2750], '0.001': [2418, 2494, 2497, 2500, 2745], 'dithiothreitol,': [2420], '0.5': [2422], 'mm': [2423], 'phenylmethylsulfonyl': [2424, 2502], 'fluoride)': [2425], 'incubated': [2427, 2947, 2967, 2983, 3057], 'ice': [2429], '15': [2431, 2445, 2506, 2976, 3050], 'Nonidet': [2435], 'P-40': [2436], '0.025': [2438], 'added.': [2441, 2787], 'vortexing': [2443], 's,': [2446], 'lysates': [2448, 4177], '13,000': [2455, 2521], 'supernatant': [2461], 'removed,': [2463], 'once': [2470, 3542], 'ml),': [2477], '0.1': [2481, 2809], 'ice-cold': [2484], 'B': [2486], '(0.020': [2487], '0.4m': [2492], 'NaCl,': [2493], 'mdithiothreitol,': [2498], 'fluoride': [2503], 'PMSF)': [2504], 'constant': [2512], 'agitation.': [2513], 'lysate': [2516], 'extract': [2532, 3088], 'collected.': [2533], 'concentration': [2535, 3042, 3453], 'protein': [2538], 'determined': [2540, 3379, 3458], '280': [2543], 'Ultra-Spec': [2546], 'spectrophotometer': [2547], '(Pharmacia': [2548], 'Biotech': [2549], 'Inc.).': [2550], 'employed': [2556, 3797], 'determine': [2558, 3635, 3897], 'capabilities': [2561], 'computer': [2581], '(Genetics': [2583, 3775], 'Computer': [2584, 3773, 3776], 'Group;': [2585, 3777], 'Ref.28Devereux': [2586], 'Haeberli': [2588, 3781], 'Smithies': [2590, 3783], '1984;': [2595, 3788], '387-395Crossref': [2597, 3790], '(12575)': [2600, 3793], 'Three': [2603], 'probes': [2604, 2913, 2945], 'amplified': [2606], 'PCR': [2617, 3182, 3209, 3591], '[γ-32P]ATP-labeled': [2619], 'sense': [2620, 2875], 'primer': [2621, 3716, 3728], 'unlabeled': [2623, 2973, 3047], 'antisense': [2624], 'primer.': [2625], 'first': [2627, 2966, 3927, 3941], 'probe,': [2628, 2647, 2666, 3012], '1,': [2633], 'spanned': [2634, 2653, 2672, 3945, 3955, 3978], '−1581': [2638], '−738': [2640], 'region.': [2644, 2663, 2682, 4458, 4470], 'second': [2646, 3954], '−721': [2657], '−399': [2659, 2678], 'third': [2665, 3974], '3,': [2671], '−587': [2676], 'published': [2692], 'methods': [2693], '(29Beg': [2694], 'A.A.': [2695], 'Finco': [2696], 'T.S.': [2697], 'Nanterment': [2698], 'P.V.': [2699], 'Baldwin': [2700], 'A.S.': [2701], 'Mol.': [2702], 'Cell.': [2703], '13:': [2706], '3301-3310Crossref': [2707], 'For': [2711, 2960, 3069], 'each': [2712, 3621], 'nicking': [2715], 'reaction,': [2716], '30–50': [2717], 'ng': [2718], 'diluted': [2725], '≈0.7': [2727], 'nm': [2728], 'final': [2731], 'volume': [2732], '(0.1': [2735, 3551], '0.02m': [2738], 'Tris-HCl': [2739], '7.4),': [2741], '0.002': [2742], 'MgCl2,': [2744], 'CaCl2,': [2747], '0.0001': [2748], '0.040m': [2751], '100': [2753], 'μg/ml': [2754, 2760, 2821], 'albumin,': [2757], 'salmon': [2761, 2822], 'sperm': [2762, 2823], 'DNA,': [2763], 'preincubated': [2765, 3038, 3085], '2–10': [2767], 'units': [2770], 'purified': [2772, 3919, 3968], 'NF-κB': [2774, 2898, 2924, 2932, 3003, 3062, 3921, 3988, 4021, 4031, 4038], 'p50': [2775, 3969, 3989], '(Promega)': [2776, 3153, 3383], 'ice.': [2781], '(30': [2784], 'ng/ml)': [2785], 'incubation': [2789, 3320], 'temperature,': [2796, 3054], 'reactions': [2797], 'terminated': [2799], 'addition': [2802, 3104, 3966], 'stop': [2804], 'reagent': [2805], '(0.05': [2806], 'EDTA': [2811, 3132], '8.0),': [2813], '0.8%': [2814], 'SDS,': [2815], '1.6m': [2816], 'ammonium': [2817], 'acetate,': [2818], '300': [2820], 'DNA.': [2824], 'extraction': [2826], 'phenol:chloroform': [2828], '(1:1),': [2829], 