Circular Proteins in Plants

Name: Work Video:
Duration: 3 min 30 s
Maria Elena Felizmenio-Quimio; Norelle L. Daly; David J. Craik
{'id': 'https://openalex.org/W1983851126', 'doi': 'https://doi.org/10.1074/jbc.m101666200', 'title': 'Circular Proteins in Plants', 'display_name': 'Circular Proteins in Plants', 'publication_year': 2001, 'publication_date': '2001-06-01', 'ids': {'openalex': 'https://openalex.org/W1983851126', 'doi': 'https://doi.org/10.1074/jbc.m101666200', 'mag': '1983851126', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11292835'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m101666200', 'pdf_url': 'http://www.jbc.org/article/S0021925820785819/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820785819/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046351131', 'display_name': 'Maria Elena Felizmenio-Quimio', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Maria Elena Felizmenio-Quimio', 'raw_affiliation_strings': ['Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Queensland, Australia'], 'affiliations': [{'raw_affiliation_string': 'Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Queensland, Australia', 'institution_ids': ['https://openalex.org/I165143802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080112340', 'display_name': 'Norelle L. Daly', 'orcid': 'https://orcid.org/0000-0002-4697-6602'}, 'institutions': [{'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Norelle L. Daly', 'raw_affiliation_strings': ['From the Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072 Queensland, Australia'], 'affiliations': [{'raw_affiliation_string': 'From the Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072 Queensland, Australia', 'institution_ids': ['https://openalex.org/I165143802']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5079308758', 'display_name': 'David J. Craik', 'orcid': 'https://orcid.org/0000-0003-0007-6796'}, 'institutions': [{'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'David J. Craik', 'raw_affiliation_strings': ['From the Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072 Queensland, Australia'], 'affiliations': [{'raw_affiliation_string': 'From the Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072 Queensland, Australia', 'institution_ids': ['https://openalex.org/I165143802']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.869, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 228, 'citation_normalized_percentile': {'value': 0.999974, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '276', 'issue': '25', 'first_page': '22875', 'last_page': '22882'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13326', 'display_name': 'Biochemical and Structural Characterization', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13326', 'display_name': 'Biochemical and Structural Characterization', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11750', 'display_name': 'Phytoplasmas and Hemiptera pathogens', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9773, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/structural-motif', 'display_name': 'Structural motif', 'score': 0.51736635}, {'id': 'https://openalex.org/keywords/protein-superfamily', 'display_name': 'Protein superfamily', 'score': 0.51165324}, {'id': 'https://openalex.org/keywords/violaceae', 'display_name': 'Violaceae', 'score': 0.46968228}], 'concepts': [{'id': 'https://openalex.org/C132677234', 'wikidata': 'https://www.wikidata.org/wiki/Q3273544', 'display_name': 'Structural motif', 'level': 2, 'score': 0.51736635}, {'id': 'https://openalex.org/C178180057', 'wikidata': 'https://www.wikidata.org/wiki/Q7251477', 'display_name': 'Protein superfamily', 'level': 3, 'score': 0.51165324}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.47827232}, {'id': 'https://openalex.org/C2778184809', 'wikidata': 'https://www.wikidata.org/wiki/Q156060', 'display_name': 'Violaceae', 'level': 2, 'score': 0.46968228}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45909888}, {'id': 'https://openalex.org/C139489369', 'wikidata': 'https://www.wikidata.org/wiki/Q770846', 'display_name': 'Structural similarity', 'level': 2, 'score': 0.4393999}, {'id': 'https://openalex.org/C2780340462', 'wikidata': 'https://www.wikidata.org/wiki/Q127450', 'display_name': 'Trypsin', 'level': 3, 'score': 0.42396173}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.38783616}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3546201}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.2689823}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.25401405}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.24355897}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.116294265}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0739311}], 'mesh': [{'descriptor_ui': 'D019662', 'descriptor_name': 'Cucurbitaceae', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D014361', 'descriptor_name': 'Trypsin Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019662', 'descriptor_name': 'Cucurbitaceae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014361', 'descriptor_name': 'Trypsin Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m101666200', 'pdf_url': 'http://www.jbc.org/article/S0021925820785819/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11292835', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m101666200', 'pdf_url': 'http://www.jbc.org/article/S0021925820785819/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land', 'score': 0.65}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1491642680', 'https://openalex.org/W1520129434', 'https://openalex.org/W1549740397', 'https://openalex.org/W1827043750', 'https://openalex.org/W1968645374', 'https://openalex.org/W1969126658', 'https://openalex.org/W1972438369', 'https://openalex.org/W1973277508', 'https://openalex.org/W1973993174', 'https://openalex.org/W1975459052', 'https://openalex.org/W1976595458', 'https://openalex.org/W1992931410', 'https://openalex.org/W1995390287', 'https://openalex.org/W2002195659', 'https://openalex.org/W2017515564', 'https://openalex.org/W2020011259', 'https://openalex.org/W2027067039', 'https://openalex.org/W2028277934', 'https://openalex.org/W2029780190', 'https://openalex.org/W2039975948', 'https://openalex.org/W2041997590', 'https://openalex.org/W2045798628', 'https://openalex.org/W2046172734', 'https://openalex.org/W2047163586', 'https://openalex.org/W2050252862', 'https://openalex.org/W2052933818', 'https://openalex.org/W2055870805', 'https://openalex.org/W2072420936', 'https://openalex.org/W2072544252', 'https://openalex.org/W2073764925', 