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1179, 1200, 1211, 1232, 1243, 1264, 1275], 'Eiheiji,': [51, 62, 80, 91, 109, 120, 138, 149, 167, 178, 196, 207, 226, 237, 1073, 1084, 1105, 1116, 1137, 1148, 1169, 1180, 1201, 1212, 1233, 1244, 1265, 1276], 'Japan': [52, 63, 81, 92, 110, 121, 139, 150, 168, 179, 197, 208, 227, 238, 1074, 1085, 1106, 1117, 1138, 1149, 1170, 1181, 1202, 1213, 1234, 1245, 1266, 1277], 'Organization': [53, 82, 111, 140, 169, 198, 228, 1075, 1107, 1139, 1171, 1203, 1235, 1267], 'for': [54, 83, 112, 141, 170, 199, 229, 264, 365, 492, 546, 640, 648, 757, 816, 1076, 1108, 1140, 1172, 1204, 1236, 1268], 'Life': [55, 84, 113, 142, 171, 200, 230, 798, 1077, 1109, 1141, 1173, 1205, 1237, 1269], 'Science': [56, 85, 114, 143, 172, 201, 231, 1078, 1110, 1142, 1174, 1206, 1238, 1270], 'Advancement': [57, 86, 115, 144, 173, 202, 232, 1079, 1111, 1143, 1175, 1207, 1239, 1271], 'Programs,': [58, 87, 116, 145, 174, 203, 233, 1080, 1112, 1144, 1176, 1208, 1240, 1272], ',': [64, 93, 122, 151, 180, 209], 'SuzukiFumiko': [66], 'Suzuki': [67, 1092], 'NishimuneAtsushi': [95], 'Nishimune': [96, 1124], 'YoshikiHatsumi': [124], 'Yoshiki': [125, 1156], 'AkinoHironobu': [153], 'Akino': [154, 1188], 'Urology,': [157, 186, 1191, 1223], 'Surgery,': [160, 189, 1194, 1226], 'School': [161, 190, 1195, 1227], 'Medicine,': [163, 192, 1197, 1229], 'YokoyamaOsamu': [182], 'Yokoyama': [183, 1220], 'MuramatsuIkunobu': [212], 'View': [239], 'All': [240, 1284], 'Author': [241], 'Informationhttps://doi.org/10.1016/j.juro.2009.09.078AboutFull': [242], 'TextPDF': [243], 'ToolsAdd': [244], 'to': [245, 282, 323, 338, 380, 456, 507, 791, 926, 1002], 'favoritesDownload': [246], 'CitationsTrack': [247], 'CitationsPermissionsReprints': [248], 'ShareFacebookLinked': [249], 'InTwitterEmail': [250], 'Abstract': [251], 'Purpose:': [252], 'Although': [253, 357], 'α1L-adrenoceptor': [254, 308], 'is': [255, 291, 448, 544, 1000], 'recognized': [256], 'as': [257, 273, 718], 'a': [258, 449, 632, 719, 753, 764, 786], 'target': [259], 'α1': [261], 'antagonist': [262, 310, 756], 'therapy': [263], 'benign': [265, 487, 759, 1007], 'prostatic': [266, 488, 760], 'hyperplasia,': [267], 'most': [269], 'common': [270], 'techniques,': [271], 'such': [272], 'immunohistochemistry': [274], 'situ': [277], 'hybridization,': [278], 'are': [279], 'not': [280, 402], 'applicable': [281], 'examine': [283], 'α1L-AR': [284, 290, 325], 'vs': [285], 'α1A-AR': [286, 298, 400], 'tissue': [287, 576, 810], 'distribution': [288], 'because': [289], 'now': [292], 'considered': [293], 'another': [294], 'phenotype': [295], 'sharing': [296], 'gene': [299, 543, 671], 'protein': [301], 'molecule.': [302], 'We': [303], 'labeled': [304], 'α1A': [306, 381, 457], 'selective': [309, 633, 711], 'silodosin': [311, 370], '(Kissei': [312], 'Pharmaceutical,': [313], 'Matsumoto,': [314], 'Japan)': [315], 'with': [316, 453, 494], 'fluorophore': [318], 'Alexa': [319, 923], 'Fluor®': [320], '488': [321], '(Alexa-488-silodosin)': [322], 'visualize': [324], 'expression.': [326], 'Materials': [327], 'Methods:': [329], 'Radioligand': [330], 'binding': [331, 372, 790, 812], 'functional': [333, 374, 641], 'bioassay': [334], 'experiments': [335], 'were': [336], 'done': [337], 'assess': [339], 'α1-AR': [340, 367], 'expression': [341, 970], 'Chinese': [343, 395, 418], 'hamster': [344, 396, 419], 'ovary': [345, 397, 420], 'cells': [346, 398, 421, 888], 'human': [348, 412, 436, 474, 573, 645, 739, 793, 796, 887, 981], 'prostate': [349, 437, 475, 574, 740, 1008], 'tissues.': [350], 'Confocal': [351, 384], 'imaging': [352, 385, 884], 