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2200, 2208, 2215, 2222, 2229, 2236, 2266], 'articles': [72, 83, 94, 105, 114, 123, 134, 145, 154, 165, 174, 183, 192, 201, 233, 2140, 2148, 2156, 2164, 2171, 2178, 2186, 2194, 2201, 2209, 2216, 2223, 2230, 2237, 2267], 'by': [73, 84, 95, 106, 115, 124, 135, 146, 155, 166, 175, 184, 193, 202, 234, 340, 1171, 1323, 1341, 1755, 2110, 2141, 2149, 2157, 2165, 2172, 2179, 2187, 2195, 2202, 2210, 2217, 2224, 2231, 2238, 2268], 'this': [74, 85, 96, 107, 116, 125, 136, 147, 156, 167, 176, 185, 194, 203, 235, 2142, 2150, 2158, 2166, 2173, 2180, 2188, 2196, 2203, 2211, 2218, 2225, 2232, 2239, 2269], 'author': [75, 86, 97, 108, 117, 126, 137, 148, 157, 168, 177, 186, 195, 204, 236, 2143, 2151, 2159, 2167, 2174, 2181, 2189, 2197, 2204, 2212, 2219, 2226, 2233, 2240, 2270], ',': [76, 87, 98, 109, 118, 127, 138, 149, 158, 169, 178, 187, 196, 205], 'ScardinoPeter': [79], 'Scardino': [81, 1886, 2070, 2146], 'CarrollPeter': [90], 'Carroll': [92, 2154], 'ZelefskyMichael': [101], 'Zelefsky': [103, 2162], 'SartorOliver': [111], 'Sartor': [112, 2169], 'HricakHedvig': [120], 'Hricak': [121, 1038, 2176], 'WheelerThomas': [130], 'Wheeler': [132, 2184], 'FineSamson': [141], 'Fine': [143, 2192], 'TrachtenbergJohn': [151], 'Trachtenberg': [152, 2199], 'RubinMark': [161], 'Rubin': [163, 2207], 'OhoriMak': [171], 'Ohori': [172, 2214], 'KuroiwaKentaro': [180], 'Kuroiwa': [181, 1044, 2221], 'RossignolMichel': [189], 'Rossignol': [190, 2228], 'AbenhaimLucien': [198], 'Abenhaim': [199, 2235], 'Other': [218, 2252], 'members:': [219, 2253], 'Tia': [220, 2254], 'Higano,': [221, 2255], 'Marberger,': [223, 2257], 'David': [224, 2258], 'F.': [225, 2259], 'Penson,': [226, 2260], 'Louis': [227, 2261], 'Potters': [228, 2262], 'Marc': [230, 2264], 'Zerbib.': [231, 2265], 'View': [237], 'All': [238, 2272], 'Author': [239], 'Informationhttps://doi.org/10.1016/j.juro.2007.08.072AboutFull': [240], 'TextPDF': [241], 'ToolsAdd': [242], 'to': [243, 326, 391, 408, 496, 516, 723, 1081, 1427, 1552, 1594, 1766], 'favoritesDownload': [244], 'CitationsTrack': [245], 'CitationsPermissionsReprints': [246], 'ShareFacebookLinked': [247], 'InTwitterEmail': [248], 'Abstract': [249], 'Purpose:': [250], 'Based': [251], 'contemporary': [253, 936], 'epidemiological': [254], 'pathological': [256, 405], 'characteristics': [257, 797, 872], 'prostate': [259, 274, 300, 324, 347, 365, 376, 492, 532, 550, 573, 593, 630, 679, 752, 772, 781, 808, 830, 842, 853, 874, 878, 915, 932, 966, 1014, 1026, 1053, 1070, 1180, 1192, 1224, 1267, 1286, 1314, 1339, 1358, 1376, 1406, 1422, 1443, 1502, 1527, 1546, 1570, 1618, 1638, 1658, 1685, 1690, 1741], 'cancer': [260, 301, 348, 377, 493, 551, 563, 631, 680, 713, 725, 773, 875, 933, 967, 995, 1054, 1092, 1225, 1242, 1268, 1340, 1359, 1377, 1547, 1571, 1639, 1711, 1719, 1742], 'we': [261, 595], 'explain': [262], 'rationale': [264], 'concerns': [267, 497], 'about': [268], 'focal': [269, 312, 433, 445, 466, 474, 529, 542, 944, 958], 