Title: Mathematical network model for bone mineral density (BMD) and bone quality assessment
Abstract: The bone fractures can appear in a patient as a result of an exceeding stress level at a specific anatomic site, depending the failure on fatigue phenomena, high loads or on a low value of bone density. Indeed, independently from physiological conditions or specific pathologies such as osteoporotic ones, bone mineral density (BMD) constitutes the main responsible of the strength of a selected bone region. In this respect, the standard and routine approach for the diagnosis of osteoporosis is to assess BMD shown to be a possible indicator of fracture risk. However, a major limitation of BMD is that it incompletely reflects variation in bone strength. Other factors like bone microarchitecture contribute substantially to bone strength and their evaluation can improve determination of bone quality and strength; yet, structural assessment has not been implemented in clinical routine because of the lack of a mathematical model for analyzing bone structure.
Publication Year: 2011
Publication Date: 2011-08-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 3
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