Platelet-derived Growth Factor Mediates Tyrosine Phosphorylation of the Cytoplasmic Domain of the Low Density Lipoprotein Receptor-related Protein in Caveolae

Name: Work Video:
Duration: 3 min 30 s
Philippe Boucher; Pingsheng Liu; Michael Gotthardt; Thomas Hiesberger; Richard G.W. Anderson; Joachim Herz
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697, 723, 732, 736, 782, 788, 1061, 1080, 1110, 1119, 1193, 1204, 1265, 1275, 1280, 1285, 1290, 1300, 1312, 1317, 1333, 1390, 1406, 1448, 1553, 1598, 1729, 1754, 1828, 1896, 2019, 2034, 2080, 2108, 2116, 2217, 2221, 2225, 2340, 2500, 2521, 2548, 2621, 2637, 2708, 2726, 2748, 2756, 2792, 2808, 2880, 2961, 2988, 2998, 3010, 3024, 3036, 3072, 3108, 3166, 3289, 3398, 3401, 3423, 3471, 3478, 3484, 3501, 3509, 3521, 3558, 3576, 3634, 3648, 3699, 3704, 3754, 3771, 3776, 3789, 3800, 3818, 3870, 3883, 3908, 3917, 3921, 3930, 3940, 4126, 4152, 4172, 4176, 4183, 4224, 4234, 4257, 4303, 4333, 4367, 4431, 4436, 4446, 4454, 4522, 4548, 4624, 4632, 4639, 4646, 4721, 4725, 4732, 4744, 4769, 4772, 4780, 4796, 4820, 4828, 4839, 4896, 4916, 4997, 5007, 5020, 5044, 5054, 5071, 5111, 5123, 5131, 5138, 5221, 5249, 5325, 5366, 5395, 5400, 5405, 5558, 5570, 5595, 5628, 5656, 5679, 5699, 5772, 5793, 5804, 5884, 5894, 5905, 5924, 5979], 'multifunctional,': [12, 230], 'endocytic': [13, 231, 538], 'cell': [14, 232, 539, 1209, 1257, 1430, 1528, 1572, 2330, 2460, 2625, 2732, 2810, 3053, 3127, 4025, 4325, 4533, 5796, 5907], 'surface': [15, 233, 540, 1210, 1270, 1431], 'receptors.': [16, 234], 'Recently,': [17, 235], 'roles': [18, 236], 'in': [19, 40, 52, 103, 237, 258, 270, 321, 561, 629, 633, 660, 686, 798, 1049, 1066, 1096, 1183, 1196, 1272, 1277, 1288, 1296, 1302, 1338, 1397, 1420, 1541, 1550, 1587, 1595, 1629, 1655, 1825, 1930, 2022, 2130, 2187, 2243, 2281, 2333, 2451, 2493, 2639, 2860, 2990, 3048, 3069, 3083, 3105, 3125, 3207, 3240, 3262, 3294, 3376, 3382, 3393, 3403, 3414, 3447, 3486, 3492, 3547, 3587, 3604, 3639, 3644, 3758, 3778, 3872, 3927, 4168, 4214, 4245, 4251, 4261, 4305, 4308, 4317, 4329, 4384, 4393, 4397, 4433, 4753, 4836, 4888, 4920, 4923, 4994, 5011, 5030, 5032, 5061, 5089, 5214, 5236, 5563, 5597, 5695, 5779, 5886], 'cellular': [20, 210, 238, 428, 1442, 4338, 5021, 5062, 5072, 5925], 'signaling': [21, 43, 211, 239, 261, 429, 726, 869, 1083, 1113, 1205, 2453, 4217, 4248, 4264, 4339, 4387, 4398, 4524, 4714, 4787, 4840, 4922, 5063, 5241, 5775, 5986], 'have': [22, 240, 716, 860, 1035, 3042, 3132, 3960, 4190, 4206, 4229, 4426, 5767], 'also': [23, 241, 559, 1186, 2373, 2928, 3055, 3227, 3381, 3794, 3815, 4014, 4243, 4391, 4619, 4724, 4901, 5009, 5375, 5685, 5932], 'emerged.': [24, 242], 'For': [25, 243, 1809], 'instance,': [26, 244], 'the': [27, 35, 47, 53, 57, 63, 67, 79, 85, 107, 138, 143, 194, 245, 253, 265, 271, 275, 281, 285, 297, 303, 325, 356, 361, 412, 504, 534, 553, 556, 562, 571, 575, 617, 634, 646, 655, 664, 667, 691, 698, 703, 711, 730, 733, 737, 773, 780, 789, 799, 1046, 1053, 1062, 1067, 1070, 1078, 1081, 1085, 1089, 1120, 1208, 1266, 1269, 1278, 1283, 1286, 1294, 1303, 1306, 1318, 1329, 1394, 1398, 1403, 1407, 1429, 1446, 1687, 1838, 1894, 1982, 2008, 2054, 2063, 2149, 2207, 2273, 2316, 2494, 2546, 2624, 2640, 2669, 2709, 2727, 2753, 2760, 2767, 2809, 2818, 2826, 2836, 2841, 2881, 2923, 2968, 2984, 2991, 3002, 3011, 3022, 3034, 3052, 3106, 3118, 3202, 3208, 3210, 3213, 3221, 3224, 3241, 3247, 3252, 3263, 3287, 3290, 3303, 3312, 3353, 3357, 3363, 3370, 3383, 3389, 3406, 3420, 3426, 3435, 3460, 3463, 3493, 3519, 3528, 3588, 3602, 3635, 3645, 3649, 3779, 3801, 3804, 3873, 3878, 3909, 3918, 3928, 3938, 4122, 4173, 4181, 4222, 4235, 4238, 4262, 4324, 4330, 4334, 4343, 4347, 4434, 4451, 4483, 4532, 4546, 4621, 4629, 4636, 4640, 4655, 4673, 4710, 4726, 4747, 4773, 4797, 4812, 4829, 4897, 4907, 4911, 4917, 4988, 5039, 5045, 5052, 5080, 5108, 5112, 5124, 5132, 5219, 5226, 5233, 5240, 5246, 5326, 5336, 5350, 5372, 5392, 5396, 5403, 5466, 5536, 5571, 5577, 5598, 5657, 5676, 5691, 5696, 5764, 5782, 5791, 5801, 5805, 5881, 5902, 5976, 5980], 'very': [28, 246, 444, 704, 3953], '(VLDLR)': [33, 251, 709], 'and': [34, 55, 105, 114, 126, 164, 188, 216, 252, 273, 323, 332, 344, 382, 406, 434, 496, 663, 710, 735, 775, 785, 857, 866, 932, 970, 1088, 1130, 1385, 1432, 1452, 1468, 1505, 1517, 1546, 1562, 1580, 1590, 1607, 1636, 1648, 1666, 1683, 1692, 1936, 1939, 1959, 1971, 2007, 2014, 2037, 2056, 2061, 2072, 2082, 2091, 2120, 2135, 2152, 2180, 2193, 2210, 2234, 2241, 2270, 2302, 2319, 2343, 2454, 2544, 2627, 2703, 2765, 2832, 2919, 2948, 2967, 3001, 3018, 3059, 3129, 3184, 3212, 3356, 3425, 3514, 3541, 3560, 3568, 3691, 3728, 3738, 3768, 3820, 4027, 4061, 4186, 4204, 4259, 4327, 4352, 4359, 4474, 4654, 4746, 4771, 4805, 4823, 4844, 4910, 5035, 5056, 5229, 5399, 5460, 5579, 5654, 5711, 5798, 5841, 5999, 6011, 6015, 6022], 'apolipoprotein': [36, 254, 450, 712], 'receptor-2': [37, 255, 714], '(apoER2)': [38, 256, 715], 'function': [39, 257, 583, 628, 4211, 4380], 'developmental': [42, 260, 725, 4216], 'pathway': [44, 212, 262, 430, 727, 4218, 4265, 4340, 4788, 5786], 'that': [45, 97, 178, 189, 213, 263, 315, 396, 407, 431, 500, 542, 594, 679, 681, 728, 977, 1037, 1051, 1093, 1105, 1115, 1261, 1379, 1386, 1414, 1433, 1444, 2470, 2752, 2766, 2795, 2814, 2825, 2855, 2940, 2965, 3021, 3101, 3235, 3408, 3411, 3430, 3443, 3462, 3475, 3761, 3811, 3821, 3825, 3914, 4066, 4114, 4189, 4219, 4231, 4256, 4341, 4375, 4515, 4526, 4542, 4712, 4777, 4789, 4815, 4832, 4885, 5016, 5050, 5068, 5084, 5091, 5100, 5154, 5205, 5243, 5385, 5390, 5535, 5555, 5753, 5776, 5878, 5965, 5990], 'regulates': [46, 264, 729], 'lamination': [48, 266, 731], 'cortical': [50, 268], 'layers': [51, 269], 'brain': [54, 272], 'involves': [56, 106, 214, 274, 324, 432, 779, 1116, 4342, 4443], 'activation': [58, 195, 276, 413, 781, 1447, 2339, 3035, 3641, 3764, 3770, 3817, 4223, 5394, 5557], 'tyrosine': [60, 81, 98, 135, 278, 299, 316, 353, 783, 872, 1043, 1056, 1098, 1117, 1122, 1132, 1191, 1331, 1395, 1426, 1449, 2635, 2666, 2706, 2877, 2932, 2996, 3038, 3409, 3421, 3441, 3469, 3482, 3499, 3651, 3701, 3746, 3752, 3766, 3774, 3906, 3915, 4124, 4170, 4225, 4246, 4301, 4349, 4444, 4666, 4719, 4778, 4818, 4894, 4903, 4984, 4995, 5119, 5388, 5546, 5561, 5568, 5687, 5750, 5756, 5997], 'kinases.': [61, 199, 279, 417, 1450, 4226], 'Furthermore,': [62, 280, 5496], 'cytoplasmic': [64, 140, 282, 358, 1047, 1404, 2670, 2761, 2831, 3650, 4174, 4452, 4637, 4728, 5247, 5697], 'domain': [65, 283, 793, 1048, 1072, 1321, 3653, 4175, 4453, 4638, 5248, 5660], 'LDL': [68, 286, 535, 550, 699, 2073, 2525, 3354, 4199, 5040, 5046, 5055, 5081], 'receptor-related': [69, 287, 442, 487], 'protein': [70, 288, 443, 479, 488, 796, 897, 1075, 2211, 2320, 2345, 2503, 2509, 2515, 2791, 2820, 2828, 2926, 2971, 3004, 3199, 3259, 3291, 3358, 3361, 3429, 4677], '(LRP)': [71, 289, 489], 'was': [72, 290, 1491, 1614, 1676, 1724, 1746, 1814, 1979, 2002, 2012, 2059, 2086, 2122, 2142, 2462, 2646, 2763, 2796, 2844, 2980, 3005, 