Publication Information

{'id': 'https://openalex.org/W1982189276', 'doi': 'https://doi.org/10.1124/mol.62.4.957', 'title': 'Sensitization by Extracellular Ca<sup>2+</sup> of Rat P2X<sub>5</sub> Receptor and Its Pharmacological Properties Compared with Rat P2X<sub>1</sub>.', 'display_name': 'Sensitization by Extracellular Ca<sup>2+</sup> of Rat P2X<sub>5</sub> Receptor and Its Pharmacological Properties Compared with Rat P2X<sub>1</sub>.', 'publication_year': 2002, 'publication_date': '2002-10-01', 'ids': {'openalex': 'https://openalex.org/W1982189276', 'doi': 'https://doi.org/10.1124/mol.62.4.957', 'mag': '1982189276', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12237343'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1124/mol.62.4.957', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62949411', 'display_name': 'Molecular Pharmacology', 'issn_l': '0026-895X', 'issn': ['0026-895X', '1521-0111'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316283', 'host_organization_name': 'American Society for Pharmacology and Experimental Therapeutics', 'host_organization_lineage': ['https://openalex.org/P4310316283'], 'host_organization_lineage_names': ['American Society for Pharmacology and Experimental Therapeutics'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://rvc-repository.worktribe.com/preview/1659487/kura-et-al-2023-can-mass-drug-administration-of-moxidectin-accelerate-onchocerciasis-elimination-in-africa.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103504265', 'display_name': 'Scott S. Wildman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I2801138448', 'display_name': 'The Royal Free Hospital', 'ror': 'https://ror.org/01ge67z96', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I169248724', 'https://openalex.org/I2801138448']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Scott S. Wildman', 'raw_affiliation_strings': ['1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I2801138448']}, {'raw_affiliation_string': '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061583589', 'display_name': 'Sean G. Brown', 'orcid': 'https://orcid.org/0000-0003-0767-0253'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I2801138448', 'display_name': 'The Royal Free Hospital', 'ror': 'https://ror.org/01ge67z96', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I169248724', 'https://openalex.org/I2801138448']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Sean G. Brown', 'raw_affiliation_strings': ['1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I2801138448']}, {'raw_affiliation_string': '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051027378', 'display_name': 'Mary Rahman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I2801138448', 'display_name': 'The Royal Free Hospital', 'ror': 'https://ror.org/01ge67z96', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I169248724', 'https://openalex.org/I2801138448']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Mary Rahman', 'raw_affiliation_strings': ['1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I2801138448']}, {'raw_affiliation_string': '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001288538', 'display_name': 'Carole Noël', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I2801138448', 'display_name': 'The Royal Free Hospital', 'ror': 'https://ror.org/01ge67z96', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I169248724', 'https://openalex.org/I2801138448']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Carole A. Noel', 'raw_affiliation_strings': ['1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I2801138448']}, {'raw_affiliation_string': '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005956633', 'display_name': 'Linda J. Churchill', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I2801138448', 'display_name': 'The Royal Free Hospital', 'ror': 'https://ror.org/01ge67z96', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I169248724', 'https://openalex.org/I2801138448']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Linda Churchill', 'raw_affiliation_strings': ['1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I2801138448']}, {'raw_affiliation_string': '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058369958', 'display_name': 'Geoffrey Burnstock', 'orcid': 