Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1983698019', 'doi': 'https://doi.org/10.1016/j.molcel.2006.03.029', 'title': 'Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB', 'display_name': 'Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB', 'publication_year': 2006, 'publication_date': '2006-04-01', 'ids': {'openalex': 'https://openalex.org/W1983698019', 'doi': 'https://doi.org/10.1016/j.molcel.2006.03.029', 'mag': '1983698019', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16603397'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molcel.2006.03.029', 'pdf_url': 'http://www.cell.com/article/S1097276506002188/pdf', 'source': {'id': 'https://openalex.org/S156208185', 'display_name': 'Molecular Cell', 'issn_l': '1097-2765', 'issn': ['1097-2765', '1097-4164'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.cell.com/article/S1097276506002188/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023663301', 'display_name': 'Dos D. Sarbassov', 'orcid': 'https://orcid.org/0000-0002-6848-1133'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}, {'id': 'https://openalex.org/I4210157710', 'display_name': 'Whitehead Institute for Biomedical Research', 'ror': 'https://ror.org/04vqm6w82', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}, {'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dos D. Sarbassov', 'raw_affiliation_strings': ['The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'institution_ids': ['https://openalex.org/I107606265']}, {'raw_affiliation_string': 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center', 'institution_ids': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088809839', 'display_name': 'Siraj M. Ali', 'orcid': 'https://orcid.org/0000-0001-7477-4023'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}, {'id': 'https://openalex.org/I4210157710', 'display_name': 'Whitehead Institute for Biomedical Research', 'ror': 'https://ror.org/04vqm6w82', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}, {'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Siraj M. Ali', 'raw_affiliation_strings': ['The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'institution_ids': ['https://openalex.org/I107606265']}, {'raw_affiliation_string': 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center', 'institution_ids': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063133338', 'display_name': 'Shomit Sengupta', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}, {'id': 'https://openalex.org/I4210157710', 'display_name': 'Whitehead Institute for Biomedical Research', 'ror': 'https://ror.org/04vqm6w82', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}, {'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shomit Sengupta', 'raw_affiliation_strings': ['The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'institution_ids': ['https://openalex.org/I107606265']}, {'raw_affiliation_string': 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center', 'institution_ids': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001371362', 'display_name': 'Joon-Ho Sheen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}, {'id': 'https://openalex.org/I4210157710', 'display_name': 'Whitehead Institute for Biomedical Research', 'ror': 'https://ror.org/04vqm6w82', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}, {'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joon-Ho Sheen', 'raw_affiliation_strings': ['The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'institution_ids': ['https://openalex.org/I107606265']}, {'raw_affiliation_string': 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center', 'institution_ids': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051689094', 'display_name': 'Peggy P. Hsu', 'orcid': 'https://orcid.org/0000-0003-1140-2454'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}, {'id': 'https://openalex.org/I4210157710', 'display_name': 'Whitehead Institute for Biomedical Research', 'ror': 'https://ror.org/04vqm6w82', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}, {'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peggy P. Hsu', 'raw_affiliation_strings': ['The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'institution_ids': ['https://openalex.org/I107606265']}, {'raw_affiliation_string': 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center', 'institution_ids': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087893065', 'display_name': 'Alex F. Bagley', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}, {'id': 'https://openalex.org/I4210157710', 'display_name': 'Whitehead Institute for Biomedical Research', 'ror': 'https://ror.org/04vqm6w82', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}, {'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alex F. Bagley', 'raw_affiliation_strings': ['The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'institution_ids': ['https://openalex.org/I107606265']}, {'raw_affiliation_string': 