3081, 3205, 3226, 3260, 3292, 3345, 3374, 3515, 3545, 3585, 3782, 3923, 4143, 4154, 4537, 4800, 5086, 5101, 5115, 5157, 5329], 'found': [73, 291, 718], 'to': [74, 124, 186, 292, 342, 404, 508, 690, 719, 863, 967, 1188, 1259, 1383, 1548, 1592, 1686, 1837, 1975, 2104, 2169, 2171, 2267, 2464, 2524, 2550, 2920, 3028, 3045, 3093, 3201, 3454, 3458, 3580, 3598, 3743, 3866, 3877, 4017, 4193, 4210, 4221, 4255, 4370, 4550, 4662, 4670, 4809, 5002, 5075, 5103, 5107, 5129, 5151, 5209, 5576, 5581, 5602, 5630, 5927, 5968, 6004, 6012], 'be': [75, 293, 720, 1040, 2449, 2663, 2771, 2830, 2929, 3031, 3046, 3418, 3795, 3827, 3832, 4194, 4519, 4663, 4992, 5141, 5411, 5788], 'substrate': [77, 295, 5464], 'for': [78, 131, 208, 296, 349, 426, 849, 1568, 1650, 1819, 1992, 2043, 2100, 2124, 2182, 2305, 3033, 3110, 3135, 3251, 3369, 3678, 3687, 3720, 4145, 4180, 4357, 5143, 5331, 5465, 5567, 5591, 5790, 6007, 6018, 6023], 'non-receptor': [80, 298, 1121, 1131, 1307, 4348, 4893], 'kinase': [82, 300, 1057, 1123, 2346, 3359, 3442, 3652, 3674, 3702, 4350, 5323, 5340, 5353, 5389, 5539, 5562, 5757], 'Src,': [83, 301], 'but': [84, 302, 1292, 2652, 2783, 2799, 2816, 2849, 2867, 3229, 3380, 3490, 4389, 4723, 4900, 5105, 5163], 'physiological': [86, 304, 1082], 'significance': [87, 305], 'this': [89, 307, 531, 597, 1197, 1339, 2705, 2749, 2917, 2962, 3070, 3126, 3285, 3415, 4067], 'phosphorylation': [90, 99, 136, 190, 308, 317, 354, 408, 787, 1060, 1099, 1118, 1192, 1284, 1332, 1389, 2636, 2707, 2859, 2874, 2997, 3065, 3422, 3470, 3483, 3500, 3537, 3544, 3584, 3753, 3767, 3775, 3814, 3907, 3916, 4125, 4137, 4151, 4171, 4302, 4314, 4445, 4623, 4720, 4743, 4757, 4768, 4779, 4819, 4996, 5137, 5156, 5347, 5360, 5379, 5404, 5569, 5678, 5688], 'event': [91, 309], 'remained': [92, 310, 2850], 'unknown.': [93, 311, 1101], 'Here': [94, 312, 4227], 'we': [95, 313, 643, 1103, 1185, 2444, 2720, 2934, 3076, 3088, 3269, 3431, 3456, 4228, 4513, 4806, 4999], 'show': [96, 314, 1104, 1260, 1378, 4113, 5204, 5534], 'LRP': [101, 139, 187, 192, 319, 357, 405, 410, 558, 650, 682, 1038, 1063, 1097, 1106, 1194, 1267, 1287, 1295, 1319, 1384, 1391, 1415, 1434, 2376, 2447, 2551, 2661, 2710, 2723, 2815, 2837, 2856, 2882, 2936, 2966, 3000, 3029, 3064, 3080, 3236, 3373, 3402, 3424, 3485, 3502, 3536, 3583, 3680, 3745, 3755, 3763, 3777, 3790, 3813, 3910, 3922, 3949, 4072, 4127, 4136, 4153, 4177, 4304, 4358, 4376, 4475, 4551, 4651, 4656, 4727, 4734, 4745, 4770, 5008, 5022, 5073, 5085, 5099, 5139, 5155, 5234, 5332, 5346, 5358, 5378, 5461, 5545, 5572, 5592, 5631, 5648, 5658, 5749, 5895, 5969], 'occurs': [102, 320, 1195, 1392, 2712, 5689], 'caveolae': [104, 322, 474, 2064, 3058, 3095, 3122, 3177, 3242, 3253, 3306, 3377, 3404, 3487, 3605, 3759, 5031, 5104, 5133], 'platelet-derived': [108, 326, 454, 1225, 4019], 'growth': [109, 327, 455, 1226, 4020, 4982], 'factor': [110, 328, 456, 1227, 4983], '(PDGF)': [111, 329], 'β': [113, 331, 1229], 'phosphoinositide': [115, 333], '3-kinase.': [116, 334], 'Receptor-associated': [117, 335], 'protein,': [118, 336, 4775], 'an': [119, 337, 494, 537, 1651, 2485, 2717, 3025, 3197, 3276, 4365, 4736, 4785, 5027, 5364, 5769, 5897], 'antagonist': [120, 338, 4366], 'ligand': [122, 130, 340, 348, 661, 777, 2522, 3027, 3465, 4356, 4368, 5096, 5149, 5165, 5649], 'binding': [123, 341, 452, 791, 1308, 2523, 2547, 3023, 3631, 3876, 4369, 4547, 5150, 5575, 5601, 5629, 5650, 5967], 'LRP,': [125, 132, 343, 350, 850, 2757, 3351, 4241, 4633, 4998, 5152, 5210, 5230, 5582], 'apoE-enriched': [127, 345, 1326], 'β-VLDL,': [128, 346, 1327], 'reduce': [133, 351], 'PDGF-induced': [134, 352, 1330, 3498, 3751, 4123, 5556, 5906], 'domain.': [141, 359, 1199, 4729], 'In': [142, 360, 1125, 1335, 2658, 2716, 2839, 3161, 3220, 3266, 3284, 3527, 3937, 5762], 'accompanying': [144, 362], 'paper': [145, 363], '(Loukinova,': [146, 364], 'E.,': [147, 365], 'Ranganathan,': [148, 366], 'S.,': [149, 151, 367, 369], 'Kuznetsov,': [150, 368], 'Gorlatova,': [152, 370], 'N.,': [153, 371], 'Migliorini,': [154, 372], 'M.,': [155, 373], 'Ulery,': [156, 374], 'P.': [157, 375, 1018, 1154, 1232, 2681, 3607, 4688, 4860, 4930, 4956, 5254, 5307, 5479], 'G.,': [158, 376], 'Mikhailenko,': [159, 377], 'I.,': [160, 378], 'Lawrence,': [161, 379], 'D.': [162, 166, 380, 384, 2419, 2594, 4488, 4594], 'L.,': [163, 381], 'Strickland,': [165, 383], 'K.': [167, 385, 3839, 5282, 5422], '(2002)': [168, 386], 'J.': [169, 387, 516, 601, 604, 746, 750, 756, 815, 905, 990, 1019, 1165, 1171, 1239, 1362, 1702, 1711, 1764, 1788, 1797, 1844, 1869, 1878, 2387, 2401, 2407, 2428, 2532, 2562, 2576, 2582, 2603, 2682, 2899, 3614, 3657, 3841, 3971, 4000, 4045, 4081, 4103, 4273, 4277, 4283, 4497, 4562, 4576, 4582, 4603, 4689, 4867, 4937, 4954, 4963, 5188, 5261, 5284, 5424, 5448, 5480, 5518, 5633, 5636, 5732, 5860, 5915, 5945], 'Biol.': [170, 388, 519, 1020, 1142, 1240, 1363, 1712, 1798, 1879, 2389, 2429, 2564, 2604, 2683, 2900, 3615, 4046, 4082, 4104, 4498, 4564, 4604, 4690, 4868, 4938, 4964, 5189, 5262, 5449, 5481, 5519, 5733, 5861, 5916, 5946], 'Chem.': [171, 389, 1021, 1241, 1364, 1713, 1799, 1880, 2430, 2605, 2684, 2901, 3616, 4047, 4083, 4105, 4499, 4605, 4691, 4869, 4939, 4965, 5190, 5263, 5450, 5482, 5520, 5734, 5862, 5917, 5947], '277,': [172, 390], '15499–15506)': [173, 391], 'Loukinova': [174, 392, 1341, 5167, 5497, 5586, 5682], 'et': [175, 393, 1342, 1898, 3318, 4402, 5168, 5498, 5587, 5683], 'al.further': [176, 394], 'demonstrate': [177, 395, 2964, 5015], 'one': [179, 397, 582], 'form': [180, 398, 1311, 3882], 'PDGF,': [182, 400, 3941], 'PDGF-BB,': [183, 401], 'binds': [184, 402, 1381, 5208], 'specifically': [185, 403, 4299, 5116, 5580], 'requires': [193, 411, 3765, 3816, 5391], 'Src': [197, 415, 4898, 5407, 5537, 5559, 5995], 'Taken': [200, 418, 1409, 4705, 5548], 'together,': [201, 419, 1410, 4706, 5549], 'these': [202, 420, 1411, 2873, 3189, 4707, 4781, 4889, 5550, 5962], 'findings': [203, 421, 4708, 5014, 5551, 5963], 'provide': [204, 422], 'biochemical': [206, 424, 1091], 'basis': [207, 425], 'apoE': [215, 433, 1745, 1818, 3967, 4116, 5666, 5809, 5879, 5930, 5966], 'LRP.': [217, 435, 585, 1334, 2806, 3472, 4371, 4821, 5406, 5680, 5700, 6000], 'VLDL': [448], 'phosphotyrosine': [451, 790], 'thrombospondin': [453, 858], 'PDGF': [457, 1301, 1380, 1387, 3531, 3630, 3792, 3871, 4385, 4912, 4918, 4989, 5127, 5206, 5216, 5227, 5251, 5327, 5338, 5351, 5373, 5397, 5414, 5574, 5596, 5704, 5754, 5773, 5885, 5992], "Dulbecco's": [459], 'modified': [460], "Eagle's": [461], 'medium': [462, 1304, 1610, 1675, 1840, 2095, 2099, 2466, 3874, 5599], 'normal': [463, 1581, 1925, 2714, 2729, 3098], 'rat': [464, 1582, 2730], 'kidney': [465, 1583, 2731], 'phosphate-buffered': [466], 'saline': [467], 'glutathione': [468], 'S-transferase': [469], 'plasma': [470, 544, 1755, 3170, 4335, 4830, 5113, 5783], 'membrane': [471, 475, 477, 1198, 1946, 2005, 2065, 3171, 4344, 4831, 5114], 'post-nuclear': [472, 1956, 3167], 'supernatant': [473, 1957, 3168], 'non-caveolae': [476, 1297, 2004, 3173, 3299, 3371, 3384, 