'https://openalex.org/W2107177621', 'https://openalex.org/W2118086089', 'https://openalex.org/W2132351632', 'https://openalex.org/W2135737340', 'https://openalex.org/W2151687360', 'https://openalex.org/W2152458717', 'https://openalex.org/W2162166182', 'https://openalex.org/W2165899507', 'https://openalex.org/W2949250147', 'https://openalex.org/W4229620401', 'https://openalex.org/W4242009576'], 'related_works': ['https://openalex.org/W4296794131', 'https://openalex.org/W4214487735', 'https://openalex.org/W2613371097', 'https://openalex.org/W2436901547', 'https://openalex.org/W2169682455', 'https://openalex.org/W2139445777', 'https://openalex.org/W2081088279', 'https://openalex.org/W2044467472', 'https://openalex.org/W1971099088', 'https://openalex.org/W1646790336'], 'abstract_inverted_index': {'Much': [0, 235], 'interest': [1, 236], 'has': [2, 198, 237, 433, 1052, 1415, 1676, 1836, 3174], 'been': [3, 200, 211, 238, 435, 446, 515, 1055, 1100, 1166, 1417, 1678, 1837, 3417], 'generated': [4, 239, 2669], 'by': [5, 213, 240, 448, 1323, 1338, 1724, 1761, 2365, 2891, 3860, 3905, 4031, 4046, 4101, 4236, 4536], 'recent': [6, 241], 'reports': [7, 242], 'on': [8, 243, 1868, 2192, 2232, 2280, 2565, 2579, 2593, 2765, 3199, 3547, 4159, 4433], 'the': [9, 22, 28, 43, 62, 67, 75, 98, 109, 138, 160, 168, 181, 190, 204, 217, 222, 231, 244, 257, 263, 278, 297, 302, 310, 333, 344, 373, 395, 403, 416, 425, 439, 452, 457, 466, 497, 546, 636, 645, 779, 817, 828, 847, 871, 1096, 1144, 1160, 1169, 1174, 1320, 1339, 1412, 1428, 1471, 1544, 1614, 1695, 1707, 1713, 1718, 1737, 1741, 1752, 1757, 1801, 1808, 1815, 1818, 1882, 1886, 1903, 1908, 1927, 1940, 1963, 1984, 1991, 2004, 2012, 2037, 2092, 2099, 2148, 2166, 2219, 2298, 2375, 2402, 2456, 2562, 2572, 2580, 2584, 2612, 2707, 2730, 2766, 2875, 2898, 2916, 2954, 2985, 3007, 3036, 3044, 3057, 3108, 3142, 3154, 3159, 3169, 3180, 3202, 3221, 3227, 3239, 3246, 3249, 3258, 3261, 3265, 3271, 3275, 3280, 3285, 3299, 3335, 3370, 3375, 3396, 3437, 3449, 3455, 3475, 3511, 3560, 3569, 3575, 3593, 3614, 3617, 3622, 3632, 3642, 3649, 3658, 3677, 3691, 3712, 3723, 3746, 3771, 3800, 3812, 3817, 3870, 3886, 3893, 3930, 3953, 3961, 3967, 3979, 3982, 3985, 4005, 4021, 4027, 4047, 4058, 4062, 4074, 4086, 4093, 4109, 4120, 4124, 4127, 4131, 4167, 4226, 4231, 4252, 4256, 4259, 4263, 4267, 4286, 4292, 4298, 4317, 4320, 4345, 4373, 4378, 4383, 4467, 4473, 4480, 4496, 4501, 4505, 4522, 4526, 4529, 4548], 'discovery': [10, 245, 1662], 'of': [11, 25, 27, 42, 50, 61, 74, 117, 128, 146, 159, 163, 167, 186, 207, 216, 219, 246, 260, 262, 277, 285, 296, 309, 352, 363, 381, 394, 398, 402, 421, 442, 451, 454, 503, 808, 836, 840, 886, 1016, 1069, 1091, 1107, 1156, 1159, 1422, 1462, 1578, 1694, 1727, 1743, 1745, 1834, 1881, 1885, 1919, 1939, 1946, 1949, 1965, 1988, 2000, 2035, 2098, 2154, 2198, 2215, 2344, 2352, 2369, 2374, 2571, 2604, 2724, 2738, 2835, 2923, 3012, 3056, 3097, 3120, 3126, 3151, 3162, 3172, 3226, 3231, 3248, 3260, 3274, 3277, 3284, 3331, 3369, 3377, 3386, 3457, 3550, 3556, 3605, 3667, 3676, 3701, 3799, 3811, 3820, 3909, 3969, 3977, 3981, 3998, 4004, 4010, 4057, 4065, 4077, 4092, 4103, 4119, 4126, 4225, 4255, 4291, 4312, 4319, 4331, 4347, 4366, 4382, 4385, 4413, 4421, 4424, 4466, 4477, 4482, 4512, 4521, 4547], 'circular': [12, 31, 119, 187, 247, 266, 354, 422, 520, 830, 877, 4268], '(i.e.': [13, 248, 3334], 'head-to-tail': [14, 249, 510], 'cyclized)': [15, 250], 'proteins': [16, 188, 251, 423, 506, 521, 831, 841, 1425], 'in': [17, 252, 517, 644, 1050, 1073, 1080, 1308, 1314, 1319, 1419, 1673, 1732, 1828, 1962, 1983, 2003, 2048, 2113, 2258, 2382, 2417, 2548, 2552, 2561, 2583, 2660, 2760, 2910, 3006, 3040, 3048, 3130, 3153, 3264, 3307, 3435, 3482, 3510, 3559, 3598, 3646, 3661, 3698, 3703, 3711, 3816, 3984, 4002, 4020, 4069, 4090, 4112, 4309, 4372, 4405, 4418, 4484, 4518], 'plants.': [18, 253, 518], 'Here': [19, 254], 'we': [20, 148, 255, 383, 843, 1754, 1794, 3268], 'report': [21, 256, 1926], 'three-dimensional': [23, 258, 786, 1154, 1182, 1832, 1883, 1928, 2077, 3166, 3272, 3384, 3801], 'structure': [24, 48, 218, 259, 283, 453, 1183, 1321, 1833, 1884, 1929, 2078, 2599, 2662, 3273, 3301, 3372, 3385, 3463, 3588, 3644, 3802, 3814, 3873, 3986, 4016, 4060, 4287], 'one': [26, 261, 1081, 3194, 3451, 4224, 4280], 'newest': [29, 264], 'such': [30, 265, 3444, 3989], 'proteins,': [32, 267], 'MCoTI-II,': [33, 147, 268, 382, 1702], 'a': [34, 40, 51, 57, 156, 176, 214, 269, 275, 286, 292, 391, 411, 449, 501, 509, 837, 883, 1088, 1104, 1180, 1263, 1272, 1277, 1281, 1309, 1333, 1407, 1420, 1475, 1540, 1563, 1575, 1623, 1725, 1917, 1972, 2008, 2046, 2082, 2110, 2122, 2137, 2152, 2161, 2185, 2193, 2212, 2233, 2281, 2335, 2341, 2367, 2671, 2761, 3121, 3163, 3441, 3699, 3804, 3840, 3876, 3910, 3999, 4013, 4081, 4150, 4184, 4190, 4206, 4215, 4241, 4329, 4339, 4438], 'novel': [35, 270], 'trypsin': [36, 172, 225, 271, 407, 460, 1556, 1580, 1618, 1628, 1698, 1875, 2094, 3485, 4164], 'inhibitor': [37, 272, 1629], 'fromMomordica': [38, 273], 'cochinchinensis,': [39, 274, 1539], 'member': [41, 158, 276, 393, 1171], 'Cucurbitaceae': [44, 232, 279, 467, 1545], 'plant': [45, 76, 102, 126, 144, 178, 233, 280, 311, 337, 361, 379, 413, 468, 848, 880, 1092, 1150, 1161, 1429, 1542, 1546, 1709, 1904, 1992, 2013, 3623, 3931, 4022], 'family.': [46, 281, 1547, 2101], 'The': [47, 121, 165, 282, 356, 400, 775, 879, 1153, 1255, 1302, 1548, 1692, 1831, 2033, 2076, 2116, 2131, 2179, 2237, 2287, 2568, 2664, 2833, 3117, 3132, 3145, 3383, 3411, 3665, 3756, 3779, 3796, 3888, 4007, 4134, 4487, 4550], 'consists': [49, 284], 'small': [52, 287, 504, 1423, 3432, 3921], 'β-sheet,': [53, 288, 1267], 'several': [54, 289, 3808, 4117], 'turns,': [55, 290], 'and': [56, 86, 100, 107, 125, 143, 175, 183, 189, 228, 291, 321, 335, 342, 360, 378, 410, 418, 424, 463, 607, 639, 784, 813, 1014, 1112, 1115, 1233, 1261, 1327, 1430, 1448, 1457, 1553, 1558, 1567, 1680, 1701, 1717, 1729, 1807, 1906, 1915, 1924, 1934, 2062, 2124, 2174, 2203, 2218, 2245, 2277, 2328, 2332, 2347, 2356, 2371, 2455, 2460, 2489, 2522, 2535, 2597, 2606, 2614, 2647, 2653, 2810, 2874, 2885, 2905, 2919, 2990, 2999, 3002, 3014, 3043, 3099, 3107, 3123, 3139, 3148, 3213, 3254, 3290, 3318, 3326, 3341, 3373, 3420, 3508, 3539, 3582, 3601, 3608, 3621, 3653, 3695, 3725, 3735, 3741, 3765, 3774, 3786, 3807, 3846, 3848, 3853, 3865, 3875, 3883, 3895, 3924, 3939, 3971, 4035, 4039, 4061, 4115, 4130, 4146, 4178, 4182, 4189, 4196, 4220, 4245, 4270, 4273, 4295, 4343, 4350, 4504, 4541], 'cystine': [58, 111, 293, 346, 1312, 1413, 1477, 1909, 2039, 4014, 4063], 'knot': [59, 112, 294, 347, 1414, 