Title: SIÇAN AKCİĞERİ VE BÖBREĞİ MİKROZOMLARINDA İLAÇ METABOLİZE EDEN ENZİMLERİN AKTİVİTELERİ ÜZERİNE ÇALIŞMALAR : STUDIES ON THE ACTIVITIES OF DRUG METABOLIZING ENZYMES IN LUNG AND KIDNEY MICROSOMES OF R
Abstract: The optimum conditions (pH, protein amount, subtrate concentration and incubation time) of 7- ethoxyresorufın-O-deethylase(ER0D), 7-pentoxyesorufın-0-deethylase(PROD), eryhtromycin-Ndemethylase (ERND), coumarin 7-hydroxylase (Coh) and p-nitrophenol (PNP) activities in the lung and kidney of rat were determined in microsomes. in this study, it was found out that, different reaction conditions are reauired for these enzyme activities in rat lund and kidney microsomes.