Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1983577624', 'doi': 'https://doi.org/10.1359/jbmr.2003.18.2.270', 'title': 'Expression of RANKL and OPG Correlates With Age‐Related Bone Loss in Male C57BL/6 Mice', 'display_name': 'Expression of RANKL and OPG Correlates With Age‐Related Bone Loss in Male C57BL/6 Mice', 'publication_year': 2003, 'publication_date': '2003-02-01', 'ids': {'openalex': 'https://openalex.org/W1983577624', 'doi': 'https://doi.org/10.1359/jbmr.2003.18.2.270', 'mag': '1983577624', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12568404'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1359/jbmr.2003.18.2.270', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/jbmr.2003.18.2.270', 'source': {'id': 'https://openalex.org/S128199769', 'display_name': 'Journal of Bone and Mineral Research', 'issn_l': '0884-0431', 'issn': ['0884-0431', '1523-4681'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/jbmr.2003.18.2.270', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051929736', 'display_name': 'Jay Cao', 'orcid': 'https://orcid.org/0000-0002-5453-0176'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}, {'id': 'https://openalex.org/I1315708478', 'display_name': 'San Francisco VA Medical Center', 'ror': 'https://ror.org/049peqw80', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1315708478', 'https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210125474', 'https://openalex.org/I4210143381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jay Cao', 'raw_affiliation_strings': ['Department of Medicine, University of California, San Francisco, California, USA', 'Division of Endocrinology, Veterans Affairs Medical Center, San Francisco, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of California, San Francisco, California, USA', 'institution_ids': ['https://openalex.org/I180670191']}, {'raw_affiliation_string': 'Division of Endocrinology, Veterans Affairs Medical Center, San Francisco, California, USA', 'institution_ids': ['https://openalex.org/I1315708478']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054793499', 'display_name': 'Laura L. Venton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}, {'id': 'https://openalex.org/I1315708478', 'display_name': 'San Francisco VA Medical Center', 'ror': 'https://ror.org/049peqw80', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1315708478', 'https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210125474', 'https://openalex.org/I4210143381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laura Venton', 'raw_affiliation_strings': ['Department of Medicine, University of California, San Francisco, California, USA', 'Division of Endocrinology, Veterans Affairs Medical Center, San Francisco, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of California, San Francisco, California, USA', 'institution_ids': ['https://openalex.org/I180670191']}, {'raw_affiliation_string': 'Division of Endocrinology, Veterans Affairs Medical Center, San Francisco, California, USA', 'institution_ids': ['https://openalex.org/I1315708478']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083726183', 'display_name': 'Toshiie Sakata', 'orcid': 'https://orcid.org/0009-0006-1406-6280'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}, {'id': 'https://openalex.org/I1315708478', 'display_name': 'San Francisco VA Medical Center', 'ror': 'https://ror.org/049peqw80', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1315708478', 'https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210125474', 'https://openalex.org/I4210143381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Takeshi Sakata', 'raw_affiliation_strings': ['Department of Medicine, University of California, San Francisco, California, USA', 'Division of Endocrinology, Veterans Affairs Medical Center, San Francisco, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of California, San Francisco, California, USA', 'institution_ids': ['https://openalex.org/I180670191']}, {'raw_affiliation_string': 'Division of Endocrinology, Veterans Affairs Medical Center, San Francisco, California, USA', 'institution_ids': ['https://openalex.org/I1315708478']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062591890', 'display_name': 'Bernard P. Halloran', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1315708478', 'display_name': 'San Francisco VA Medical Center', 'ror': 'https://ror.org/049peqw80', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1315708478', 'https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210125474', 'https://openalex.org/I4210143381']}, {'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bernard P Halloran', 'raw_affiliation_strings': ['Department of Medicine, University of California, San Francisco, California, USA', 'Division of Endocrinology, Veterans Affairs Medical Center, San Francisco, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Endocrinology, Veterans Affairs Medical Center, San Francisco, California, USA', 