3494, 3529, 3729, 3780], 'receptor-associated': [478, 2514], 'phosphatidylinositol': [480], '3-kinase': [481], '(LDL)1': [486], 'is': [490, 533, 580, 683, 978, 1107, 1271, 2517, 2700, 3237, 3391, 3438, 3444, 3596, 3676, 4069, 4178, 4242, 4361, 4527, 4642, 5023, 5369, 5462, 5565, 5589, 5626, 5759], 'member': [492, 4233, 5043], 'ancient': [495], 'multifunctional': [497, 598, 4239], 'has': [501, 651, 677, 964, 4013, 4063, 4925, 5057, 5811, 5876, 5931], 'arisen': [502], 'during': [503, 4438, 5800, 5975], 'transition': [505], 'from': [506, 552, 654, 1458, 1472, 1484, 1493, 1509, 1522, 1535, 1576, 1678, 1748, 1751, 1757, 1955, 2088, 2255, 2467, 2623, 2724, 2937, 3096, 3272, 3302, 5038, 5094], 'unicellular': [507], 'multicellular': [509], 'organisms': [510], '(1Willnow': [511], 'T.E.': [512], 'Nykjaer': [513], 'A.': [514, 809, 951, 1777, 1857, 1914, 3152, 3334, 3655, 3890, 3984, 5610], 'Herz': [515, 755, 814, 1763, 1787, 1843, 1868, 2531, 3970, 3999, 4282], 'Nat.': [517, 886, 2360, 4416], 'Cell': [518, 906, 2388, 2563, 4563], '1999;': [520, 758, 817, 838, 924, 4285, 5314, 5828], '1:': [521], 'E157-E162Crossref': [522], 'PubMed': [523, 610, 766, 825, 841, 891, 911, 927, 955, 1000, 1030, 1146, 1159, 1176, 1219, 1250, 1373, 1720, 1781, 1806, 1861, 1887, 1918, 2365, 2393, 2411, 2439, 2539, 2568, 2586, 2614, 2693, 2910, 3156, 3338, 3625, 3665, 3712, 3858, 3898, 3988, 4007, 4038, 4056, 4092, 4293, 4421, 4467, 4508, 4568, 4586, 4614, 4700, 4854, 4878, 4948, 4974, 5199, 5272, 5301, 5317, 5441, 5457, 5491, 5529, 5618, 5642, 5743, 5831, 5853, 5871, 5956], 'Scopus': [524, 611, 767, 826, 842, 892, 928, 956, 1031, 1147, 1160, 1177, 1220, 1251, 1374, 1782, 1862, 1919, 2366, 2394, 2412, 2440, 2540, 2569, 2587, 2615, 2694, 2911, 3157, 3339, 3626, 3666, 3713, 3859, 3899, 3989, 4008, 4057, 4093, 4294, 4422, 4468, 4509, 4569, 4587, 4615, 4701, 4855, 4879, 4949, 4975, 5200, 5273, 5302, 5318, 5442, 5492, 5530, 5619, 5643, 5744, 5832, 5872, 5957], '(184)': [525], 'Google': [526, 613, 769, 828, 844, 894, 912, 930, 958, 1001, 1033, 1149, 1162, 1179, 1222, 1253, 1376, 1721, 1784, 1807, 1864, 1888, 1921, 2368, 2396, 2414, 2442, 2542, 2571, 2589, 2617, 2696, 2913, 3159, 3341, 3628, 3668, 3715, 3861, 3901, 3991, 4010, 4039, 4059, 4095, 4109, 4296, 4424, 4470, 4511, 4571, 4589, 4617, 4703, 4857, 4881, 4951, 4977, 5202, 5275, 5304, 5320, 5444, 5458, 5494, 5532, 5621, 5645, 5746, 5834, 5854, 5874, 5921, 5959], 'Scholar).': [527, 614, 770, 845, 959, 1002, 1254, 1722, 1808, 1889, 1922, 2369, 2618, 2697, 2914, 3160, 3342, 3629, 3669, 3862, 4011, 4110, 4297, 4471, 4704, 4882, 4978, 5321, 5495, 5835, 5922, 5960], 'namesake': [529], 'receptor,': [536, 3355, 3601, 3636, 4641, 5041, 5374], 'controls': [543], 'cholesterol': [545], 'levels': [546, 4758], 'by': [547, 574, 772, 974, 1006, 1305, 1315, 1726, 1732, 2157, 2262, 2337, 2648, 2654, 2775, 2785, 2884, 2983, 3008, 3182, 3186, 3280, 3316, 3518, 3642, 3718, 3733, 3791, 3798, 3829, 3875, 3963, 4071, 4196, 4363, 4399, 4441, 4529, 4539, 4762, 4784, 5026, 5121, 5144, 5371, 5413, 5585, 5600, 5651, 5661, 5838, 5896, 5929, 5983], 'removing': [548], 'cholesterol-rich': [549, 3049, 4321, 4826], 'particles': [551], 'circulation': [554], 'via': [555], 'liver.': [557, 576], 'participates': [560], 'removal': [563], 'specific': [566, 5337, 5703], 'particles,': [570], 'chylomicron': [572], 'remnants,': [573], 'However,': [577, 673, 1077, 2698, 4140, 4756, 5349], 'clearance': [579], 'only': [581, 2801, 3542, 4379, 4717], 'At': [586], 'present': [587, 3047, 3082, 3206, 3239, 3392, 5765], 'over': [588], '30': [589, 2101, 2306, 3507, 3688, 3721, 3724], 'different': [590, 867, 4480, 5077, 5093, 5702], 'ligands': [591, 619, 669, 848, 1435], 'are': [592, 1094, 1181, 2972, 3123, 3412, 4163, 4825, 4833, 4886, 6002], 'known': [593, 618, 3056, 3597, 5059], 'interact': [595, 2374, 2834], 'with': [596, 1069, 1322, 1422, 1556, 1601, 1622, 1646, 1811, 1817, 1934, 1950, 1967, 2016, 2031, 2093, 2097, 2139, 2166, 2177, 2191, 2206, 2231, 2257, 2272, 2315, 2375, 2484, 2630, 2737, 2777, 2805, 2835, 2847, 2956, 3013, 3193, 3311, 3347, 3480, 3551, 3690, 3723, 3735, 3740, 3803, 3905, 3965, 4148, 4165, 4450, 4650, 4672, 4735, 5126, 5148, 5239], '(2Herz': [600, 5632], 'Strickland': [602, 939, 1360, 1707, 2402, 2426, 2577, 2601, 4495, 4577, 4601, 5186, 5516, 5634, 5730, 6014], 'D.K.': [603, 940, 1361, 1706, 2403, 2427, 2578, 2602, 4030, 4042, 4076, 4098, 4496, 4578, 4602, 5187, 5517, 5635, 5731, 5845, 5857, 5910], 'Clin.': [605, 5637], 'Invest.': [606, 5638], '2001;': [607, 1022, 2685, 3855, 4035, 4048, 4106, 4692, 5298, 5438, 5483, 5639, 5850, 5863, 5918, 5948], '108:': [608, 5640], '779-784Crossref': [609, 5641], '(869)': [612, 5644], 'Most': [615], 'fall': [620], 'into': [621], 'two': [622, 694, 3365], 'classes,': [623], 'depending': [624], 'on': [625, 1042, 1268, 1393, 1735, 1943, 1981, 2148, 2185, 2665, 2931, 2974, 3275, 3535, 4121, 4482, 4665, 5118, 5245, 5690], 'whether': [626, 2446, 2702, 2872, 2922, 3063, 3079, 3672, 3868, 4981, 5004], 'they': [627, 2868, 3959], 'lipid': [630], 'metabolism': [631], 'or': [632, 1314, 1424, 1440, 2096, 2113, 2480, 2498, 2506, 2742, 2950, 2986, 3176, 5673], 'regulation': [635, 4435, 5792], 'extracellular': [637, 688, 1320, 3026, 5659], 'protease': [638, 1935, 2192, 2301], 'activity.': [639], 'Much': [640], 'what': [642], 'know': [644], 'about': [645], 'biological': [647, 1086], 'functions': [648, 5090], 'been': [652, 717, 861, 965, 2473, 2889, 2942, 3043, 3103, 3133, 3961, 4015, 4064, 4191, 4208, 4660, 4926, 5933], 'derived': [653], 'study': [656, 1337], 'its': [658, 3504, 3600], 'role': [659, 4396, 4430, 4915, 5060, 5814, 5974], 'endocytosis': [662, 5053], 'routing': [665], 'endocytosed': [668], 'toward': [670], 'lysosomal': [671], 'degradation.': [672], 'recently': [674, 4207, 4659], 'increasing': [675], 'evidence': [676], 'accumulated': [678], 'suggests': [680, 4374], 'likely': [684, 979, 1108, 4250, 5554], 'involved': [685, 1095, 2450, 3833, 4244, 4993], 'transducing': [687], 'signals': [689, 1443, 2332, 4188, 5416], 'cell.': [692], 'First,': [693], 'other': [695], 'members': [696, 2528, 4202, 5409], 'family,': [702, 4237], 'E': [713], 'obligate': [721, 4520], 'components': [722, 4521], 'cortex': [734], 'cerebellum': [738], '(3Trommsdorff': [739, 4266], 'M.': [740, 742, 805, 881, 982, 992, 1014, 1353, 2355, 2530, 2677, 4074, 4267, 4269, 4411, 4684, 5179, 5475, 5509, 5723], 'Gotthardt': [741, 4268], 'Hiesberger': [743, 4270], 'T.': [744, 803, 1167, 3707, 4271, 4958, 5942], 'Shelton': [745, 4272], 'Stockinger': [747, 4274], 'W.': [748, 3996, 4275], 'Nimpf': [749, 4276], 'Hammer': [751, 4278], 'R.E.': [752, 4279], 'Richardson': [753, 4280], 'J.A.': [754, 813, 835, 4281], 'Cell.': [757, 1141, 3658, 4284], '97:': [759, 953, 4286], '689-701Abstract': [760, 4287], 'Full': [761, 763, 820, 822, 1025, 1027, 1245, 1247, 1368, 1370, 1717, 1803, 1884, 2434, 2436, 2609, 2611, 2688, 2690, 2905, 2907, 3620, 3622, 3662, 4051, 4053, 4087, 4089, 4288, 4290, 4503, 4505, 4609, 