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[24], 'by': [25, 68, 135, 169], 'a': [26, 96, 148, 170, 214], 'rise': [27, 39, 64, 109], 'free': [29], 'Ca2+': [30, 38, 63, 71, 84, 108, 137, 152, 250], 'egg': [33, 45, 87, 112, 126, 202, 253], 'cytosol': [34], 'at': [35, 154, 252], 'fertilization.': [36, 155], 'This': [37], 'crucial': [41, 180], 'for': [42, 181], 'subsequent': [44, 111], 'steps,': [47], 'such': [48], 'as': [49, 227], 'cortical': [50, 116, 172, 197], 'granule': [51, 117], 'exocytosis,': [52], 'which': [53, 102, 175], 'modifies': [54], 'vitelline': [56], 'membrane': [57], 'polyspermy.': [60], 'The': [61, 77], 'cytosolic': [62, 107], 'primarily': [66], 'initiated': [67], 'inositol': [69], '1,4,5-trisphosphate(IP3)-mediated': [70], 'release': [72, 85, 153, 251], 'from': [73, 199], 'endoplasmic': [75], 'reticulum.': [76], 'genes': [78], 'involved': [79], 'regulating': [81, 244], 'IP3-mediated': [83, 151, 249], 'during': [86], 'remain': [89], 'largely': [90], 'unknown.': [91], 'Here': [92], 'we': [93], 'report': [94], 'on': 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