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[37, 220, 1074, 2899], 'insertion': [38, 221], 'motif': [42, 225], 'that': [43, 77, 226, 260, 658, 720, 1260, 1292, 1461, 2164, 2482, 2545, 3086, 3118, 3287, 3993, 4023], 'binds': [44, 227], 'structural': [46, 229], '(noncatalytic)': [47, 230], 'zinc': [48, 231], 'of': [49, 70, 84, 122, 162, 173, 232, 253, 267, 305, 345, 356, 369, 477, 528, 727, 769, 792, 798, 800, 880, 1070, 1184, 1270, 1867, 1890, 1970, 1986, 2027, 2031, 2193, 2301, 2352, 2552, 2594, 2617, 2623, 2625, 2705, 2895, 3010, 3096, 3694, 3717, 3798, 3814, 3855, 3859, 4056], 'MMPs.': [50, 94, 233, 277, 2539], 'Strikingly,': [51, 234], 'homologously': [53, 236, 2066, 3894], 'inserted': [54, 237], 'is': [56, 90, 239, 273, 458, 471, 1258, 2069, 2282, 2295, 3084, 3897], 'also': [57, 166, 240, 349, 777, 1466, 1818, 2602, 3292, 3645], 'found': [58, 241, 2070, 2163, 3898, 3992, 4022], 'Xenopus': [60, 243, 664, 2488], 'XMMP': [61, 78, 244, 261, 2073, 3901], 'human': [63, 246, 2075, 3903], 'MMP19,': [64, 247, 2076, 3904], 'two': [65, 248, 2077, 3905], 'recently': [66, 249, 2078, 3906], 'members': [69, 83, 252, 266, 879, 1269, 2704, 3095], 'MMP': [72, 86, 255, 269, 657, 882, 1272, 2033, 2481, 2707, 3098, 3861], 'family.': [73, 256], 'Phylogenetic': [74, 257], 'analysis': [75, 258], 'suggest': [76, 259], 'MMP19': [80, 263], 'represent': [81, 264], 'founding': [82, 265], 'family,': [87, 270, 2034, 3862], 'whereas': [88, 271], 'related': [91, 274], 'to': [92, 275, 460, 765, 1820, 2284, 2590, 3647, 4067, 4092], 'collagenase': [93, 276, 1286, 3112], 'Bacterially': [95, 278], 'produced': [96, 279, 1174, 2167, 3000, 3996, 4026], 'recombinant': [97, 280], '(without': [99, 282], 'amino-terminal': [101, 284, 1186, 3012], 'inhibition': [102, 285], 'domain),': [103, 286], 'which': [104, 287, 1178, 3004], 'was': [105, 126, 148, 165, 288, 309, 331, 348], 'autoproteolyzed': [106, 289], 'at': [107, 290, 749, 1097, 1265, 2574, 2922, 3091], 'carboxyl-terminal': [109, 292, 1037, 2862], 'digested': [111, 294], 'casein': [112, 295], 'gelatin.': [114, 297], 'As': [115, 298], 'shown': [116, 299], 'by': [117, 137, 151, 300, 320, 334, 474, 1073, 1181, 2298, 2898, 3007], 'Northern': [118, 301], 'blotting,': [119, 302], 'mRNA': [121, 161, 304, 344], '1.8': [123, 163, 306, 346], 'kilobase': [124, 307, 414, 456, 2238, 2280], 'pairs': [125, 308], 'constitutively': [127, 310], 'expressed': [128, 311, 382, 424, 1473, 1674, 2206, 2248, 3300, 3501], 'fibroblasts': [134, 317], 'up-regulated': [136, 179, 319, 362], 'tumor': [138, 321, 392, 434, 1826, 2216, 2258, 3653], 'necrosis': [139, 322, 393, 435, 2217, 2259], 'factor-α': [140, 323], 'phorbol': [143, 326], 'ester': [144, 327], '12-O-tetradecanoylphorbol-13-acetate,': [145, 328], 'but': [146, 329, 1029, 2854], 'it': [147, 330, 1257, 3083], 'not': [149, 332, 1026, 2188, 2851, 4017, 4047], 'regulated': [150, 333], 'interleukin-1,': [152, 335], 'basic': [153, 336], 'fibroblast': [154, 337, 386, 428, 2210, 2252], 'growth': [155, 338, 387, 429, 466, 1491, 1827, 2211, 2253, 2290, 3318, 3654], 'factor,': [156, 339], 'or': [157, 340], 'retinoic': [158, 341], 'acid.': [159, 342], 'kb': [164, 347], 'detected': [167, 350], 'head': [170, 353], 'body': [172, 355], '8-day-old': [174, 357], 'embryos': [176, 359, 666, 1990, 2490, 3818], 'dramatically': [178, 361], '9-day-old': [181, 364], 'embryos.': [182, 365], 'Degradation': [366, 2190], 'remodeling': [368, 1303, 1678, 1974, 2192, 3129, 3505, 3802], 'extracellular': [371, 379, 421, 2195, 2203, 2245], '(ECM)': [373, 2197], '1The': [374, 416, 2198, 2240], 'abbreviations': [375, 417, 2199, 2241], 'used': [376, 418, 2200, 2242], 'are:': [377, 419, 2201, 2243], 'ECM,': [378, 420, 2202, 2244], 'matrix;': [380, 422, 2204, 2246], 'EST,': [381, 423, 2205, 2247], 'tag;': [384, 426, 2208, 2250], 'FGF,': [385, 427, 2209, 2251], 'factor;': [388, 430, 2212, 2254], 'IL-1,': [389, 431, 2213, 2255], 'interleukin-1β;': [390, 432, 2214, 2256], 'TNF,': [391, 433, 2215, 2257], 'factor-α;': [394, 436, 2218, 2260], 'MMP,': [395, 437, 2219, 2261], 'metalloproteinase;': [397, 439, 2221, 2263], 'MOPS,': [398, 440, 2222, 2264], '4-morpholinepropanesulfonic': [399, 441, 