'nucleic': [2830], 'acids': [2831], 'ethanol-precipitated,': [2833], 'dried,': [2834], 'dissolved': [2836], '0.003': [2838], 'formamide': [2841], '(96%,': [2842], 'v/v)': [2843], 'tracking': [2845], 'dyes.': [2846], 'Samples': [2847, 3111], 'loaded': [2850, 3114], 'onto': [2851, 3115], 'urea': [2857], '(7': [2858], 'm)': [2859], 'electrophoresed.': [2861], 'Based': [2886], 'indicating': [2895], 'only': [2897, 3742, 3925], '2': [2902, 2934, 3008, 3248, 4014], 'functional,': [2907], 'created': [2915, 3146], 'annealing': [2917], 'oligonucleotides': [2919, 2974, 2987, 3048], '5′-CTCGGAGGGAGTTTCTGCTA-3′': [2920], '5′-TAGCAGAAACTCCCTCCGAG-3′': [2922], '5′-AGAGTGGGGAACCCCTCCCA-3′': [2928], '5′-TGGGAGGGGTTCCCCACTCT-3′': [2930], '[γ-32P]ATP.': [2938], 'Approximately': [2939], '150': [2940], 'pg': [2941], 'labeled': [2944, 3107, 3516], 'competition': [2961], 'assays,': [2962, 3071], '100-fold': [2969], 'excess': [2970], 'condition': [2994], 'above.': [2996, 3068, 3229], 'if': [2999, 3636], 'sequences': [3000, 3837, 3865, 4005, 4142], 'competed': [3009], 'consensus': [3011, 3061, 3828, 3836, 3864, 4022, 4039], 'HeLa': [3017], '(Promega;': [3019], '30Kristie': [3021], 'T.M.': [3022], 'LeBowitz': [3023], 'Sharp': [3025], 'P.A.': [3026], '8:': [3030], '4229-4238Crossref': [3031], '(196)': [3034], 'promoter-specific': [3046], 'supershift': [3070], 'antibody': [3072], 'p50,': [3074, 3922], 'p65': [3075], 'c-Rel': [3077], '(Santa': [3078], 'Cruz': [3079], 'Biotechnology,': [3080], 'Santa': [3081], 'Cruz,': [3082], 'oligonucleotides.': [3110], 'gels': [3117], 'run': [3119], '0.09': [3123], 'Tris': [3125], 'borate': [3126], '8.3)': [3128], '0.0025': [3130], 'V/cm': [3135], 'h.': [3138, 3307, 3324], 'utilized': [3141, 3645], 'experiments': [3144], 'pGL3-Basic': [3151, 3215, 3598, 4157], 'vector': [3152, 3216, 3599, 4158, 4188, 4193], 'different': [3154], 'gene,': [3166], 'either': [3167, 4381], 'compatible': [3170], 'restriction': [3171], 'amplifying': [3175], 'specific': [3177], 'regions': [3178, 4321], 'PCR.': [3180, 3588], 'study': [3187], 'designed': [3189], '1),': [3203, 3846, 3951], 'all': [3205], 'inserts': [3206], 'derived': [3207], 'amplification': [3210], 'sequenced': [3218], 'strands.': [3221], 'Cells': [3222, 3295], 'grown/maintained': [3226], 'Transfection': [3230, 4379], 'LipofectAMINE': [3238, 3302], 'recommendations.': [3246], '105cells': [3250], 'plated': [3252], 'wells': [3255], 'six-well': [3257], 'culture': [3259], 'plates': [3260], '(Corning,': [3261], 'Corning,': [3262], 'NY)': [3263], 'day': [3265], 'transfection.': [3268], 'mixture': [3271, 3300], 'composed': [3273], '(2': [3277, 3536], 'μg)': [3278], 'pSV': [3280], 'β-galactosidase': [3281, 3398, 4218], '(0.5': [3282], 'μg),': [3283], 'internal': [3288], 'normalize': [3291, 3574], 'activities': [3292], 'luciferase.': [3294], 'Following': [3308], 'removal': [3309], 'reagent,': [3313], 'fresh': [3314], 'continued': [3321], '48': [3323, 4172], 'Where': [3362], 'indicated,': [3363, 4101], 'stimulus': [3364], '(LPS)': [3365], 'harvesting.': [3375], 'Luciferase': [3376], 'standard': [3381], 'reagents': [3382], 'luminometer': [3388], '(Wallac,': [3389], 'Gaithersburg,': [3390], 'MD)': [3391], 'directed,': [3393], 'standardized': [3396], 'activity.': [3399], 'Acid': [3400], 'phenol-guanidinium': [3401], 'thiocyanate': [3402], 'procedure': [3403], '(31Chirgwin': [3404], 