Title: The Cholecystokinin Hypothesis of Anxiety and Panic Disordera
Abstract: Annals of the New York Academy of SciencesVolume 713, Issue 1 p. 273-282 The Cholecystokinin Hypothesis of Anxiety and Panic Disordera JACQUES BRADWEJN, JACQUES BRADWEJN Department of Psychiatry McGill University St Mary's Hospital 3830 Lacombe Ave. Montreal, Quebec, Canada H3T 1M5Search for more papers by this authorDIANA KOSZYCKI, DIANA KOSZYCKI Department of Psychiatry McGill University St Mary's Hospital 3830 Lacombe Ave. Montreal, Quebec, Canada H3T 1M5Search for more papers by this author JACQUES BRADWEJN, JACQUES BRADWEJN Department of Psychiatry McGill University St Mary's Hospital 3830 Lacombe Ave. Montreal, Quebec, Canada H3T 1M5Search for more papers by this authorDIANA KOSZYCKI, DIANA KOSZYCKI Department of Psychiatry McGill University St Mary's Hospital 3830 Lacombe Ave. Montreal, Quebec, Canada H3T 1M5Search for more papers by this author First published: March 1994 https://doi.org/10.1111/j.1749-6632.1994.tb44075.xCitations: 62 a The clinical studies reviewed in this paper received financial support from the Fonds de la Recherche en Santé du Québec, the Medical Research Council of Canada, St Mary's Hospital Foundation, and Psychopharmacology Fund. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 American Psychiatric Association. 1987. Diagnostic and Statistical Manual for Mental Disorders. 3rd Ed., revised. American Psychiatric Association Press. Washington , DC . 2 Faravelli, C. 1985. Life events preceding the onset of panic disorder. J. Affect. Dis. 9: 103–105. 3 Robins, L. N. & D. A. Reiger. 1990. Psychiatric Disorders in America.: 155–179. The Free Press. New York , NY . 4 Klein, D. & H. Klein. 1989. The nosology, genetics and theory of spontaneous panic attacks and phobia. In Psychopharmacology of Anxiety. P. Tyrer, Ed.: 163–179. Oxford University Press. Oxford , UK . 5 Markowitz, J. F., M. M. Weissman, R. Ouellete, J. D. Lish & G. L. Klerman. 1989. Quality of life in panic disorder. Arch. Gen. Psychiat. 46: 984–992. 6 Wittchen, H.-U. 1990. The natural course and spontaneous remissions of untreated anxiety disorders: Results from the Munich follow-up study (MFS). In Panic and Phobia 2: Treatment and Variables Affecting Course and Outcome. I. Hand & H.-U. Wittchen, Eds.: 3–17. Springer-Verlag. Berlin . 7 Bowen, R. C., C. D'Arcy & R. C. Orchard. 1991. The prevalence of anxiety disorders among patients with mitral valve prolapse syndrome and chest pain. Psychosomatics 4: 400–406. 8 Walker, E. A., P. P. Roy-Byrne & W. J. Katon. 1990. Irritable bowel syndrome and psychiatric illness. Am. J. Psychiatry 147: 565–572. 9 Stewart, W. F., M. S. Linet & D. D. Celentano. 1989. Migraine headaches and panic attacks. Psychosom. Med. 51: 559–569. 10 Johnson, J., M. M. Weissmann & G. L. Klerman. 1990. Panic disorder, comorbidity and suicide attempts. Arch. Gen. Psychiatry 47: 805–808. 11 Cox, B. J., G. R. Norton, R. P. Swinson & N. S. Endler. 1990. Substance abuse and panic-related anxiety: A critical review. Behav. Res. Ther. 28: 385–393. 12 Noyes, R., R. S. Crowe, R. L. Harris, B. J. Hamra, C. H. McChesney & D. R. Chaudhry. 1986. Relationship between panic disorder and agoraphobia. Arch. Gen. Psychiatry 43: 227–232. 13 Crowe, R. R. 1990. Panic disorder: Genetic considerations. J. Psychiat. Res. 24 (Suppl. 2): 129–134. 14 Torgerson, S. 1983. Genetic factors in anxiety disorders. Arch. Gen. Psychiatry 40: 1085–1092. 15 Hokfelt, T., O. Johansson & M. Goldstein. 1984. Chemical anatomy of the brain. Science 225: 1326–1329. 