Title: Further studies on the infection of pig-kidney cells by foot-and-mouth disease virus
Abstract: Foot-and-mouth disease virus attaches to pig-kidney tissue-culture cells in the presence of calcium ions. At low temperature (2–4°) the virus does not penetrate the cells but remains on the surface. The viral ribonucleic acid is not released from the virus and most of the attached virus can be eluted from the cells with EDTA. At 37° the virus penetrates the cell and is broken down into its nucleic acid and protein components. Disruption of the virus can also be achieved by cells which have been broken down by freezing and thawing. Virus also attaches to cells which have been killed with merthiolate or iodoacetate but penetration does not occur.
Publication Year: 1962
Publication Date: 1962-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 25
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