Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1982073037', 'doi': 'https://doi.org/10.1080/09553009314551581', 'title': 'Lack of Correlation of Human Fibroblast Radiosensitivity<i>in Vitro</i>with Early Skin Reactions in Patients Undergoing Radiotherapy', 'display_name': 'Lack of Correlation of Human Fibroblast Radiosensitivity<i>in Vitro</i>with Early Skin Reactions in Patients Undergoing Radiotherapy', 'publication_year': 1993, 'publication_date': '1993-01-01', 'ids': {'openalex': 'https://openalex.org/W1982073037', 'doi': 'https://doi.org/10.1080/09553009314551581', 'mag': '1982073037', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7901301'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/09553009314551581', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44383424', 'display_name': 'International Journal of Radiation Biology', 'issn_l': '0955-3002', 'issn': ['0955-3002', '1362-3095'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5112218412', 'display_name': 'Adrian C. Begg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'A.C. Begg', 'raw_affiliation_strings': ['Department of Experiment Therapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoekhuis, Amsterdam.'], 'affiliations': [{'raw_affiliation_string': 'Department of Experiment Therapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoekhuis, Amsterdam.', 'institution_ids': ['https://openalex.org/I2898336195']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000718039', 'display_name': 'Nicola S. Russell', 'orcid': 'https://orcid.org/0000-0003-3507-9620'}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'N.S. Russell', 'raw_affiliation_strings': ['Department of Radiotherapy The Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis) Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiotherapy The Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis) Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I2898336195']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007676945', 'display_name': 'H. Knaken', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'H. Knaken', 'raw_affiliation_strings': ['Department of Experiment Therapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoekhuis, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Experiment Therapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoekhuis, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I2898336195']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111560840', 'display_name': 'J.V. Lebesque', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'J.V. Lebesque', 'raw_affiliation_strings': ['Department of Radiotherapy The Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis) Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiotherapy The Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis) Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I2898336195']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.077, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 82, 'citation_normalized_percentile': {'value': 0.918051, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '64', 'issue': '4', 'first_page': '393', 'last_page': '405'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11359', 'display_name': 'Effects of Radiation Exposure', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11359', 'display_name': 'Effects of Radiation Exposure', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.967, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11455', 'display_name': 'Microbial Inactivation Methods', 'score': 0.9417, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/radiosensitivity', 'display_name': 'Radiosensitivity', 'score': 0.8610012}, {'id': 'https://openalex.org/keywords/erythema', 'display_name': 'Erythema', 'score': 0.77156293}, {'id': 'https://openalex.org/keywords/human-skin', 'display_name': 'Human skin', 'score': 0.49022895}], 'concepts': [{'id': 'https://openalex.org/C206684579', 'wikidata': 'https://www.wikidata.org/wiki/Q4387689', 'display_name': 'Radiosensitivity', 'level': 3, 'score': 0.8610012}, {'id': 'https://openalex.org/C2779121184', 'wikidata': 'https://www.wikidata.org/wiki/Q1166142', 'display_name': 'Erythema', 'level': 2, 'score': 0.77156293}, {'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.5851965}, {'id': 'https://openalex.org/C2989005', 'wikidata': 'https://www.wikidata.org/wiki/Q214963', 'display_name': 'Nuclear medicine', 'level': 1, 'score': 0.5319683}, {'id': 'https://openalex.org/C2777459323', 'wikidata': 'https://www.wikidata.org/wiki/Q5259911', 'display_name': 'Human skin', 'level': 2, 'score': 0.49022895}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.46384317}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4383973}, {'id': 'https://openalex.org/C2780381497', 'wikidata': 'https://www.wikidata.org/wiki/Q463418', 'display_name': 'Fibroblast', 'level': 3, 'score': 0.42700723}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.41875657}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.34646142}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3294777}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3265587}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.23402265}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': True}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': True}, {'descriptor_ui': 'D004890', 'descriptor_name': 'Erythema', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': True}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': True}, {'descriptor_ui': 'D011836', 'descriptor_name': 'Radiation Tolerance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004307', 'descriptor_name': 'Dose-Response Relationship, Radiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004583', 'descriptor_name': 