16 Bradwejn, J. & C. de Montigny. 1984. Benzodiazepines antagonize cholecystokinininduced activation of rat hippocampal neurons. Nature 312: 363–364. 17 Bradwejn, J. & C. de Montigny. 1985. Effects of PK 8165, a partial benzodiazepine receptor agonist, on cholecystokinin-induced activation of hippocampal pyramidal neurons: A microiontophoretic study in the rat. Eur. J. Pharmacol. 112: 415–418. 18 Rehfeld, J. F. 1992. CCK and anxiety: Introduction. In Multiple Cholecystokinin Receptors in Man. S. Iversen, C. Dourish & F. Cooper, Eds.: 117–120. Oxford University Press. Oxford , England . 19 Vanderhaeghen, J. & J. Crawley. 1985. Neuronal cholecystokinin. Ann. N.Y. Acad. Sci. 448: 1–697. 20 Bradwejn, J., D. Koszycki & G. Meterissian. 1990. Cholecystokinin-tetrapeptide induced panic attacks in patients with panic disorder. Canad. J. Psychiatry 35: 83–85. 21 de Montigny, C. 1989. Cholecystokinin tetrapeptide induces panic-like attacks in healthy volunteers: Preliminary findings. Arch. Gen. Psychiatry 46: 511–517. 22 Guttmacher, L. B., D. L. Murphy & T. R. Insel. 1983. Pharmacologic models of anxiety Compr Psychiatry 24: 312–326. 23 Gorman, J. M., M. R. Fyer, M. R. Liebowitz & D. F. Klein. 1987. Pharmacologic provocation of panic attacks. In Psychopharmacology: A Third Generation of Progress. H. Y. Meltzer, Ed.: 980–983. Raven Press. New York , NY . 24 Bradwejn, J. & D. Koszycki. 1992. CCK-4 and panic attacks in man. In Multiple Cholecystokinin Receptors in Man. S. Iversen, C. Dourish & F. Cooper, Eds.: 121–131. Oxford University Press. Oxford , England . 25 Bradwejn, J., D. Koszycki & C. Shriqui. 1991. Enhanced sensitivity to cholecystokinin-tetrapeptide in PD: Clinical and behavioral findings. Arch. Gen. Psychiatry 48: 603–607. 26 Abelson, J. L. & R. M. Nesse. 1990. Cholecystokinin-4 and panic. Arch. Gen. Psychiatry 47: 395. 27 Bradwejn, J., D. Koszycki, R. Payeur, M. Bourin & H. Borthwick. 1992. Study of the replication of action of cholecystokinin in panic disorders. Am. J. Psychiatry 149: 962–964. 28 Bradwejn, J., D. Koszycki, L. Annable, A. Couetoux du Tertre, S. Reines & C. Karkanias. 1992. A dose-ranging study of the behavioral and cardiovascular effects of CCK-tetrapeptide in PD. Biol. Psychiatry 32: 903–912. 29 Bradwejn, J., D. Koszycki & M. Bourin. 1991. Dose ranging study of the effect of CCK4 in healthy volunteers. J. Psychiatry Neurosci. 16: 260–264. 30 Bradwejn, J. & D. Koszycki. 1994. Imipramine antagonism of the panicogenic effects of cholecystokinin tetrapeptide in panic disorder patients Am. J. Psychiatry, In press. 31 Bradwejn, J., D. Koszycki, A. Couetoux-du-Tertre, M. Paradis & M. Bourin. 1993. Lack of effect of flumazenil on CCK-4-panic Psychopharmacology, In press. 32 Bradwejn, J. & D. Koszycki. 1991. Comparison of CO2-induced panic attacks with cholecystokinin-induced panic attacks in PD. Prog. Neuro-Psychopharmacol. Biol. Psychiat. 15: 237–239. 33 Koszycki, D., J. Bradwejn & M. Bourin. 1991. Comparison of the effects of cholecysto-kinin and carbon dioxide in healthy volunteers. Eur. Neuropharmacol. 1: 137–141. 34 Karkanias, C. D., G. A. Block, S. Reines & J. Bradwejn. 1989. Neurobiology of panic disorder. Letter. Am. J. Psychiatry 146: 1357. 35 Margraf, J., A. Ehlers & W. T. Roth. 1986. Sodium lactate infusions and panic attacks: A review and critique. Psychosom. Med. 48: 23–51. 36 Ervin, F., R. Palmour & J. Bradwejn. 1991. A new primate model for PD. New Research Program and Abstracts, 144rd Meeting of the American Psychiatric Association. New Orleans, NR 216: 100. 37 Friedman, S., G. S. Sunderland & L. A. Rosenblaum. 