Title: Contrast-Agent–Induced Acute Renal Dysfunction — Is Iodixanol the Answer?
Abstract: In this issue of the Journal, Aspelin et al.1 report findings from a prospective, randomized, double-blind trial that compared iodixanol, a third-generation, iso-osmolar, dimeric, nonionic iodinated contrast agent, with iohexol, a low-osmolar, monomeric, nonionic contrast agent. The use of iodixanol resulted in significantly fewer nephrotoxic effects in high-risk patients undergoing arteriography than iohexol did — findings that are important because a beneficial effect of this iso-osmolar agent on renal function had not previously been conclusively demonstrated in a randomized study.Before the late 1960s, all iodinated contrast agents used for radiologic imaging were ionic monomers with an ionizing carboxyl group . . .
Publication Year: 2003
Publication Date: 2003-02-06
Language: en
Type: letter
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 64
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