'Electrons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004890', 'descriptor_name': 'Erythema', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/09553009314551581', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44383424', 'display_name': 'International Journal of Radiation Biology', 'issn_l': '0955-3002', 'issn': ['0955-3002', '1362-3095'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7901301', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.74, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1484954434', 'https://openalex.org/W1582871837', 'https://openalex.org/W1591941252', 'https://openalex.org/W1968137140', 'https://openalex.org/W1968595116', 'https://openalex.org/W1970292521', 'https://openalex.org/W1978381767', 'https://openalex.org/W1998455232', 'https://openalex.org/W1999752219', 'https://openalex.org/W2000576450', 'https://openalex.org/W2010901031', 'https://openalex.org/W2012192362', 'https://openalex.org/W2014036544', 'https://openalex.org/W2014459040', 'https://openalex.org/W2016627831', 'https://openalex.org/W2035154953', 'https://openalex.org/W2036113503', 'https://openalex.org/W2041413912', 'https://openalex.org/W2046650471', 'https://openalex.org/W2063864444', 'https://openalex.org/W2074598451', 'https://openalex.org/W2076116565', 'https://openalex.org/W2097587976', 'https://openalex.org/W2102458977', 'https://openalex.org/W2107215120', 'https://openalex.org/W2111738955', 'https://openalex.org/W2129868577', 'https://openalex.org/W2136768706', 'https://openalex.org/W2147065939', 'https://openalex.org/W2154563673', 'https://openalex.org/W2312625750', 'https://openalex.org/W2322279633', 'https://openalex.org/W2329987756', 'https://openalex.org/W2410763330', 'https://openalex.org/W2416327829', 'https://openalex.org/W2604338383', 'https://openalex.org/W3021808902', 'https://openalex.org/W4235019056', 'https://openalex.org/W4238353533', 'https://openalex.org/W4244130264', 'https://openalex.org/W4255244349'], 'related_works': ['https://openalex.org/W3137590180', 'https://openalex.org/W2561211421', 'https://openalex.org/W2392186915', 'https://openalex.org/W2380110850', 'https://openalex.org/W2377869450', 'https://openalex.org/W2375910701', 'https://openalex.org/W2111712489', 'https://openalex.org/W2109327145', 'https://openalex.org/W2041844070', 'https://openalex.org/W2030272140'], 'abstract_inverted_index': {'Fibroblasts': [0], 'from': [1, 11, 70, 203], 'breast': [2, 273], 'cancer': [3, 274], 'patients': [4, 27, 228], 'were': [5, 28, 39, 61, 75, 112, 129, 152, 161], 'obtained': [6], 'as': [7, 31, 90, 244], 'outgrowths': [8], 'in': [9, 18, 24, 64, 81, 108, 117, 154, 224, 261, 272], 'vitro': [10, 262], 'punch': [12], 'biopsies': [13, 56], 'and': [14, 42, 59, 73, 105, 143, 165, 221], 'their': [15], 'radiosensitivity': [16, 58, 246, 259], 'tested': [17], 'early': [19], 'passages.': [20], 'Skin': [21, 185], 'erythema': [22, 60, 222, 268], 'reactions': [23, 269], 'the': [25, 51, 91, 100, 109, 144, 155, 199, 225, 245], 'same': [26], 'also': [29], 'measured,': [30], 'degree': [32], 'of': [33, 86, 119, 137, 198, 210, 238], 'redness': [34, 186], 'using': [35, 84, 114, 242], 'reflectance': [36], 'spectrophotometry.': [37], 'Measurements': [38], 'taken': [40], 'before': [41], 'during': [43, 194], 'a': [44, 173, 208, 211], '4-week': [45], 'radiotherapy': [46, 271], 'treatment': [47], 'with': [48, 99, 126, 132, 157, 192, 207], 'electrons': [49], 'to': [50, 147, 189, 205, 266, 270], 'thoracic': [52], 'wall.': [53], 'Of': [54], '59': [55], 'studied,': [57], 'concurrently': [62], 'studied': [63], '32.': [65], 'In': [66], '24,': [67], 'evaluable': [68, 227], 'data': [69, 255], 'both': [71], 'clinic': [72], 'laboratory': [74], 'obtained.': [76], 'A': [77, 235], 'population': [78], 'growth': [79, 106], 'assay': [80, 111], '96-well': [82], 'plates,': [83], 'absorption': [85], 'sulphur': [87], 'rhodamine': [88], 'B': [89], 'stain': [92], 'for': [93], 'cell': [94], 'numbers,': [95], 'showed': [96], 'good': [97], 'agreement': [98], 'colony-formation': [101], 'assay.': [102], 'Plating': [103], 'efficiencies': [104], 'rates': [107], 'colony': [110], 'higher': [113], 'human': [115, 127], 'serum': [116, 128], 'place': [118], 'foetal': [120], 'calf': [121], 'serum.': [122], 'Cell': [123], 'survival': [124, 138, 150, 179], 'curves': [125], 'mostly': [130], 'exponential': [131], 'little': [133], 'shoulder.': [134], 'The': [135, 196], 'parameters': [136, 181], 'at': [139], '2': [140], 'Gy': [141], '(SF2)': [142], 'dose': [145], 'required': [146], 'give': [148], '10%': [149], '(D10)': [151], 'used': [153, 265], 'correlations': [156], 'clinical': [158], 'data;': [159], 'these': [160, 177], '0.25': [162], '+/-': [163, 167], '0.09': [164], '3.03': [166], '0.50': [168], 'Gy,': [169], 'respectively.': [170], 'There': [171], 'was': [172, 187, 217, 240], 'strong': [174], 'correlation': [175, 216, 239], 'between': [176, 219], 'two': [178], 'curve': [180], '(r': [182, 229, 248], '=': [183, 230, 249], '0.98).': [184], 'found': [188, 218, 241], 'linearly': [190], 'increase': [191, 200], 'time': [193], 'radiotherapy.': [195], 'slope': [197], 'differed': [201], 'markedly': [202], 'patient': [204], 'patient,': [206], 'range': [209], 'factor': [212], 'approx.': [213], '10.': [214], 'No': [215], 'SF2': [220], 'response': [223], '24': [226], '0.13,': [231], 'p': [232, 251], '>': [233, 252], '0.5).': [234, 253], 'similar': [236], 'lack': [237], 'D10': [243], 'parameter': [247], '0.12,': [250], 'These': [254], 'indicate': [256], 'that': [257], 'fibroblast': [258], 'measured': [260], 'cannot': [263], 'be': [264], 'predict': [267], 'patients.': [275]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1982073037', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-10T03:20:11.968371', 'created_date': '2016-06-24'}