2223, 2265], 'acid;': [400, 442, 2224, 2266], 'MT-MMP,': [401, 443, 2225, 2267], 'membrane-type': [402, 444, 714, 885, 2226, 2268, 2538, 2710], 'MMP;': [403, 445, 2227, 2269], 'PCR,': [404, 446, 2228, 2270], 'polymerase': [405, 447, 2229, 2271], 'chain': [406, 448, 2230, 2272], 'reaction;': [407, 449, 2231, 2273], 'TPA,': [408, 450, 2232, 2274], '12-O-tetradecanoylphorbol-13-acetate;': [409, 451, 2233, 2275], 'bp,': [410, 452, 2234, 2276], 'base': [411, 453, 2235, 2277], 'pair(s);': [412, 454, 2236, 2278], 'kb,': [413, 455, 2237, 2279], 'pair(s).': [415, 457, 2239, 2281], 'thought': [459, 1819, 2283, 3646], 'play': [461, 1821, 2285, 3648], 'important': [462, 2286], 'morphogenic': [463, 2287], 'roles': [464, 1487, 2288, 3314], 'during': [465, 1475, 1692, 2289, 3302, 3519], 'development.': [468, 2292], 'ECM': [469, 799, 841, 1080, 1300, 1971, 2293, 2624, 2666, 2905, 3126, 3799], 'degradation': [470, 1096, 1301, 1972, 2294, 2921, 3127, 3800], 'largely': [472, 2296], 'controlled': [473, 2297], 'superfamily': [476, 2300], 'zinc-dependent': [478, 2302], 'endopeptidases': [479, 2303], 'metalloproteinases': [482, 1987, 2306, 3815], '(MMPs).': [483, 2307], 'At': [484, 2308], 'present,': [485, 2309], '18': [486, 2310], 'different': [487, 829, 2311, 2654], 'MMPs': [488, 689, 830, 886, 1489, 1671, 1816, 1982, 2081, 2312, 2513, 2655, 2711, 2998, 3298, 3316, 3498, 3643, 3810, 3909], 'have': [489, 698, 2161, 2313, 2522, 3990, 4020], 'been': [490, 2314], 'characterized': [493, 1066, 2317, 2891], '(1Woessner': [494, 2318], 'Jr.,': [495, 521, 1883, 2319, 2345, 3710], 'J.F.': [496, 2320], 'FASEB': [497, 2321], 'J.': [498, 554, 580, 605, 638, 673, 897, 947, 965, 1008, 1105, 1122, 1129, 1157, 1203, 1240, 1315, 1330, 1356, 1387, 1406, 1444, 1504, 1554, 1568, 1572, 1574, 1616, 1659, 1711, 1753, 1758, 1782, 1805, 1951, 2004, 2083, 2120, 2142, 2322, 2378, 2404, 2429, 2462, 2497, 2722, 2772, 2790, 2833, 2930, 2947, 2954, 2982, 3029, 3066, 3141, 3156, 3182, 3213, 3232, 3270, 3331, 3381, 3395, 3399, 3401, 3443, 3486, 3538, 3580, 3585, 3609, 3632, 3778, 3832, 3911, 3948, 3970], '1991;': [499, 2323], '5:': [500, 2324], '2145-2154Crossref': [501, 2325], 'PubMed': [502, 548, 570, 595, 617, 649, 684, 821, 871, 908, 937, 952, 976, 1019, 1061, 1116, 1140, 1168, 1214, 1227, 1251, 1319, 1339, 1367, 1391, 1417, 1455, 1515, 1535, 1560, 1601, 1622, 1640, 1665, 1722, 1739, 1788, 1811, 1843, 1858, 1920, 1934, 1962, 2015, 2099, 2131, 2153, 2326, 2372, 2394, 2419, 2441, 2473, 2508, 2646, 2696, 2733, 2762, 2777, 2801, 2844, 2886, 2941, 2965, 2993, 3040, 3053, 3077, 3145, 3165, 3193, 3217, 3243, 3281, 3342, 3362, 3387, 3428, 3449, 3467, 3492, 3549, 3566, 3615, 3638, 3670, 3685, 3747, 3761, 3789, 3843, 3927, 3959, 3981], 'Scopus': [503, 549, 571, 596, 618, 650, 685, 822, 872, 909, 938, 953, 977, 1020, 1062, 1117, 1141, 1169, 1215, 1228, 1252, 1320, 1368, 1392, 1418, 1456, 1516, 1536, 1602, 1623, 1641, 1723, 1740, 1789, 1812, 1844, 1859, 1935, 1963, 2016, 2100, 2132, 2154, 2327, 2373, 2395, 2420, 2442, 2474, 2509, 2647, 2697, 2734, 2763, 2778, 2802, 2845, 2887, 2942, 2966, 2994, 3041, 3054, 3078, 3146, 3194, 3218, 3244, 3282, 3343, 3363, 3429, 3450, 3468, 3550, 3567, 3616, 3639, 3671, 3686, 3762, 3790, 3844, 3928, 3960, 3982], '(3072)': [504, 2328], 'Google': [505, 551, 573, 598, 620, 652, 687, 824, 874, 911, 940, 955, 979, 996, 1022, 1064, 1119, 1143, 1171, 1217, 1230, 1254, 1322, 1340, 1370, 1394, 1420, 1458, 1518, 1538, 1561, 1587, 1604, 1625, 1643, 1666, 1725, 1742, 1764, 1791, 1814, 1846, 1861, 1921, 1937, 1965, 2018, 2102, 2134, 2156, 2329, 2375, 2397, 2422, 2444, 2476, 2511, 2649, 2699, 2736, 2765, 2780, 2804, 2821, 2847, 2889, 2944, 2968, 2996, 3043, 3056, 3080, 3148, 3166, 3196, 3220, 3246, 3284, 3345, 3365, 3388, 3414, 3431, 3452, 3470, 3493, 3552, 3569, 3591, 3618, 3641, 3673, 3688, 3748, 3764, 3792, 3846, 3930, 3962, 3984], 'Scholar,': [506, 513, 538, 552, 574, 599, 621, 912, 941, 956, 980, 997, 1120, 1144, 1218, 1231, 1323, 1341, 1371, 1395, 1519, 1539, 1562, 1588, 1605, 1626, 1644, 1726, 1743, 1765, 1792, 1847, 1900, 1922, 1938, 2103, 2135, 2330, 2337, 2362, 2376, 2398, 2423, 2445, 2737, 2766, 2781, 2805, 2822, 2945, 2969, 3044, 3057, 