1478, 1910, 2040, 4064], 'arrangement': [60, 295, 4026], 'three': [63, 298, 770, 1157, 1303, 1568, 4128], 'disulfide': [64, 299, 773, 1304, 1325, 1341, 1569, 2042, 3412, 3438, 3467, 3476, 3594, 3634, 4008, 4049, 4135, 4264, 4488, 4498], 'bonds.': [65, 300, 774, 1570], 'Interestingly,': [66, 301], 'molecular': [68, 303, 2887, 3177], 'topology': [69, 304], 'is': [70, 305, 1336, 1467, 1748, 1826, 1890, 1951, 1981, 1997, 2052, 3135, 3313, 3447, 3671, 3709, 3857, 3915, 3925, 3956, 4044, 4067, 4079, 4089, 4138, 4221, 4234, 4296, 4353, 4495], 'similar': [71, 306, 1901, 2293, 3243, 4017], 'to': [72, 170, 307, 405, 778, 845, 916, 954, 1077, 1085, 1102, 1450, 1459, 1574, 1686, 1872, 1895, 1902, 1956, 2014, 2147, 2171, 2294, 2405, 2414, 2449, 2511, 2641, 2912, 2915, 2994, 2997, 3020, 3179, 3188, 3302, 3425, 3454, 3480, 3574, 3960, 4018, 4084, 4279, 4316, 4356, 4493, 4500, 4538, 4543], 'that': [73, 150, 192, 308, 385, 427, 507, 768, 827, 842, 1059, 1146, 1335, 1622, 1666, 1681, 1735, 1812, 1952, 2091, 3238, 3568, 3718, 3744, 3990, 4019, 4098, 4228, 4304, 4370], 'cyclotides': [77, 169, 312, 404, 849, 881, 1097, 1710, 1905, 3624, 3932], '(Craik,': [78, 313], 'D.': [79, 314, 1522, 1603, 1783, 1858, 2057, 2865, 2944, 2976, 3079, 3490, 3934], 'J.,': [80, 315, 2058, 3935], 'Daly,': [81, 316, 2059, 3936], 'N.': [82, 317, 2060, 3937], 'L.,': [83, 318, 2061, 3938], 'Bond,': [84, 319], 'T.,': [85, 320], 'Waine,': [87, 322], 'C.': [88, 323, 745, 795, 857, 1243, 1290, 1396, 1438, 1487, 2465, 2627, 3521], '(1999)': [89, 324], 'J.': [90, 325, 534, 571, 596, 624, 662, 706, 727, 746, 796, 858, 904, 943, 1035, 1195, 1222, 1244, 1291, 1488, 1506, 1587, 1650, 1767, 1842, 2023, 2065, 2317, 2434, 2472, 2630, 2695, 2749, 2781, 2822, 2849, 2928, 2960, 3063, 3355, 3492, 3495, 3522, 3942, 4449], 'Mol.': [91, 326, 747, 797, 859, 1223, 1245, 1292, 1489, 1651, 2318, 2435, 2631, 2750, 3496, 3523], 'Biol.': [92, 327, 748, 798, 860, 1224, 1246, 1293, 1364, 1490, 1652, 2319, 2436, 2632, 2751, 3497, 3524, 4450], '294,': [93, 328], '1327–1336),': [94, 329], 'which': [95, 330, 1179, 1315, 1473, 1994, 2165, 3215, 3436, 4239, 4250], 'derive': [96, 331], 'from': [97, 133, 230, 332, 368, 465, 635, 642, 890, 1426, 1537, 1543, 1582, 1633, 1712, 1921, 1993, 2011, 2109, 2388, 2397, 2493, 3641, 3869, 4285], 'Rubiaceae': [99, 334, 637], 'Violaceae': [101, 336, 646], 'families,': [103, 338], 'have': [104, 210, 339, 445, 508, 514, 1098, 1164, 1755, 3241, 3269], 'antimicrobial': [105, 340], 'activities,': [106, 341, 816], 'exemplify': [108, 343], 'cyclic': [110, 141, 345, 376, 1476, 1627, 1740, 2038, 2300], 'structural': [113, 139, 348, 374, 1410, 4087], 'motif': [114, 349, 1479], 'as': [115, 155, 350, 390, 822, 846, 1065, 1271, 1722, 2045, 2087, 2089, 2843, 3035, 3114, 3305, 3470, 3628, 3753, 3867, 3907, 3996], 'part': [116, 351, 835, 2097, 3908, 3997], 'their': [118, 353, 809, 876, 1047, 1070, 1328, 2886, 4040, 4310], 'backbone.': [120, 355, 878, 3224], 'sequence,': [122, 357], 'biological': [123, 358, 815, 887, 1071], 'activity,': [124, 359], 'family': [127, 179, 362, 414, 647, 839, 1163, 3666, 3819], 'MCoTI-II': [129, 151, 220, 364, 386, 455, 1554, 1728, 1835, 1920, 2906, 2924, 3013, 3127, 3173, 3278, 3387, 3670, 4011, 4066, 4078, 4478], 'are': [130, 194, 365, 429, 1061, 1148, 1257, 1306, 1555, 1572, 1613, 1669, 1684, 1739, 1954, 1968, 3112, 3128, 3320, 3683, 3719, 3751, 3761, 3782, 3803, 3901, 3988, 3992, 4099, 4275, 4397, 4507, 4534], 'all': [131, 366, 1258, 3553, 3654, 3775, 4003], 'different': [132, 367], 'known': [134, 369, 829, 1708, 1955], 'cyclotides.': [135, 370, 4023], 'However,': [136, 371, 3913], 'given': [137, 372, 2416, 3129, 3752, 4068], 'similarity,': [140, 375], 'backbone,': [142, 377, 1566, 1721], 'origin': [145, 380], 'propose': [149, 384], 'can': [152, 387, 4410], 'be': [153, 388, 820, 1078, 1451, 1687, 1957, 2995, 3303, 4411], 'classified': [154, 389], 'new': [157, 177, 392, 412, 1533, 1697, 1887, 2093], 'cyclotide': [161, 396, 1162, 2100, 3512], 'class': [162, 397, 1899, 1948], 'proteins.': [164, 399], 'expansion': [166, 401], 'include': [171, 406, 522], 'inhibitory': [173, 408], 'activity': [174, 409, 918, 956], 'highlights': [180, 415, 4116], 'importance': [182, 417], 'functional': [184, 419], 'variability': [185, 420], 'fact': [191, 426], 'they': [193, 428, 1060, 1147, 1953, 3991], 'more': [195, 430, 1671, 1683, 4288], 'common': [196, 431, 1089, 1672], 'than': [197, 432, 1675, 2519, 2530, 4289], 'previously': [199, 434, 1677, 2845, 2899, 3506], 'believed.': [201, 436], 'Insights': [202, 437], 'into': [203, 438, 4247], 'possible': [205, 440, 3554, 4348], 'roles': [206, 441], 'backbone': [208, 443, 513, 1330, 1810, 3772, 4042, 4076, 4110, 4269], 'cyclization': [209, 444], 'gained': [212, 447], 'comparison': [215, 450, 1726], 'with': [221, 456, 1276, 1453, 1706, 2126, 2211, 2242, 2340, 2349, 2495, 2508, 2554, 2735, 2840, 2897, 3023, 3054, 3245, 3279, 3474, 3592, 3613, 3616, 3648, 3657, 3823, 4161, 4399, 4429], 'homologous': [223, 458, 1573, 3618], 'acyclic': [224, 459, 4163, 4422], 'inhibitors': [226, 461, 1557, 1581, 1619, 2095, 3486, 3620], 'CMTI-I': [227, 462], 'EETI-II': [229, 464], 'family.1IB9': [234, 469], 'reversed-phase': [470], 'high': [471, 1455, 4340], 'performance': [472], 'liquid': [473], 'chromatography': [474], 'Momordica': [475, 1538], 'cochinchinensis': [476, 1923, 2106, 2837], 'two-dimensional': [477, 484, 2288], 'total': [478], 'correlation': [479, 490], 'spectroscopy': [480, 486, 491, 1933, 3185], 'nuclear': [481], 'Overhauser': [482], 'effect': [483], 'NOE': [485, 2555, 2643, 3205, 3286], 'double': [487], 'quantum': [488], 'filtered': [489], 'root': [492], 'mean': [493], 'square': [494], 'deviation': [495], 'Over': [496], 'last': [498], 'few': [499, 3684], 'years': [500], 'number': [502, 3150, 4346], 'disulfide-rich': [505, 1424, 3433, 3922], 'cyclized': [511, 1564], 'peptide': [512, 1177, 1565, 1720, 2257, 2301, 2378, 2986, 3223, 4075], 'discovered': [516, 1688], 'These': [519], 'kalata': [523, 1172, 1730, 1966, 1995, 4425], 'B1': [524, 894, 1731, 1996], '(1Saether': [525, 895, 1186], 'O.': [526, 896, 1187], 'Craik': [527, 897, 1003, 1188, 1220, 1377, 2315, 2432, 4447], 'D.J.': [528, 739, 789, 851, 898, 1004, 1189, 1221, 1237, 1284, 1378, 1392, 1434, 1481, 2316, 2433, 2776, 3515, 4448], 'Campbell': [529, 899, 1190], 'I.D.': [530, 900, 1191], 'Sletten': [531, 901, 1192, 2021], 'K.': [532, 683, 902, 967, 1193, 2022, 2064, 2409, 2471, 2629, 3095, 3941], 'Juul': [533, 903, 1194], 'Norman': [535, 905, 1196], 'D.G.': [536, 589, 655, 699, 906, 1197], 'Biochemistry.': [537, 907, 1005, 1198, 1523, 1604, 