Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1981643724', 'doi': 'https://doi.org/10.1111/j.1471-4159.2008.05741.x', 'title': 'Impact of heme oxygenase‐1 on cholesterol synthesis, cholesterol efflux and oxysterol formation in cultured astroglia', 'display_name': 'Impact of heme oxygenase‐1 on cholesterol synthesis, cholesterol efflux and oxysterol formation in cultured astroglia', 'publication_year': 2008, 'publication_date': '2008-11-18', 'ids': {'openalex': 'https://openalex.org/W1981643724', 'doi': 'https://doi.org/10.1111/j.1471-4159.2008.05741.x', 'mag': '1981643724', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19046352'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1471-4159.2008.05741.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1111/j.1471-4159.2008.05741.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002178036', 'display_name': 'Jacob Hascalovici', 'orcid': 'https://orcid.org/0000-0001-5424-4527'}, 'institutions': [{'id': 'https://openalex.org/I2801824472', 'display_name': 'Jewish General Hospital', 'ror': 'https://ror.org/056jjra10', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801824472']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Jacob R Hascalovici', 'raw_affiliation_strings': ['Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, Montreal, Quebec, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, Montreal, Quebec, Canada.', 'institution_ids': ['https://openalex.org/I2801824472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101812913', 'display_name': 'Wei Song', 'orcid': 'https://orcid.org/0009-0005-9202-9541'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wei Song', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007531628', 'display_name': 'Jacob Vaya', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jacob Vaya', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066261675', 'display_name': 'Soliman Khatib', 'orcid': 'https://orcid.org/0000-0002-6762-2408'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Soliman Khatib', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016973217', 'display_name': 'Bianca Fuhrman', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Bianca Fuhrman', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052487247', 'display_name': 'Michael Aviram', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Michael Aviram', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019914836', 'display_name': 'Hyman M. Schipper', 'orcid': 'https://orcid.org/0000-0001-7319-1985'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hyman M Schipper', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.407, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 28, 'citation_normalized_percentile': {'value': 0.76517, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '108', 'issue': '1', 'first_page': '72', 'last_page': '81'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase and Carbon Monoxide Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase and Carbon Monoxide Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12910', 'display_name': 'Metabolism and Function of Arachidonic Acid Derivatives', 'score': 0.9908, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12068', 'display_name': 'Management of Hyperbilirubinemia in Newborn Infants', 'score': 0.9877, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/oxysterol', 'display_name': 'Oxysterol', 'score': 0.88530296}, {'id': 'https://openalex.org/keywords/efflux', 'display_name': 'Efflux', 'score': 0.6165783}, {'id': 'https://openalex.org/keywords/heme-oxygenase-1', 'display_name': 'Heme Oxygenase-1', 'score': 0.562925}, {'id': 'https://openalex.org/keywords/homeostasis', 'display_name': 'Homeostasis', 'score': 0.42476243}, {'id': 'https://openalex.org/keywords/liver-x-receptor', 'display_name': 'Liver X receptor', 'score': 0.42458835}], 'concepts': [{'id': 'https://openalex.org/C2778111914', 'wikidata': 'https://www.wikidata.org/wiki/Q7116159', 'display_name': 'Oxysterol', 'level': 3, 'score': 0.88530296}, {'id': 'https://openalex.org/C2779219270', 'wikidata': 'https://www.wikidata.org/wiki/Q419972', 'display_name': 'Heme oxygenase', 'level': 4, 'score': 0.6772944}, {'id': 'https://openalex.org/C200082930', 'wikidata': 'https://www.wikidata.org/wiki/Q22327148', 'display_name': 'Efflux', 'level': 2, 'score': 0.6165783}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5867141}, {'id': 'https://openalex.org/C2776217839', 'wikidata': 'https://www.wikidata.org/wiki/Q189621', 