3149, 3167, 3197, 3221, 3346, 3366, 3389, 3415, 3432, 3453, 3471, 3553, 3570, 3592, 3619, 3674, 3727, 3749, 3765, 3931, 3963], '2Matrisian': [507, 2331], 'L.M.': [508, 1594, 1769, 1851, 2332, 3421, 3596, 3678], 'BioEssays.': [509, 2333], '1992;': [510, 1333, 2334, 3159], '6:': [511, 1585, 1599, 2335, 3412, 3426], '121-125Google': [512, 2336], '3Werb': [514, 2338], 'Z.': [515, 1529, 1732, 1877, 2339, 3356, 3559, 3704], 'Alexander': [516, 1878, 2340, 3705], 'C.M.': [517, 1879, 2341, 3706], 'Kelley': [518, 1880, 2342, 3707], 'W.M.': [519, 1881, 2343, 3708], 'Harris': [520, 1882, 2344, 3709], 'E.D.': [522, 1884, 2346, 3711], 'Ruddy': [523, 1885, 2347, 3712], 'S.': [524, 633, 932, 1046, 1050, 1128, 1433, 1437, 1564, 1833, 1886, 1940, 2115, 2348, 2457, 2757, 2871, 2875, 2953, 3259, 3263, 3391, 3660, 3713, 3767, 3943, 4075], 'Sledge': [525, 1887, 2349, 3714], 'C.B.': [526, 1888, 2350, 3715], 'Textbook': [527, 1889, 2351, 3716], 'Rheumatology.': [529, 1891, 2353, 3718], '4th': [530, 1892, 2354, 3719], 'Ed.': [531, 1893, 2355, 3720], 'W.': [532, 1126, 1894, 2356, 2951, 3721], 'B.': [533, 945, 1401, 1551, 1895, 2357, 2770, 3227, 3378, 3722], 'Saunders': [534, 1896, 2358, 3723], 'Co.,': [535, 1897, 2359, 3724], 'Philadelphia1994:': [536, 1898, 2360, 3725], '248-268Google': [537, 1899, 2361, 3726], '4Birkedal-Hansen': [539, 2363], 'H.': [540, 891, 943, 960, 1152, 1237, 1329, 1385, 1435, 1443, 1576, 1912, 2364, 2716, 2768, 2785, 2977, 3063, 3155, 3211, 3261, 3269, 3403, 3739, 4076], 'Curr.': [541, 2365], 'Opin.': [542, 2366], 'Cell': [543, 1555, 1581, 1617, 1660, 1759, 1806, 1838, 2367, 3382, 3408, 3444, 3487, 3586, 3633, 3665], 'Biol.': [544, 590, 639, 674, 966, 1009, 1106, 1130, 1158, 1204, 1241, 1331, 1357, 1407, 1445, 1505, 1596, 1618, 1712, 1807, 1839, 1952, 2005, 2121, 2143, 2368, 2414, 2463, 2498, 2791, 2834, 2931, 2955, 2983, 3030, 3067, 3157, 3183, 3233, 3271, 3332, 3423, 3445, 3539, 3634, 3666, 3779, 3833, 3949, 3971], '1995;': [545, 868, 934, 949, 968, 1206, 1224, 1359, 1557, 1584, 1598, 1637, 1714, 1736, 1855, 2369, 2693, 2759, 2774, 2793, 3032, 3050, 3185, 3384, 3411, 3425, 3464, 3541, 3563, 3682], '7:': [546, 593, 2370, 2417], '728-735Crossref': [547, 2371], '(974)': [550, 2374], '5Cossins': [553, 2377], 'Dudgeon': [555, 2084, 2379, 3912], 'T.J.': [556, 2085, 2380, 3913], 'Catlin': [557, 2086, 2381, 3914], 'G.': [558, 635, 988, 1196, 1235, 1305, 1403, 1405, 2087, 2117, 2382, 2459, 2813, 3022, 3061, 3131, 3229, 3231, 3915, 3945], 'Gearing': [559, 2088, 2383, 3916], 'A.J.H.': [560, 2089, 2384, 3917], 'Clements': [561, 2090, 2385, 3918], 'J.M.': [562, 1700, 2091, 2386, 3527, 3919], 'Biochem.': [563, 948, 1314, 1386, 2092, 2387, 2773, 3140, 3212, 3920], 'Biophys.': [564, 1056, 2093, 2388, 2881, 3921], 'Res.': [565, 992, 2094, 2389, 2817, 3922], 'Commun.': [566, 2095, 2390, 3923], '1996;': [567, 592, 614, 993, 1011, 1108, 1132, 1243, 1409, 1507, 1761, 1954, 2007, 2096, 2391, 2416, 2438, 2818, 2836, 2933, 2957, 3069, 3235, 3334, 3588, 3781, 3835, 3924], '228:': [568, 2097, 2392, 3925], '494-498Crossref': [569, 2098, 2393, 3926], '(102)': [572, 2101, 2396, 3929], '6Stolov': [575, 2399], 'M.A.': [576, 2400], 'Bauzon': [577, 2401], 'D.D.': [578, 2402], 'Li': [579, 2403], 'Sedgwick': [581, 2405], 'T.': [582, 893, 958, 1052, 1427, 1429, 1646, 2406, 2718, 2783, 2877, 3253, 3255, 3473], 'Liang': [583, 2407], 'V.C.-T.': [584, 2408], 'Sang': [585, 2409, 4060], 'Q.A.': [586, 2410], 'Shi': [587, 2411], 'Y.-B.': [588, 2412], 'Mol.': [589, 1595, 2413, 3422], 'Cell.': [591, 1597, 2415, 3424], '1471-1483Crossref': [594, 2418], '(125)': [597, 2421], '7Bartlett': [600, 2424], 'J.D.': [601, 859, 2425, 2684], 'Simmer': [602, 2426], 'J.P.': [603, 1590, 2427, 3417], 'Xue': [604, 2428], 'Margolis': [606, 2430], 'H.C.': [607, 2431], 'Moreno': [608, 2432], 'E.C.': [609, 2433], 'Gene': [610, 2434], '(': [611, 2435], 'Amst.': [612, 2436], ').': [613, 2437], '183:': [615, 2439], '123-128Crossref': [616, 2440], '(176)': [619, 2443], '8Pendas': [622, 2104, 2446, 3932], 'A.M.': [623, 984, 1906, 1950, 2105, 2447, 2809, 3733, 3777, 3933], 'Knauper': [624, 2106, 2448, 3934], 'V.': [625, 1373, 1397, 1541, 2107, 2449, 3199, 3223, 3368, 3935], 'Puente': [626, 2108, 2450, 3936], 'X.S.': [627, 982, 2109, 2451, 2807, 3937], 'Llano': [628, 2110, 2452, 3938], 'E.': [629, 901, 986, 1146, 1349, 1747, 1908, 2111, 2453, 2726, 2811, 2971, 3175, 3574, 3735, 3939], 'Mattei': [630, 2112, 2454, 3940], 'M.