Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1982816939', 'doi': 'https://doi.org/10.1002/bdra.20219', 'title': 'Role of retinoic acid receptors α1 and γ in the response of murine limbs to retinol in vitro', 'display_name': 'Role of retinoic acid receptors α1 and γ in the response of murine limbs to retinol in vitro', 'publication_year': 2006, 'publication_date': '2006-01-01', 'ids': {'openalex': 'https://openalex.org/W1982816939', 'doi': 'https://doi.org/10.1002/bdra.20219', 'mag': '1982816939', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16397886'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/bdra.20219', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S23975315', 'display_name': 'Birth Defects Research', 'issn_l': '2472-1727', 'issn': ['2472-1727'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5066026004', 'display_name': 'Eugene Galdones', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Eugene Galdones', 'raw_affiliation_strings': ['Department of Pharmacology and Therapeutics, McGill University, Montréal, Canada;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Therapeutics, McGill University, Montréal, Canada;', 'institution_ids': ['https://openalex.org/I5023651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105309403', 'display_name': 'David Lohnes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I153718931', 'display_name': 'University of Ottawa', 'ror': 'https://ror.org/03c4mmv16', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I153718931']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'David Lohnes', 'raw_affiliation_strings': ['Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada;'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada;', 'institution_ids': ['https://openalex.org/I153718931']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064334381', 'display_name': 'Barbara F. Hales', 'orcid': 'https://orcid.org/0000-0002-1730-8883'}, 'institutions': [{'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Barbara F. Hales', 'raw_affiliation_strings': ['Department of Pharmacology and Therapeutics, McGill University, Rm 110, 3655 Promenade Sir William Osler, Montréal, Québec, Canada H3G 1Y6'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Therapeutics, McGill University, Rm 110, 3655 Promenade Sir William Osler, Montréal, Québec, Canada H3G 1Y6', 'institution_ids': ['https://openalex.org/I5023651']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3350, 'currency': 'USD', 'value_usd': 3350, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.282, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 6, 'citation_normalized_percentile': {'value': 0.522134, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 78, 'max': 79}, 'biblio': {'volume': '76', 'issue': '1', 'first_page': '39', 'last_page': '45'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11559', 'display_name': 'Role of Retinoic Acid in Biological Processes', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11559', 'display_name': 'Role of Retinoic Acid in Biological Processes', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11077', 'display_name': 'Sex Determination and Differentiation in Organisms', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11510', 'display_name': 'Immunological Mechanisms in Pregnancy and Fetal-Maternal Interface', 'score': 0.9739, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chondrogenesis', 'display_name': 'Chondrogenesis', 'score': 0.5564351}, {'id': 'https://openalex.org/keywords/limb-development', 'display_name': 'Limb development', 'score': 0.5203906}, {'id': 'https://openalex.org/keywords/vitamin-a-metabolism', 'display_name': 'Vitamin A Metabolism', 'score': 0.506674}, {'id': 'https://openalex.org/keywords/retinoic-acid', 'display_name': 'Retinoic Acid', 'score': 0.506332}, {'id': 'https://openalex.org/keywords/retinyl-palmitate', 'display_name': 'Retinyl palmitate', 'score': 0.4145477}, {'id': 'https://openalex.org/keywords/tretinoin', 'display_name': 'Tretinoin', 'score': 0.41266608}], 'concepts': [{'id': 'https://openalex.org/C2779573558', 'wikidata': 'https://www.wikidata.org/wiki/Q424976', 'display_name': 'Retinol', 'level': 3, 'score': 0.89849764}, {'id': 'https://openalex.org/C2775954498', 'wikidata': 'https://www.wikidata.org/wiki/Q420418', 'display_name': 'Retinoid', 'level': 4, 'score': 0.89573777}, {'id': 'https://openalex.org/C2781121885', 'wikidata': 'https://www.wikidata.org/wiki/Q425517', 'display_name': 'Retinoic acid', 'level': 3, 'score': 0.8426359}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.6001888}, {'id': 'https://openalex.org/C120197328', 'wikidata': 'https://www.wikidata.org/wiki/Q2838685', 'display_name': 'Retinoic acid receptor', 'level': 4, 'score': 