'display_name': 'Heme', 'level': 3, 'score': 0.539105}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.5292508}, {'id': 'https://openalex.org/C25498285', 'wikidata': 'https://www.wikidata.org/wiki/Q1981368', 'display_name': 'Neuroprotection', 'level': 2, 'score': 0.49319428}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.48048916}, {'id': 'https://openalex.org/C63645605', 'wikidata': 'https://www.wikidata.org/wiki/Q103191', 'display_name': 'Homeostasis', 'level': 2, 'score': 0.42476243}, {'id': 'https://openalex.org/C167400880', 'wikidata': 'https://www.wikidata.org/wiki/Q3454539', 'display_name': 'Liver X receptor', 'level': 5, 'score': 0.42458835}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.36292687}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3617654}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33185965}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3236692}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.25585082}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.112045914}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.08644053}, {'id': 'https://openalex.org/C63932345', 'wikidata': 'https://www.wikidata.org/wiki/Q422500', 'display_name': 'Nuclear receptor', 'level': 4, 'score': 0.07225764}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001253', 'descriptor_name': 'Astrocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051547', 'descriptor_name': 'Heme Oxygenase-1', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000831', 'descriptor_name': 'Animals, Newborn', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001253', 'descriptor_name': 'Astrocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001253', 'descriptor_name': 'Astrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001663', 'descriptor_name': 'Bilirubin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001663', 'descriptor_name': 'Bilirubin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001692', 'descriptor_name': 'Biological Transport', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001692', 'descriptor_name': 'Biological Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002248', 'descriptor_name': 'Carbon Monoxide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002248', 'descriptor_name': 'Carbon Monoxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005290', 'descriptor_name': 'Ferric Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005290', 'descriptor_name': 'Ferric Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051547', 'descriptor_name': 'Heme Oxygenase-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071518', 'descriptor_name': 'Liver X Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008665', 'descriptor_name': 'Metalloporphyrins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008665', 'descriptor_name': 'Metalloporphyrins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009566', 'descriptor_name': 'Nitrates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009566', 'descriptor_name': 'Nitrates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009571', 'descriptor_name': 'Nitrilotriacetic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009571', 'descriptor_name': 'Nitrilotriacetic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009942', 'descriptor_name': 'Organometallic Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009942', 'descriptor_name': 'Organometallic Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057093', 'descriptor_name': 'Orphan Nuclear Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1471-4159.2008.05741.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19046352', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1471-4159.2008.05741.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.58, 'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 53, 'referenced_works': ['https://openalex.org/W1534400312', 'https://openalex.org/W1602494991', 'https://openalex.org/W189082475', 'https://openalex.org/W1965523901', 'https://openalex.org/W1966720966', 'https://openalex.org/W1972163077', 'https://openalex.org/W1977029135', 'https://openalex.org/W1980029336', 'https://openalex.org/W1980987756', 'https://openalex.org/W1981596580', 'https://openalex.org/W1983417600', 'https://openalex.org/W1983899061', 'https://openalex.org/W1990583076', 'https://openalex.org/W1991104802', 'https://openalex.org/W1996457468', 'https://openalex.org/W1998448397', 'https://openalex.org/W2004127466', 'https://openalex.org/W2007674547', 'https://openalex.org/W2010426144', 