1784, 1859, 2866, 2945, 2977, 3080], '1995;': [538, 908, 1199, 1365, 3358], '34:': [539, 909, 1200], '4147-4158Crossref': [540, 910, 1201], 'PubMed': [541, 602, 630, 668, 712, 733, 752, 802, 864, 911, 992, 1009, 1041, 1137, 1202, 1228, 1250, 1297, 1354, 1368, 1386, 1401, 1443, 1494, 2028, 2323, 2440, 2478, 2636, 2684, 2701, 2755, 2805, 2828, 3361, 3501, 3528, 3834, 4460], 'Scopus': [542, 578, 603, 631, 669, 713, 734, 753, 803, 865, 912, 950, 993, 1010, 1042, 1138, 1203, 1229, 1251, 1298, 1355, 1369, 1387, 1402, 1444, 1495, 1527, 1608, 1656, 1788, 1863, 2029, 2324, 2441, 2479, 2637, 2685, 2702, 2756, 2787, 2806, 2829, 2870, 2949, 2981, 3084, 3362, 3502, 3529, 3835, 4461], '(373)': [543, 913, 1204], 'Google': [544, 580, 605, 633, 671, 715, 736, 755, 805, 867, 914, 952, 995, 1012, 1044, 1140, 1205, 1231, 1253, 1300, 1357, 1371, 1389, 1404, 1446, 1497, 1529, 1610, 1658, 1790, 1865, 2031, 2326, 2443, 2481, 2639, 2687, 2704, 2758, 2789, 2808, 2831, 2872, 2951, 2983, 3086, 3105, 3364, 3504, 3531, 3837, 4463], 'Scholar),': [545, 606, 1013, 1141, 1206, 1232, 1447, 1611], 'circulins': [547], '(2Gustafson': [548, 920], 'K.R.': [549, 583, 649, 921], 'Sowder': [550, 586, 652, 692, 922], 'R.C.,': [551, 923], 'II': [552, 560, 924, 932, 4148], 'Henderson': [553, 925], 'L.E.': [554, 926], 'Parsons': [555, 927], 'I.C.': [556, 928], 'Kashman': [557, 929], 'Y.': [558, 930], 'Cardellina': [559, 592, 658, 702, 931], 'J.H.': [561, 933], 'McMahon': [562, 934], 'J.B.': [563, 935], 'Buckheit': [564, 936], 'Jr.,': [565, 937], 'R.W.': [566, 619, 938, 1030], 'Pannell': [567, 590, 656, 694, 939], 'L.K.': [568, 585, 591, 651, 657, 695, 940], 'Boyd': [569, 594, 660, 704, 941, 1216, 2311, 2428], 'M.R.': [570, 595, 661, 705, 942, 1217, 2312, 2429], 'Am.': [572, 944], 'Chem.': [573, 708, 945, 2783, 4451], 'Soc.': [574, 946], '1994;': [575, 627, 947, 1038, 1383, 2681], '116:': [576, 948], '9337-9338Crossref': [577, 949], '(259)': [579, 951], 'Scholar,': [581, 672, 689, 716, 737, 973, 996, 1358, 1372, 1390, 2688], '3Gustafson': [582], 'Walton': [584, 650], 'R.C.I.': [587, 653, 693], 'Johnson': [588, 654, 698], 'J.H.I.': [593, 659, 703], 'Nat.': [597, 625, 663, 728, 1036], 'Prod.': [598, 626, 664, 729, 1037], '2000;': [599, 665, 709, 1524, 1605, 1785, 1860, 2025, 2867, 2946, 2978, 3081, 4452], '63:': [600, 666], '176-178Crossref': [601, 667], '(100)': [604, 670], 'cyclopsychotride': [608], 'A': [609, 1020, 1208, 2303, 3311, 3855, 4054], '(4Witherup': [610, 1021], 'K.M.': [611, 1022], 'Bogusky': [612, 1023], 'M.J.': [613, 1024], 'Anderson': [614, 1025], 'P.S.': [615, 1026], 'Ramjit': [616, 1027], 'H.': [617, 1028], 'Ransom': [618, 1029], 'Wood': [620, 1031], 'T.': [621, 674, 720, 743, 793, 855, 958, 1032, 1241, 1288, 1485, 1517, 1598, 1778, 1853, 2860, 2939, 2971, 3074, 3494, 3519], 'Sardana': [622, 1033], 'M.': [623, 1034, 1922, 2469, 2746, 2780, 2836], '57:': [628, 1039], '1619-1625Crossref': [629, 1040], '(228)': [632, 1043], 'Scholar)': [634, 1530, 1866, 2327, 2640, 2705, 2759, 2809, 2873, 2984, 3106, 3505, 3532, 3838, 3952], 'family,': [638], 'various': [640, 4132, 4386], 'peptides': [641, 1535, 1668, 1889, 2882, 3513, 3923], 'plants': [643, 1051, 1583, 1674], '(3Gustafson': [648], '5Schöpke': [673], 'Hasan': [675, 959], 'Agha': [676, 960], 'M.I.': [677, 961], 'Kraft': [678, 962], 'R.': [679, 701, 963, 1215, 2310, 2427, 2819], 'Otto': [680, 964], 'A.': [681, 965, 988, 1133, 1212, 1514, 1595, 1775, 1850, 2307, 2424, 2857, 2936, 2968, 3071, 3350], 'Hiller': [682, 966], 'Sci.': [684, 968, 985, 1130, 1382, 2801, 3830], 'Pharm.': [685, 969], '1993;': [686, 970, 1348], '61:': [687, 971], '145-153Google': [688, 972], '6Hallock': [690], 'Y.F.': [691], 'Hughes': [696], 'C.B.': [697], 'Gulakowski': [700], 'Org.': [707], '65:': [710], '124-128Crossref': [711], '(106)': [714], '7Göransson': [717], 'U.': [718, 986, 1131], 'Luijendijk': [719], 'Johansson': [721], 'S.': [722, 987, 1000, 1132, 1637, 2778], 'Bohlin': [723], 'L.': [724, 1508, 1589, 1769, 1844, 2018, 2851, 2930, 2962, 3065], 'Claeson': [725], 'P.': [726, 2467, 2625], '1999;': [730, 749, 799, 861, 989, 1006, 1134, 1225, 1247, 1294, 1491, 1653, 2320, 2437, 3525], '62:': [731], '283-286Crossref': [732], '(155)': [735], '8Craik': [738], 'Daly': [740, 790, 852, 1238, 1285, 1393, 1435, 1482, 2418, 3516], 'N.L.': [741, 791, 853, 998, 1210, 1239, 1286, 1394, 1436, 1483, 2305, 2422, 3517, 4446], 'Bond': [742, 792, 854, 1240, 1287, 1484, 3518], 'Waine': [744, 794, 856, 1242, 1289, 1395, 1437, 1486, 3520], '294:': [750, 800, 862, 1248, 1295, 1492, 3526], '1327-1336Crossref': [751, 801, 863, 1249, 1296, 1493, 3527], '(648)': [754, 804, 866, 1252, 1299, 1496, 3530], 'Scholar).': [756, 806, 868, 1254, 1301, 1405, 1498, 1791, 2032, 2075, 2444, 2482, 2722, 2790, 2832, 2952, 3087, 3410, 4464], 'They': [757, 869, 1571], 'contain': [758, 870, 1262, 1474], '∼30': [759], 'amino': [760, 1561, 4217, 4358, 4387], 'acids,': [761, 1562], 'including': [762, 1168, 4123], 'six': [763, 1802, 1809, 4094, 4474], 'highly': [764, 1259, 1958, 4151], 'conserved': [765, 872, 1260], 'cysteine': [766, 873, 1715, 1803, 1819, 4443, 4475, 4532], 'residues': [767, 1716, 1804, 1820, 2543, 2559, 2574, 3211, 3252, 3316, 3327, 3694, 3729, 3738, 3759, 3794, 3844, 3851, 3863, 3881, 3896, 4171, 4187, 4194, 4203, 4476, 4491, 4533], 'form': [769, 834, 2096, 3195, 3219, 3440, 4012], 'structurally': [771], 'important': [772, 3424], 'latter': [776], 'contribute': [777], 'molecules': [780, 818, 1463, 1738, 1950, 3240, 3434], 'having': [781], 'well': [782, 810, 1273, 2088, 3137, 3164, 3672, 3962, 4544], 'defined': [783, 811, 1274, 1827, 3165, 3673, 3963, 4545], 'stable': [785, 1959], 'structures': [787, 812, 1155, 1256, 1945, 2618, 2667, 2726, 3562, 3604, 3668, 3750, 3822, 4262, 4306], '(8Craik': [788, 850, 1236, 1283, 1480, 3514], 'Because': [807], 'potent': [814], 'may': [819, 4323], 'regarded': [821], 'miniproteins.': [823], 'We': [824, 1892, 1912], 'recently': [825, 1631], 'proposed': [826, 3633], 'most': [832, 1062, 1973, 3675, 4299], 'likely': [833, 1063, 1685], 'large': [838, 1576, 3149], 'refer': [844], 'spacing': [874], 'CX3-CX4-CX4–7-CX1-CX4–5-CX5–7within': [875], 'display': [882, 1103], 'diverse': [884], 'range': [885, 1106, 1577, 3688], 'activities': [888, 1072, 1109], 'ranging': [889], 'uterotonic': [891], 'action': [892], '(kalata': [893], 'Scholar)),': [915, 953], 'anti-HIV': [917], '(circulins': [919], 'hemolytic': [955], '(5Schöpke': [957], '9Tam': [974], 'J.P.': [975, 1120, 1512, 1593, 1773, 1848, 2855, 2934, 2966, 3069], 'Lu': [976, 1121], 'Y.A.': [977, 1122], 'Yang': [978, 1123], 'J.L.': [979, 1124], 'Chiu': [980, 