Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1982729908', 'doi': 'https://doi.org/10.1016/j.jmb.2010.07.012', 'title': 'The Role of the T7 Gp2 Inhibitor of Host RNA Polymerase in Phage Development', 'display_name': 'The Role of the T7 Gp2 Inhibitor of Host RNA Polymerase in Phage Development', 'publication_year': 2010, 'publication_date': '2010-09-01', 'ids': {'openalex': 'https://openalex.org/W1982729908', 'doi': 'https://doi.org/10.1016/j.jmb.2010.07.012', 'mag': '1982729908', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20650282', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2941873'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.jmb.2010.07.012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S46058472', 'display_name': 'Journal of Molecular Biology', 'issn_l': '0022-2836', 'issn': ['0022-2836', '1089-8638'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2941873?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072972461', 'display_name': 'Dhruti Savalia', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dhruti Savalia', 'raw_affiliation_strings': ['Waksman Institute for Microbiology, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA.'], 'affiliations': [{'raw_affiliation_string': 'Waksman Institute for Microbiology, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004282488', 'display_name': 'William P. Robins', 'orcid': 'https://orcid.org/0000-0003-4786-399X'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William Robins', 'raw_affiliation_strings': ['University of Texas at Austin#TAB#'], 'affiliations': [{'raw_affiliation_string': 'University of Texas at Austin#TAB#', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033602624', 'display_name': 'Sergei Nechaev', 'orcid': 'https://orcid.org/0000-0002-0803-7188'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sergei Nechaev', 'raw_affiliation_strings': ['Waksman Institute for Microbiology, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA.'], 'affiliations': [{'raw_affiliation_string': 'Waksman Institute for Microbiology, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002014371', 'display_name': 'Ian J. Molineux', 'orcid': 'https://orcid.org/0000-0003-0184-7652'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ian J Molineux', 'raw_affiliation_strings': ['Molecular Biosciences'], 'affiliations': [{'raw_affiliation_string': 'Molecular Biosciences', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056880626', 'display_name': 'Konstantin Severinov', 'orcid': 'https://orcid.org/0000-0001-9706-450X'}, 'institutions': [{'id': 'https://openalex.org/I102322142', 'display_name': 'Rutgers, The State University of New Jersey', 'ror': 'https://ror.org/05vt9qd57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I102322142']}, {'id': 'https://openalex.org/I4210110167', 'display_name': 'Institute of Gene Biology', 'ror': 'https://ror.org/01yq9ya27', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I1313323035', 'https://openalex.org/I4210110167', 'https://openalex.org/I4210129690']}], 'countries': ['RU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Konstantin Severinov', 'raw_affiliation_strings': ['Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA', 'Institutes of Gene Biology and Molecular Genetics, Russian Academy of Sciences, Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA', 'institution_ids': ['https://openalex.org/I102322142']}, {'raw_affiliation_string': 'Institutes of Gene Biology and Molecular Genetics, Russian Academy of Sciences, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210110167']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4250, 'currency': 'USD', 'value_usd': 4250, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.132, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.867797, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '402', 'issue': '1', 'first_page': '118', 'last_page': '126'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11048', 'display_name': 'Ecology and Evolution of Viruses in Ecosystems', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2303', 'display_name': 'Ecology'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11048', 'display_name': 'Ecology and Evolution of Viruses in Ecosystems', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2303', 'display_name': 'Ecology'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10120', 'display_name': 'Bacterial Physiology and Genetics', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription (linguistics)', 'score': 0.7431787}, {'id': 'https://openalex.org/keywords/trna', 'display_name': 'tRNA', 'score': 0.48308}, {'id': 'https://openalex.org/keywords/t7-rna-polymerase', 'display_name': 'T7 RNA polymerase', 'score': 0.4128133}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7861526}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.7431787}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.72256386}, {'id': 'https://openalex.org/C2776449523', 'wikidata': 'https://www.wikidata.org/wiki/Q272631', 'display_name': 'RNA polymerase', 'level': 4, 'score': 0.6782893}, {'id': 'https://openalex.org/C2776441376', 'wikidata': 'https://www.wikidata.org/wiki/Q165028', 'display_name': 'Bacteriophage', 'level': 4, 'score': 0.6156285}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.57047063}, {'id': 'https://openalex.org/C82381507', 'wikidata': 'https://www.wikidata.org/wiki/Q416878', 'display_name': 'Polymerase', 'level': 3, 'score': 0.521107}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.500257}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.43625283}, {'id': 'https://openalex.org/C2780048736', 'wikidata': 'https://www.wikidata.org/wiki/Q418713', 