'therapy': [270, 434, 446, 475, 543, 674, 959, 1441, 1568, 1589], 'low': [272, 548, 1553], 'risk': [273, 549, 1634], 'cancer,': [275], 'review': [276], 'potential': [277, 472], 'methods': [278], 'delivery': [280], 'propose': [282], 'study': [283], 'design': [284], 'parameters.': [285], 'Materials': [286], 'Methods:': [288], 'Articles': [289], 'regarding': [290], 'epidemiology,': [292], 'diagnosis,': [293], 'imaging,': [294, 1012], 'treatment': [295, 805, 828, 1404, 1419], 'pathology': [297], 'localized': [299, 807, 1179, 1357], 'were': [302], 'reviewed': [303], 'with': [304, 360, 401, 470, 534, 547, 599, 677, 963, 1055, 1096, 1285, 1378, 1479, 1526, 1744, 1813], 'a': [305, 319, 341, 361, 507, 597, 935, 1058, 1112, 1288, 1424, 1575], 'particular': [306], 'emphasis': [307], 'technologies': [309, 469, 525], 'applicable': [310], 'therapy,': [313, 511], 'defined': [314], 'as': [315, 1545, 1735], 'targeted': [316], 'ablation': [317, 484], 'limited': [320, 449], 'area': [321], 'expected': [325], 'contain': [327], 'dominant': [329, 1470], 'or': [330, 437, 520, 602], 'only': [331], 'focus': [332], 'cancer.': [334, 831, 1027, 1181, 1407, 1619], 'consensus': [336], 'summary': [337], 'was': [338], 'constructed': [339], 'multidisciplinary': [342], 'international': [343], 'task': [344], 'force': [345], 'experts,': [349], 'forming': [350], 'basis': [352], 'current': [355, 1595], 'review.': [356], 'Results:': [357], 'In': [358, 393], 'regions': [359, 730], 'high': [362, 477], 'prevalence': [363, 717, 929], 'specific': [366, 782, 843, 879, 1118, 1691, 1717], 'antigen': [367, 783, 844, 880, 1692], 'screening': [368], 'over': [370, 851], 'detection': [371, 490], 'subsequent': [373], 'overtreatment': [374, 601], 'is': [378, 389, 397, 429, 850, 989], 'common.': [379], 'The': [380, 441, 568, 743, 841, 1133, 1216], 'incidence': [381, 614, 769], 'unifocal': [383, 436, 439, 931], 'cancers': [384, 501, 916, 1659], 'in': [385, 432, 544, 552, 576, 617, 633, 681, 727, 753, 826, 846, 857, 896, 917, 934, 961, 1020, 1144, 1167, 1174, 1247, 1271, 1311, 1325, 1344, 1401, 1450, 1679, 1740, 1770, 1848], 'radical': [386, 510, 918, 939, 971, 1122, 1248, 1641], 'prostatectomy': [387, 919, 940, 972, 1249, 1273], 'specimens': [388], '13%': [390], '38%.': [392], 'many': [394, 500, 512], 'others': [395], 'there': [396, 428], 'an': [398], 'index': [399], 'lesion': [400], 'secondary': [402, 457], 'foci': [403, 458], 'containing': [404], 'features': [406], 'similar': [407], 'those': [409], 'found': [410], 'incidentally': [411], 'at': [412, 701, 775, 991, 1121], 'autopsy.': [413], 'Because': [414], 'biopsy': [415, 1015, 1173, 1193, 1222, 1687, 1713, 1733], 'strategies': [416], 'imaging': [418, 1076, 1080], 'techniques': [419], 'can': [420], 'provide': [421], 'more': [422], 'precise': [423], 'tumor': [424, 1093, 1136], 'localization': [425, 1024], 'characterization,': [427], 'growing': [430], 'interest': [431], 'targeting': [435], 'biologically': [438], 'tumors.': [440, 1299], 'major': [442], 