'was': [353, 432], 'subsequently': [354], 'performed.': [355], 'Results:': [356], 'Alexa-488-silodosin': [358, 447, 461, 1055], 'had': [359, 377], 'about': [360], '10': [361, 680], 'times': [362], 'lower': [363], 'affinity': [364, 639], 'all': [366], 'subtypes': [368], 'than': [369], 'studies,': [375], 'it': [376], 'high': [378, 454], 'selectivity': [379, 455, 732], 'α1L-ARs.': [383, 459], 'revealed': [386], 'clear': [387], 'localization': [388, 866], 'fluorescence': [390, 431, 929], 'on': [391], 'membrane': [393], 'expressing': [399], 'but': [401, 430], 'α1B-and': [403], 'α1D-ARs,': [404], 'muscle': [408, 470, 872], 'layer': [409, 471], 'prostate.': [413, 556, 982], 'The': [414, 541, 992], 'fluorescent': [415, 451], 'signal': [416], 'disappeared': [422], 'presence': [425, 441], '3': [427, 521], 'nM': [428, 444], 'prazosin': [429], 'observed': [433], 'even': [438], '100': [443], 'prazosin.': [445], 'Conclusions:': [446], 'powerful': [450, 814], 'probe': [452], 'Thus,': [460], 'successfully': [462], 'visualizes': [463], 'site': [465], 'α1L-ARs': [467], 'without': [476], 'losing': [477], 'its': [478, 666, 716], 'distinct': [479, 947], 'pharmacological': [480], 'profile.': [481], 'References': [482], '1': [483], ':': [484, 505, 522, 540, 565, 587, 609, 627, 658, 681, 705, 730, 751, 781, 805, 831, 861, 882, 903, 918, 944, 967, 991], 'Alpha-adrenoceptors': [485], 'hyperplasia:': [489, 761], 'basic': [490], 'principles': [491], 'treatment': [493], 'alpha-adrenoceptor': [495], 'antagonists.': [496], 'World': [497], 'J': [498, 515, 531, 558, 579, 600, 620, 674, 698, 723, 743, 823, 874, 894, 936, 960, 983, 1010], 'Urol2002;': [499], '19:': [500, 877], '390.': [501], 'Google': [502, 519, 537, 562, 584, 606, 624, 655, 678, 702, 727, 748, 778, 802, 828, 858, 879, 900, 915, 941, 964, 988, 1015], 'Scholar': [503, 520, 538, 563, 585, 607, 625, 656, 679, 703, 728, 749, 779, 803, 829, 859, 880, 901, 916, 942, 965, 989, 1016], '2': [504], 'Guide': [506], 'receptors': [508], 'channels': [510], '(GRAC),': [511], '3rd': [512], 'edition.': [513], 'Br': [514, 557, 619, 673, 697, 722, 959], 'Pharmacol2008;': [516, 559, 675, 699], '153:': [517, 700], 'S1.': [518], 'Identification': [523, 566, 659, 682], 'alpha-1L': [525, 568], 'adrenoceptor': [526, 649, 949], 'rabbit': [528], 'ear': [529], 'artery.': [530], 'Pharmacol': [532, 601, 824, 895], 'Exp': [533, 602, 896], 'Ther2004;': [534], '310:': [535], '995.': [536], '4': [539], 'alpha1A-adrenoceptor': [542], 'required': [545], 'alpha1L-adrenoceptor-mediated': [548], 'response': [549, 592], 'isolated': [551], 'preparations': [552], 'mouse': [555], '155:': [560, 676], '103.': [561], '5': [564], 'alpha-1A': [570], 'adrenoceptors': [571], 'segment': [577, 811], 'binding.': [578], 'Urol2007;': [580], '177:': [581], '377.': [582], 'Link,': [583, 747, 987, 1014], '6': [586], 'Alpha-1': [588], 'alpha-2': [590], 'adrenoceptor:': [591], 'coupling': [593], 'canine': [595], 'saphenous': [596], 'femoral': [598], 'veins.': [599], 'Ther1986;': [603], '238:': [604], '131.': [605], '7': [608], 'Pharmacological': [610, 706, 782, 862], 'subclassification': [611], 'alpha': [613, 634, 642, 661, 669], '1-adrenoceptors': [614, 643], 'vascular': [616], 'smooth': [617, 871], 'muscle.': [618], 'Pharmacol1990;': [621], '99:': [622], '197.': [623], '8': [626], 'RS-17053': [628], '(N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha,': [629], 'alpha-dimethyl-1H-indole-3-ethanamine': [630], 'hydrochloride),': [631], '1A-adrenoceptor': [635, 670], 'antagonist,': [636, 713, 737], 'displays': [637], 'low': [638], 'prostate:': [646], 'implications': [647, 