1125], 'K.W.': [981, 1126], 'Proc.': [982, 1127], 'Natl.': [983, 1128], 'Acad.': [984, 1129], '96:': [990, 1135], '8913-8918Crossref': [991, 1136], '(406)': [994, 1139], '10Daly': [997], 'Love': [999], 'Alewood': [1001], 'P.F.': [1002], '38:': [1007], '10606-10614Crossref': [1008], '(194)': [1011], 'inhibition': [1015], 'neurotensin': [1017], 'binding': [1018], '(cyclopsychotride': [1019], 'Scholar)).': [1045, 1659], 'Although': [1046, 1406], 'precise': [1048], 'role': [1049], 'not': [1053, 3416, 3902, 3927, 3993], 'yet': [1054], 'reported,': [1056], 'it': [1057, 3422, 4363], 'appears': [1058], 'present': [1064, 2909, 3314], 'defense': [1066, 1093, 1151], 'molecules.': [1067, 1094, 1152, 1978, 3192], 'All': [1068], 'mammalian': [1074], 'systems': [1075, 3038], 'seem': [1076], 'related': [1079, 2299, 3920], 'way': [1082, 3600, 4083, 4114], 'or': [1083, 2262, 3686, 4096, 4327, 4368], 'another': [1084], 'membrane': [1086], 'interactions,': [1087], 'feature': [1090, 1975], 'Recently': [1095, 1499], 'also': [1099, 3157, 3639, 3916, 4139, 4297], 'reported': [1101, 1531, 1616, 1632, 2079], 'wide': [1105], 'anti-microbial': [1108], 'against': [1110, 1116], 'Gram-positive': [1111], 'Gram-negative': [1113], 'bacteria,': [1114], 'certain': [1117, 2001], 'fungi': [1118], '(9Tam': [1119], 'further': [1142], 'enhancing': [1143], 'likelihood': [1145], 'indeed': [1149], 'members': [1158], 'now': [1165, 1416], 'determined,': [1167], 'prototypic': [1170], 'B1,': [1173, 1967, 4426], 'first': [1175, 1615, 3160, 3692], 'macrocyclic': [1176, 1534, 1617, 1667, 1719, 1888, 2041, 2901], 'for': [1178, 1470, 1799, 1943, 1976, 2084, 2176, 2250, 2297, 2515, 2526, 2541, 2611, 2645, 3631, 3669, 3690, 3722, 3728, 3737, 3758, 3770, 3791, 3918, 4375, 4442, 4472, 4510, 4528], 'full': [1181], 'was': [1184, 1630, 1900, 2134, 2145, 2158, 2168, 2181, 2227, 2240, 2727, 2877, 2992, 3004, 3029, 3186, 3388, 3423, 3545, 3626, 4364, 4391], 'determined': [1185, 1930, 2591, 3270, 3389, 3418], 'circulin': [1207, 2302], '(11Daly': [1209, 2304, 2421], 'Koltay': [1211, 2306, 2423], 'Gustafson': [1213, 2308, 2425], 'K.,': [1214, 2309, 2426], 'Casas-Finet': [1218, 2313, 2430], 'J.R.': [1219, 2314, 2431], '285:': [1226, 2321, 2438], '333-345Crossref': [1227, 2322, 2439], '(114)': [1230, 2325, 2442], 'cycloviolacin': [1234], 'O1': [1235], 'distorted': [1264], 'triple': [1265], 'stranded': [1266], 'perhaps': [1268], 'better': [1269], 'described': [1270, 2844], 'β-hairpin': [1275, 3312, 3856], 'third': [1278, 1340, 3954, 4048], 'strand': [1279, 4254], 'forming': [1280], 'β-bulge': [1282], 'bonds': [1305, 1326, 2589, 3439, 3468, 3595, 3637, 4009, 4265], 'arranged': [1307], 'so': [1310, 1469, 3421], 'called': [1311], 'knot,': [1313], 'an': [1316, 2549, 3175, 3445, 3548, 4419], 'embedded': [1317, 4028], 'ring': [1318, 1334, 4029], 'formed': [1322, 4030], 'two': [1324, 1532, 1549, 1696, 3262, 4176, 4179], 'connecting': [1329, 4041, 4490], 'segments': [1331, 4043], 'forms': [1332, 2922], 'penetrated': [1337], 'bond': [1342, 2602, 2655, 2987, 4136, 4489, 4499], '(12McDonald': [1343], 'N.Q.': [1344], 'Hendrickson': [1345], 'W.A.': [1346], 'Cell.': [1347], '73:': [1349], '421-424Abstract': [1350], 'Full': [1351, 4455, 4457], 'Text': [1352, 4456, 4458], 'PDF': [1353, 4459], '(475)': [1356], '13Isaacs': [1359], 'N.W.': [1360], 'Curr.': [1361], 'Opin.': [1362], 'Struct.': [1363], '5:': [1366, 2803, 3359, 3832], '391-395Crossref': [1367], '(180)': [1370], '14Pallaghy': [1373], 'P.K.': [1374], 'Nielsen': [1375], 'K.J.': [1376], 'Norton': [1379], 'R.S.': [1380, 1639, 3352], 'Protein': [1381, 2800, 3829], '3:': [1384], '1833-1839Crossref': [1385], '(469)': [1388], '15Craik': [1391], 'Toxicon.': [1397, 1439], '2001;': [1398, 1440], '39:': [1399, 1441, 1525, 1606, 1786, 1861, 2868, 2947, 2979, 3082], '43-60Crossref': [1400, 1442], '(417)': [1403, 1445], 'seemingly': [1408], 'unlikely': [1409], 'motif,': [1411], 'seen': [1418, 1723], 'variety': [1421], 'both': [1427, 3232, 4511], 'animal': [1431], 'kingdoms': [1432], '(15Craik': [1433], 'seems': [1449], 'associated': [1452, 4398], 'exceptionally': [1454], 'stability': [1456], 'resistance': [1458], 'proteolytic': [1460], 'cleavage': [1461, 3460], 'containing': [1464], 'it.': [1465], 'This': [1466, 1660, 1823, 1979, 3543, 3565, 3708, 4322], 'particularly': [1468], 'cyclotides,': [1472], 'Hernandez': [1500], 'et': [1501, 2419], 'al.': [1502, 1763, 2420], '(16Hernandez': [1503, 1584, 1764, 1839, 2846, 2925, 2957, 3060], 'J.F.': [1504, 1585, 1765, 1840, 2847, 2926, 2958, 3061], 'Gagnon': [1505, 1586, 1766, 1841, 2848, 2927, 2959, 3062], 'Chiche': [1507, 1588, 1768, 1843, 2850, 2929, 2961, 3064], 'Nguyen': [1509, 1521, 1590, 1602, 1770, 1782, 1845, 1857, 2852, 2864, 2931, 2943, 2963, 2975, 3066, 3078], 'T.M.': [1510, 1591, 1771, 1846, 2853, 2932, 2964, 3067], 'Andrieu': [1511, 1592, 1772, 1847, 2854, 2933, 2965, 3068], 'Heitz': [1513, 1594, 1774, 1849, 2856, 2935, 2967, 3070], 'Trinh': [1515, 1596, 1776, 1851, 2858, 2937, 2969, 3072], 'Hong': [1516, 1597, 1777, 1852, 2859, 2938, 2970, 3073], 'Pham': [1518, 1599, 1779, 1854, 2861, 2940, 2972, 3075], 'T.T.': [1519, 1600, 1780, 1855, 2862, 2941, 2973, 3076], 'Le': [1520, 1601, 1781, 1856, 2863, 2942, 2974, 3077], '30-5722Crossref': [1526, 1607, 1787, 1862, 2869, 2948, 2980, 3083], '(297)': [1528, 1609, 1789, 1864, 2871, 2950, 2982, 3085], 'derived': [1536, 4121], 'vine': [1541], 'molecules,': [1550], 'named': [1551], 'MCoTI-I': [1552, 1700, 2903], 'comprise': [1559], '34': [1560], 'open-chain': [1579], 'but': [1612, 1750, 3379, 3731, 4204], '(although': [1620], 'note': [1621], 'smaller,': [1624], 'single': [1625, 4216], 'disulfide-containing': [1626], 'sunflower': [1634], 'seeds': [1635, 2118, 2834], '(17Luckett': [1636], 'Garcia': [1638], 'Barker': [1640], 'J.J.': [1641], 'Konarev': [1642], 'A.V.': [1643], 'Shewry': [1644], 'P.R.': [1645], 'Clarke': [1646], 'A.R.': [1647], 'Brady': [1648], 'R.L.': [1649], '290:': [1654], '33-525Crossref': [1655], '(321)': [1657], 'exciting': [1661], 'supports': [1663, 4479], 'our': [1664, 1796], 'view': [1665], 'much': [1670], 'realized,': [1679], 'many': [1682], 'over': [1689, 2401, 3674, 3793], 'coming': [1690], 'years.': [1691], 'sequences': [1693, 1816], 'inhibitors,': [1699, 1876, 4165], 'show': [1703], 'little': [1704], 'homology': [1705, 4160], 'apart': [1711], 'six-conserved': [1714], 'Fig.1.': [1733], 'Note': [1734], 'because': [1736], 'choice': [1742], 'numbering': [1744, 1758, 1824], 'residue': [1746], '1': [1747, 2255, 2408], 'arbitrary': [1749], 'throughout': [1751], 'text': [1753], 'adopted': [1756, 1795], 