'display_name': 'T7 RNA polymerase', 'level': 5, 'score': 0.4128133}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3810322}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.3497188}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.32607484}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.30553097}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.11851016}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017123', 'descriptor_name': 'Bacteriophage T7', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': True}, {'descriptor_ui': 'D017123', 'descriptor_name': 'Bacteriophage T7', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012321', 'descriptor_name': 'DNA-Directed RNA Polymerases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017123', 'descriptor_name': 'Bacteriophage T7', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012321', 'descriptor_name': 'DNA-Directed RNA Polymerases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012321', 'descriptor_name': 'DNA-Directed RNA Polymerases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029968', 'descriptor_name': 'Escherichia coli Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029968', 'descriptor_name': 'Escherichia coli Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D029968', 'descriptor_name': 'Escherichia coli Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012689', 'descriptor_name': 'Sequence Homology, Nucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001616', 'descriptor_name': 'beta-Galactosidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001616', 'descriptor_name': 'beta-Galactosidase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.jmb.2010.07.012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S46058472', 'display_name': 'Journal of Molecular Biology', 'issn_l': '0022-2836', 'issn': ['0022-2836', '1089-8638'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2941873', 'pdf_url': 'https://europepmc.org/articles/pmc2941873?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941873', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20650282', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2941873', 'pdf_url': 'https://europepmc.org/articles/pmc2941873?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1516273831', 'https://openalex.org/W1516950933', 'https://openalex.org/W1517176219', 'https://openalex.org/W1546824097', 'https://openalex.org/W1584156833', 'https://openalex.org/W1817935073', 'https://openalex.org/W1968357735', 'https://openalex.org/W1969192031', 'https://openalex.org/W1975993749', 'https://openalex.org/W1976799117', 'https://openalex.org/W2002043114', 'https://openalex.org/W2002841189', 'https://openalex.org/W2016525744', 'https://openalex.org/W2022178560', 'https://openalex.org/W2027592626', 'https://openalex.org/W2039363391', 'https://openalex.org/W2074699320', 'https://openalex.org/W2080034069', 'https://openalex.org/W2090009283', 'https://openalex.org/W2115998641', 'https://openalex.org/W2138108312', 'https://openalex.org/W2140564010', 'https://openalex.org/W2150237825', 'https://openalex.org/W2150394101', 'https://openalex.org/W2160039792', 'https://openalex.org/W2213536111', 'https://openalex.org/W98389323'], 'related_works': ['https://openalex.org/W4205708916', 'https://openalex.org/W2970236921', 'https://openalex.org/W2371175271', 'https://openalex.org/W2138968083', 'https://openalex.org/W2048863389', 'https://openalex.org/W2042233418', 'https://openalex.org/W2005697656', 'https://openalex.org/W2005166450', 'https://openalex.org/W1999220636', 'https://openalex.org/W1969906365'], 'abstract_inverted_index': {'Bacteriophage': [0], 'T7': [1, 41, 79], 'relies': [2], 'on': [3], 'its': [4, 11], 'own': [5], 'RNA': [6], 'polymerase': [7], '(RNAp)': [8], 'to': [9, 93, 106, 157], 'transcribe': [10], 'middle': [12, 40], 'and': [13, 37, 56, 148], 'late': [14, 59], 'genes.': [15], 'Early': [16], 'genes,': [17], 'which': [18], 'include': [19], 'the': [20, 27, 50, 69, 85, 96, 140, 150], 'viral': [21, 90], 'RNAp': [22, 29, 76, 138], 'gene,': [23], 'are': [24], 'transcribed': [25], 'by': [26, 136], 'host': [28, 51, 75, 137], 'from': [30, 100, 139], 'three': [31], 'closely': [32], 'spaced': [33], 'strong': [34, 47], 'promoters—A1,': [35], 'A2,': [36], 'A3.': [38], 'One': [39], 'gene': [42], 'product,': [43], 'gp2,': [44, 88], 'is': [45, 54, 57, 104, 127, 143, 156], 'a': [46], 'inhibitor': [48], 'of': [49, 71, 87, 124], 'RNAp.': [52], 'Gp2': [53, 113], 'essential': [55, 152], 'required': [58], 'in': [60, 73, 84], 'infection,': [61], 'during': [62, 78], 'phage': [63, 111, 146], 'DNA': [64], 'packaging.': [65], 'Here,': [66], 'we': [67], 'explore': [68], 'role': [70, 153], 'gp2': [72, 108, 155], 'controlling': [74], 'transcription': [77, 99, 135], 'infection.': [80, 97, 112], 'We': [81], 'demonstrate': [82], 'that': [83, 133, 149], 'absence': [86], 'early': [89, 101, 125], 'transcripts': [91], 'continue': [92], 'accumulate': [94], 'throughout': [95], 'Decreasing': [98], 'promoter': [102, 142], 'A3': [103, 141], 'sufficient': [105], 'make': [107], 'dispensable': [109, 116], 'for': [110, 154], 'also': [114], 'becomes': [115], 'when': [117], 'an': [118], 'antiterminating': [119], 'element': [120], 'boxA,': [121], 'located': [122], 'downstream': [123], 'promoters,': [126], 'deleted.': [128], 'The': [129], 'results': [130], 'thus': [131], 'suggest': [132], 'antiterminated': [134], 'interfering': [144], 'with': [145], 'development': [147], 'only': [151], 'prevent': [158], 'this': [159], 'transcription.': [160]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1982729908', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-08-20T08:23:20.481093', 'created_date': '2016-06-24'}