863], 'classification.': [650], 'Mol': [651], 'Pharmacol1996;': [652], '49:': [653], '209.': [654], '9': [657], '1L-adrenoceptor': [662], 'mice': [664], 'abolition': [667], 'knockout.': [672], '1224.': [677], 'alpha(1L)-adrenoceptor': [685], 'rat': [687], 'cerebral': [688], 'cortex': [689], 'possible': [691], 'relationship': [692], 'between': [693, 833], 'alpha(1L)-': [694], 'alpha(1A)-adrenoceptors.': [696], '1485.': [701], '11': [704], 'analysis': [707, 819], 'novel,': [710], 'alpha1-adrenoceptor': [712, 788], 'KMD-3213,': [714, 734], 'suitability': [717], 'tritiated': [720], 'radioligand.': [721], 'Pharmacol1999;': [724, 876], '127:': [725, 913], '19.': [726], '12': [729], 'an': [735, 851], 'alpha(1)-adrenoreceptor': [736], 'vasculature.': [742], 'Urol2000;': [744], '164:': [745], '578.': [746], '13': [750], 'Silodosin,': [752], 'new': [754], 'alpha1A-adrenoceptor-selective': [755], 'treating': [758], 'results': [762], 'phase': [765], 'III': [766], 'randomized,': [767], 'placebo-controlled,': [768], 'double-blind': [769], 'study': [770], 'Japanese': [772], 'men.': [773], 'BJU': [774], 'Int2006;': [775], '98:': [776, 826], '1019.': [777], '14': [780], 'characterization': [783], '[3H]-JTH-601,': [785], 'novel': [787], 'antagonist:': [789], 'recombinant': [792], 'alpha1-adrenoceptors': [794, 868], 'prostates.': [797], 'Sci2000;': [799], '67:': [800], '2443.': [801], '15': [804], 'Quantifying': [806], 'receptor': [807], 'properties:': [808], 'method—a': [813], 'tool': [815], 'pharmacome': [818], 'native': [821, 870], 'receptors.': [822], 'Sci2005;': [825], '331.': [827], '16': [830], 'Relationship': [832], 'inhibition': [835, 848], 'constant': [836], '(K1)': [837], 'concentration': [840], 'inhibitor': [842], 'which': [843], 'causes': [844], '50': [845], 'per': [846], 'cent': [847], '(I50)': [849], 'enzymatic': [852], 'reaction.': [853], 'Biochem': [854], 'Pharmacol1973;': [855], '22:': [856], '3099.': [857], '17': [860], 'cellular': [865], 'cells.': [873, 910], 'Auton': [875], '303.': [878], '18': [881], 'Quantitative': [883, 919], 'live': [886], 'reveals': [889], 'intracellular': [890], 'alpha(1)-adrenoceptor': [891], 'ligand-binding': [892], 'sites.': [893], 'Ther2000;': [897], '294:': [898], '434.': [899], '19': [902], 'Heterogeneous': [904], 'transportation': [905], 'alpha1B-adrenoceptor': [907], 'living': [909], 'Biophys': [911], 'Chem2007;': [912], '149.': [914], '20': [917], 'comparison': [920], 'long-wavelength': [922], 'Fluor': [924], 'dyes': [925, 932], 'Cy': [927], 'dyes:': [928], 'their': [934], 'bioconjugates.': [935], 'Histochem': [937], 'Cytochem2003;': [938], '51:': [939], '1699.': [940], '21': [943], 'Expression': [945], 'alpha1-': [948], 'phenotypes': [950], 'iris': [953], 'pigmented': [955], 'albino': [957], 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'hyperplasiaAcknowledgmentsDr.': [1039], 'Mamoru': [1040], 'Kobayashi,': [1041], 'Fukui': [1042, 1047], 'Medical': [1043], 'School,': [1044], 'Kissei': [1049], 'Pharmaceutical': [1050], 'Co.,': [1051], 'Ltd.': [1052], 'provided': [1053], 'silodosin,': [1054], '[3H]-silodosin.MetricsAuthor': [1057], 'Information': [1058], 'More': [1086, 1118, 1150, 1182, 1214, 1246, 1278], 'articles': [1087, 1119, 1151, 1183, 1215, 1247, 1279], 'this': [1089, 1121, 1153, 1185, 1217, 1249, 1281], 'author': [1090, 1122, 1154, 1186, 1218, 1250, 1282], 'Expand': [1283], 'PDF': [1286], 'downloadLoading': [1287], '...': [1288]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1982160295', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': 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