-G.': [631, 2113, 2455, 3941], 'Apte': [632, 2114, 2456, 3942], 'Murphy': [634, 1404, 2116, 2458, 3230, 3944], 'Lopez-Otin': [636, 989, 1398, 2118, 2460, 2814, 3224, 3946], 'C.': [637, 990, 1399, 1609, 1611, 1777, 1796, 2119, 2461, 2815, 3225, 3436, 3438, 3604, 3623, 3947], 'Chem.': [640, 675, 817, 967, 1010, 1107, 1131, 1159, 1205, 1242, 1332, 1358, 1408, 1446, 1506, 1713, 1953, 2006, 2122, 2144, 2464, 2499, 2642, 2792, 2835, 2932, 2956, 2984, 3031, 3068, 3158, 3184, 3234, 3272, 3333, 3540, 3780, 3834, 3950, 3972], '1997;': [641, 676, 1058, 1160, 1447, 1662, 1808, 2123, 2145, 2465, 2500, 2883, 2985, 3273, 3489, 3635, 3951, 3973], '272:': [642, 677, 1161, 1448, 2124, 2146, 2466, 2501, 2986, 3274, 3952, 3974], '4281-4286Abstract': [643, 2125, 2467, 3953], 'Full': [644, 646, 679, 681, 971, 973, 1014, 1016, 1111, 1113, 1135, 1137, 1163, 1165, 1209, 1211, 1246, 1248, 1336, 1362, 1364, 1412, 1414, 1450, 1452, 1510, 1512, 1717, 1719, 1957, 1959, 2010, 2012, 2126, 2128, 2148, 2150, 2468, 2470, 2503, 2505, 2796, 2798, 2839, 2841, 2936, 2938, 2960, 2962, 2988, 2990, 3035, 3037, 3072, 3074, 3162, 3188, 3190, 3238, 3240, 3276, 3278, 3337, 3339, 3544, 3546, 3784, 3786, 3838, 3840, 3954, 3956, 3976, 3978], 'Text': [645, 647, 680, 682, 972, 974, 1015, 1017, 1112, 1114, 1136, 1138, 1164, 1166, 1210, 1212, 1247, 1249, 1337, 1363, 1365, 1413, 1415, 1451, 1453, 1511, 1513, 1718, 1720, 1958, 1960, 2011, 2013, 2127, 2129, 2149, 2151, 2469, 2471, 2504, 2506, 2797, 2799, 2840, 2842, 2937, 2939, 2961, 2963, 2989, 2991, 3036, 3038, 3073, 3075, 3163, 3189, 3191, 3239, 3241, 3277, 3279, 3338, 3340, 3545, 3547, 3785, 3787, 3839, 3841, 3955, 3957, 3977, 3979], 'PDF': [648, 683, 975, 1018, 1115, 1139, 1167, 1213, 1250, 1338, 1366, 1416, 1454, 1514, 1721, 1961, 2014, 2130, 2152, 2472, 2507, 2800, 2843, 2940, 2964, 2992, 3039, 3076, 3164, 3192, 3242, 3280, 3341, 3548, 3788, 3842, 3958, 3980], '(180)': [651, 2133, 2475, 3961], 'Scholar),': [653, 2477], 'we': [659, 1979, 2021, 2483, 3807, 3849], 'frog': [663, 2487], 'laevis': [665, 2489], '(9Yang': [667, 2491], 'M.': [668, 672, 903, 964, 999, 1003, 1007, 1048, 1154, 1239, 1431, 1439, 1495, 1499, 1503, 1650, 1654, 1946, 1995, 1999, 2003, 2137, 2141, 2492, 2496, 2728, 2789, 2824, 2828, 2832, 2873, 2979, 3065, 3257, 3265, 3322, 3326, 3330, 3477, 3481, 3773, 3823, 3827, 3831, 3965, 3969], 'Murray': [669, 850, 2138, 2493, 2675, 3966], 'M.T.': [670, 2139, 2494, 3967], 'Kurkinen': [671, 1006, 1238, 1502, 1945, 2002, 2140, 2495, 2831, 3064, 3329, 3772, 3830, 3968], '13527-13533Abstract': [678, 2147, 2502, 3975], '(45)': [686, 2155, 2510, 3983], 'Scholar).': [688, 825, 875, 1023, 1255, 1421, 1667, 1815, 2019, 2512, 2650, 2700, 2848, 2997, 3081, 3247, 3494, 3642, 3793, 3847, 3985], 'share': [690, 2514], 'similar': [691, 2515], 'domains': [692, 2516], 'with': [693, 831, 2517, 2656], 'distinct': [694, 1486, 2518, 3313], 'structure': [695, 2519], 'function,': [697, 2521], 'wide': [699, 832, 2523, 2657], 'often': [701, 1477, 2525, 3304], 'overlapping': [702, 2526], 'substrate': [703, 833, 2527, 2658], 'specificities,': [704, 2528], 'are': [706, 716, 827, 1025, 1173, 1179, 1472, 1672, 1817, 1980, 2530, 2541, 2652, 2850, 2999, 3005, 3299, 3499, 3644, 3808, 4090], 'usually': [707, 2531], 'grouped': [708, 2532], 'as': [709, 732, 779, 1175, 1681, 1871, 2533, 2557, 2604, 3001, 3508, 3698], 'collagenases,': [710, 785, 2534, 2610], 'gelatinases,': [711, 2535], 'stromelysins,': [712, 2536], 'MMPs.Collagenases': [715], 'only': [718, 2071, 2543, 3899], 'enzymes': [719, 2544], 'can': [721, 837, 1465, 2546, 2662, 3291], 'cleave': [722, 1083, 2174, 2547, 2908, 4003, 4033], 'triple': [724, 2549], 'helical': [725, 2550], 'regions': [726, 2551], 'interstitial': [728, 1275, 2553, 3101], 'fibrillar': [729, 771, 2176, 2554, 2596, 4005, 4035], 'collagens': [730, 2555], 'such': [731, 1680, 1870, 2556, 3507, 3697], 'collagen': [733, 762, 788, 2179, 2558, 2587, 2613, 4008, 