4611, 4695, 4697, 4873, 4875, 4943, 4945, 4969, 4971, 5194, 5196, 5267, 5269, 5454, 5486, 5488, 5524, 5526, 5738, 5740, 5866, 5868, 5951, 5953], 'Text': [762, 764, 821, 823, 1026, 1028, 1246, 1248, 1369, 1371, 1718, 1804, 1885, 2435, 2437, 2610, 2612, 2689, 2691, 2906, 2908, 3621, 3623, 3663, 4052, 4054, 4088, 4090, 4289, 4291, 4504, 4506, 4610, 4612, 4696, 4698, 4874, 4876, 4944, 4946, 4970, 4972, 5195, 5197, 5268, 5270, 5455, 5487, 5489, 5525, 5527, 5739, 5741, 5867, 5869, 5952, 5954], 'PDF': [765, 824, 1029, 1249, 1372, 1719, 1805, 1886, 2438, 2613, 2692, 2909, 3624, 3664, 4055, 4091, 4292, 4507, 4613, 4699, 4877, 4947, 4973, 5198, 5271, 5456, 5490, 5528, 5742, 5870, 5955], '(1067)': [768, 4295], 'Signaling': [771, 4440, 4883], 'VLDLR': [774, 4203, 4258], 'apoER2': [776, 4205, 4260], 'Reelin': [778, 4263], 'kinases': [784, 873, 898, 1133, 1427, 2886, 3041, 3410, 3824, 4843, 4895, 4904, 4985], 'subsequent': [786], '(PTB)': [792], 'containing': [794, 1073, 1611, 1631, 1657, 1830, 2132, 2237, 2300, 3305, 4675], 'adaptor': [795, 1074, 4676], 'Disabled-1': [797], 'migrating': [800], 'neurons': [801], '(4Hiesberger': [802], 'Trommsdorff': [804], 'Howell': [806], 'B.W.': [807, 831], 'Goffinet': [808], 'Mumby': [810], 'M.C.': [811], 'Cooper': [812, 834], 'Neuron.': [816], '24:': [818], '481-489Abstract': [819], '(772)': [827], 'Scholar,': [829, 913, 1150, 1163, 1865, 2397, 2415, 2572, 2590, 3992, 4040, 4096, 4572, 4590, 4858, 4952, 5276, 5305, 5445, 5855], '5Howell': [830], 'Herrick': [832], 'T.M.': [833], 'Genes': [836], 'Dev.': [837], '13:': [839], '643-648Crossref': [840], '(353)': [843], 'Second,': [846], 'several': [847], 'e.g.': [851], 'urokinase-type': [852], 'plasminogen': [853, 962], 'activator,': [854], 'activated': [855, 3828, 5250, 5370, 5412], 'α2-macroglobulin,': [856], '(TSP),': [859], 'shown': [862, 966, 1036, 3044, 4016, 4192, 4230, 4427, 4661, 5584], 'activate': [864, 3599], 'distinct': [865], 'intracellular': [868], 'pathways,': [870], 'including': [871, 1224, 4842], '(6Jimenez': [874, 2348, 4404], 'B.': [875, 1012, 2349, 2675, 3835, 4405, 4682, 5278, 5418, 5473], 'Volpert': [876, 2350, 4406], 'O.V.': [877, 2351, 4407], 'Crawford': [878, 2352, 4408], 'S.E.': [879, 2353, 4409], 'Febbraio': [880, 2354, 4410], 'Silverstein': [882, 2356, 4412], 'R.L.': [883, 2357, 4413], 'Bouck': [884, 2358, 4414], 'N.': [885, 1351, 2359, 4415, 5177, 5507, 5721], 'Med.': [887, 2361, 4417], '2000;': [888, 908, 952, 997, 2362, 3895, 4418, 5615], '6:': [889, 2363, 4036, 4419, 5851], '41-48Crossref': [890, 2364, 4420], '(838)': [893, 2367, 4423], 'Scholar),': [895, 931, 1223, 2443, 3716, 4060, 4512, 5459, 5646, 5747], 'mitogen-activated': [896], '(7Webb': [899], 'D.J.': [900, 3886, 5606], 'Nguyen': [901], 'D.H.': [902], 'Gonias': [903, 3891, 5611], 'S.L.': [904, 3892, 5612], 'Sci.': [907, 948, 1774, 1854, 1911, 3149, 3331, 3894, 3981, 5614], '113:': [909], '123-134Crossref': [910], '8Chapman': [914], 'H.A.': [915, 4457], 'Wei': [916], 'Y.': [917, 986, 1234, 1903, 2894, 3141, 3323, 3609, 4862, 4932, 5256, 5940], 'Simon': [918], 'D.I.': [919], 'Waltz': [920], 'D.A.': [921, 5944], 'Thromb.': [922], 'Haemost.': [923], '82:': [925], '291-297Crossref': [926], '(132)': [929, 4094], 'Ca2+': [933], 'currents': [934], '(9Bacskai': [935], 'B.J.': [936], 'Xia': [937], 'M.Q.': [938], 'Rebeck': [941], 'G.W.': [942], 'Hyman': [943], 'B.T.': [944], 'Proc.': [945, 1771, 1851, 1908, 3146, 3328, 3978], 'Natl.': [946, 1772, 1852, 1909, 3147, 3329, 3979], 'Acad.': [947, 1773, 1853, 1910, 3148, 3330, 3980], 'U.': [949, 1775, 1855, 1912, 3150, 3332, 3982, 3994], 'S.': [950, 1347, 1349, 1776, 1856, 1913, 2378, 2384, 2553, 2559, 3151, 3333, 3983, 4553, 4559, 5173, 5175, 5503, 5505, 5717, 5719, 5826], '11551-11556Crossref': [954], '(169)': [957], 'Third,': [960], 'tissue-type': [961], 'activator': [963], 'enhance': [968], 'neurotransmission': [969], 'long': [971], 'term': [972], 'potentiation': [973], 'mechanism': [976], 'LRP-dependent': [980, 4786, 5770], '(10Zhuo': [981], 'Li': [983], 'D.M.': [984, 2898], 'Holtzman': [985, 2897], 'Osaka': [987], 'H.': [988, 1010, 2399, 2574, 2673, 4574, 4680, 5471], 'DeMaro': [989], 'Jacquin': [991], 'Bu': [993], 'G.': [994, 2380, 2425, 2555, 2600, 2892, 3998, 4100, 4494, 4555, 4600, 5912], 'J': [995], 'Neurosci.': [996], '20:': [998], '542-549Crossref': [999], 'Finally,': [1003], 'recent': [1004], 'work': [1005, 5837], 'Barneset': [1007], 'al.': [1008, 1343, 1899, 3319, 4403, 5169, 5499, 5684], '(11Barnes': [1009, 2672, 4679, 5470], 'Larsen': [1011, 2674, 4681, 5472], 'Tyers': [1013, 2676, 4683, 5474], 'van': [1015, 2678, 4685, 5476], 'Der': [1016, 2679, 4686, 5477], 'Geer': [1017, 2680, 4687, 5478], '276:': [1023, 2686, 4049, 4693, 5484, 5864, 5949], '19119-19125Abstract': [1024, 2687, 4694, 5485], '(97)': [1032, 2695, 4702, 5493], 'Scholar)': [1034, 1180, 1377, 2543, 3902, 4425, 4618, 5203, 5533, 5622, 5875], 'can': [1039, 2328, 2372, 2662, 2857, 3826, 3950, 5410], 'phosphorylated': [1041, 2664, 2764, 2798, 2930, 2973, 4664, 5117], 'residues': [1044, 2667, 2769, 5120], 'within': [1045, 1402, 2668], 'cells': [1050, 1276, 1585, 1619, 1641, 1682, 2090, 2336, 2469, 2642, 2863, 2939, 3012, 3802, 4307, 5125, 5578], 'overexpress': [1052], 'constitutively': [1054, 5467], 'active': [1055, 3646, 5468], 'v-Src.': [1058], 'Tyrosine': [1059, 3040, 5322], 'tail': [1064, 1405, 2671, 2711, 2883, 4657, 5235, 5333, 5359, 5698], 'results': [1065, 2747, 2960, 3638, 4112], 'association': [1068], 'PTB': [1071], 'Shc.': [1076], 'nature': [1079, 4795], 'molecules,': [1084, 4841], 'significance,': [1087], 'underlying': [1090], 'mechanisms': [1092, 4814], 'remain': [1100], 'Here,': [1102], 'part': [1109, 4332, 5110], 'TSP-1-mediated': [1112, 4622], 'cascade': [1114], 'Fyn.': [1124], 'as': [1126, 1128, 1417, 1616, 1698, 2077, 2145, 2324, 3057, 3117, 3367, 4212, 4381, 4906, 4987, 5583], 'much': [1127], '(12Robbins': [1134], 'S.M.': [1135], 'Quintrell': [1136], 'N.A.': [1137, 4078], 'Bishop': [1138], 'J.M.': [1139], 'Mol.': [1140], '1995;': [1143, 1915, 2390, 2565, 3153, 3335, 3709, 4565], '15:': [1144], '3507-3515Crossref': [1145], '(227)': [1148], '13Draberova': [1151], 'L.': [1152, 5447], 'Draber': [1153], 'Pnas.': [1155], '1993;': [1156, 1173], '90:': [1157], '3611-3615Crossref': [1158], '(117)': [1161], '14Bohuslav': [1164], 'Cinek': [1166], 'Horejsi': [1168], 'V.': [1169, 1768, 1848, 3975], 'Eur.': [1170], 'Immunol.': [1172], '23:': [1174], '825-831Crossref': [1175], '(90)': [1178], 'enriched': [1182, 3962, 4835, 5667], 'caveolae/rafts,': [1184], 'looked': [1187], 'see': [1189], 'if': [1190], 'Caveolae/rafts': [1200], 'compartmentalize': [1201], 'variety': [1203, 4838], 'molecules': [1206, 4884], 'at': [1207, 1428, 1668, 1822, 1988, 1995, 2039, 2046, 2203, 2312, 3051, 4323, 4479, 4531, 5781], '(15Anderson': [1211, 4846], 'R.G.': [1212, 4847, 5309], 'Annu.': [1213, 2533, 3852, 4848, 5295, 5435], 'Rev.': [1214, 2534, 3853, 4849, 5296, 5436], 'Biochem.': [1215, 2406, 2535, 2581, 3854, 4581, 