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center', 'institution_ids': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054236100', 'display_name': 'Andrew L. Markhard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}, {'id': 'https://openalex.org/I4210157710', 'display_name': 'Whitehead Institute for Biomedical Research', 'ror': 'https://ror.org/04vqm6w82', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}, {'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew L. Markhard', 'raw_affiliation_strings': ['The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'institution_ids': ['https://openalex.org/I107606265']}, {'raw_affiliation_string': 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center', 'institution_ids': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013582936', 'display_name': 'David M. Sabatini', 'orcid': 'https://orcid.org/0000-0002-1446-7256'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}, {'id': 'https://openalex.org/I4210157710', 'display_name': 'Whitehead Institute for Biomedical Research', 'ror': 'https://ror.org/04vqm6w82', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}, {'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'David M. Sabatini', 'raw_affiliation_strings': ['The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Seven Cambridge Center, Cambridge, Massachusetts 02142', 'institution_ids': ['https://openalex.org/I107606265']}, {'raw_affiliation_string': 'Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center', 'institution_ids': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5013582936'], 'corresponding_institution_ids': ['https://openalex.org/I107606265', 'https://openalex.org/I4210157710', 'https://openalex.org/I63966007'], 'apc_list': {'value': 9080, 'currency': 'USD', 'value_usd': 9080, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 50.893, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2517, 'citation_normalized_percentile': {'value': 0.999981, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '22', 'issue': '2', 'first_page': '159', 'last_page': '168'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9929, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Nucleotide Metabolism and Enzyme Regulation', 'score': 0.9782, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mtorc2', 'display_name': 'mTORC2', 'score': 0.9730929}, {'id': 'https://openalex.org/keywords/rapamycin', 'display_name': 'rapamycin', 'score': 0.5857}, {'id': 'https://openalex.org/keywords/sirolimus', 'display_name': 'Sirolimus', 'score': 0.44945776}], 'concepts': [{'id': 'https://openalex.org/C107846503', 'wikidata': 'https://www.wikidata.org/wiki/Q14876061', 'display_name': 'mTORC2', 'level': 5, 'score': 0.9730929}, {'id': 'https://openalex.org/C98490376', 'wikidata': 'https://www.wikidata.org/wiki/Q14876060', 'display_name': 'mTORC1', 'level': 4, 'score': 0.91109663}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.86621}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.7977149}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.657138}, {'id': 'https://openalex.org/C2777949483', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'Mechanistic target of rapamycin', 'level': 4, 'score': 0.5110003}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4789127}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.47757795}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.4613469}, {'id': 'https://openalex.org/C2777921159', 'wikidata': 'https://www.wikidata.org/wiki/Q32089', 'display_name': 'Sirolimus', 'level': 2, 'score': 0.44945776}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.41085163}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11444259}], 'mesh': [{'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D020123', 'descriptor_name': 'Sirolimus', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019073', 'descriptor_name': 'HT29 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015151', 'descriptor_name': 'Immunoblotting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019169', 'descriptor_name': 'Jurkat Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009368', 'descriptor_name': 'Neoplasm Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011233', 'descriptor_name': 'Precipitin Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012190', 'descriptor_name': 'Retroviridae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012190', 'descriptor_name': 'Retroviridae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D020123', 'descriptor_name': 'Sirolimus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014183', 'descriptor_name': 'Transplantation, Heterologous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molcel.2006.03.029', 'pdf_url': 'http://www.cell.com/article/S1097276506002188/pdf', 'source': {'id': 'https://openalex.org/S156208185', 'display_name': 'Molecular Cell', 'issn_l': '1097-2765', 