4038], 'types': [734, 2559], 'I,': [735, 2560], 'II,': [736, 2561], 'III,': [738, 2563], 'most': [740, 2565], 'abundant': [741, 2566], 'proteins': [742, 2567], 'body.': [745, 2570], 'cleavage': [747, 2572], 'occurs': [748, 2573], 'one': [750, 2575], 'specific': [751, 2576], 'bond,': [753, 2578], 'Gly775–Ile776': [754, 2579], '(Leu776': [755, 2580], 'α2(I)-chain)': [758, 2583], 'type': [760, 783, 797, 1087, 1284, 2177, 2585, 2608, 2622, 2912, 3110, 4006, 4036], 'I': [761, 2178, 2586, 4007, 4037], 'leads': [764, 2589], 'unfolding': [766, 2591], 'denaturation': [768, 2593], 'collagens.': [772, 2597], 'Gelatinases': [773, 2598], 'A': [774, 2043, 2065, 2599, 3871, 3893], 'B,': [776, 2601], 'known': [778, 2603], '72-': [780, 2605], '92-kDa': [782, 1283, 2607, 3109], 'IV': [784, 1088, 1285, 2609, 2913, 3111], 'digest': [786, 2611], 'denatured': [787, 2612], '(gelatin)': [789, 2614], 'components': [791, 2616], 'basement': [793, 2618], 'membranes,': [794, 2619], 'special': [796, 1296, 2621, 3122], 'epithelial,': [801, 2626], 'endothelial,': [802, 2627], 'fat,': [803, 2628], 'muscle,': [804, 2629], 'peripheral': [806, 2631], 'nerve': [807, 2632], 'cells': [808, 1993, 2633, 3821], '(10Martin': [809, 2634], 'G.R.': [810, 2635], 'Timpl': [811, 2636], 'R.': [812, 1566, 1628, 2637, 3393, 3455], 'Kuhn': [813, 2638], 'K.': [814, 1001, 1148, 1343, 1497, 1615, 1997, 2639, 2826, 2973, 3169, 3324, 3442, 3825], 'Adv.': [815, 2640], 'Prot.': [816, 2641], '1988;': [818, 2643], '39:': [819, 2644], '1-50Crossref': [820, 2645], '(114)': [823, 2648], 'Stromelysins': [826, 2651], 'three': [828, 2653], 'specificity,': [834, 2659], 'stromelysin-1': [836, 1261, 1293, 2661, 3087, 3119], 'degrade': [838, 1079, 2663, 2904], 'almost': [839, 2664], 'any': [840, 2665], 'component': [842, 2667], 'cartilage': [844, 2669], 'proteoglycans': [845, 2670], '(11Bonassar': [846, 2671], 'L.J.': [847, 2672], 'Frank': [848, 2673], 'E.H.': [849, 2674], 'J.C.': [851, 2676], 'Paguio': [852, 2677], 'C.G.': [853, 2678], 'Moore': [854, 2679], 'V.L.': [855, 2680], 'Lark': [856, 2681], 'M.W.': [857, 2682], 'Sandy': [858, 2683], 'Wu': [860, 2685], 'J.J.': [861, 1327, 2686, 3153], 'Eyre': [862, 2687], 'D.R.': [863, 2688], 'Grodzinsky': [864, 2689], 'A.J.': [865, 2690], 'Arthritis': [866, 1929, 2691, 3756], 'Rheum.': [867, 1930, 2692, 3757], '38:': [869, 2694], '173-183Crossref': [870, 2695], '(140)': [873, 2698], 'Recently,': [876, 1040, 1422, 2701, 2865, 3248], 'four': [877, 2702], 'new': [878, 2703], 'family': [883, 1273, 2708, 3099], '(MT-MMPs)': [887, 2712], 'were': [888, 2713], '(12Sato': [890, 2715], 'Takino': [892, 2717], 'Okada': [894, 1155, 1354, 1750, 2719, 2980, 3180, 3577], 'Y.': [895, 1054, 1150, 1156, 1325, 1345, 1351, 1355, 1441, 1547, 1751, 1755, 1798, 1904, 2720, 2879, 2975, 2981, 3151, 3171, 3177, 3181, 3267, 3374, 3578, 3582, 3625, 3731], 'Cao': [896, 2721], 'Shinagawa': [898, 961, 2723, 2786], 'A.': [899, 914, 933, 962, 1124, 1383, 1570, 1698, 1794, 1944, 2724, 2739, 2758, 2787, 2949, 3209, 3397, 3525, 3621, 3771], 'Yamamoto': [900, 2725], 'Seiki': [902, 963, 1153, 2727, 2788, 2978], 'Nature.': [904, 1223, 2729, 3049], '1994;': [905, 1619, 1785, 1917, 1931, 2730, 3446, 3612, 3744, 3758], '370:': [906, 2731], '61-65Crossref': [907, 2732], '(2365)': [910, 2735], '13Okada': [913, 2738], 'Bellocq': [915, 1799, 2740, 3626], 'J.-P.': [916, 1800, 2741, 3627], 'Royer': [917, 2742], 'N.': [918, 1353, 1706, 1728, 1773, 2743, 3179, 3533, 3555, 3600], 'Chenard': [919, 2744], 'M.-P.': [920, 2745], 'Rio': [921, 1801, 2746, 3628], 'M.-C.': [922, 1802, 2747, 3629], 'Chambon': [923, 2748], 'P.': [924, 926, 1545, 1580, 1607, 1749, 1775, 1804, 1942, 2749, 2751, 3372, 3407, 3434, 3576, 3602, 3631, 3769], 'Basset': [925, 1803, 2750, 3630], 'Proc.': [927, 2752], 'Natl.': [928, 2753], 'Acad.': [929, 2754], 'Sci.': [930, 1556, 1661, 1760, 2755, 3383, 3488, 3587], 'U.': [931, 1233, 2756, 3059], '92:': [935, 2760], '2730-2734Crossref': [936, 2761], '(486)': [939, 2764], '14Will': [942, 2767], 'Hinzmann': [944, 2769], 'Eur.': [946, 2771], '231:': [950, 2775], '602-608Crossref': [951, 2776], '(317)': [954, 2779], '15Takino': [957, 2782], 'Sato': [959, 1151, 2784, 