'scheme': [1759, 1825], 'used': [1760, 2296, 2610, 3187], 'Hernandezet': [1762], 'In': [1792, 2953, 3929, 4024, 4258, 4393], 'addition,': [1793], 'earlier': [1797], 'nomenclature': [1798], 'defining': [1800, 4333], '(labeled': [1805], 'I-VI)': [1806], 'loops': [1811, 4271, 4294], 'make': [1813, 4229], 'up': [1814, 4230], 'between': [1817, 2988, 3190, 3210, 3323, 3337, 3552, 3733, 3843, 3850, 3862, 3880, 3892, 4143, 4186, 4193], '(loops': [1821], '1–6).': [1822], 'Fig.': [1829, 3308, 3662, 4070, 4301], '1.': [1830], 'modeled': [1838], 'based': [1867, 2564, 2578, 2592, 2764, 3546, 4158, 4432], 'its': [1869, 3015, 4209], 'sequence': [1870, 2339, 3059], 'similarity': [1871, 3259], 'open': [1873], 'chain': [1874], 'however,': [1877, 3681], 'no': [1878, 3380, 4201], 'experimental': [1879], 'determination': [1880], 'available.': [1891], 'were': [1893, 2107, 2119, 2209, 2272, 2292, 2363, 2386, 2395, 2411, 2447, 2458, 2485, 2502, 2539, 2560, 2575, 2590, 2609, 2619, 2657, 2668, 2792, 2838, 2883, 2889, 2908, 3018, 3051, 3089, 3472, 3590, 3638, 3655], 'interested': [1894], 'see': [1896], 'whether': [1897, 4362], 'this': [1898, 1947, 3003, 3140, 3218, 3324, 3367, 3427, 3599, 3625, 3696, 3704, 3914, 4025, 4113, 4313, 4334, 4519], 'contained': [1907, 2254], 'motif.': [1911], 'therefore': [1913], 'isolated': [1914, 2884, 2900, 3019], 'purified': [1916, 2878], 'sample': [1918], 'herewith': [1925], 'using': [1931, 2036, 2121, 2136, 2160, 2189, 2229, 2334, 2462, 2487, 2544, 2622, 2670, 2729, 2794, 2879, 3032, 3091, 3390, 3428], 'NMR': [1932, 2252, 2289, 3024, 3033, 3096, 3184, 3429], 'simulated': [1935], 'annealing': [1936], 'calculations.': [1937, 2600, 2663], 'One': [1938], 'motivating': [1941], 'factors': [1942], 'examining': [1944], 'and,': [1960], 'indeed,': [1961], 'case': [1964], 'apparently': [1969], 'orally': [1970], 'bioavailable,': [1971], 'unusual': [1974], 'peptide-based': [1977], 'bioavailability': [1980], 'demonstrated': [1982], 'native': [1985], 'medicine': [1986], 'applications': [1987, 2051], 'Oldenlandia': [1989], 'affinis,': [1990], 'derived.': [1998], 'Women': [1999], 'tribes': [2002], 'Congo': [2005], 'region': [2006, 2404, 3134, 3250, 3705, 3806, 4503, 4520], 'ingest': [2007], 'tea': [2009], 'made': [2010, 3090], 'accelerate': [2015], 'labor': [2016], '(18Gran': [2017], 'Sandberg': [2019], 'F.': [2020], 'Ethnopharmacol.': [2024], '70:': [2026], '197-203Crossref': [2027], '(123)': [2030], 'possibility': [2034], 'knotted': [2043, 4015], 'framework': [2044], 'template': [2047], 'pharmaceutical': [2049], 'design': [2050], 'thus': [2053], 'very': [2054, 3136, 3242, 4277], 'attractive': [2055], '(19Craik,': [2056, 3933], 'Nielsen,': [2063, 3940], '(2000)': [2066, 3943], 'PCT': [2067, 3944], 'Int.': [2068, 3945], 'Patent': [2069, 3946], 'Appl.': [2070, 3947], '43': [2071, 3948], 'pp': [2072, 3949], 'WO': [2073, 3950], '0015654.Google': [2074, 3951], 'here': [2080], 'provides': [2081], 'basis': [2083], 'these': [2085, 2661, 2725, 3191, 3602, 4513], 'applications,': [2086], 'demonstrating': [2090], 'Ripe': [2102], 'frozen': [2103], 'fruits': [2104], 'ofM.': [2105], 'purchased': [2108], 'Vietnamese': [2111], 'store': [2112], 'Melbourne,': [2114], 'Australia.': [2115], 'dormant': [2117], 'homogenized': [2120], 'blender': [2123], 'extracted': [2125, 2839], '20': [2127, 3747, 3847], 'mm': [2128, 2256], 'sodium': [2129, 2450, 2841], 'acetate.': [2130], 'fine': [2132], 'debris': [2133], 'removed': [2135], 'cotton': [2138], 'plug.': [2139], '40%': [2140], 'Acetone,': [2141], 'H2O': [2142], '(v/v)': [2143, 2267], 'solution': [2144], 'added': [2146], 'crude': [2149], 'extract': [2150, 2876], 'at': [2151, 2222, 2268, 2274, 2452], 'ratio': [2153], '∼1:1': [2155], '(v/v).': [2156], 'Acetone': [2157], 'reduced': [2159, 4354], 'rotary': [2162], 'evaporator': [2163], 'after': [2164], 'mixture': [2167], 'cooled': [2169], 'down': [2170], '4': [2172, 3212, 3253, 3296, 3309, 3663, 3899, 4213], '°C': [2173], 'centrifuged': [2175], '30': [2177], 'min.': [2178], 'supernatant': [2180], 'then': [2182], 'passed': [2183], 'through': [2184], 'filter': [2186], 'before': [2187], 'purification': [2188, 2226], 'preparative': [2190], 'RP-HPLC1': [2191], 'Vydac': [2194, 2234], 'C18': [2195, 2235], 'column.': [2196, 2236], 'Gradients': [2197], '0.1%': [2199], 'aqueous': [2200], 'trifluoroacetic': [2201, 2207], 'acid': [2202, 2208, 3027, 4218, 4388], '90%': [2204, 2263], 'acetonitrile,': [2205], '0.09%': [2206], 'employed': [2210, 2291], 'flow': [2213], 'rate': [2214], '8': [2216, 2406, 4492], 'ml/min,': [2217], 'eluant': [2220], 'monitored': [2221], '230': [2223], 'nm.': [2224], 'Further': [2225], 'performed': [2228, 3030, 3591], 'semipreparative': [2230], 'RP-HPLC': [2231, 2244], 'final': [2238, 2665, 3818, 4260], 'purity': [2239], 'examined': [2241], 'analytical': [2243], 'electrospray': [2246], 'mass': [2247, 2892], 'spectrometry.': [2248, 2893], 'Samples': [2249], '1H': [2251, 3109], 'measurements': [2253], 'either': [2259], '99.99%': [2260], 'D2O': [2261, 2266], 'H2O,': [2264], '10%': [2265], 'pH': [2269], '3.5.': [2270], 'Spectra': [2271, 2410], 'recorded': [2273], '288,': [2275], '293,': [2276], '298': [2278], 'K': [2279], 'Bruker': [2282], 'AVANCE': [2283], '750': [2284], 'MHz': [2285], 'spectrometer.': [2286], 'experiments': [2290], 'those': [2295, 3055, 3481, 3509, 4427], 'included': [2329, 2659, 3469], 'DQF-COSY,': [2330], 'E-COSY,': [2331], 'TOCSY': [2333, 2372, 3041, 3122], 'MLEV-17': [2336], 'spin': [2337, 3037], 'lock': [2338], 'mixing': [2342, 2350], 'time': [2343], '80': [2345], 'ms,': [2346], 'NOESY': [2348, 2585, 3049, 3124, 3155], 'times': [2351], '150,': [2353], '200,': [2354], '250,': [2355], '300': [2357], 'ms.': [2358], 'Slowly': [2359], 'exchanging': [2360, 3973], 'NH': [2361], 'protons': [2362, 2570, 3294, 3975], 'detected': [2364], 'acquiring': [2366], 'series': [2368], 'one-dimensional': [2370], 'spectra': [2373, 2390, 2457, 3042, 3050, 3125], 'fully': [2376], 'protonated': [2377], 'immediately': [2379], 'following': [2380], 'dissolution': [2381], 'D2O.3': [2383], 'JαH-βHcoupling': [2384], 'constants': [2385, 2394, 2546, 3289], 'measured': [2387, 2396, 2547], 'E-COSY': [2389], 'and3': [2391], 'JNH-αH': [2392, 2505, 2517, 2528], 'coupling': [2393, 2506, 2545, 3288], 'DQF-COSY': [2398], 'spectra,': [2399], 'transformed': [2400], 'fingerprint': [2403, 3118], '×': [2407], 'processed': [2412], 'according': [2413], 'methods': [2415], 'Chemical': [2445], 'shifts': [2446, 3111, 3230, 3333, 3340, 4403, 4409], 'referenced': [2448], '2,2-dimethyl-2-silapentane-5-sulfonate': [2451], '0.00': [2453], 'ppm': [2454, 