4850, 5297, 5310, 5437], '1998;': [1216, 2902, 4084, 4851], '67:': [1217, 4852], '199-225Crossref': [1218, 4853], '(1711)': [1221, 4856], '(PDGFR-β)': [1230], '(16Liu': [1231, 3606, 4929, 5253], 'Ko': [1233, 3608, 4861, 4931, 5255], 'Ying': [1235, 1902, 3140, 3322, 3610, 4863, 4933, 5257], 'Y.G.': [1236, 3611, 4864, 4934, 5258], 'Anderson': [1237, 1906, 3144, 3326, 3612, 4865, 4935, 5259, 5308], 'R.G.W.': [1238, 1907, 3145, 3327, 3613, 4866, 4936, 5260], '1996;': [1242, 2408, 2583, 3617, 4583, 4870, 4940, 5264], '271:': [1243, 3618, 4871, 4941, 5265], '10299-10303Abstract': [1244, 3619, 4872, 4942, 5266], '(336)': [1252, 3627, 4880, 4950, 5274], 'We': [1255, 1564, 3113, 3863, 6001], 'used': [1256, 1565, 2076, 3089], 'fractionation': [1258, 3281], 'substantial': [1263, 3399, 4742, 5018], 'portion': [1264, 5019], 'caveolae/rafts.': [1273], 'Incubation': [1274], 'presence': [1279, 2499, 2987, 3397, 3929], 'PDGF-BB': [1281, 1451, 3466, 3595, 4298], 'stimulated': [1282], 'fractions': [1289, 2277, 3190, 3215, 3295, 3307, 3385, 3562, 3730, 3781], 'caveolae/rafts': [1291, 5564, 5780], 'not': [1293, 2474, 2653, 2784, 2817, 2870, 2951, 2981, 3491, 3783, 3786, 4328, 4378, 4716, 4760, 4791, 4802, 5106, 5158, 5356], 'fractions.': [1298, 2084], 'Sequestration': [1299, 5594], 'competent,': [1309], 'native': [1310, 3933, 5603], 'α2-macroglobulin': [1313, 1506, 3884, 3934, 3942, 5604], 'occupation': [1316, 5655], 'large': [1324, 5663], 'ligand,i.e.': [1325], 'reduced': [1328, 3926, 4135, 5675, 5901], 'another': [1336, 3267, 4232, 5042], 'issue,': [1340], '(17Loukinova': [1344, 5170, 5500, 5714], 'E.': [1345, 5171, 5501, 5715], 'Ranganathan': [1346, 5172, 5502, 5716], 'Kuznetsov': [1348, 5174, 5504, 5718], 'Gorlatova': [1350, 5176, 5506, 5720], 'Migliorini': [1352, 5178, 5508, 5722], 'Ulery': [1354, 5180, 5510, 5724], 'P.G.': [1355, 5181, 5511, 5725], 'Mikhailenko': [1356, 5182, 5512, 5726], 'I.': [1357, 2382, 2417, 2557, 2592, 4486, 4557, 4592, 5183, 5513, 5727], 'Lawrence': [1358, 5184, 5514, 5728], 'D.L.': [1359, 5185, 5515, 5729], '2002;': [1365, 5191, 5521, 5735], '277:': [1366, 4107, 5192, 5522, 5736, 5919], '15499-15506Abstract': [1367, 5193, 5523, 5737], '(205)': [1375, 5201, 5531, 5745], 'directly': [1382], 'receptor-dependent': [1388, 4311, 4386], 'residue': [1396], 'second': [1399, 2024, 5692], 'NPXY': [1400, 5693], 'motif': [1401, 5694], 'receptor.': [1408, 4913], 'data': [1412, 4162], 'suggest': [1413, 5964], 'serves': [1416], 'coreceptor': [1419, 4383], 'conjunction': [1421], 'transmembrane': [1423, 3440], 'membrane-associated': [1425], 'may': [1436, 2829, 2927, 3030, 3417, 3831, 4377, 4390, 5787, 5970], 'thereby': [1437, 5231], 'either': [1438, 2472], 'transduce': [1439], 'modulate': [1441], 'involve': [1445, 4792], 'anti-phosphotyrosine': [1453, 2631, 3741, 4737], 'antibodies': [1454, 1470, 2632, 3348, 3742], '(4G10)': [1455], 'were': [1456, 1471, 1483, 1507, 1520, 1530, 1533, 1539, 1574, 1627, 1642, 1663, 1696, 1891, 1928, 1948, 1965, 1985, 2028, 2075, 2118, 2128, 2155, 2164, 2175, 2198, 2228, 2253, 2278, 2309, 2491, 3180, 3191, 3249, 3563, 3578, 3685, 3731, 4759, 5092], 'purchased': [1457, 1492, 1508, 1521], 'Upstate': [1459], 'Biotechnology': [1460], 'Inc.': [1461, 1487], '(Lake': [1462], 'Placid,': [1463], 'NY).': [1464, 1500], 'Rabbit': [1465, 1744], 'anti-caveolin': [1466], '1': [1467, 1820, 2000, 2032, 2478, 4146], 'anti-rack': [1469], 'Transduction': [1473], 'Laboratories': [1474], '(Franklin': [1475], 'Lakes,': [1476], 'KY).': [1477], 'ECL': [1478], 'Western': [1479], 'blotting': [1480], 'detection': [1481], 'reagents': [1482], 'Amersham': [1485], 'Biosciences,': [1486, 1740], '(Piscataway,': [1488], 'NJ).': [1489, 1743], 'OptiPrep': [1490, 1968, 1977, 2021, 2036, 3277], 'Accurate': [1494], 'Chemical': [1495, 1511], '&': [1496], 'Scientific': [1497], 'Corp.': [1498], '(Westbury,': [1499], 'Protein': [1501, 3893, 5613], 'A-Sepharose': [1502, 2212, 2321], 'CL4B': [1503], 'beads': [1504, 2214, 2256, 2323], 'Sigma': [1510], 'Co.': [1512], '(St.': [1513], 'Louis,': [1514], 'MO).': [1515], 'Wortmannin': [1516], 'tyrphostin': [1518, 3693, 5342, 5707, 5712], '9': [1519, 3749, 5343, 5708], 'BIOMOL': [1523], '(Plymouth': [1524], 'Meeting,': [1525], 'PA).': [1526], 'Three': [1527], 'types': [1529], 'used.': [1531, 1672], 'Caveolae': [1532, 1890, 3727, 4822], 'isolated': [1534, 1747, 1892, 1949], 'human': [1536, 1926, 3099, 3115, 3273, 3448, 3683, 5033], 'fibroblasts.': [1537], 'Cells': [1538, 2127, 2174, 2490], 'seeded': [1540, 1586], '150-mm': [1542], 'dishes': [1543, 1567, 1589], '(300,000': [1544], 'cells/dish)': [1545], 'grown': [1547, 1591, 1628, 1649], 'confluency': [1549], '20': [1551, 1752, 1941, 2183], 'ml': [1552, 1597, 1753, 1827, 2001, 2011, 2018, 2033], 'DMEM': [1554, 1599, 1630, 1656, 1829], 'supplemented': [1555, 1600, 1933, 2190], '10%': [1557, 1602, 1632, 1976], '(v/v)': [1558, 1603, 2280], 'fetal': [1559, 1604, 1633], 'calf': [1560, 1605, 1634], 'serum': [1561, 1606, 1635, 1660, 1833, 3109], 'antibiotics.': [1563, 1608, 1637], 'five': [1566], 'each': [1569], 'treatment.': [1570], 'Whole': [1571], 'lysates': [1573, 2197, 2626, 2725], 'prepared': [1575, 1615, 1684, 1697, 1725, 1750], 'J774': [1577, 2459, 2641, 2938, 4754], 'mouse': [1578], 'macrophages': [1579], '(NRK-SA6)': [1584], '100-mm': [1588], '80–90%': [1593], 'confluence': [1594], '10': [1596, 2244], 'Conditioned': [1609], 'recombinant': [1612, 3014], 'TSP-1': [1613, 2327, 2371, 2452, 2549, 2989, 4432, 4442, 4478, 4530, 4549, 4713], 'follows:': [1617], 'HEK293': [1618], 'stably': [1620], 'transfected': [1621, 1680, 2475, 2481], 'pCDNA3.1-TSP-1': [1624], 'expression': [1625, 2486], 'cassette': [1626], 'After': [1638], '48': [1639, 1653], 'h,': [1640], 'washed': [1643, 2176, 2229], 'three': [1644], 'times': [1645, 1942], 'PBS': [1647, 2131, 2179], 'additional': [1652], 'h': [1654, 1821, 4147], '0.2%': [1658, 1831], 'bovine': [1659, 1832], 'albumin.': [1661], 'Media': [1662], 'then': [1664, 1960, 1986, 2029, 2200], 'collected': [1665, 1929, 2013, 2060], 'stored': [1667], '−80': [1669], '°C': [1670, 1824, 2205, 2314], 'until': [1671], 'Control': [1673], 'conditioned': [1674, 2465], 'obtained': [1677, 1756], 'mock': [1679], '293': [1681, 2468], 'according': [1685], 'same': [1688], 'protocol.': [1689], 'Human': [1690], 'GST-RAP': [1691, 1730, 2501], 'GST': [1693, 2507, 2655], 'fusion': [1694, 2502], 'proteins': [1695, 2154, 3577, 4782], 'described': [1699, 2146, 2325, 3315], 'previously': [1700, 2888], '(18Herz': [1701], 'Goldstein': [1703, 1765, 1795, 1845, 1876, 3972], 'J.L.': [1704, 1766, 1796, 1846, 1877, 3973], 'Ho': [1705], 'Y.K.': [1708], 'Brown': [1709, 1769, 1793, 1849, 1874, 3976], 'M.S.': [1710, 1770, 1794, 1850, 1875, 3977], '1991;': [1714], '266:': [1715], '21232-21238Abstract': [1716], 'RAP': [1723, 2649, 2843, 3015, 3522, 4765, 5652], 'thrombin': [1727], 'cleavage': [1728], 'followed': [1731, 3279, 3717], 'anion-exchange': [1733], 'chromatography': [1734], 'Mono-Q': [1737], 