'Przbyla': [3406], 'MacDonald': [3408], 'Rutter': [3410], 'Biochemistry.': [3412], '1979;': [3413], '18:': [3414], '5294-5299Crossref': [3415], '(18696)': [3418], 'isolate': [3424], 'total': [3425, 3455, 3464], 'absence': [3435], '16': [3443], '(after': [3447], 'deprivation': [3449], 'above).': [3451], 'adsorption': [3460], 'atA': [3461], '260/280': [3462], '(20': [3466], 'μg/lane)': [3467], 'subjected': [3469, 3559, 3601], 'electrophoresis.': [3471], 'separation': [3474], 'formaldehyde': [3477], '(0.7%),': [3479], 'transferred': [3483], 'Gene': [3486], 'Screen': [3487], 'filter': [3489, 3500, 3557], '(DuPont': [3490], 'NEN)': [3491], 'UV': [3496], 'cross-linker': [3497], 'full-length': [3506], 'glyceraldehyde-3-phosphate': [3512], 'dehydrogenase': [3513, 3567], '[γ-32P]dCTP': [3518], 'Random': [3521], 'Labeling': [3523], 'System': [3524], 'washing': [3527], '(15': [3532], 'min/wash)': [3533], 'SSC': [3535, 3550], '×)': [3537, 3552], 'SDS': [3539, 3554], '(0.1%)': [3540], '60': [3547], '(0.1%),': [3555], 'autoradiography': [3561], 'overnight': [3562], '−80': [3564], 'Glyceraldehyde-3-phosphate': [3566], 'message': [3568, 3580], 'counts': [3576], 'densitometry.': [3582], 'Mutation': [3583], 'generated': [3586], 'studies.': [3608], 'pGL-B': [3609, 4102, 4134, 4236, 4259, 4400, 4413, 4507], 'contains': [3610], 'wild-type': [3612], 'construct,': [3613], '−1543': [3614, 3625], '+49.': [3616], 'pGL-C,': [3617], 'pGL-D,': [3618], 'pGL-G': [3620], 'contain': [3622], '+49,': [3627], 'but': [3628, 3720, 4135], 'mutation(s)': [3631], 'below.': [3633], 'differences': [3637], 'between': [3638, 3641], 'various': [3643], 'statistically': [3650], 'significant,': [3651], 'variance': [3654], '(ANOVA)': [3655], 'used.': [3657], 'transcription': [3666, 3745, 3801, 3820, 3825, 4069, 4110], 'start': [3667, 3673, 3746, 3756, 3821, 4111, 4122, 4344, 4354, 4365, 4433], 'identify': [3670, 3886, 4320], 'sites,': [3674], 'designed,': [3678], 'cDNA.': [3705], 'An': [3706], 'extended': [3707, 3722], 'product': [3708, 3723], '41': [3710], '2),': [3719], 'no': [3721, 4547], '(data': [3730], 'not': [3731, 3998, 4064], 'shown).': [3732, 3999], 'major': [3744], 'site,': [3747, 3976], 'thymidine': [3749], 'residue,': [3750], 'designated': [3751], '"+1."': [3753], 'translation': [3755], 'bold': [3762], 'arrow': [3763], '"A"': [3766], 'ATG': [3769], 'codon': [3770], '1).': [3772, 3877, 3963], '28Devereux': [3779], 'match': [3799], 'factor': [3802, 3826, 4070], 'comparison': [3810], 'upstream': [3816, 4107, 4118, 4150, 4340, 4350, 4361, 4430], 'known': [3824], 'sequences.': [3829], 'search': [3831], '(GDRRADYCCC)': [3838], '−1518': [3840], '−1510': [3842], '(referred': [3843, 3850, 3858], '−671': [3847], '−663': [3849], '−467': [3855], '458': [3857], '3).': [3861, 3939], 'Other': [3862], 'general': [3863], 'SP1,': [3868], 'AP-2,': [3869], 'γ-IRE,': [3870], 'NF-IL6': [3872], 'However,': [3878], 'further': [3879], 'examination': [3880], 'failed': [3884, 3970], 'classic': [3887], 'TATA': [3888], 'CAAT': [3890], 'boxes': [3891], 'appropriate': [3894], 'positions.': [3895], 'capacity': [3900], 'located': [3907], 'within': [3908, 4455, 4467], 'performed.': [3917], 'Using': [3918], 'protection': [3923], '(sites': [3932], 'nucleotide': [3946, 3956, 3979], 'coordinates': [3947, 3957, 3980], '−1518/−1510': [3948], '(NF-κB': [3949, 