'https://orcid.org/0000-0001-8152-7979'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I2801138448', 'display_name': 'The Royal Free Hospital', 'ror': 'https://ror.org/01ge67z96', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I169248724', 'https://openalex.org/I2801138448']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Geoffrey Burnstock', 'raw_affiliation_strings': ['1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I2801138448']}, {'raw_affiliation_string': '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031062920', 'display_name': 'Robert J. Unwin', 'orcid': 'https://orcid.org/0000-0001-7839-6031'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I2801138448', 'display_name': 'The Royal Free Hospital', 'ror': 'https://ror.org/01ge67z96', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I169248724', 'https://openalex.org/I2801138448']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Robert J. Unwin', 'raw_affiliation_strings': ['1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I2801138448']}, {'raw_affiliation_string': '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5053049512', 'display_name': 'Brian F. King', 'orcid': 'https://orcid.org/0000-0002-0463-409X'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I2801138448', 'display_name': 'The Royal Free Hospital', 'ror': 'https://ror.org/01ge67z96', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I169248724', 'https://openalex.org/I2801138448']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Brian F. King', 'raw_affiliation_strings': ['1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '1Department of Physiology (Centre for Nephrology) (S.S.W., C.A.N., L.C., R.J.U., B.F.K), and \n2Autonomic Neuroscience Institute (G.B., R.J.U., B.F.K.), Royal Free and University College Medical School, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I2801138448']}, {'raw_affiliation_string': '3Department of Clinical Pharmacology, The Rayne Institute (S.G.B.) and \n4Department of Anatomy and Developmental Biology (M.R., G.B.), University College London, London, United Kingdom', 'institution_ids': ['https://openalex.org/I45129253']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.857, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 67, 'citation_normalized_percentile': {'value': 0.832338, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '62', 'issue': '4', 'first_page': '957', 'last_page': '966'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11193', 'display_name': 'Adenosine and Purinergic Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11193', 'display_name': 'Adenosine and Purinergic Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11541', 'display_name': 'Neuroendocrine regulation and behavior', 'score': 0.9946, 'subfield': {'id': 'https://openalex.org/subfields/3207', 'display_name': 'Social Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}, {'id': 'https://openalex.org/T10854', 'display_name': 'Bipolar Disorder and Treatment', 'score': 0.9924, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/homomeric', 'display_name': 'Homomeric', 'score': 0.47293165}], 'concepts': [{'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.74754703}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.5492159}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4886904}, {'id': 'https://openalex.org/C2776104367', 'wikidata': 'https://www.wikidata.org/wiki/Q5891451', 'display_name': 'Homomeric', 'level': 4, 'score': 0.47293165}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.4483949}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.3766238}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.35624677}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.25388774}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.21008784}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1797924}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018048', 'descriptor_name': 'Receptors, Purinergic P2', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004594', 'descriptor_name': 'Electrophysiology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018048', 'descriptor_name': 'Receptors, Purinergic P2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058469', 'descriptor_name': 'Receptors, Purinergic P2X', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058485', 'descriptor_name': 'Receptors, Purinergic