2976], '270:': [969, 1207, 1360, 1715, 2794, 3033, 3186, 3542], '23013-23020Abstract': [970, 2795], '(447)': [978, 2803], '16Puente': [981, 2806], 'Pendas': [983, 2808], 'Liano': [985, 2810], 'Velasco': [987, 2812], 'Cancer': [991, 1852, 2816, 3679], '56:': [994, 2819], '944-949PubMed': [995, 2820], '17Yang': [998, 2823], 'Hayashi': [1000, 1002, 1496, 1498, 1996, 1998, 2825, 2827, 3323, 3325, 3824, 3826], 'Fujii': [1004, 1149, 1350, 1500, 2000, 2829, 2974, 3176, 3327, 3828], 'J.T.': [1005, 1501, 2001, 2830, 3328, 3829], '271:': [1012, 1109, 1133, 1244, 1410, 1508, 1955, 2008, 2837, 2934, 2958, 3070, 3236, 3335, 3782, 3836], '25548-25554Abstract': [1013, 1509, 2009, 2838, 3336, 3837], '(37)': [1021, 1517, 2017, 2846, 3344, 3845], 'They': [1024, 2849], 'secreted': [1027, 1068, 2852, 2893], 'extracellularly': [1028, 2853], 'remain': [1030, 2855], 'on': [1031, 2856, 4085], 'cell': [1033, 1099, 2858, 2924], 'surface': [1034, 1100, 2859, 2925], 'through': [1035, 2860], 'their': [1036, 1185, 2861, 3011], 'transmembrane': [1038, 2863], 'domain.': [1039, 2064, 2864, 3892], 'however,': [1041, 2866], 'Matsumoto': [1042, 2867], 'et': [1043, 1424, 2868, 3250], 'al.': [1044, 1425, 2869, 3251], '(18Matsumoto': [1045, 2870], 'Katoh': [1047, 2872], 'Saito': [1049, 2874], 'Watanabe': [1051, 2876], 'Masuho': [1053, 2878], 'Biochim.': [1055, 2880], 'Acta.': [1057, 2882], '1354:': [1059, 2884], '159-170Crossref': [1060, 2885], '(87)': [1063, 2888], 'Scholar)': [1065, 1459, 1862, 2890, 3285, 3689], 'form': [1069, 2894], 'MT3-MMP': [1071, 2896], 'encoded': [1072, 2897], 'alternatively': [1075, 2900], 'spliced': [1076, 2901], 'mRNA.': [1077, 2902], 'MT-MMPs': [1078, 2903], 'components,': [1081, 2906], 'proteolytically': [1082, 1263, 2907, 3089], 'activate': [1085, 1467, 2910, 3293], '72-kDa': [1086, 2911], 'collagenase,': [1089, 2914], 'therefore': [1091, 2916], 'may': [1092, 2917], 'regulate': [1093, 2918], 'pericellular': [1094, 2919], '(19Pei': [1101, 2926], 'D.': [1102, 1220, 1549, 2927, 3046, 3376], 'Weiss': [1103, 1221, 2928, 3047], 'S.J.': [1104, 1222, 2929, 3048], '9135-9140Abstract': [1110, 2935], '(364)': [1118, 2943], '20Cao': [1121, 2946], 'Rehemtulla': [1123, 2948], 'Bahou': [1125, 2950], 'Zucker': [1127, 2952], '30174-30180Abstract': [1134, 2959], '(101)': [1142, 2967], '21Ohuchi': [1145, 2970], 'Imai': [1147, 2972], '2446-2451Abstract': [1162, 2987], '(827)': [1170, 2995], 'Scholar).MMPs': [1172], 'inactive': [1176, 3002], 'precursors,': [1177, 3003], 'activated': [1180, 2169, 3006, 3998, 4028], 'proteolytic': [1182, 3008], 'removal': [1183, 3009], '78–178-residue-long': [1189, 3015], 'propeptide': [1190, 3016], '(22Strongin': [1191, 3017], 'A.Y.': [1192, 3018], 'Collier': [1193, 3019], 'I.': [1194, 1347, 1613, 1745, 3020, 3173, 3440, 3572], 'Bannikov': [1195, 3021], 'Marmer': [1197, 3023], 'B.L.': [1198, 3024], 'Grant': [1199, 3025], 'G.A.': [1200, 1708, 3026, 3535], 'Goldberg': [1201, 3027], 'G.I.': [1202, 3028], '5331-5338Abstract': [1208, 3034], '(1434)': [1216, 3042], '23Pei': [1219, 3045], '375:': [1225, 3051], '244-247Crossref': [1226, 3052], '(530)': [1229, 3055], '24Benbow': [1232, 3058], 'Butticé': [1234, 3060], 'Nagase': [1236, 1328, 1911, 3062, 3154, 3738, 4080], '10715-10722Abstract': [1245, 3071], '(24)': [1253, 3079], 'Thus,': [1256, 3082], 'striking': [1259, 3085], '(MMP3)': [1262, 3088], 'activates': [1264, 3090], 'least': [1266, 3092], 'five': [1267, 3093], 'other': [1268, 1868, 3094, 3695], 'collagenase-1': [1276, 3102], '(MMP1),': [1277, 3103], 'matrilysin': [1278, 3104], '(MMP7),': [1279, 3105], 'neutrophil': [1280, 3106], 'collagenase-2': [1281, 3107], '(MMP8),': [1282, 3108], '(MMP9),': [1287, 3113], 'collagenase-3': [1289, 3115], '(MMP13),': [1290, 3116], 'suggesting': [1291, 1485, 3117, 3312], 'plays': [1294, 3120], '"upstream"': [1297, 3123], 'role': [1298, 1824, 1969, 3124, 3651, 3797], '(25Murphy': [1304, 3130], 'Cockett': [1306, 3132], 'M.I.': [1307, 3133], 'Stephens': [1308, 3134], 'P.E.': [1309, 3135], 'Smith': [1310, 1400, 3136, 3226], 'B.J.': [1311, 3137], 'Docherty': [1312, 3138], 'A.J.P.': [1313, 3139], '1987;': [1316, 3142], '248:': [1317, 3143], '265-268Crossref': [1318, 