'arguments': [443], 'against': [444], 'are': [447, 514], 'multifocality,': [448], 'accuracy': [450, 1169], 'staging,': [452], 'unpredictable': [454], 'aggressiveness': [455], 'lack': [461], 'established': [463], 'technology': [464], 'ablation.': [467, 945], 'Emerging': [468], 'include': [476], 'intensity': [478, 1438], 'focused': [479, 1362], 'ultrasound,': [480], 'cryotherapy,': [481], 'radio': [482], 'frequency': [483, 744], 'photodynamic': [486], 'therapy.': [487], 'Conclusions:': [488], 'Early': [489, 591], 'has': [494], 'led': [495], 'that': [498, 556], 'while': [499], 'now': [502], 'diagnosed': [503], 'pose': [504], 'too': [505], 'little': [506], 'threat': [508], 'men': [513, 546, 676, 799, 1145, 1284], 'reluctant': [515], 'accept': [517], 'watchful': [518, 801], 'waiting': [519, 802], 'active': [521], 'surveillance.': [522], 'Several': [523], 'emerging': [524], 'seem': [526], 'capable': [527], 'destruction': [530], 'tissue': [533], 'minimal': [535], 'morbidity.': [536], 'We': [537], 'encourage': [538], 'investigation': [540], 'select': [545], 'prospective': [553], 'clinical': [554, 577, 911, 1738], 'trials': [555], 'carefully': [557], 'document': [558], 'safety,': [559], 'functional': [560], 'outcomes': [561, 1400], 'control.': [564], 'References': [565], '1': [566], ':': [567, 590, 612, 627, 669, 710, 742, 765, 793, 821, 840, 870, 891, 908, 927, 956, 986, 1006, 1066, 1090, 1109, 1132, 1162, 1190, 1215, 1236, 1259, 1282, 1308, 1336, 1354, 1371, 1393, 1414, 1436, 1464, 1496, 1516, 1540, 1566, 1587, 1605, 1628, 1652, 1674, 1705, 1729], 'changing': [569], 'face': [570], 'low-risk': [572, 1052], 'cancer:': [574, 809, 854, 1071, 1287, 1423, 1444], 'trends': [575, 795], 'presentation': [578], 'primary': [580, 1316, 1403, 1421], 'management.': [581, 1153], 'J': [582, 604, 649, 685, 734, 757, 785, 813, 832, 862, 883, 946, 975, 1028, 1124, 1154, 1182, 1205, 1228, 1251, 1300, 1328, 1385, 1454, 1486, 1530, 1558, 1579, 1597, 1620, 1645, 1666, 1697, 1721, 1746, 1889, 2023, 2073], 'Clin': [583, 650, 735, 833, 1621], 'Oncol2004;': [584], '22:': [585], '2141.': [586], 'Google': [587, 609, 624, 654, 666, 691, 707, 739, 762, 790, 818, 837, 867, 888, 905, 924, 953, 983, 1003, 1033, 1063, 1087, 1106, 1129, 1159, 1187, 1212, 1233, 1256, 1279, 1305, 1333, 1351, 1368, 1390, 1411, 1433, 1461, 1493, 1513, 1537, 1563, 1584, 1602, 1625, 1649, 1671, 1702, 1726, 1751], 'Scholar': [588, 610, 625, 655, 667, 692, 708, 740, 763, 791, 819, 838, 868, 889, 906, 925, 954, 984, 1004, 1034, 1064, 1088, 1107, 1130, 1160, 1188, 1213, 1234, 1257, 1280, 1306, 1334, 1352, 1369, 1391, 1412, 1434, 1462, 1494, 1514, 1538, 1564, 1585, 1603, 1626, 1650, 1672, 1703, 1727, 1752], '2': [589], 'stage': [592, 965, 1226, 1312], 'cancer—do': [594], 'have': [596], 'problem': [598], 'over-detection,': [600], 'both?.': [603], 'Urol2005;': [605, 786, 1029, 1155, 1229, 1252, 1698], '173:': [606, 1699], '1061.': [607], 'Link,': [608, 761, 789, 817, 866, 887, 952, 982, 1032, 1128, 1158, 1186, 1232, 1255, 1304, 