4540], 'analyzed': [2459, 2793, 2890], 'assigned': [2461, 2577], 'XEASY': [2463, 2488], '(20Eccles': [2464], 'Guntert': [2466], 'Billeter': [2468], 'Wüthrich': [2470, 2628], 'Biomol.': [2473, 2823, 3356], 'NMR.': [2474, 2824, 3357], '1991;': [2475], '1:': [2476], '111-130Crossref': [2477], '(269)': [2480], 'Peak': [2483], 'volumes': [2484], 'integrated': [2486], 'distance': [2490], 'restraints': [2491, 2501, 2538, 2603, 2644, 2656, 3471], 'obtained': [2492, 2540], 'CALIBA': [2494], 'appropriate': [2496], 'pseudoatom': [2497], 'corrections.': [2498], 'Backbone': [2499], 'dihedral': [2500], 'inferred': [2503, 3640], 'from3': [2504], 'constants,': [2507], 'φ': [2509, 3724], 'restrained': [2510], '120': [2512], '±': [2513, 2524, 3763, 3767, 3784, 3788], '30°': [2514, 2525], 'a3': [2516, 2527], 'greater': [2518], '9': [2520], 'Hz,': [2521], '65': [2523], 'less': [2529], '6': [2531, 4283, 4337], 'Hz.': [2532], 'Stereospecific': [2533], 'assignments': [2534], 'χ1': [2536], 'angle': [2537, 2652, 2673, 3392], '7': [2542], 'ECOSY': [2550], 'spectrum': [2551, 3156], 'conjunction': [2553, 3647], 'intensities.': [2556], 'Both': [2557], 'proline': [2558, 2573], 'trans-conformation': [2563], 'characteristic': [2566, 3976], 'NOEs.': [2567], 'β-methylene': [2569], 'stereospecifically': [2576], 'peak': [2581], 'intensities': [2582], 'spectra.': [2586], 'Six': [2587], 'hydrogen': [2588, 2654], 'slow': [2594, 3291, 3650], 'exchange': [2595, 3292, 3651, 4435], 'data': [2596], 'preliminary': [2598, 3561, 3643, 3871], 'Hydrogen': [2601, 3636], '1.7–2.2': [2605], '2.7–3.2': [2607], 'Å': [2608, 3769, 3790], 'HNi-Oj': [2613], 'Ni-Ojdistances,': [2615], 'respectively.': [2616, 3778], 'Three-dimensional': [2617], 'initially': [2620], 'calculated': [2621, 3821], 'DYANA': [2623], '(21Guntert': [2624], 'Mumenthaler': [2626], '1997;': [2633, 2698], '273:': [2634], '283-298Crossref': [2635], '(2555)': [2638], 'check': [2642], 'violations': [2646], 'resolve': [2648], 'ambiguous': [2649], 'cross-peaks.': [2650], 'Dihedral': [2651], 'subsequently': [2658], '50': [2666], 'torsion': [2672, 3391], 'dynamics': [2674, 3393], 'protocol': [2675], '(22Rice': [2676], 'L.M.': [2677, 2692], 'Brünger': [2678, 2693, 2743], 'A.T.': [2679, 2694, 2712, 2744, 3400], 'Proteins.': [2680], '19:': [2682], '277-290Crossref': [2683], '(382)': [2686], '23Stein': [2689], 'E.G.': [2690, 2797, 3826], 'Rice': [2691], 'Magn.': [2696], 'Reson.': [2697], '124:': [2699], '154-164Crossref': [2700], '(283)': [2703], 'within': [2706, 3315, 3395, 4208, 4223], 'program': [2708, 2767, 3397], 'X-PLOR': [2709, 2713, 3401], '3.851': [2710], '(24Brünger': [2711, 3399], 'Manual': [2714, 3402], 'Version': [2715, 3403], '3.851.': [2716, 3404], 'Yale': [2717, 3405], 'University,': [2718, 3406], 'New': [2719, 3103, 3407], 'Haven,': [2720, 3408], 'CT1996Google': [2721, 3409], 'Refinement': [2723], 'achieved': [2728], 'conjugate': [2731], 'gradient': [2732], 'Powell': [2733], 'algorithm': [2734], '1000': [2736], 'cycles': [2737], 'energy': [2739, 3607, 3749], 'minimization': [2740], '(25Clore': [2741], 'G.M.': [2742], 'Karplus': [2745, 2779], 'Gronenborn': [2747], 'A.M.': [2748], '1986;': [2752], '191:': [2753], '523-551Crossref': [2754], '(257)': [2757], 'refined': [2762], 'forcefield': [2763], 'CHARMm': [2768], '(26Brooks': [2769], 'B.R.': [2770], 'Bruccoleri': [2771], 'R.E.': [2772], 'Olafson': [2773], 'B.D.': [2774, 3354], 'States': [2775], 'Swaminathan': [2777], 'Comput.': [2782], '1983;': [2784], '4:': [2785], '187-217Crossref': [2786], '(13967)': [2788], 'Structures': [2791], 'PROMOTIF': [2795, 3824, 3861, 3906], '(27Hutchinson': [2796, 3825], 'Thornton': [2798, 2820, 3827], 'J.M.': [2799, 2821, 3828], '1996;': [2802, 2825, 3831], '212-220Crossref': [2804, 3833], '(997)': [2807, 3836], 'PROCHECK-NMR': [2811], '(28Laskowski': [2812], 'R.A.': [2813], 'Rullmannn': [2814], 'J.A.': [2815], 'MacArthur': [2816], 'M.W.': [2817], 'Kaptein': [2818], '8:': [2826], '477-486Crossref': [2827], '(4428)': [2830], 'acetate': [2842], 'RP-HPLC.': [2880], 'Various': [2881], 'weights': [2888, 2895], 'Molecular': [2894], 'consistent': [2896, 3053, 3473, 3656], 'peptides,': [2902], '(3480)': [2904], '(3453),': [2907], 'addition': [2911], 'isomers': [2913, 3233], 'corresponding': [2914, 3780, 4162], 'β-aspartyl': [2917, 3000, 3016, 3170], '(3453)': [2918], 'succinimide': [2920, 2998], '(3435.5)': [2921], 'previous': [2955], 'study': [2956, 3267], 'Asp-4': [2989], 'Gly-5': [2991], 'shown': [2993, 3306, 3660], 'susceptible': [2996], 'formation': [3001], 'confirmed': [3005], 'current': [3008, 3266], 'study.': [3009], 'Sufficient': [3010], 'quantities': [3011], 'isomer': [3017, 3276], 'allow': [3021], 'characterization': [3022], 'spectroscopy.': [3025], 'Amino': [3026], 'sequencing': [3028], 'essentially': [3031, 4508], 'spectroscopy,': [3034], 'observed': [3039, 3047, 3338, 3891], 'sequential': [3045, 3204], 'connectivities': [3046, 3206, 3477], 'completely': [3052], 'published': [3058], 'Assignments': [3088], 'established': [3092, 3257], 'techniques': [3093], '(29Wüthrich': [3094], 'Proteins': [3098], 'Nucleic': [3100], 'Acids.': [3101], 'Wiley-Interscience,': [3102], 'York1986Crossref': [3104], 'chemical': [3110, 3229, 3339, 4379, 4469], 'supplied': [3113], 'supplementary': [3115, 3754], 'material.': [3116], 'regions': [3119, 4546], 'Fig.2.': [3131], 'amide': [3133, 3293, 3974, 4434], 'dispersed': [3138], 'facilitated': [3141], 'assignment': [3143], 'process.': [3144], 'excellent': [3146, 3609], 'dispersion': [3147, 4441], 'cross-peaks': [3152], 'provided': [3158], 'indication': [3161], 'structure.': [3167], 'As': [3168], 'homologue': [3171], 'identical': [3176, 3479], 'weight': [3178], 'normal': [3181], '(α-aspartyl)': [3182], 'isomer,': [3183], 'discriminate': [3189], 'Only': [3193], '(i.e.that': [3196], 'eluting': [3197], 'later': [3198], 'HPLC)': [3200], 'displayed': [3201, 4437], 'expected': [3203, 3868], '(Fig.': [3207, 3234, 3295, 3898], '3': [3208, 3235, 4199], 'a)': [3209, 3297], '5,': [3214, 4238], 'strongly': [3216], 'suggests': [3217, 3237], 'contains': [3220, 4149, 4175, 4200, 4214, 4240, 4338], '“normal”': [3222], 'Comparison': [3225], 'αH': [3228], 'b)': [3236, 3900], 'structures,': [3244, 4122], 'exception': [3247], 'surrounding': [3251], '5.': [3255], 'Having': [3256], 'forms,': [3263], 'α-Asp-4': [3281], 'configuration.': [3282], 'Analysis': [3283, 3810, 4465], 'data,': [3287, 3652], 'allowed': [3298], 'secondary': [3300, 3332, 3371, 3813, 3872, 4059], 'elucidated': [3304], 'b.': [3310, 3664, 4072], '26–34': [3317], 'there': [3319, 3682], 'β-sheet': [3321, 3659, 3805, 