P2X5', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014982', 'descriptor_name': 'Xenopus laevis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015032', 'descriptor_name': 'Zinc', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015032', 'descriptor_name': 'Zinc', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1124/mol.62.4.957', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62949411', 'display_name': 'Molecular Pharmacology', 'issn_l': '0026-895X', 'issn': ['0026-895X', '1521-0111'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316283', 'host_organization_name': 'American Society for Pharmacology and Experimental Therapeutics', 'host_organization_lineage': ['https://openalex.org/P4310316283'], 'host_organization_lineage_names': ['American Society for Pharmacology and Experimental Therapeutics'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://researchonline.rvc.ac.uk/id/eprint/1003/', 'pdf_url': 'https://rvc-repository.worktribe.com/preview/1659487/kura-et-al-2023-can-mass-drug-administration-of-moxidectin-accelerate-onchocerciasis-elimination-in-africa.pdf', 'source': {'id': 'https://openalex.org/S4306402069', 'display_name': 'RVC Research Online (Royal Veterinary College)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I133836048', 'host_organization_name': 'Royal Veterinary College', 'host_organization_lineage': ['https://openalex.org/I133836048'], 'host_organization_lineage_names': ['Royal Veterinary College'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.540.8560', 'pdf_url': 'http://www.ucl.ac.uk/ani/GB%27s PDF file copies/CV1211.pdf', 'source': {'id': 'https://openalex.org/S4306400349', 'display_name': 'CiteSeer X (The Pennsylvania State University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I130769515', 'host_organization_name': 'Pennsylvania State University', 'host_organization_lineage': ['https://openalex.org/I130769515'], 'host_organization_lineage_names': ['Pennsylvania State University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12237343', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'http://researchonline.rvc.ac.uk/id/eprint/1003/', 'pdf_url': 'https://rvc-repository.worktribe.com/preview/1659487/kura-et-al-2023-can-mass-drug-administration-of-moxidectin-accelerate-onchocerciasis-elimination-in-africa.pdf', 'source': {'id': 'https://openalex.org/S4306402069', 'display_name': 'RVC Research Online (Royal Veterinary College)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I133836048', 'host_organization_name': 'Royal Veterinary College', 'host_organization_lineage': ['https://openalex.org/I133836048'], 'host_organization_lineage_names': ['Royal Veterinary College'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1503124774', 'https://openalex.org/W1527046284', 'https://openalex.org/W1585581856', 'https://openalex.org/W1607766476', 'https://openalex.org/W1775244163', 'https://openalex.org/W1852253371', 'https://openalex.org/W1967667749', 'https://openalex.org/W1979882055', 'https://openalex.org/W1989518583', 'https://openalex.org/W1990539640', 'https://openalex.org/W1994090325', 'https://openalex.org/W2000236009', 'https://openalex.org/W2004755602', 'https://openalex.org/W2008602135', 'https://openalex.org/W2012510435', 'https://openalex.org/W2030668938', 'https://openalex.org/W2037524928', 'https://openalex.org/W2042954879', 'https://openalex.org/W2044564551', 'https://openalex.org/W2047462949', 'https://openalex.org/W2051271802', 'https://openalex.org/W2064222655', 'https://openalex.org/W2079854296', 'https://openalex.org/W2081089616', 'https://openalex.org/W2089202360', 'https://openalex.org/W2089314265', 'https://openalex.org/W2089894643', 'https://openalex.org/W2095128196', 'https://openalex.org/W2099244605', 'https://openalex.org/W2099757747', 'https://openalex.org/W2100447139', 'https://openalex.org/W2112671639', 'https://openalex.org/W2114775457', 'https://openalex.org/W2124580120', 'https://openalex.org/W2136134177', 'https://openalex.org/W2139683239', 'https://openalex.org/W2166646331', 'https://openalex.org/W2280241881', 'https://openalex.org/W2311800445', 'https://openalex.org/W2467988684', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4319928916', 'https://openalex.org/W4240239855', 'https://openalex.org/W3004998459', 'https://openalex.org/W2146952421', 'https://openalex.org/W2104979716', 