'column': [1738], '(Amersham': [1739], 'Inc.,': [1741], 'Piscataway,': [1742], 'β-VLDL': [1749, 1813, 4133, 4142, 5668], 'cholesterol/coconut': [1758], 'oil-fed': [1759], 'rabbits': [1760], '(19Kowal': [1761, 1841, 3968], 'R.C.': [1762, 1786, 1842, 1867, 3969], 'Esser': [1767, 1847, 3974], '1989;': [1778, 1858, 3985, 4004], '86:': [1779, 1859, 3986], '5810-5814Crossref': [1780, 1860, 3987], '(452)': [1783, 1863, 3990], 'Scholar,20Kowal': [1785], 'Weisgraber': [1789, 1870], 'K.H.': [1790, 1871], 'Mahley': [1791, 1872], 'R.W.': [1792, 1873], '1990;': [1800, 1881, 3659], '265:': [1801, 1882], '10771-10779Abstract': [1802, 1883], 'enrichment': [1810], 'apoE,': [1812, 4149], 'incubated': [1815, 2201, 2310, 2492], 'together': [1816], '37': [1823], '0.5': [1826, 2295], 'albumin': [1834], 'before': [1835], 'addition': [1836, 3520], 'culture': [1839], '20Kowal': [1866], 'using': [1893], 'method': [1895, 3092, 3313], 'Smart': [1897, 3317], '(21Smart': [1900, 3138, 3320], 'E.J.': [1901, 3139, 3321], 'Mineo': [1904, 3142, 3324], 'C.': [1905, 3143, 3325], '92:': [1916, 3154, 3336], '10104-10108Crossref': [1917, 3155, 3337], '(671)': [1920, 3158, 3340], 'Briefly,': [1923], 'confluent': [1924], 'fibroblasts': [1927, 3100, 3116, 3274, 3449, 3684, 5034], 'hypertonic': [1931], 'buffer': [1932, 2189, 2233, 2236, 2283], 'phosphatase': [1937, 2136, 2194, 2303, 2780, 2787], 'inhibitors': [1938, 2304], 'Dounce-homogenized': [1940], 'ice.': [1944], 'Plasma': [1945], '(PM)': [1947], '30%': [1952], 'sucrose': [1953], 'gradient': [1954, 1978, 2159, 3278], '(PNS)': [1958], 'sonicated.': [1961], 'sonicated': [1963], 'samples': [1964, 2027, 3248], 'mixed': [1966, 2015], '(23%': [1969], 'final)': [1970], 'linear': [1973], '20%': [1974], 'overlaid': [1980, 2030], 'samples.': [1983], 'Samples': [1984], 'centrifuged': [1987, 2038], '52,000': [1989, 2040], '×': [1990, 2041], 'g': [1991, 2042], '90': [1993, 2044], 'min': [1994, 2045, 2102, 2184, 3477, 3508, 3689, 3722], '4': [1996, 2017, 2047, 2204, 2313, 3017, 4131], '°C.': [1997, 2048], 'bottom': [1999], 'designated': [2003, 2062], '(NCM),': [2006, 3175], 'top': [2009], '5': [2010, 2219, 2289, 3164, 3931], '50%': [2020], 'tube.': [2025], '5%': [2035, 2057], 'An': [2049], 'opaque': [2050], 'band': [2051, 3225], 'located': [2052], 'between': [2053, 5225], '15': [2055, 3476], 'interface': [2058], '(CM)': [2066, 3179], 'fraction.': [2067, 3243, 3265, 3372], 'Antibodies': [2068], 'against': [2069, 3350], 'caveolin-1,': [2070, 3352], 'Rack,': [2071, 3362], 'control': [2078, 2508], 'marker': [2079, 3254], 'CM': [2081, 3214, 3552, 3559], 'NCM': [2083, 3222, 3264, 3548, 3561, 3589], 'Medium': [2085], 'removed': [2087, 2774], 'NRK-SA6': [2089, 2728], 'replaced': [2092], 'methionine/cysteine-free': [2094], 'phosphate-free': [2098], 'prior': [2103, 2168, 5128, 5393], 'labeling.': [2105], '150': [2106, 2114], 'μCi': [2107, 2115], 'Tran35S-label': [2109], '(PerkinElmer': [2110], 'Life': [2111], 'Sciences)': [2112], '[32P]orthophosphate': [2117, 2743], 'added,': [2119], 'incubation': [2121, 2776, 2992, 3009, 3964], 'continued': [2123], '3': [2125, 2947], 'h.': [2126, 3112], 'lysed': [2129, 2181, 2279], '1%': [2133, 2292], 'TX-100': [2134], 'inhibitors.': [2137, 2195], 'Immunoprecipitation': [2138], 'anti-LRP': [2140, 3194, 3736], 'antibody': [2141, 2209, 2318, 3195, 4738], 'carried': [2143, 2821], 'out': [2144], 'below': [2147], 'cleared': [2150], 'lysates,': [2151], 'labeled': [2153, 2803, 2845], 'separated': [2156, 2261, 3181, 3270, 3301, 5037], 'non-reducing': [2158], 'SDS-gel': [2160], 'electrophoresis.': [2161], '35S-Labeled': [2162], 'gels': [2163], 'treated': [2165, 2943, 2952], 'Enhance': [2167], 'exposure': [2170], 'x-ray': [2172], 'film.': [2173], 'ice-cold': [2178], 'ice': [2186], 'lysis': [2188, 2232, 2235], 'precleared': [2199], 'overnight': [2202, 2311], 'indicated': [2208, 2274, 2317], 'CL-4B': [2213, 2322], '(500': [2215, 3556], 'μg': [2216, 2220, 3165], 'protein;': [2218], 'IgG;': [2222], '50': [2223, 2249], 'μl': [2224], 'beads).': [2226], 'Immunoprecipitates': [2227], 'twice': [2230, 2242], '2': [2238], 'm': [2239], 'NaCl,': [2240], 'mm': [2245, 2250, 2285, 2290, 2296], 'Tris,': [2246], 'pH': [2247, 2287], '8,': [2248], 'NaCl.': [2251], 'Proteins': [2252], 'eluted': [2254], 'SDS': [2258], 'sample': [2259], 'buffer,': [2260], 'SDS-polyacrylamide': [2263], 'gel': [2264], 'electrophoresis,': [2265], 'transferred': [2266], 'nitrocellulose': [2268], 'membrane,': [2269], 'blotted': [2271], 'antibody.': [2275], 'Caveolae-enriched': [2276], 'TETN': [2282], '(25': [2284], 'Tris-HCl,': [2286], '7.5,': [2288], 'EDTA,': [2291], 'Triton': [2293], 'X-100,': [2294], 'benzamidine,': [2297], '60': [2298], 'mmoctylglucoside)': [2299], 'min.': [2307], 'Lysates': [2308], 'above.': [2326], 'induce': [2329, 3468, 4718, 5218], 'death': [2331], 'vascular': [2334, 4022, 5806, 5887, 5981], 'endothelial': [2335], 'sequential': [2338], 'CD36,': [2341, 4346, 4360], 'p59fyn,': [2342, 4351, 4447, 4722], 'stress-activated': [2344], 'p38': [2347], 'Because': [2370, 3434, 4472], '(22Godyna': [2377, 2552, 4552], 'Liau': [2379, 2424, 2554, 2599, 4493, 4554, 4599], 'Popa': [2381, 2556, 4556], 'Stefansson': [2383, 2558, 4558], 'Argraves': [2385, 2420, 2560, 2595, 4489, 4560, 4595], 'W.S.': [2386, 2561, 4561], '129:': [2391, 2566, 4566], '1403-1410Crossref': [2392, 2567, 4567], '(126)': [2395, 2570, 4570], '23Chen': [2398, 2573, 4573], 'Sottile': [2400, 2575, 4575], 'Mosher': [2404, 2579, 4579], 'D.F.': [2405, 2580, 4580], '318:': [2409, 2584, 4584], '959-963Crossref': [2410, 2585, 4585], '(53)': [2413, 2588, 4588], '24Mikhailenko': [2416, 2591, 4591], 'Krylov': [2418, 2593, 4487, 4593], 'K.M.': [2421, 2596, 4490, 4596], 'Roberts': [2422, 2597, 4491, 4597], 'D.D.': [2423, 2598, 4492, 4598], '1997;': [2431, 2606, 4500, 4606, 4966], '272:': [2432, 2607, 4501, 4607, 4967], '6784-6791Abstract': [2433, 2608, 4502, 4608], '(98)': [2441, 2616, 4510, 4616], 'tested': [2445], 'might': [2448, 3066, 3467, 4518, 4715, 4816, 4991, 5217], 'p59fyn': [2455, 2622, 2638, 4625], 'phosphorylation.': [2456, 3747, 5547, 5593], 'macrophage-like': [2458], 'line': [2461, 2733], 'exposed': [2463], 'had': [2471, 2721, 2887, 2941, 3102, 3432, 3532, 3944, 4118, 4658], '(Fig.1A,': [2476], 'lanes': [2477, 2740, 2946, 3571, 3593, 4130], 'and2)': [2479], '(lanes': [2482, 2496, 2744, 2953, 3016, 3216, 3488, 3496], '3–5)': [2483], 'plasmid': [2487], 'encoding': [2488], 'TSP-1.': [2489, 4400, 4793], 'absence': [2495, 2985, 3107, 3939], '1–3)': [2497], '(lane': [2504, 2510, 2643, 2650, 2656, 2781, 2788, 3232, 3935, 3947, 4138], '4)': [2505, 2949], '5).': [2511, 2657, 3948], '39-kDa': [2513], '(RAP)': [2516], 'universal': [2519], 'inhibitor': [2520, 3698, 3806, 5341, 5365, 5540], '(25Krieger': [2529], '1994;': [2536, 4464, 5451], '63:': [2537], '601-637Crossref': [2538], '(1055)': [2541], 'blocks': [2545, 4545], 'Subsequent': [2619], 'immunoprecipitation': [2620, 3734], 'immunoblot': [2628], 'analysis': [2629, 4731], 'revealed': [2633, 