1332, 1389, 1562, 1583, 1601, 1670, 1701, 1725, 1750], '3': [611], 'mortality': [616, 632, 645], 'Europe,': [618], '2004.': [619], 'Ann': [620], 'Oncol2005;': [621, 651, 834, 1622], '16:': [622], '481.': [623], '4': [626], 'Comparison': [628, 766, 1007, 1993], 'five': [634, 719], 'countries:': [635], 'France,': [636], 'Italy,': [637], 'Japan,': [638], 'UK': [639], 'USA': [641], 'from': [642, 811, 1637, 1656], 'WHO': [644], 'database': [646], '(1960-2000).': [647], 'Jpn': [648], '35:': [652], '690.': [653], '5': [656], 'Facts': [658], 'Figures.': [660], 'Atlanta,': [661], 'Georgia:': [662], 'American': [663, 1756, 2111], 'Society2006.': [665], '6': [668], 'Incidence': [670], 'initial': [672, 804], 'local': [673], 'among': [675], 'lower-risk': [678], 'United': [683, 848], 'States.': [684], 'Natl': [686], 'Inst2006;': [688], '98:': [689], '1134.': [690], '7': [693], 'Research': [695, 698], 'UK,': [696], 'Information': [697, 2135], 'Centre.': [699], 'Available': [700], 'http://info.cancerresearchuk.org/cancerstats/types/prostate/?a=5441.': [702], 'Accessed': [703], 'July': [704], '9,': [705], '2006.': [706], '8': [709], 'Patterns': [711], 'incidence,': [714], 'mortality,': [715], 'across': [718], 'continents:': [720], 'defining': [721], 'priorities': [722], 'reduce': [724], 'disparities': [726], 'different': [728], 'geographic': [729], 'world.': [733], 'Oncol2006;': [736], '24:': [737], '2137.': [738], '9': [741], 'carcinoma': [746], 'intraepithelial': [748], 'neoplasia': [749], 'young': [754], 'male': [755], 'patients.': [756, 1203, 1346, 1452], 'Urol1993;': [758], '150:': [759], '379.': [760], '10': [764], 'latent': [771], 'detected': [774, 876, 1322], 'autopsy': [776], 'before': [777, 1660], 'after': [779, 1520, 1573, 1613, 1640], 'era.': [784], '174:': [787, 1030, 1156, 1230, 1253], '1785.': [788], '11': [792], 'Time': [794], 'choosing': [800], 'results': [810], 'CaPSURE.': [812], 'Urol2003;': [814, 1301, 1386], '170:': [815, 1302, 1387], '1804.': [816], '12': [820], 'Geographic': [822], 'socioeconomic': [824], 'variation': [825], '23:': [835, 1623], '7881.': [836], '13': [839], 'era': [845], 'States': [849], 'what': [855], 'happened': [856], 'last': [859], '20': [860, 1005], 'years?.': [861], 'Urol2004;': [863, 1183, 1559, 1722], '172:': [864], '1297.': [865], '14': [869], 'Pathological': [871], 'through': [877], 'based': [881, 1683], 'screening.': [882], 'Urol2006;': [884, 947, 976, 1000, 1125, 1598], '175:': [885, 948, 977, 1126, 1599], '902.': [886], '15': [890], 'Heterogeneity': [892], 'Gleason': [894, 1198], 'grade': [895], 'multifocal': [897, 914], 'adenocarcinoma': [898, 1315], 'prostate.': [901], 'Cancer2004;': [902], '100:': [903], '2362.': [904], '16': [907], 'Morphologic': [909], 'significance': [912], 'specimens.': [920, 974, 1250, 1274], 'Urology2002;': [921, 1408, 1430], '60:': [922, 1409, 1431], '264.': [923], '17': [926], 'Increased': [928], 'series': [937], 'specimens:': [941], 'implications': [942, 1200], '374.': [949], 'abstract': [950, 