3889, 4001], 'interactions': [3322, 3890], 'hairpin': [3325, 3894], '13–15.': [3328], 'An': [3329], 'analysis': [3330, 3549, 4420], 'differences': [3336], 'random': [3342], 'coil': [3343], 'values': [3344, 3781], '(30Wishart': [3345], 'D.S.': [3346], 'Bigam': [3347], 'C.G.': [3348], 'Holm': [3349], 'Hodges': [3351], 'Sykes': [3353], '67-81Crossref': [3360], '(1419)': [3363], 'Scholar))': [3365], 'supported': [3366], 'interpretation': [3368], 'indicated': [3374], 'presence': [3376, 3968], 'β-strands': [3378, 4129, 4227], 'helical': [3381], 'regions.': [3382], 'coded': [3394], 'XPLOR': [3398], 'bonding': [3413], 'pattern': [3414], 'had': [3415], 'chemically': [3419], 'define': [3426, 3745], 'methods.': [3430], 'For': [3431, 4416], 'compact': [3442], 'core': [3443, 4318], 'approach': [3446], 'often': [3448], 'only': [3450, 3957], 'available': [3452], 'due': [3453], 'difficulty': [3456], 'obtaining': [3458], 'suitable': [3459], 'products.': [3461], 'Preliminary': [3462], 'calculations': [3464, 3589, 3645, 3987], 'without': [3465], 'any': [3466, 4290], 'being': [3478], 'linear': [3483], 'squash': [3484, 3619], '(31Holak': [3487], 'T.A.': [3488], 'Gondol': [3489], 'Otlewski': [3491], 'Wilusz': [3493], '1989;': [3498], '210:': [3499], '635-648Crossref': [3500], '(139)': [3503], 'characterized': [3507], '(i.e.Cys': [3533], 'I-Cys': [3534, 3577, 4033], 'IV,': [3535, 3578], 'Cys': [3536, 3540, 3576, 3579, 3583, 4032, 4036, 4051, 4105, 4144, 4147], 'II-Cys': [3537, 3580, 4037], 'V,': [3538, 3581], 'III-Cys': [3541, 3584, 4052], 'VI).': [3542], 'conclusion': [3544], 'distances': [3551], 'pairs': [3555, 4102], 'S': [3557], 'atoms': [3558, 3773], '(Supplementary': [3563, 3716], 'Material).': [3564], 'clearly': [3566], 'shows': [3567, 4108, 4303], 'optimal': [3570], 'S-S': [3571], 'pairing': [3572], 'corresponds': [3573], 'VI': [3585], 'connectivity.': [3586, 3635], 'Subsequent': [3587], 'formally': [3596, 3858, 3903, 3994], 'connected': [3597, 3959], 'yielded': [3603], 'low': [3606], 'covalent': [3610], 'geometry.': [3611], 'Combined': [3612], 'consistency': [3615], 'taken': [3627], 'strong': [3629], 'evidence': [3630], 'molecule': [3678], '(residues': [3679], '8–34),': [3680], 'medium': [3685], 'long': [3687], 'NOEs': [3689, 3970, 4332], 'seven': [3693], 'results': [3697, 4371], 'lack': [3700, 4330, 4365], 'definition': [3702], '(Fig.5': [3706], 'a).': [3707], 'reflected': [3710], 'angular': [3713], 'order': [3714], 'parameters': [3715], 'Material)': [3717], 'generally': [3720], '>0.9': [3721], 'ψ': [3726], 'angles': [3727], '8–34,': [3730], 'vary': [3732, 4307], '0.2': [3734], '0.9': [3736], '1–7.': [3739], 'Geometric': [3740], 'energetic': [3742], 'statistics': [3743], 'lowest': [3748], 'data.': [3755], "RMSD's": [3757], '8–34': [3760], '0.70': [3762], '0.17': [3764, 4537], '1.86': [3766], '0.38': [3768], 'heavy': [3776], 'atoms,': [3777], '0.45': [3783], '0.11': [3785], '1.56': [3787], '0.22': [3789], 'superimposition': [3792], '12–34.': [3795], 'major': [3797], 'features': [3798, 4088, 4118], 'turns.': [3809, 4133], 'elements': [3815], 'reveals': [3839], 'γ': [3841, 4191], 'turn': [3842, 4192], '18': [3845, 4195], 'β-turns': [3849], '15–18': [3852, 4188], '22–25.': [3854], 'recognized': [3859, 3904, 3995], '26': [3864], '34,': [3866], 'analysis,': [3874], 'type': [3877, 4242], 'I': [3878, 4145, 4243], 'β-turn': [3879, 4185, 4207, 4244], '28': [3882], '31': [3884], 'connects': [3885], 'strands.': [3887], '13–15': [3897], 'triple-stranded': [3911, 4000], 'β-sheet.': [3912], 'found': [3917], 'other': [3919, 4293], 'hence': [3926, 4344, 4351], 'surprising.': [3928], 'β-strand': [3955], 'loosely': [3958], 'β-hairpin.': [3964, 4232, 4257], 'Thus,': [3965], 'despite': [3966], 'slowly': [3972], 'β-sheets,': [3978], 'orientations': [3980], 'strands': [3983], 'structures.': [4006], 'IV': [4034], 'V': [4038], 'threaded': [4045], 'bond,': [4050], 'VI.': [4053], 'schematic': [4055], 'representation': [4056], '5': [4071, 4274, 4302], 'Since': [4073], 'cyclic,': [4080], 'convenient': [4082], 'describe': [4085], 'terms': [4091], 'segments,': [4095], 'loops,': [4097], 'flanked': [4100], 'successive': [4104], 'residues.': [4106], 'Fig.6': [4107], 'considered': [4111], 'location': [4125], 'connectivity': [4137], 'shown.': [4140], 'Loop': [4141, 4173, 4198, 4212, 4282, 4336], '1,': [4142], 'positively': [4152], 'charged': [4153, 4202], '(+3)': [4154], 'hexapeptide': [4155], 'segment': [4156], 'which,': [4157], 'comprises': [4166], 'putative': [4168], 'active': [4169], 'site': [4170], 'Lys/Ile.': [4172], '2': [4174, 4272], 'positive': [4177], 'negative': [4180], 'charges': [4181], 'includes': [4183], '20.': [4197], 'incorporates': [4205, 4251], 'PGA': [4210], 'sequence.': [4211], '(I)': [4219], 'incorporated': [4222], 'It': [4233], 'followed': [4235], 'loop': [4237, 4248, 4314, 4376, 4485], 'leads': [4246], '6,': [4249, 4377], 'second': [4253], 'folded': [4261], '“pinch”': [4266], 'drawn': [4276], 'close': [4278], 'another.': [4281], 'protrudes': [4284], 'disordered.': [4300], 'individual': [4305], 'widely': [4308, 4400], 'placement': [4311], 'relative': [4315, 4355], 'molecule.': [4321, 4523, 4549], 'reflect': [4324], 'intrinsic': [4325], 'flexibility': [4326, 4369, 4483, 4551], 'simply': [4328], 'region.': [4335], 'Gly': [4341], 'content': [4342], 'protons,': [4349], 'NOEs,': [4352, 4367], 'larger': [4357], 'acids.': [4359], 'To': [4360], 'assess': [4361], 'disorder': [4374], 'shift': [4380, 4440, 4470], 'separation': [4381], 'β-protons': [4384, 4444, 4506], 'side': [4389], 'chains': [4390], 'examined.': [4392], 'general,': [4394], 'rigid': [4395], 'conformations': [4396], 'separated': [4401, 4535], 'β-proton': [4402, 4408, 4468], 'while,': [4404], 'contrast,': [4406, 4525], 'degenerate': [4407, 4509], 'indicative': [4412], 'conformational': [4414, 4516], 'averaging.': [4415], 'example,': [4417], 'permutants': [4423, 4428], 'decreased': [4430, 4439], 'stability,': [4431], 'rates,': [4436], '(32Daly': [4445], '275:': [4453], '19068-19075Abstract': [4454], '(101)': [4462], 'separations': [4471], 'proposal': [4481], '6.': [4486], '25': [4494], 'closest': [4497], 'disordered': [4502], 'residues,': [4514], 'suggesting': [4515], 'averaging': [4517], 'By': [4524], 'β-shifts': [4527], 'remaining': [4530], 'four': [4531], '0.34': [4539], 'correspond': [4542], 'i': [4552]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1983851126', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 19}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2025-01-04T16:04:00.070895', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