'institution_ids': ['https://openalex.org/I1315708478']}, {'raw_affiliation_string': 'Department of Medicine, University of California, San Francisco, California, USA', 'institution_ids': ['https://openalex.org/I180670191']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3710, 'currency': 'USD', 'value_usd': 3710, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.245, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 157, 'citation_normalized_percentile': {'value': 0.999977, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '18', 'issue': '2', 'first_page': '270', 'last_page': '277'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11219', 'display_name': 'Molecular Mechanisms of Osteoclast Differentiation and Bone Remodeling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11219', 'display_name': 'Molecular Mechanisms of Osteoclast Differentiation and Bone Remodeling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11221', 'display_name': 'Bisphosphonates in Cancer Treatment and Bone Health', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10071', 'display_name': 'Osteoporosis', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/2732', 'display_name': 'Orthopedics and Sports Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cancellous-bone', 'display_name': 'Cancellous bone', 'score': 0.62516975}, {'id': 'https://openalex.org/keywords/rankl-signaling', 'display_name': 'RANKL Signaling', 'score': 0.560915}, {'id': 'https://openalex.org/keywords/osteoblast-differentiation', 'display_name': 'Osteoblast Differentiation', 'score': 0.529889}, {'id': 'https://openalex.org/keywords/osteoclast-differentiation', 'display_name': 'Osteoclast Differentiation', 'score': 0.524431}, {'id': 'https://openalex.org/keywords/bone-remodeling', 'display_name': 'Bone remodeling', 'score': 0.5067814}], 'concepts': [{'id': 'https://openalex.org/C2779428903', 'wikidata': 'https://www.wikidata.org/wiki/Q418934', 'display_name': 'RANKL', 'level': 4, 'score': 0.9458319}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.81432676}, {'id': 'https://openalex.org/C2780426850', 'wikidata': 'https://www.wikidata.org/wiki/Q3357478', 'display_name': 'Osteoprotegerin', 'level': 4, 'score': 0.8047901}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.77454793}, {'id': 'https://openalex.org/C2778260815', 'wikidata': 'https://www.wikidata.org/wiki/Q917177', 'display_name': 'Osteoblast', 'level': 3, 'score': 0.7434304}, {'id': 'https://openalex.org/C2776350087', 'wikidata': 'https://www.wikidata.org/wiki/Q265868', 'display_name': 'Cancellous bone', 'level': 2, 'score': 0.62516975}, {'id': 'https://openalex.org/C131075544', 'wikidata': 'https://www.wikidata.org/wiki/Q415863', 'display_name': 'Osteocalcin', 'level': 4, 'score': 0.6042956}, {'id': 'https://openalex.org/C2776033226', 'wikidata': 'https://www.wikidata.org/wiki/Q828410', 'display_name': 'Osteoclast', 'level': 3, 'score': 0.5815714}, {'id': 'https://openalex.org/C170033053', 'wikidata': 'https://www.wikidata.org/wiki/Q952019', 'display_name': 'Bone remodeling', 'level': 2, 'score': 0.5067814}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42935646}, {'id': 'https://openalex.org/C673006', 'wikidata': 'https://www.wikidata.org/wiki/Q4941581', 'display_name': 'Bone resorption', 'level': 2, 'score': 0.42017132}, {'id': 'https://openalex.org/C160160445', 'wikidata': 'https://www.wikidata.org/wiki/Q24769688', 'display_name': 'Alkaline phosphatase', 'level': 3, 'score': 0.34193757}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.30733567}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2986867}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.120304614}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.11682457}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.10699317}, {'id': 'https://openalex.org/C88045685', 'wikidata': 'https://www.wikidata.org/wiki/Q174576', 'display_name': 'Activator (genetics)', 'level': 3, 'score': 0.09071946}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.04354596}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D010024', 'descriptor_name': 'Osteoporosis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001835', 'descriptor_name': 'Body Weight', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001842', 'descriptor_name': 'Bone and Bones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001842', 'descriptor_name': 'Bone and Bones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010024', 'descriptor_name': 'Osteoporosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053244', 'descriptor_name': 'Osteoprotegerin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053245', 'descriptor_name': 'RANK Ligand', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053246', 'descriptor_name': 'Receptor Activator of Nuclear Factor-kappa B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018124', 'descriptor_name': 'Receptors, Tumor Necrosis Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1359/jbmr.2003.18.2.270', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/jbmr.2003.18.2.270', 