Title: ZnO nanoparticles as an oxidase mimic-mediated flow-injection chemiluminescence system for sensitive determination of carvedilol
Abstract: A simple, rapid and sensitive method was developed using ZnO nanoparticle (ZnO-NP) amplified flow-injection chemiluminescence to detect carvedilol, a non-cardioselective β-blocker. It has been found that carvedilol strongly inhibits the chemiluminescence of luminol-H2O2 catalyzed by ZnO-NPs. Under optimum conditions, a linear working range for carvedilol concentrations from 5 × 10(-8) to 1.0 × 10(-6) mol L(-1) (r > 0.9894, n = 8) was obtained with a detection limit of 3.25 × 10(-9) mol L(-1). The relative standard deviation for 8 repetitive determinations was less than 2.9% and recoveries of 99% and 102% were obtained. ZnO-NPs were synthesized using a green mechanochemical route. Transmission electron microscopy and x-ray diffraction were used to characterize ZnO-NPs. The method was successfully applied to detect carvedilol in pharmaceutical formulations.
Publication Year: 2014
Publication Date: 2014-12-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 46
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