3144], '(390)': [1321, 3147], '26Ogata': [1324, 3150], 'Enghild': [1326, 3152], '267:': [1334, 1737, 3160, 3564], '3581-3584Abstract': [1335, 3161], '27Imai': [1342, 3168], 'Yokohama': [1344, 3170], 'Nakanishi': [1346, 3172], 'Ohuchi': [1348, 3174], 'Nakai': [1352, 3178], '6691-6697Abstract': [1361, 3187], '(264)': [1369, 3195], '28Knauper': [1372, 3198], 'Wilhelm': [1374, 3200], 'S.M.': [1375, 3201], 'Seperack': [1376, 3202], 'P.K.': [1377, 3203], 'DeClerck': [1378, 3204], 'Y.A.': [1379, 3205], 'Langley': [1380, 3206], 'K.E.': [1381, 3207], 'Osthues': [1382, 3208], 'Tschesche': [1384, 3210], '1993;': [1388, 1840, 3214, 3667], '295:': [1389, 3215], '581-586Crossref': [1390, 3216], '(152)': [1393, 3219], '29Knauper': [1396, 3222], 'Knight': [1402, 3228], '1544-1558Abstract': [1411, 3237], '(782)': [1419, 3245], 'Okamoto': [1423, 3249], '(30Okamoto': [1426, 3252], 'Akaike': [1428, 3254], 'Suga': [1430, 3256], 'Tanase': [1432, 3258], 'Horie': [1434, 3260], 'Miyajima': [1436, 3262], 'Ando': [1438, 3264], 'Ichinose': [1440, 3266], 'Maeda': [1442, 3268], '6059-6066Abstract': [1449, 3275], '(139)': [1457, 3283], 'reported': [1460, 3286], 'various': [1462, 3288], 'bacterial': [1463, 3289], 'proteinases': [1464, 3290], 'MMP1,': [1468, 3294], 'MMP2,': [1469, 3295], 'MMP9.MMPs': [1471], 'widely': [1474, 3301], 'embryogenesis,': [1476, 3303], 'highly': [1480, 3307], 'tissue-': [1481, 3308], 'cell-specific': [1483, 3310], 'pattern,': [1484, 3311], 'for': [1488, 3315, 4053, 4061, 4081, 4096, 4100], 'development': [1493, 3320], '(17Yang': [1494, 1994, 3321, 3822], '31Brenner': [1520, 3347], 'C.A.': [1521, 3348], 'Adler': [1522, 3349], 'R.R.': [1523, 3350], 'Rappolee': [1524, 3351], 'D.A.': [1525, 3352], 'Pedersen': [1526, 3353], 'R.A.': [1527, 3354], 'Werb': [1528, 1731, 3355, 3558], 'Genes': [1530, 3357], 'Dev.': [1531, 1635, 3358, 3462], '1989;': [1532, 3359], '3:': [1533, 3360], '848-859Crossref': [1534, 3361], '(239)': [1537, 3364], '32Mattot': [1540, 3367], 'Raes': [1542, 3369], 'M.B.': [1543, 3370], 'Henriet': [1544, 1748, 3371, 3575], 'Eeckhout': [1546, 1754, 3373, 3581], 'Stehelin': [1548, 3375], 'Vandenbunder': [1550, 3377], 'Desbiens': [1552, 3379], 'X.': [1553, 3380], '108:': [1558, 3385], '529-535Crossref': [1559, 3386], '33Gack': [1563, 3390], 'Vallon': [1565, 3392], 'Schmidt': [1567, 3394], 'Grigoriadis': [1569, 3396], 'Tuckermann': [1571, 3398], 'Schenkel': [1573, 3400], 'Wiher': [1575, 3402], 'Wagner': [1577, 3404], 'E.F.': [1578, 3405], 'Angel': [1579, 3406], 'Growth': [1582, 3409], 'Differ.': [1583, 3410], '759-767PubMed': [1586, 3413], '34Witty': [1589, 3416], 'Wright': [1591, 3418], 'J.H.': [1592, 3419], 'Matrisian': [1593, 1768, 1850, 3420, 3595, 3677], '1287-1303Crossref': [1600, 3427], '(169)': [1603, 3430], '35Reponen': [1606, 3433], 'Sahlberg': [1608, 3435], 'Munaut': [1610, 3437], 'Thesleff': [1612, 3439], 'Tryggvason': [1614, 3441], '124:': [1620, 3447], '1091-1102Crossref': [1621, 3448], '(249)': [1624, 3451], '36Canete-Soler': [1627, 3454], 'Gui': [1629, 3456], 'Y.-H.': [1630, 3457], 'Linask': [1631, 3458], 'K.K.': [1632, 3459], 'Muschel': [1633, 3460], 'R.J.': [1634, 3461], 'Dyn.': [1636, 3463], '204:': [1638, 3465], '30-40Crossref': [1639, 3466], '(54)': [1642, 3469], '37Sato': [1645, 3472], 'del': [1647, 3474], 'Carmen': [1648, 3475], 'Ovejero': [1649, 3476], 'Heegaard': [1651, 3478], 'A.-M.': [1652, 3479], 'Kumegawa': [1653, 3480], 'Foged': [1655, 3482], 'N.T.': [1656, 3483], 'Delaisse': [1657, 3484], 'J.-M.': [1658, 3485], '110:': [1663, 3490], '589-596Crossref': [1664, 3491], 'In': [1668, 3495], 'adult': [1669, 3496], 'life,': [1670, 3497], 'rarely': [1673, 3500], 'except': [1675, 3502], 'rapidly': [1677, 3504], 'tissues': [1679, 3506], 'term': [1683, 3510], 'placenta,': [1684, 3511], 'menstrual': [1685, 3512], 'endometrium,': [1686, 3513], 'involuting': [1688, 3515], 'mammary': [1689, 3516], 'glands': [1690, 3517], 'wound': [1693, 3520], 'healing': [1694, 3521], 'inflammation': [1696, 3523], '(38Belaaouaj': [1697, 3524], 'Shipley': [1699, 3526], 'Kobayashi': [1701, 3528], 'D.K.': [1702, 3529], 'Zimonjic': [1703, 3530], 'D.B.': [1704, 3531], 'Popescu': [1705, 3532], 'Silverman': [1707, 