3959], '−671/−663': [3958], 'contrast,': [3965, 4460], 'protect': [3972], '−467/−458,': [3981], 'even': [3982], 'increasing': [3984], 'amount': [3986, 3991], '(total': [3990], 'units;': [3996], 'data': [3997, 4221, 4423], 'observations,': [4003], 'comprising': [4008, 4030], 'footprints': [4009], '95%': [4016], '50%': [4018, 4035], 'identical': [4019], 'sequences,': [4023, 4040], 'respectively.': [4024], 'Despite': [4025], 'fact': [4027], '3': [4033], 'identity': [4036], 'lack': [4042], 'footprint': [4045], 'indicates': [4049], 'impact': [4053], 'capacity,': [4058], 'NF-κB.': [4071], 'assess': [4073], 'portions': [4075], 'involved': [4080], 'series': [4089], 'promoter-luciferase': [4093], 'developed': [4097], '(Fig.4': [4098, 4420], 'A).': [4099, 4161, 4369], 'consisted': [4103], '1543': [4105], 'bp': [4106, 4117, 4339, 4349, 4360, 4429], 'pGL-E': [4114, 4245, 4261, 4415, 4526], '738': [4116], 'pGL-B-R,': [4124], 'negative': [4127, 4461], 'control,': [4128], 'opposite': [4138], 'orientation.': [4139], 'plasmids': [4164], 'transfected': [4167, 4374], 'RSMCs.': [4171, 4378], 'after': [4174], 'transfection,': [4175], 'tested': [4181], 'assay.': [4185], 'pGL-3': [4186], '(Promega),': [4189], 'SV40': [4196], 'enhancer,': [4199], 'positive': [4202], 'control.': [4203], 'Efficiency': [4204], 'assessed': [4208], 'monitoring': [4210], '(Thus,': [4220], 'reported': [4223], 'normalized': [4225], 'measurement': [4230], 'β-galactosidase.)': [4232], 'Although': [4233], 'construct': [4235, 4244, 4276, 4304], 'weaker': [4238], 'than': [4242, 4312, 4396], '(p': [4251, 4278], '<': [4252, 4279, 4520, 4539], '0.05': [4253], 'cases),': [4256], 'resulted': [4262, 4385], 'significant': [4264], 'increases': [4265], 'types': [4272, 4419], 'pGL-B-R': [4277], '0.001).': [4280], '−1543/+49': [4286], '−738/+49': [4288], 'motifs': [4291, 4436, 4445], 'RSMCs,': [4300], 'although': [4301, 4389], 'latter': [4303], 'seemed': [4305], 'greater': [4309], 'former': [4314], 'present': [4317], 'conditions.': [4318], 'additional': [4330], 'promoter-reporter': [4333], 'constructs,': [4335], 'pGL-21': [4336, 4382], '(containing': [4337, 4347, 4358], '587': [4338], 'site),': [4345, 4355], 'pGL-22': [4346, 4404], '202': [4348], 'pGL-23': [4357, 4384], '55': [4359, 4428], 'site)': [4366], 'less': [4395], 'pGL-E.': [4402], 'strikingly': [4406], 'diminished': [4407], 'B).': [4421], 'demonstrating': [4437], 'enhancement': [4444], 'may': [4453], 'exist': [4454], 'elements': [4463], '−202/−55': [4469], '5′-Deletion': [4471], 'transfect': [4478], 'A)': [4482], '(Fig.5': [4485], 'B)': [4486], 'alone': [4487], 'LPS.': [4493], 'types,': [4497], '(∼4.1-fold': [4508], '∼6.0-fold': [4512], 'conditions;': [4518, 4537], 'p': [4519, 4538], '0.01': [4521, 4540], 'cases)': [4524], '(∼3.7-fold': [4527], '∼3.8-fold': [4531], 'cases).': [4543], 'Unlike': [4544], 'signi': [4548]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1984830754', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 19}, {'year': 2019, 'cited_by_count': 18}, {'year': 2018, 'cited_by_count': 20}, {'year': 2017, 'cited_by_count': 25}, {'year': 2016, 'cited_by_count': 18}, {'year': 2015, 'cited_by_count': 31}, {'year': 2014, 'cited_by_count': 22}, {'year': 2013, 'cited_by_count': 32}, {'year': 2012, 'cited_by_count': 30}], 'updated_date': '2024-12-08T18:58:58.329770', 'created_date': '2016-06-24'}