2813, 2854, 4741, 5768], 'TSP-1-dependent': [2634], '3),': [2644], 'which': [2645, 2758, 3637, 4169, 4448, 4544, 4634, 5146, 5215, 5368, 5625], 'blocked': [2647, 4362, 5377, 5544], '4),': [2651], 'Src-transformed': [2659], 'cells,': [2660], 'it': [2699, 3451, 4062, 4669, 5553], 'unclear': [2701], 'how': [2704], 'under': [2713, 2864, 2976, 4750], 'conditions.': [2715, 2978], 'early': [2718], 'experiment,': [2719], 'immunoprecipitated': [2722, 2935, 3564, 4733], 'after': [2734, 3506, 3958], 'metabolic': [2735], 'labeling': [2736], '[35S]methionine': [2738, 2848], '(Fig.1B,': [2739], '1–4)': [2741], '5–8).': [2745], 'experiment': [2750, 2963], 'demonstrated': [2751, 5877], '85-kDa': [2754, 3919, 4630], 'subunit': [2755, 3204, 3920, 4631], 'contains': [2759, 5991], 'tail,': [2762], 'phosphate': [2768], 'could': [2770, 3793, 5140], 'most': [2772], 'effectively': [2773], 'potato': [2778], 'acid': [2779], '7)': [2782], 'alkaline': [2786], '6).': [2789, 4139], 'A': [2790], '∼60': [2793, 4647], 'kDa': [2794, 4648], 'heavily': [2797], 'biosynthetically': [2800], 'poorly': [2802], 'coprecipitated': [2804, 2827, 2924, 2969, 4748], 'Treatment': [2807], 'lysate': [2811], 'withN-glycanase': [2812], '60-kDa': [2819, 2925, 2970, 3003, 3428, 4774], 'N-linked': [2822], 'carbohydrates,': [2823], 'suggesting': [2824, 3020, 3388, 3760, 3810, 5153, 5211], 'thus': [2833, 4801, 5036], 'tail.': [2838, 3911, 5573], 'contrast,': [2840], 'ER-chaperone': [2842], 'efficiently': [2846], 'unphosphorylated.': [2851], 'These': [2852, 4161], 'experiments': [2853], 'undergo': [2858], 'untransfected': [2861], 'cultured': [2862, 4306], 'steady-state': [2865, 2977, 4751], 'conditions,': [2866], 'did': [2869, 4790], 'determine': [2871, 2921, 3867], 'events': [2875], 'include': [2876, 4892], 'residues.': [2878], 'Phosphorylation': [2879], 'serine/threonine': [2885], 'reported': [2890, 5934], '(26Bu': [2891], 'Sun': [2893], 'Schwartz': [2895], 'A.L.': [2896], '273:': [2903, 4085], '13359-13365Abstract': [2904], '(61)': [2912], 'To': [2915, 3061, 3085, 3670, 4979], 'address': [2916], 'question': [2918], 'residues,': [2933, 4667], '(Fig.': [2944, 3256, 3282, 3511, 3523, 3538, 3565, 3591, 3756, 3808, 4128, 4157, 4626, 4652, 4739, 5064, 5134, 5380, 5623, 5669], '1C,': [2945], '1,2,': [2954], '5)': [2955], 'TSP-1-conditioned': [2957], 'medium.': [2958, 2993], 'tyrosines': [2975], 'This': [2979, 4313, 4372, 4535, 5382, 5785], 'affected': [2982, 3784], 'Interestingly,': [2994], 'however,': [2995], 'both': [2999, 3394, 4476, 4516], 'completely': [3006, 4155, 4766, 5376, 5543], 'abolished': [3007, 4767, 5344, 5672], '5),': [3019, 3233], 'required': [3032, 3677, 4179, 5164, 5330], 'kinase.': [3039], 'microdomains': [3050, 4827], 'surface,': [3054, 4326], 'rafts.': [3060], 'test': [3062, 3459], 'take': [3067], 'place': [3068, 4316, 5778], 'type': [3071], 'specialized': [3073, 4320], 'subcellular': [3074, 4890], 'domain,': [3075], 'first': [3077, 4810, 5000], 'investigated': [3078, 4803, 4928], 'caveolae.': [3084, 5012], 'achieve': [3086], 'this,': [3087], 'detergent-free': [3091], 'purify': [3094], 'quiescent': [3097], 'maintained': [3104], '12': [3111], 'chose': [3114], 'model': [3119, 5213], 'system,': [3120], 'because': [3121, 5335, 5362], 'abundant': [3124, 3375, 3413], 'type,': [3128], 'standardized': [3130], 'methods': [3131], 'established': [3134], 'their': [3136], 'purification': [3137], 'our': [3162, 4540], 'experiments,': [3163], '(PNS),': [3169], '(PM),': [3172], 'membranes': [3174, 3178, 3271], 'electrophoresis': [3183], 'analyzed': [3185, 3732], 'immunoblotting.': [3187], 'When': [3188, 3573, 4628], 'detected': [3192], '(Fig.2A),': [3196], '∼85-kDa': [3198], 'corresponding': [3200], 'smaller': [3203], 'PNS,': [3209], 'PM,': [3211], '1,': [3217], '3,': [3218], 'and4).': [3219], 'fraction,': [3223, 3300, 3530], 'present,': [3228], 'less': [3230], 'intense': [3231], 'indicating': [3234, 4776, 5752], 'primarily': [3238], 'As': [3244, 5681], 'expected,': [3245], 'when': [3246, 3553, 4141], 'immunoblotted': [3250, 3346, 3739], 'caveolin-1': [3255, 3304], '2A),': [3257], 'no': [3258, 3533, 3582, 3945, 5058], 'detectable': [3261], 'approach,': [3268, 3286], '2B).': [3283], 'bulk': [3288], 'recovered': [3293], '8–13': [3296], '(Fig.2C),': [3297], 'termed': [3298], '(fractions': [3308], '1–7),': [3309], 'consistent': [3310, 4164], 'originally': [3314], 'Each': [3343], 'fraction': [3344, 3495, 3549, 3590, 5006, 5070], 'directed': [3349], 'C-anchoring': [3360], 'latter': [3364], 'serving': [3366], 'markers': [3368], '(numbers': [3378, 3386], '1–8),': [3379], '9–14)': [3387], 'compartments.': [3395], 'amounts': [3400, 3575], 'raised': [3405, 4709], 'possibility': [3407, 3461, 4711], 'compartment': [3416, 5078], 'mediating': [3419], 'associated': [3427], 'observed.': [3433], 'PDGFβ': [3436, 4310], 'highly': [3445], 'expressed': [3446], 'where': [3450, 5808], 'preferentially': [3452], 'localizes': [3453, 5074], 'caveolae,': [3455, 4318], 'decided': [3457, 4808], 'β-receptor-specific': [3464], 'Fig.3A': [3473], 'shows': [3474, 3913], 'treatment': [3479, 3510], 'PDGF-BB-induced': [3481, 5345], '1–8)': [3489], '9–16).': [3497], 'reached': [3503], 'maximum': [3505], '3B,lanes': [3512], '1–6)': [3513], 'partly': [3516], 'decreased': [3517], '3A,': [3524], 'lane': [3525, 4159], '4).': [3526, 3936], 'effect': [3534, 3946, 4068, 4120, 5883], '3A,lanes': [3539, 3566], '9–16),': [3540], 'background': [3543], 'observed': [3546], 'compared': [3550], 'equal': [3554], 'volumes': [3555], 'μl)': [3557], '9–16': [3567], 'Fig.': [3569], '3B,': [3570, 3592], '7–12).': [3572], 'comparable': [3574], 'subjected': [3579], 'immunoprecipitation,': [3581], 'seen': [3586], '13–18).': [3594], 'PDGFR-β': [3603, 3673, 3705], 'causes': [3632], 'dimerization': [3633], 'transphosphorylation': [3643], 'loop': [3647], '(27Ullrich': [3654], 'Schlessinger': [3656], '61:': [3660], '203-212Abstract': [3661], '(4569)': [3667], 'determine,': [3671, 4980], 'activity': [3675, 3703, 5324, 5758], 'PDGF-BB-mediated': [3679, 3762, 3812], 'activation,': [3681], 'serum-starved': [3682], 'preincubated': [3686, 4144], 'without': [3692], '9,': [3694], 'potent': [3696], 'reversible': [3697], 'intrinsic': [3700], '(28Pawson': [3706], 'Nature.': [3708, 4003], '373:': [3710], '573-580Crossref': [3711], '(2211)': [3714], 'stimulation': [3719, 5122], 'ng/ml': [3725], 'PDGF-BB.': [3726], 'antibodies,': [3737], 'detect': [3744], 'Tyrphostin': [3748], 'prevented': [3750, 3797, 4156, 4620, 5748], '4A)': [3757], 'therefore': [3769, 3822], 'PDGFR-β.': [3772], 'Residual': [3773], '(data': [3785], 'shown).': [3787], 'Activation': [3788], 'largely': [3796], 'pretreatment': [3799], 'PI3K': [3805, 3830, 5401], 'wortmannin': [3807], '4B)': [3809], 'PI3K,': [3819, 5367, 5994], 'Src-family': [3823], '(29Vanhaesebroeck': [3834, 5417], 'Leevers': [3836, 5279, 5419], 'S.J.': [3837, 5280, 5420, 5820], 'Ahmadi': [3838, 5281, 5421], 'Timms': [3840, 5283, 5423], 'Katso': [3842, 5285, 5425], 