Title: COMPARISON OF ORAL THEOPHYLLINE AND SALBUTAMOL BY INHALATION IN ASTHMATIC PATIENTS
Abstract: The bronchodilator effects of 375 mg theophylline orally and 200 μg salbutamol by pressurized aerosol were compared in a randomized, cross‐over, double‐blind trial in fourteen asthmatic patients. The mean peak percentage FEV 1 increase from control was 43.7% at 60 min after salbutamol and 30.3% at 180 min after theophylline. Salbutamol produced significantly greater bronchodilatation than theophylline for the initial 30 min ( P <0.01). Theophylline demonstrated a longer duration of action than salbutamol, with a significantly greater FEV 1 response at 360 min ( P < 0.02). There was no significant difference between the total effect of each drug for the 360 min period, as calculated by the areas under the respective FEV 1 response curves.