'https://openalex.org/W2061718039', 'https://openalex.org/W2048562538', 'https://openalex.org/W2045237222', 'https://openalex.org/W2039418964', 'https://openalex.org/W2000749144'], 'abstract_inverted_index': {'The': [0], 'recombinant': [1], 'rat': [2], 'P2X<sub>5</sub>': [3], '(rP2X<sub>5</sub>)': [4], 'receptor,': [5], 'a': [6, 164], 'poorly': [7], 'understood': [8, 22], 'ATP-gated': [9], 'ion': [10, 181], 'channel,': [11], 'was': [12, 130, 195], 'studied': [13], 'under': [14], 'voltage-clamp': [15], 'conditions': [16], 'and': [17, 89, 105, 114, 148, 179, 255, 261], 'compared': [18], 'with': [19, 26, 43, 65, 116], 'the': [20, 55, 146, 190, 215, 230, 248, 256], 'better': [21], 'homomeric': [23, 232, 241], 'rP2X<sub>1</sub>': [24, 171], 'receptor': [25, 188, 234], 'which': [27], 'it': [28, 243], 'may': [29], 'coexist': [30], 'in': [31, 34, 54, 163, 173, 237], 'vivo.': [32], 'Expressed': [33], 'defolliculated': [35], '<i>Xenopus': [36], 'laevis</i>': [37], 'oocytes,': [38], 'rP2X<sub>5</sub>': [39, 101, 194, 233], 'responded': [40, 102], 'to': [41, 103, 240], 'ATP': [42, 104, 161], 'slowly': [44], 'desensitizing': [45], 'inward': [46], 'currents': [47], 'that,': [48], 'for': [49, 81, 126, 132], 'successive': [50], 'responses,': [51], 'ran': [52], 'down': [53], 'presence': [56], 'of': [57, 63, 79, 84, 123, 150, 259], 'extracellular': [58, 143, 153], 'Ca<sup>2+</sup>': [59, 64, 80], '(1.8': [60], 'mM).': [61], 'Replacement': [62], 'either': [66], 'Ba<sup>2+</sup>': [67], 'or': [68], 'Mg<sup>2+</sup>prevented': [69], 'rundown,': [70], 'although': [71, 134], 'agonist': [72, 91, 184, 238], 'responses': [73, 162], 'were': [74], 'very': [75], 'small,': [76], 'whereas': [77, 152], 'reintroduction': [78], 'short': [82], 'periods': [83], 'time': [85], '(&lt;300': [86], 's)': [87], 'before': [88], 'during': [90], 'application': [92], 'yielded': [93], 'consistently': [94], 'larger': [95], 'responses.': [96], 'Using': [97], 'this': [98], 'Ca<sup>2+</sup>-pulse': [99], 'conditioning,': [100], 'other': [106], 'nucleotides': [107], '(ATP,': [108], '2-methylthio-ATP,': [109], 'adenosine-5′-<i>O</i>-(thiotriphosphate),': [110], '2′-&amp;-3′-<i>O</i>-(4-benzoylbenzoyl)-ATP,': [111], 'α,β-methylene-ATP,': [112], 'P<sup>1</sup>-P<sup>(4)</sup>-diadenosine-5′-phosphate,': [113], 'more)': [115], 'pEC<sub>50</sub>': [117], 'values': [118], 'within': [119], '1': [120], 'log': [121], 'unit': [122], 'respective': [124], 'determinations': [125], 'rP2X<sub>1</sub>.': [127], 'Only': [128], 'GTP': [129, 251], 'selective': [131], 'rP2X<sub>5</sub>,': [133, 141], '60-fold': [135], 'less': [136], 'potent': [137], 'than': [138], 'ATP.': [139], 'At': [140], 'lowering': [142], 'pH': [144], 'reduced': [145], 'potency': [147, 191, 216], 'efficacy': [149], 'ATP,': [151], 'Zn<sup>2+</sup>': [154, 180, 262], 'ions': [155], '(0.1–1000': [156], 'μM)': [157], 'potentiated': [158], 'then': [159], 'inhibited': [160], 'concentration-dependent': [165], 'manner.': [166], 'However,': [167], 'these': [168], 'modulators': [169], 'affected': [170], 'receptors': [172], 'subtly': [174], 'different': [175], 'ways–with': [176], 'increasing': [177], 'H<sup>+</sup>': [178, 260], 'concentrations': [182], 'reducing': [183], 'potency.': [185], 'For': [186], 'P2': [187], 'antagonists,': [189], 'order': [192, 217], 'at': [193, 218], 'pyridoxal-5-phosphate-6-azophenyl-2′,4′-disulfonic': [196], 'acid': [197], '(PPADS)': [198], '&gt;': [199, 202, 204, 209, 223, 225], '2′,3′-<i>O</i>-(2,4,6-trinitrophenyl)ATP': [200], '(TNP-ATP)': [201], 'suramin': [203, 226], 'reactive': [205], 'blue': [206], '2': [207], '(RB-2)': [208], 'diinosine': [210], 'pentaphosphate': [211], '(Ip<sub>5</sub>I).': [212], 'In': [213], 'contrast,': [214], 'rP2X<sub>1</sub>was': [219], 'TNP-ATP': [220], '=': [221, 227], 'Ip<sub>5</sub>I': [222], 'PPADS': [224], 'RB-2.': [228], 'Thus,': [229], 'Ca<sup>2+</sup>-sensitized': [231], 'is': [235], 'similar': [236], 'profile': [239], 'rP2X<sub>1</sub>—although': [242], 'can': [244], 'be': [245], 'distinguished': [246], 'from': [247], 'latter': [249], 'by': [250], 'agonism,': [252], 'antagonist': [253], 'profile,': [254], 'modulatory': [257], 'effects': [258], 'ions.': [263]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1982189276', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-13T17:39:46.613352', 'created_date': '2016-06-24'}