980], '1163.': [951, 1002], '18': [955], 'Is': [957], 'reasonable': [960], 'patients': [962, 1525], 'early': [964, 1445], '(CaP)—an': [968], 'analysis': [969], '(RP)': [973], '507.': [978], 'suppl.,': [979], '1574.': [981], '19': [985], 'How': [987], 'good': [988], 'MRI': [990], 'detecting': [992], 'characterising': [994], 'within': [996], 'prostate?.': [998], 'Eur': [999, 1347], '50:': [1001], 'endorectal': [1009, 1097], 'magnetic': [1010, 1056, 1505], 'resonance': [1011, 1506], 'guided': [1013], 'digital': [1017, 1694], 'rectal': [1018, 1695], 'examination': [1019], 'preoperative': [1022], 'anatomical': [1023], '2158.': [1031], '21': [1035], 'Shukla-Dave': [1036], 'A,': [1037, 1867, 1926, 1962, 2011, 2013, 2051], 'H,': [1039, 1922, 2009], 'Kattan': [1040], 'M,': [1041, 1790, 1833, 1875, 1920, 2015, 2059], 'Pucar': [1042], 'D,': [1043], 'K,': [1045, 1829], 'Chen': [1046], 'H': [1047, 1794], 'et': [1048], 'al:': [1049], 'Predicting': [1050], 'very': [1051], 'resonance:': [1057], 'new': [1059, 1425], 'nomogram.': [1060], 'Unpublished': [1061], 'data.': [1062], '22': [1065], 'Prediction': [1067, 1675], 'organ-confined': [1069], 'incremental': [1072], 'value': [1073, 1662], 'MR': [1075, 1078, 1098, 1100], 'spectroscopic': [1079, 1101, 1507], 'staging': [1082], 'nomograms.': [1083], 'Radiology2006;': [1084], '238:': [1085], '597.': [1086], '23': [1089], 'volume:': [1094], 'measurement': [1095], 'imaging.': [1102, 1508], 'Radiology2002;': [1103], '223:': [1104], '91.': [1105], '24': [1108], 'Validation': [1110], 'nomogram': [1113, 1289], 'prediction': [1115, 1238], 'side': [1117, 1716], 'extracapsular': [1119], 'extension': [1120, 1678], 'prostatectomy.': [1123, 1642], '939.': [1127], '25': [1131], 'relationship': [1134], 'between': [1135], 'volume': [1137, 1241], 'number': [1140], 'positive': [1142, 1732], 'cores': [1143, 1734], 'undergoing': [1146], 'multisite': [1147], 'extended': [1148, 1220], 'biopsy:': [1149], 'implication': [1150], 'expectant': [1152], '2164.': [1157], '26': [1161], 'Assessment': [1163], 'enhancement': [1166], 'predictive': [1168], 'provided': [1170, 2130], 'systematic': [1172, 1664], 'predicting': [1175, 1291], 'outcome': [1176, 1449, 1519, 1739], 'clinically': [1178, 1654], '171:': [1184, 1560, 1723], '200.': [1185], '27': [1189], 'Extended': [1191], 'scheme': [1194], 'improves': [1195], 'reliability': [1196], 'grading:': [1199], 'radiotherapy': [1202, 1616], 'Int': [1204, 1453, 1485, 1529], 'Radiat': [1206, 1455, 1487, 1531], 'Oncol': [1207, 1456, 1488, 1532], 'Biol': [1208, 1457, 1489, 1533], 'Phys2004;': [1209], '59:': [1210], '386.': [1211], '28': [1214], 'independent': [1217], 'impact': [1218], 'pattern': [1221], 'migration.': [1227], '1789.': [1231], '29': [1235], 'Preoperative': [1237, 1629], 'small': [1240], '(less': [1243], 'than': [1244], '0.5': [1245], 'ml)': [1246, 1270], '898.': [1254], '30': [1258], 'Anatomic': [1260], 'distribution': [1261], 'pathologic': 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