3534], 'Shapiro': [1709, 3536], 'S.D.': [1710, 3537], '14568-14575Abstract': [1716, 3543], '(137)': [1724, 3551], '39Boudreau': [1727, 3554], 'Sympson': [1729, 3556], 'C.J.': [1730, 3557], 'Bissell': [1733, 3560], 'M.J.': [1734, 3561], 'Science.': [1735, 3562], '891-893Crossref': [1738, 3565], '(1113)': [1741, 3568], '40Kokorine': [1744, 3571], 'Marbaix': [1746, 3573], 'Donnez': [1752, 3579], 'Courtoy': [1756, 3583], 'P.J.': [1757, 3584], '109:': [1762, 3589], '2151-21608PubMed': [1763, 3590], '41Rodgers': [1766, 3593], 'W.H.': [1767, 3594], 'Giudice': [1770, 3597], 'L.L.': [1771, 3598], 'Dsupin': [1772, 3599], 'Cannon': [1774, 3601], 'Svitek': [1776, 3603], 'Gorstein': [1778, 3605], 'F.': [1779, 3606], 'Osteen': [1780, 3607], 'K.G.': [1781, 3608], 'Clin.': [1783, 3610], 'Invest.': [1784, 3611], '94:': [1786, 3613], '946-953Crossref': [1787, 3614], '(358)': [1790, 3617], '42Okada': [1793, 3620], 'Tomasetto': [1795, 3622], 'Lutz': [1797, 3624], '137:': [1809, 3636], '67-77Crossref': [1810, 3637], '(192)': [1813, 3640], 'critical': [1823, 3650], 'metastasis': [1829, 3656], '(43Stetler-Stevenson': [1830, 3657], 'W.G.': [1831, 3658], 'Aznavoorian': [1832, 3659], 'Liotta': [1834, 3661], 'L.A.': [1835, 3662], 'Annu.': [1836, 3663], 'Rev.': [1837, 1854, 3664, 3681], '9:': [1841, 3668], '541-573Crossref': [1842, 3669], '(1515)': [1845, 3672], '44MacDougall': [1848, 3675], 'J.R.': [1849, 3676], 'Metastasis': [1853, 3680], '14:': [1856, 1918, 3683, 3745], '351-362Crossref': [1857, 3684], '(400)': [1860, 3687], 'progression': [1866, 3693], 'diseases': [1869, 3696], 'arthritis,': [1872, 3699], 'atherosclerosis,': [1873, 3700], 'aneurysm': [1875, 3702], '(3Werb': [1876, 3703], '45Newman': [1901, 3728], 'K.M.': [1902, 3729], 'Ogata': [1903, 3730], 'Malon': [1905, 3732], 'Irizarry': [1907, 3734], 'Gandhi': [1909, 3736], 'R.H.': [1910, 3737], 'Tilson': [1913, 3740], 'M.D.': [1914, 3741], 'Arterioscler.': [1915, 3742], 'Thromb.': [1916, 3743], '1315-1320Crossref': [1919, 3746], '46Vincenti': [1923, 3750], 'M.P.': [1924, 3751], 'Clark': [1925, 3752], 'I.M.': [1926, 3753], 'Brinckerhoff': [1927, 3754], 'C.E.': [1928, 3755], '37:': [1932, 3759], '1115-1126Crossref': [1933, 3760], '(189)': [1936, 3763], '47Ye': [1939, 3766], 'Eriksson': [1941, 3768], 'Hamsten': [1943, 3770], 'Humphries': [1947, 3774], 'S.E.': [1948, 3775], 'Henney': [1949, 3776], '13055-13060Abstract': [1956, 3783], '(438)': [1964, 3791], 'Scholar).To': [1966], 'study': [1967, 3795], 'early': [1976, 3804], 'vertebrate': [1977, 3805], 'development,': [1978, 3806], 'cloning': [1981, 2024, 3809, 3852], 'tissue': [1984, 3812], 'inhibitors': [1985, 3813], 'Here': [2020, 3848], 'describe': [2022, 3850], 'characterization': [2026, 3854], 'member': [2030, 3858], 'CMMP,': [2036, 2171, 3864, 4000, 4030], 'placed': [2067, 3895], 'inXenopus': [2072, 3900], '(5Cossins': [2082, 3910], '9Yang': [2136, 3964], 'Scholar).Note': [2157], 'Added': [2158, 3987], 'ProofWe': [2160, 3989], 'now': [2162, 3991, 4021], 'bacteria': [2166, 3995, 4025], 'full-length': [2170, 3999, 4029], 'XMMP,': [2173, 4002, 4032], 'native': [2175, 4004, 4034], 'into': [2180, 4009, 4039], 'characteristic': [2182, 4011, 4041], 'three-quarter': [2183, 4012, 4042], 'one-quarter': [2185, 4014, 4044], 'products': [2186, 4015, 4045], '(data': [2187, 4016, 4046], 'shown).': [2189, 4018, 4048], 'Collagenases': [2540], 'MMP9.': [3297], 'To': [3794], 'Note': [3986], 'thank': [4050], 'Michael': [4051], 'Hagen': [4052], 'synthesis': [4055], 'many': [4057], 'oligodeoxynucleotides;': [4058], 'Amy': [4059], 'ofXenopus': [4064], 'collagenase-4': [4065], 'prior': [4066], 'publication;': [4068], 'Irina': [4070], 'Massova,': [4071], 'Shahriar': [4072], 'Mobashery,': [4073], 'Minoru': [4074], 'Ko,': [4077], 'Hideaki': [4079], 'help': [4082], 'comments': [4084], 'manuscript.': [4087], 'Special': [4088], 'thanks': [4089], 'due': [4091], 'Anton': [4093], 'Scott': [4094], 'Goustin': [4095], 'helpful': [4097], 'discussions': [4098], 'Fig.': [4101], '4.': [4102]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1982146541', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-08T15:30:20.933926', 'created_date': '2016-06-24'}