0.5852815}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5576489}, {'id': 'https://openalex.org/C35496256', 'wikidata': 'https://www.wikidata.org/wiki/Q5104524', 'display_name': 'Chondrogenesis', 'level': 3, 'score': 0.5564351}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.54821104}, {'id': 'https://openalex.org/C86370654', 'wikidata': 'https://www.wikidata.org/wiki/Q2277862', 'display_name': 'Limb development', 'level': 3, 'score': 0.5203906}, {'id': 'https://openalex.org/C2777326149', 'wikidata': 'https://www.wikidata.org/wiki/Q7316807', 'display_name': 'Retinyl palmitate', 'level': 4, 'score': 0.4145477}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.41365504}, {'id': 'https://openalex.org/C2779963572', 'wikidata': 'https://www.wikidata.org/wiki/Q29417', 'display_name': 'Tretinoin', 'level': 4, 'score': 0.41266608}, {'id': 'https://openalex.org/C2776940978', 'wikidata': 'https://www.wikidata.org/wiki/Q34956', 'display_name': 'Vitamin', 'level': 2, 'score': 0.3960059}, {'id': 'https://openalex.org/C2780550940', 'wikidata': 'https://www.wikidata.org/wiki/Q502730', 'display_name': 'Cartilage', 'level': 2, 'score': 0.326865}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32165056}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.29669425}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.21736592}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.1923151}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.16681811}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.1409005}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.087269634}], 'mesh': [{'descriptor_ui': 'D017880', 'descriptor_name': 'Limb Deformities, Congenital', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D018168', 'descriptor_name': 'Receptors, Retinoic Acid', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D013723', 'descriptor_name': 'Teratogens', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D014801', 'descriptor_name': 'Vitamin A', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D000704', 'descriptor_name': 'Analysis of Variance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020219', 'descriptor_name': 'Chondrogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020219', 'descriptor_name': 'Chondrogenesis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D024043', 'descriptor_name': 'Collagen Type II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024043', 'descriptor_name': 'Collagen Type II', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005121', 'descriptor_name': 'Extremities', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005121', 'descriptor_name': 'Extremities', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005865', 'descriptor_name': 'Gestational Age', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006609', 'descriptor_name': 'High Mobility Group Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006609', 'descriptor_name': 'High Mobility Group Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017880', 'descriptor_name': 'Limb Deformities, Congenital', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009924', 'descriptor_name': 'Organ Culture Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011247', 'descriptor_name': 'Pregnancy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018168', 'descriptor_name': 'Receptors, Retinoic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018168', 'descriptor_name': 'Receptors, Retinoic Acid', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018168', 'descriptor_name': 'Receptors, Retinoic Acid', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D000072482', 'descriptor_name': 'Retinoic Acid Receptor alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000097768', 'descriptor_name': 'Retinoic Acid Receptor gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055758', 'descriptor_name': 'SOX9 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013723', 'descriptor_name': 'Teratogens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014801', 'descriptor_name': 'Vitamin A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/bdra.20219', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S23975315', 'display_name': 'Birth Defects Research', 'issn_l': '2472-1727', 'issn': ['2472-1727'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16397886', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1509243264', 'https://openalex.org/W1666476357', 'https://openalex.org/W1841957993', 'https://openalex.org/W1906119900', 'https://openalex.org/W1939881246', 'https://openalex.org/W1973295687', 'https://openalex.org/W1974322323', 'https://openalex.org/W1976252079', 'https://openalex.org/W1980723482', 'https://openalex.org/W1983587675', 'https://openalex.org/W1992994796', 'https://openalex.org/W1999182497', 