Title: On the origin of trimethylamine oxide in the spiny dogfish, Squalus acanthias
Abstract: Abstract 1. 1. The ability to synthesize trimethylamine oxide (TMAO) from 14 C-labeled precursors was examined in intact dogfish and in isolated liver preparations. 2. 2. There was no incorporation of 14 C-trimethylamine or choline-methyl- 14 C into TMAO in vivo or in slices and homogenates. Neither was there incorporation of l -methionine-methyl- 14 C by slices. 3. 3. Maintenance of constant plasma levels of TMAO during starvation was attributed to slow release of the base from the large pool present in muscle and to the low rate of excretion.
Publication Year: 1967
Publication Date: 1967-06-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 46
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