'issn': ['1097-2765', '1097-4164'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16603397', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molcel.2006.03.029', 'pdf_url': 'http://www.cell.com/article/S1097276506002188/pdf', 'source': {'id': 'https://openalex.org/S156208185', 'display_name': 'Molecular Cell', 'issn_l': '1097-2765', 'issn': ['1097-2765', '1097-4164'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.81, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1518126931', 'https://openalex.org/W1526978170', 'https://openalex.org/W1546930353', 'https://openalex.org/W1625966995', 'https://openalex.org/W1668086213', 'https://openalex.org/W1726025741', 'https://openalex.org/W1783498278', 'https://openalex.org/W1972239225', 'https://openalex.org/W1983112008', 'https://openalex.org/W1988609792', 'https://openalex.org/W1990332775', 'https://openalex.org/W2005496215', 'https://openalex.org/W2006559495', 'https://openalex.org/W2006796385', 'https://openalex.org/W2008932991', 'https://openalex.org/W2018002561', 'https://openalex.org/W2021012077', 'https://openalex.org/W2025654952', 'https://openalex.org/W2026351725', 'https://openalex.org/W2030762824', 'https://openalex.org/W2035016947', 'https://openalex.org/W2036016293', 'https://openalex.org/W2036837630', 'https://openalex.org/W2044472016', 'https://openalex.org/W2056158543', 'https://openalex.org/W2057106513', 'https://openalex.org/W2065887259', 'https://openalex.org/W2075639584', 'https://openalex.org/W2075997152', 'https://openalex.org/W2076994758', 'https://openalex.org/W2082770517', 'https://openalex.org/W2102648794', 'https://openalex.org/W2103228630', 'https://openalex.org/W2107674876', 'https://openalex.org/W2108360575', 'https://openalex.org/W2114859236', 'https://openalex.org/W2126783165', 'https://openalex.org/W2137035181', 'https://openalex.org/W2144000788', 'https://openalex.org/W2146013126', 'https://openalex.org/W2146415848', 'https://openalex.org/W2147398227', 'https://openalex.org/W2152289580', 'https://openalex.org/W2158612356', 'https://openalex.org/W2168230338', 'https://openalex.org/W4238567307'], 'related_works': ['https://openalex.org/W3199970584', 'https://openalex.org/W3132255180', 'https://openalex.org/W2885215830', 'https://openalex.org/W2765242536', 'https://openalex.org/W2550775385', 'https://openalex.org/W2131978771', 'https://openalex.org/W2102328908', 'https://openalex.org/W2078821200', 'https://openalex.org/W2054117275', 'https://openalex.org/W1597855498'], 'abstract_inverted_index': {'The': [0, 44, 108], 'drug': [1], 'rapamycin': [2, 25, 64, 81, 94, 114, 125, 136], 'has': [3], 'important': [4], 'uses': [5], 'in': [6, 89, 117, 146], 'oncology,': [7], 'cardiology,': [8], 'and': [9, 28, 41, 50, 58, 68, 87, 110], 'transplantation': [10], 'medicine,': [11], 'but': [12], 'its': [13], 'clinically': [14], 'relevant': [15], 'molecular': [16], 'effects': [17, 112], 'are': [18, 115], 'not': [19, 54, 60], 'understood.': [20], 'When': [21], 'bound': [22], 'to': [23, 62, 104, 143], 'FKBP12,': [24], 'interacts': [26], 'with': [27, 56], 'inhibits': [29, 82], 'the': [30, 83, 97], 'kinase': [31], 'activity': [32], 'of': [33, 38, 47, 74, 85, 99, 113, 133], 'a': [34, 71], 'multiprotein': [35], 'complex': [36, 46], 'composed': [37], 'mTOR,': [39, 48], 'mLST8,': [40, 49], 'raptor': [42], '(mTORC1).': [43], 'distinct': [45], 'rictor': [51], '(mTORC2)': [52], 'does': [53], 'interact': [55], 'FKBP12-rapamycin': [57], 'is': [59, 124], 'thought': [61], 'be': [63, 141], 'sensitive.': [65], 'mTORC2': [66, 86, 100], 'phosphorylates': [67], 'activates': [69], 'Akt/PKB,': [70], 'key': [72], 'regulator': [73], 'cell': [75, 91, 148], 'survival.': [76], 'Here': [77], 'we': [78], 'show': [79], 'that': [80, 123, 137], 'assembly': [84], 'that,': [88], 'many': [90], 'types,': [92], 'prolonged': [93], 'treatment': [95], 'reduces': [96], 'levels': [98], 'below': [101], 'those': [102], 'needed': [103], 'maintain': [105], 'Akt/PKB': [106, 121, 145], 'signaling.': [107], 'proapoptotic': [109], 'antitumor': [111], 'suppressed': [116], 'cells': [118], 'expressing': [119], 'an': [120, 130], 'mutant': [122], 'resistant.': [126], 'Our': [127], 'work': [128], 'describes': [129], 'unforeseen': [131], 'mechanism': [132], 'action': [134], 'for': [135], 'suggests': [138], 'it': [139], 'can': [140], 'used': [142], 'inhibit': [144], 'certain': [147], 'types.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1983698019', 'counts_by_year': [{'year': 2024, 'cited_by_count': 36}, {'year': 2023, 'cited_by_count': 72}, {'year': 2022, 'cited_by_count': 101}, {'year': 2021, 'cited_by_count': 117}, {'year': 2020, 'cited_by_count': 132}, {'year': 2019, 'cited_by_count': 111}, {'year': 2018, 'cited_by_count': 131}, {'year': 2017, 'cited_by_count': 121}, {'year': 2016, 'cited_by_count': 156}, {'year': 2015, 'cited_by_count': 192}, {'year': 2014, 'cited_by_count': 211}, {'year': 2013, 'cited_by_count': 192}, {'year': 2012, 'cited_by_count': 214}], 'updated_date': '2024-09-12T21:08:59.299870', 'created_date': '2016-06-24'}