Title: RO 23-6240 (AM-833), a new fluoroquinolone: In vitro antimicrobial activity and tentative disk diffusion interpretive criteria
Abstract: The susceptibility of over 7000 recent clinical bacterial isolates to RO 23-6240, a new trifluorinated quinolone, was determined at four medical centers. Over 99% of Enterobacteriaceae and 97% of staphylococci were inhibited by ⩽2.0 μg/ml of RO 23-6240. Only 71% of Pseudomonas spp. were inhibited by this concentration. Streptococci and enterococci were resistant to RO 23-6240. Clinical isolates of Haemophilus spp., pathogenic Neisseria spp., and Branhamella catarrhalis were inhibited by ⩽0.25 μg/ml of RO 23-6240. This drug's antibacterial activity was comparable with that of enoxacin and norfloxacin, but was less than that of ciprofloxacin against most species. Using ⩽2.0 μg/ml and ⩾8.0 μg/ml as the susceptible and resistant MIC breakpoints for RO 23-6240, the regression analysis-derived disk diffusion zone diameter breakpoints for the 5 μg disk are: Susceptible ⩾19 mm intermediate 16–18 mm, and resistant ⩽15 mm.
Publication Year: 1987
Publication Date: 1987-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 30
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