'https://openalex.org/W2011972906', 'https://openalex.org/W2013889250', 'https://openalex.org/W2017461950', 'https://openalex.org/W2018923286', 'https://openalex.org/W2020355061', 'https://openalex.org/W2022706428', 'https://openalex.org/W2030365747', 'https://openalex.org/W2037129983', 'https://openalex.org/W2045942675', 'https://openalex.org/W2051628968', 'https://openalex.org/W2059778110', 'https://openalex.org/W2062614945', 'https://openalex.org/W2064642280', 'https://openalex.org/W2066980314', 'https://openalex.org/W2071322203', 'https://openalex.org/W2074545089', 'https://openalex.org/W2079616833', 'https://openalex.org/W2083715632', 'https://openalex.org/W2088436733', 'https://openalex.org/W2097498628', 'https://openalex.org/W2105057579', 'https://openalex.org/W2111629711', 'https://openalex.org/W2111920850', 'https://openalex.org/W2112107066', 'https://openalex.org/W2117842413', 'https://openalex.org/W2118416292', 'https://openalex.org/W2118782534', 'https://openalex.org/W2121877708', 'https://openalex.org/W2125483042', 'https://openalex.org/W2132508894', 'https://openalex.org/W2144676492', 'https://openalex.org/W2236164220', 'https://openalex.org/W2473870361', 'https://openalex.org/W626206249'], 'related_works': ['https://openalex.org/W2955174352', 'https://openalex.org/W2918649353', 'https://openalex.org/W2155385401', 'https://openalex.org/W2155240851', 'https://openalex.org/W2088436733', 'https://openalex.org/W2040417680', 'https://openalex.org/W2022530316', 'https://openalex.org/W2003151572', 'https://openalex.org/W1972044040', 'https://openalex.org/W1968647954'], 'abstract_inverted_index': {'Abstract': [0], 'Up‐regulation': [1], 'of': [2, 13, 26, 37, 71, 118, 141, 168, 183], 'heme': [3, 145], 'oxygenase‐1': [4], '(HO‐1)': [5], 'and': [6, 40, 50, 57, 89, 120, 151, 179], 'altered': [7, 166], 'cholesterol': [8], '(CH)': [9], 'metabolism': [10], 'are': [11], 'characteristic': [12], 'Alzheimer‐diseased': [14], 'neural': [15], 'tissues.': [16], 'The': [17], 'liver': [18], 'X': [19], 'receptor': [20], '(LXR)': [21], 'is': [22], 'a': [23, 83, 90, 116], 'molecular': [24], 'sensor': [25], 'CH': [27, 53, 55, 72, 87, 94, 114, 123, 142, 170], 'homeostasis.': [28, 171], 'In': [29, 148], 'the': [30, 35, 69, 101, 139, 173], 'current': [31], 'study,': [32], 'we': [33], 'determined': [34], 'effects': [36, 97], 'HO‐1': [38, 156, 185], 'over‐expression': [39, 75], 'its': [41], 'byproducts': [42], 'iron': [43, 121, 126], '(Fe': [44], '2+': [45], '),': [46], 'carbon': [47], 'monoxide': [48], '(CO)': [49], 'bilirubin': [51], 'on': [52], 'biosynthesis,': [54], 'efflux': [56], 'oxysterol': [58, 128], 'formation': [59, 129], 'in': [60, 68, 82, 86, 93, 138, 195], 'cultured': [61], 'astroglia.': [62], 'HO‐1/LXR': [63], 'interactions': [64], 'were': [65, 98], 'also': [66], 'investigated': [67], 'context': [70], 'efflux.': [73, 95, 124], 'hHO‐1': [74], 'for': [76], '3': [77], 'days': [78], '(∼2–3‐fold': [79], 'increase)': [80], 'resulted': [81], '30%': [84], 'increase': [85], 'biosynthesis': [88], 'two‐fold': [91], 'rise': [92], 'Both': [96], 'abrogated': [99], 'by': [100, 144], 'competitive': [102], 'HO': [103], 'inhibitor,': [104], 'tin': [105], 'mesoporphyrin.': [106], 'CO,': [107], 'released': [108], 'from': [109], 'administered': [110], 'CORM‐3,': [111], 'significantly': [112], 'enhanced': [113], 'biosynthesis;': [115], 'combination': [117], 'CO': [119], 'stimulated': [122], 'Free': [125], 'increased': [127], 'three‐fold.': [130], 'Co‐treatment': [131], 'with': [132, 197], 'LXR': [133, 136], 'antagonists': [134], 'implicated': [135], 'activation': [137], 'modulation': [140, 182], 'homeostasis': [143], 'degradation': [146], 'products.': [147], 'Alzheimer’s': [149], 'disease': [150], 'other': [152, 190], 'neuropathological': [153], 'states,': [154], 'glial': [155, 169, 184], 'induction': [157], 'may': [158, 175, 192], 'transduce': [159], 'ambient': [160], 'noxious': [161], 'stimuli': [162], '(e.g.': [163], 'β‐amyloid)': [164], 'into': [165], 'patterns': [167], 'As': [172], 'latter': [174], 'impact': [176], 'synaptic': [177], 'plasticity': [178], 'neuronal': [180], 'repair,': [181], 'expression': [186], '(by': [187], 'pharmacological': [188], 'or': [189], 'means)': [191], 'confer': [193], 'neuroprotection': [194], 'patients': [196], 'degenerative': [198], 'brain': [199], 'disorders.': [200]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1981643724', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-19T20:08:07.493164', 'created_date': '2016-06-24'}