1987. A non-human model or PD. Psychiatry Res. 23: 65–75. 38 Harro, J., E. Vasar & J. Bradwejn. 1993. Cholecystokinin in animal and human research on anxiety. Trends Pharmacol. Sci. (TIPS) 14: 244–249. 39 Bradwejn, J., D. Koszycki, A. Couetoux-du-Tertre, H. van Megen, J. den Boer, H. Westenberg, C. Karkanias & J. Haigh. 1992. L-365, 260: A CCK-B antagonist blocks CCK4-panic in panic disorder. Clin. Neuropharmacol. 15 (Suppl. 1): 59B. 40 Bouthillier, A. & C. de Montigny. 1988. Long term benzodiazepine treatment reduces neuronal responsiveness to cholecystokinin: An electrophysiological study in the rat. Eur. J. Pharmacol. 115: 135–138. 41 Palmour, R., J. Bradwejn & F. Ervin. 1992. The anxiogenic effects of CCK4 in monkeys are reduced by CCK-B antagonists, benzodiazepines or adenosine A2 agonists. Clin. Neuropharmacol. 15 (Suppl. 1): 489B. 42 Vasar, E., E. Peuranen, T. Ööpik, J. Harro & P. Männistö. 1993. Ondansetron, and antagonist of 5HT3 receptors, antagonizes the anti-exploratory effect of caerulein, an agonist of CCK receptors, in the elevated plus maze. Psychopharmacology 110: 213–218. 43 Jordan, D. & K. M. Spyer. 1986. Brainstem integration of cardiovascular and pulmonary afferent activity. Prog. Brain Res. 67: 295–314. 44 Dampney, R. A. L., A. K. Goodchild, L. G. Robertson & W. Montgomery. 1982. Role of ventrolateral medulla in vasomotor regulation: A correlative anatomical and physiological study. Brain Res. 249: 223–235. 45 Pilowsky, R., M. West & J. Chalmers. 1985. Renal sympathetic nerve responses to stimulation, inhibition and destruction of the ventrolateral medulla in the rabbit. Neurosci. Lett. 60: 51–55. 46 Marovitch, S., M. Kumada & D. J. Reis. 1982. Role of parabrachialis in cardiovascular regulation in the cat. Brain Res. 232: 57–75. 47 Dampney, R. A. L., J. Czachurski, K. Dembowsky, A. K. Goodchild & H. Seller. 1977. Afferent connections and spinal projections of the pressor region in the rostral ventrolateral medulla of the cat. J. Auton. Nerv. Syst. 20: 73–86. 48 Ross, C. A., D. A. Ruggiero, D. H. Park, T. H. Joh, A. F. Sved, J. Fernandez-Pardal, J. M. Saaverda & D. J. Reis. 1984. Tonic vasomotor control by the rostral ventrolateral medulla: Effect of electrical or chemical stimulation of the area containing C1 adrenaline neurons on arterial pressure, heart rate, and plasma catecholamines and vasopressin. J. Neurosci. 4: 474–494. 49 Gorman, J. M., M. R. Liebowitz, A. J. Fyer & J. Stein. 1989. Neuro-anatomical hypothesis for panic disorder. Am. J. Psychiatry 146: 148–161. 50 Denavit-Saubié, M., M. A. Hurlé, M. P. Morin-Surun, A. S. Foutz & J. Champagnat. 1985. The effects of cholecystokinin-8 in the nucleus tractus solitarius. In Neuronal Cholecystokinin, J. J. Vanderhaeghen & J. N. Crawley, Eds. Ann. N. Y. Acad. Sci. 448: 375–384. 51 Lydiard, B., J. Ballenger, M. Laraia, R. Payeur & M. Beinfeld. 1992. CCK-8 concentrations in CSF of panic disorder and normal controls. Am. J. Psychiatry 149: 691–693. 52 Branchereau, P., G. A. Böhme, J. Champagnat, M. P. Morin-Surun, C. Durieux, J. C. Blanchard, B. P. Roques & M. Denavit-Saubie. 1992. CholecystokininA and cholecystokininB receptors in neurons of the brainstem solitary complex of the rat: Pharmacological identification. J. Pharmacol. Exp. Ther. 260: 1433–1440. Citing Literature Volume713, Issue1CholecystokininMarch 1994Pages 273-282 ReferencesRelatedInformation
Publication Year: 1994
Publication Date: 1994-03-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 93
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