'source': {'id': 'https://openalex.org/S128199769', 'display_name': 'Journal of Bone and Mineral Research', 'issn_l': '0884-0431', 'issn': ['0884-0431', '1523-4681'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12568404', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1359/jbmr.2003.18.2.270', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/jbmr.2003.18.2.270', 'source': {'id': 'https://openalex.org/S128199769', 'display_name': 'Journal of Bone and Mineral Research', 'issn_l': '0884-0431', 'issn': ['0884-0431', '1523-4681'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1534645474', 'https://openalex.org/W1974709212', 'https://openalex.org/W1977013832', 'https://openalex.org/W1987459855', 'https://openalex.org/W1992460009', 'https://openalex.org/W1992764172', 'https://openalex.org/W2000647744', 'https://openalex.org/W2019917228', 'https://openalex.org/W2029051823', 'https://openalex.org/W2046390154', 'https://openalex.org/W2048299560', 'https://openalex.org/W2054498103', 'https://openalex.org/W2054602383', 'https://openalex.org/W2054797498', 'https://openalex.org/W2057737927', 'https://openalex.org/W2058262190', 'https://openalex.org/W2081263818', 'https://openalex.org/W2081298964', 'https://openalex.org/W2100323821', 'https://openalex.org/W2114935509', 'https://openalex.org/W2128791904', 'https://openalex.org/W2129651548', 'https://openalex.org/W2139996507', 'https://openalex.org/W2144698989', 'https://openalex.org/W2167886526', 'https://openalex.org/W2198276008', 'https://openalex.org/W2889962791', 'https://openalex.org/W4247332231', 'https://openalex.org/W4254301228'], 'related_works': ['https://openalex.org/W4310330039', 'https://openalex.org/W3032163834', 'https://openalex.org/W2405442170', 'https://openalex.org/W2393213763', 'https://openalex.org/W2377224820', 'https://openalex.org/W2373306182', 'https://openalex.org/W2361950189', 'https://openalex.org/W2359313837', 'https://openalex.org/W2355713854', 'https://openalex.org/W1982381891'], 'abstract_inverted_index': {'Abstract': [0], 'Osteoblasts': [1], 'regulate': [2], 'the': [3, 33, 234], 'recruitment': [4], 'and': [5, 13, 22, 27, 42, 45, 55, 63, 73, 86, 101, 106, 129, 146, 169, 183, 208, 216, 229, 239], 'activity': [6], 'of': [7, 11, 20, 36, 47, 142, 186, 206], 'osteoclasts': [8], 'through': [9], 'expression': [10, 19, 46, 123, 205], 'RANKL': [12, 21, 93, 122, 143, 162, 193, 207], 'osteoprotegerin': [14], '(OPG).': [15], 'To': [16], 'determine': [17], 'whether': [18], 'OPG': [23, 115, 130, 147, 209], 'change': [24, 210], 'with': [25, 111, 119, 137, 211, 242], 'age': [26, 120, 200, 212], 'how': [28], 'these': [29], 'changes': [30, 222], 'relate': [31], 'to': [32, 84, 91], 'bone': [34, 40, 62, 98, 139, 215, 237], 'loss': [35], 'aging,': [37], 'we': [38], 'measured': [39], 'mass': [41], 'cancellous': [43, 138], 'volume,': [44], 'RANKL,': [48], 'OPG,': [49], 'alkaline': [50], 'phosphatase': [51], '(AP),': [52], 'osteocalcin': [53], '(OC),': [54], 'alpha': [56], 'I': [57], 'collagen': [58], '(COLL)': [59], 'in': [60, 66, 96, 104, 149, 155, 165, 175, 192, 195, 213, 217, 232, 236], 'whole': [61, 97, 214], 'osteoblast-like': [64, 196, 219], 'cells': [65, 150, 166, 176, 197], 'culture': [67, 156], 'using': [68], '6-week-': [69], '(young),': [70], '6-month-': [71], '(adult),': [72], '24-month-old': [74], '(old)': [75], 'mice.': [76], 'Cancellous': [77], 'volume': [78], 'decreased': [79, 118], 'by': [80, 87], '20%': [81], 'from': [82, 89, 151, 167, 177], 'young': [83, 112, 168], 'adult': [85, 90, 105, 170], '52%': [88], 'old.': [92], 'mRNA': [94, 116, 163, 194], 'levels': [95, 117, 164, 174], 'were': [99, 190], '2.1-fold': [100], '4.4-fold': [102], 'higher': [103, 145], 'old': [107, 178], 'mice,': [108, 113], 'respectively,': [109], 'compared': [110], 'whereas': [114, 173], 'slightly.': [121], 'was': [124, 131, 144], 'negatively': [125], '(r': [126, 133], '=': [127, 134], '−0.99)': [128], 'positively': [132], '0.92)': [135], 'correlated': [136], 'volume.': [140], 'Expression': [141], 'lower': [148], 'older': [152], 'animals': [153, 179], 'early': [154], '(day': [157], '7).': [158], 'With': [159], 'cell': [160], 'maturation,': [161], 'mice': [171], 'increased,': [172], 'decreased.': [180], 'By': [181], '21': [182], '28': [184], 'days': [185], 'culture,': [187], 'no': [188], 'differences': [189], 'found': [191], 'among': [198], 'different': [199], 'groups.': [201], 'We': [202], 'conclude': [203], 'that': [204], 'cultured': [218], 'cells.': [220], 'These': [221], 'favor': [223], 'increased': [224], 'osteoclast': [225], 'over': [226], 'osteoblast': [227], 'activity,': [228], 'may': [230], 'explain,': [231], 'part,': [233], 'imbalance': [235], 'formation': [238], 'resorption': [240], 'associated': [241], 'aging.': [243]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1983577624', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-09-13T20:30:52.444746', 'created_date': '2016-06-24'}