'https://openalex.org/W1999553822', 'https://openalex.org/W2004981320', 'https://openalex.org/W2015285381', 'https://openalex.org/W2019493722', 'https://openalex.org/W2021390768', 'https://openalex.org/W2022891913', 'https://openalex.org/W2049307310', 'https://openalex.org/W2056561438', 'https://openalex.org/W2056661971', 'https://openalex.org/W2063611876', 'https://openalex.org/W2069778851', 'https://openalex.org/W2074786828', 'https://openalex.org/W2088120545', 'https://openalex.org/W2091929104', 'https://openalex.org/W2096089878', 'https://openalex.org/W2098159639', 'https://openalex.org/W2106907374', 'https://openalex.org/W2115494923', 'https://openalex.org/W2132837491', 'https://openalex.org/W2140979305', 'https://openalex.org/W2141568746', 'https://openalex.org/W2150134228', 'https://openalex.org/W2151664346', 'https://openalex.org/W2156575042', 'https://openalex.org/W2164954416', 'https://openalex.org/W2170167935', 'https://openalex.org/W217219525', 'https://openalex.org/W2172256092', 'https://openalex.org/W2181875588', 'https://openalex.org/W2403615320'], 'related_works': ['https://openalex.org/W2736904585', 'https://openalex.org/W2572716113', 'https://openalex.org/W2100443055', 'https://openalex.org/W2090537316', 'https://openalex.org/W2074031892', 'https://openalex.org/W2046104019', 'https://openalex.org/W2036806937', 'https://openalex.org/W1989454003', 'https://openalex.org/W1988775016', 'https://openalex.org/W1771328711'], 'abstract_inverted_index': {'BACKGROUND': [0], 'Derivatives': [1], 'of': [2, 51, 87, 103, 147, 160, 190, 203, 223, 231], 'retinol': [3, 58, 89, 125, 214], '(vitamin': [4], 'A),': [5, 239], 'commonly': [6], 'referred': [7], 'to': [8, 56, 106, 208, 213], 'as': [9], 'retinoids,': [10], 'signal': [11], 'through': [12], 'retinoic': [13], 'acid': [14], 'and': [15, 20, 66, 80, 110, 112, 117, 133, 142, 162, 192], 'retinoid': [16], 'X': [17], 'receptors': [18], '(RARs/RXRs)': [19], 'are': [21], 'essential': [22], 'for': [23, 97, 127], 'normal': [24], 'limb': [25, 37, 45, 113, 140, 233], 'formation.': [26], 'Retinoid': [27], 'imbalances': [28], 'or': [29, 94, 182], 'perturbations': [30], 'in': [31, 35, 59, 82, 84, 144, 155, 167, 177, 194, 198, 216], 'receptor': [32], 'function': [33], 'result': [34], 'aberrant': [36], 'development.': [38], 'To': [39], 'examine': [40], 'the': [41, 49, 85, 145, 188, 201, 221], 'mechanisms': [42], 'underlying': [43], 'retinol-induced': [44], 'defects,': [46], 'we': [47], 'determined': [48], 'responsiveness': [50], 'limbs': [52, 135, 178, 200], 'from': [53, 179], 'RARα1−/−γ': [54], 'mice': [55, 63], 'excess': [57], 'vitro.': [60], 'METHODS': [61], 'RARα1−/−γ+/−': [62, 134, 181], 'were': [64, 69, 78, 119, 164], 'bred': [65], 'their': [67, 180], 'embryos': [68], 'recovered': [70], 'at': [71], 'gestational': [72], 'day': [73], '(GD)': [74], '12.5.': [75], 'The': [76, 100, 158], 'forelimbs': [77], 'excised': [79], 'cultured': [81], 'vitro': [83], 'presence': [86, 146], 'all-trans': [88], 'acetate': [90], '(0,': [91], '1.25,': [92], '12.5,': [93], '62.5': [95], 'μM)': [96], '6': [98], 'days.': [99], 'expression': [101, 173, 189, 202], 'profiles': [102], 'genes': [104, 205], 'known': [105], 'affect': [107], 'chondrogenesis': [108, 143], '(sox9': [109], 'col2a1)': [111], 'outgrowth': [114, 141], '(meis1,': [115], 'meis2,': [116], 'pbx1a)': [118], 'examined': [120], 'by': [121], 'real-time': [122], 'qRT-PCR': [123], 'following': [124], 'exposure': [126, 186], '3': [128], 'hr.': [129], 'RESULTS': [130], 'Whereas': [131], 'RARα1−/−γ+/+': [132, 169, 195], 'exhibited': [136], 'deleterious': [137], 'effects': [138], 'on': [139], 'exogenous': [148], 'retinol,': [149], 'this': [150], 'outcome': [151], 'was': [152, 174, 206], 'significantly': [153, 165], 'attenuated': [154], 'RARα1−/−γ−/−': [156, 183, 199], 'limbs.': [157, 170], 'expressions': [159], 'sox9': [161], 'col2a1': [163], 'decreased': [166], 'retinol-exposed': [168], 'In': [171, 220], 'contrast,': [172], 'not': [175], 'altered': [176], 'littermates.': [184], 'Retinol': [185], 'upregulated': [187], 'meis1': [191], 'meis2': [193], 'limbs;': [196], 'however,': [197], 'both': [204], 'unresponsive': [207, 212], 'retinol.': [209], 'Pbx1a': [210], 'remained': [211], 'treatment': [215], 'all': [217], 'genotypes.': [218], 'CONCLUSION': [219], 'absence': [222], 'RARα1,': [224], 'RARγ': [225], 'is': [226], 'a': [227], 'functionally': [228], 'important': [229], 'mediator': [230], 'retinoid-induced': [232], 'dysmorphogenesis.': [234], 'Birth': [235], 'Defects': [236], 'Research': [237], '(Part': [238], '2005.': [240], '©': [241], '2005': [242], 'Wiley-Liss,': [243], 'Inc.': [244]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1982816939', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-12T15:57:44.750704', 'created_date': '2016-06-24'}