'R.': [3843, 3847, 5286, 5290, 5426, 5430], 'Driscoll': [3844, 5287, 5427], 'P.C.': [3845, 5288, 5428], 'Woscholski': [3846, 5289, 5429], 'Parker': [3848, 5291, 5431], 'P.J.': [3849, 5292, 5432], 'Waterfield': [3850, 5293, 5433], 'M.D.': [3851, 5294, 5434], '70:': [3856, 5299, 5439], '535-602Crossref': [3857, 5300, 5440], '(1347)': [3860, 5303, 5443], 'next': [3864], 'sought': [3865, 5001], 'sequestration': [3869], 'native,': [3879], 'receptor-binding': [3880], 'incompetent': [3881], '(30Webb': [3885, 5605], 'Roadcap': [3887, 5607], 'D.W.': [3888, 5608], 'Dhakephalkar': [3889, 5609], '9:': [3896, 5616], '1986-1992Crossref': [3897, 5617], '(28)': [3900, 5620], 'would': [3903], 'interfere': [3904], 'Fig.5A': [3912], 'indeed': [3924, 5024, 5087], 'markedly': [3925], 'μg/ml': [3932], 'alone': [3943, 4117], 'bind': [3951, 4477], 'β-migrating': [3952], 'lipoproteins': [3956], '(β-VLDL)': [3957], 'exogenous': [3966], '31Beisiegel': [3993], 'Weber': [3995], 'Ihrke': [3997], 'Stanley': [4001], 'K.K.': [4002], '341:': [4005], '162-164Crossref': [4006], '(542)': [4009], 'ApoE': [4012], 'inhibit': [4018], 'factor-induced': [4021], 'smooth': [4023, 5794, 5888], 'muscle': [4024, 5795, 5889], 'migration': [4026, 4185, 5797, 5908], 'proliferation': [4028, 4187, 5799], '(32Swertfeger': [4029, 5844], 'Hui': [4031, 4043, 4079, 4101, 5840, 5846, 5858, 5913], 'D.Y.': [4032, 4044, 4080, 4102, 5847, 5859, 5914], 'Front.': [4033, 5848], 'Biosci.': [4034, 5849], 'D526-D535Crossref': [4037, 5852], '33Swertfeger': [4041, 5856], '25043-25048Abstract': [4050, 5865], '(56)': [4058, 5873], 'suggested': [4065, 5083], 'mediated': [4070], '(34Ishigami': [4073], 'Swertfeger': [4075, 4099, 5911], 'Granholm': [4077], '20156-20161Abstract': [4086], '35Bu': [4097], '4141-4146PubMed': [4108, 5920], 'Our': [4111, 5013], 'purified': [4115], 'little': [4119], '5B,': [4129, 4158], 'and5).': [4132], 'marginally': [4134], 'PDGF-dependent': [4150, 5677], '7).': [4160], 'model,': [4167], 'transmission': [4182], 'PDGF-mediated': [4184, 5136, 5985], 'down-regulated': [4195], 'apoE.': [4197], 'recognized': [4209], 'coreceptors': [4213], 'leads': [4220], 'kinase-mediated': [4247], 'events,': [4249], 'manner': [4253], 'analogous': [4254], 'induced': [4300, 4761], 'manner.': [4312], 'took': [4315], 'microdomain': [4322], 'non-caveolar': [4331, 5109], 'membrane.': [4336, 5784], 'Another': [4337], 'TSP-1,': [4353, 4763], 'common': [4355], 'RAP,': [4364, 4543, 5145], 'finding': [4373, 4541, 5067, 5383], 'pathways': [4388], 'participate': [4392], 'similar': [4395], 'Jimenez': [4401], 'CD36-dependent': [4429], 'apoptosis': [4437], 'angiogenesis.': [4439], 'interacts': [4449], 'CD36': [4455, 4473], '(36Bull': [4456], 'Brickell': [4458], 'P.M.': [4459, 4461], 'Dowd': [4460], 'FEBS': [4462], 'Lett.': [4463], '351:': [4465], '41-44Crossref': [4466], '(84)': [4469], 'sites': [4481], 'molecule': [4484], '(24Mikhailenko': [4485], 'hypothesized': [4514], 'receptors': [4517, 5252], 'complex': [4525, 5224, 5242, 5989], 'assembled': [4528], 'surface.': [4534], 'hypothesis': [4536], 'supported': [4538], '1A).': [4627], 'harbors': [4635], 'phosphorylated,': [4643], 'phosphoprotein': [4645, 4749, 4799], 'coprecipitates': [4649], '1B),': [4653], 'allowing': [4668], 'associate': [4671], 'PTB-domain': [4674], 'Shc': [4678], 'Immunoblot': [4730], '1C)': [4740], 'conditions': [4752], 'cells.': [4755, 5890], 'yet,': [4764], 'occurred': [4783], 'coprecipitating': [4798], 'further,': [4804], 'instead': [4807], 'explore': [4811], 'potential': [4813], 'mediate': [4817, 5357], 'rafts': [4824], 'selectively': [4834], 'phosphatases': [4845], '16Liu': [4859], 'concentrated': [4887, 5025], 'domains': [4891], 'such': [4905, 4986], 'EGF': [4908], 'caveolar': [4921, 5387], 'particular': [4924], 'extensively': [4927], '37Oh': [4953], 'Liu': [4955], 'Horner': [4957], 'Rogers': [4959], 'R.A.': [4960], 'Schnitzer': [4961], 'J.E.': [4962], '7211-7222Abstract': [4968], '(242)': [4976], 'investigate': [5003], 'resides': [5010], 'estimated': [5028], '40-fold': [5029], 'mediates': [5051, 5402], '2).': [5065], 'than': [5079], 'engaged': [5088], 'mere': [5095, 5160], 'endocytosis.': [5097], 'Only': [5098], 'localized': [5102], 'isolation': [5130], '3).': [5135], 'competed': [5142], 'interferes': [5147], 'bystander': [5161], 'effect,': [5162], 'association.': [5166], 'itself': [5207, 5354], 'formation': [5220], 'transient': [5223], 'bringing': [5232], 'close': [5237], 'contact': [5238], 'assembles': [5244], '29Vanhaesebroeck': [5277], '38Liu': [5306], 'Biophys.': [5311], 'Res.': [5312], 'Commun.': [5313], '261:': [5315], '695-700Crossref': [5316], '(43)': [5319], 'phosphorylation,': [5334, 5751], '(Fig.4A).': [5348], 'does': [5355], 'directly,': [5361], 'wortmannin,': [5363], '4B).': [5381], 'indicates': [5384], 'receptor/PI3K-dependent': [5415], '39Claesson-Welsh': [5446], '269:': [5452], '32023-32026Abstract': [5453], 'v-Src': [5469], 'PP2': [5541], 'almost': [5542], 'make': [5552], 'responsible': [5566], 'al.,': [5588], 'necessary': [5590], '5A),': [5624], 'incapable': [5627], 'blocking': [5647], '(Fig.3A),': [5653], 'competing': [5664], 'ligand,': [5665], '5B),': [5670], 'all': [5671], 'greatly': [5674], 'show,': [5686], 'Two': [5701], 'inhibitors,': [5706], '(this': [5709], 'study)': [5710], 'AG1296': [5713], 'absolutely': [5760], 'required.': [5761], 'summary,': [5763], 'studies': [5766], 'branch': [5771], 'takes': [5777], 'important': [5789], 'atherosclerotic': [5802, 5977], 'transformation': [5803, 5978], 'wall': [5807, 5982], 'locally': [5810], 'protective': [5813, 5973], '(40Hasty': [5815], 'A.H.': [5816], 'Linton': [5817], 'M.F.': [5818], 'Brandt': [5819], 'Babaev': [5821], 'V.R.': [5822], 'Gleaves': [5823], 'L.A.': [5824], 'Fazio': [5825], 'Circulation.': [5827], '99:': [5829], '2571-2576Crossref': [5830], '(105)': [5833], 'Pioneering': [5836], 'David': [5839], 'his': [5842], 'group': [5843], 'counteracts': [5880], 'migration-promoting': [5882], 'Moreover,': [5891], 'knockdown': [5893], 'antisense': [5898], 'approach': [5899], 'significantly': [5900], 'apoE-mediated': [5903], 'inhibition': [5904], '(35Bu': [5909], 'Alteration': [5923], 'responses': [5926], 'mitogens': [5928], '(41Ho': [5935], 'Y.Y.': [5936], 'Deckelbaum': [5937], 'R.J.': [5938], 'Chen': [5939], 'Vogel': [5941], 'Talmage': [5943], '43455-43462Abstract': [5950], '(23)': [5958], 'Together,': [5961], 'play': [5971], 'modulating': [5984], 'through': [5987], 'receptors,': [5993], 'kinases,': [5998], 'indebted': [6003], 'Wen-Ling': [6005], 'Niu': [6006], 'excellent': [6008], 'technical': [6009], 'assistance': [6010], 'Dudley': [6013], 'Philippe': [6016], 'Soriano': [6017], 'sharing': [6019], 'unpublished': [6020], 'information': [6021], 'helpful': [6024], 'discussions.': [6025]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1983376590', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-14T06:52:05.309176', 'created_date': '2016-06-24'}
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