Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1981543052', 'doi': 'https://doi.org/10.1038/nature10102', 'title': 'Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells', 'display_name': 'Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells', 'publication_year': 2011, 'publication_date': '2011-05-08', 'ids': {'openalex': 'https://openalex.org/W1981543052', 'doi': 'https://doi.org/10.1038/nature10102', 'mag': '1981543052', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21552279', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3124347'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nature10102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137773608', 'display_name': 'Nature', 'issn_l': '0028-0836', 'issn': ['0028-0836', '1476-4687'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124347', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5037086547', 'display_name': 'William A. Pastor', 'orcid': 'https://orcid.org/0000-0003-4176-5299'}, 'institutions': [{'id': 'https://openalex.org/I1288882113', 'display_name': "Boston Children's Hospital", 'ror': 'https://ror.org/00dvg7y05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1288882113']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William A. Pastor', 'raw_affiliation_strings': ["Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, Massachusetts 02115, USA."], 'affiliations': [{'raw_affiliation_string': "Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, Massachusetts 02115, USA.", 'institution_ids': ['https://openalex.org/I1288882113']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084657632', 'display_name': 'Utz Johann Pape', 'orcid': 'https://orcid.org/0000-0002-1802-6810'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I1288882113', 'display_name': "Boston Children's Hospital", 'ror': 'https://ror.org/00dvg7y05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1288882113']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Utz J. Pape', 'raw_affiliation_strings': ['Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, USA', 'Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Boston, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, USA', 'institution_ids': ['https://openalex.org/I4210117453']}, {'raw_affiliation_string': 'Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Boston, USA', 'institution_ids': ['https://openalex.org/I1288882113']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044336968', 'display_name': 'Yun Huang', 'orcid': 'https://orcid.org/0000-0001-5950-9168'}, 'institutions': [{'id': 'https://openalex.org/I1311191458', 'display_name': 'La Jolla Institute For Allergy & Immunology', 'ror': 'https://ror.org/05vkpd318', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1311191458']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yun Huang', 'raw_affiliation_strings': ['La Jolla Institute for Allergy & Immunology, La Jolla, USA'], 'affiliations': [{'raw_affiliation_string': 'La Jolla Institute for Allergy & Immunology, La Jolla, USA', 'institution_ids': ['https://openalex.org/I1311191458']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055860574', 'display_name': 'Hope R. Henderson', 'orcid': 'https://orcid.org/0000-0002-1373-296X'}, 'institutions': [{'id': 'https://openalex.org/I1288882113', 'display_name': "Boston Children's Hospital", 'ror': 'https://ror.org/00dvg7y05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1288882113']}, {'id': 'https://openalex.org/I1311191458', 'display_name': 'La Jolla Institute For Allergy & Immunology', 'ror': 'https://ror.org/05vkpd318', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1311191458']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hope R. Henderson', 'raw_affiliation_strings': ['Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Boston, USA', 'La Jolla Institute for Allergy & Immunology, La Jolla, USA'], 'affiliations': [{'raw_affiliation_string': 'Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Boston, USA', 'institution_ids': ['https://openalex.org/I1288882113']}, {'raw_affiliation_string': 'La Jolla Institute for Allergy & Immunology, La Jolla, USA', 'institution_ids': ['https://openalex.org/I1311191458']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057408603', 'display_name': 'Ryan Lister', 'orcid': 'https://orcid.org/0000-0001-6637-7239'}, 'institutions': [{'id': 'https://openalex.org/I1307098950', 'display_name': 'Salk Institute for Biological Studies', 'ror': 'https://ror.org/03xez1567', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1307098950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ryan Lister', 'raw_affiliation_strings': ['Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, USA'], 'affiliations': [{'raw_affiliation_string': 'Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, USA', 'institution_ids': ['https://openalex.org/I1307098950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008186315', 'display_name': 'Myunggon Ko', 'orcid': 'https://orcid.org/0000-0002-6007-2570'}, 'institutions': [{'id': 'https://openalex.org/I1311191458', 'display_name': 'La Jolla Institute For Allergy & Immunology', 'ror': 'https://ror.org/05vkpd318', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1311191458']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Myunggon Ko', 'raw_affiliation_strings': ['La Jolla Institute for Allergy & Immunology, La Jolla, USA'], 'affiliations': [{'raw_affiliation_string': 'La Jolla Institute for Allergy & Immunology, La Jolla, USA', 'institution_ids': ['https://openalex.org/I1311191458']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049150120', 'display_name': 'Erin M. McLoughlin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Erin M. McLoughlin', 'raw_affiliation_strings': ['Division of Hematology/Oncology, Children’s Hospital Boston; Dana-Farber Cancer Institute; Harvard Stem Cell Institute,'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology/Oncology, Children’s Hospital Boston; Dana-Farber Cancer Institute; Harvard Stem Cell Institute,', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058260183', 'display_name': 'Yevgeny Brudno', 'orcid': 'https://orcid.org/0000-0003-2963-3293'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yevgeny Brudno', 'raw_affiliation_strings': ['Department of Chemistry & Chemical Biology, Harvard University, Cambridge, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry & Chemical Biology, Harvard University, Cambridge, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048285935', 'display_name': 'Sahasransu Mahapatra', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1311191458', 'display_name': 'La Jolla Institute For Allergy & Immunology', 'ror': 'https://ror.org/05vkpd318', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1311191458']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sahasransu Mahapatra', 'raw_affiliation_strings': ['La Jolla Institute for Allergy & Immunology, La Jolla, USA'], 'affiliations': [{'raw_affiliation_string': 'La Jolla Institute for Allergy & Immunology, La Jolla, USA', 'institution_ids': ['https://openalex.org/I1311191458']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008738173', 'display_name': 'Philipp Kapranov', 'orcid': 'https://orcid.org/0000-0003-2647-4856'}, 'institutions': [{'id': 'https://openalex.org/I908450791', 'display_name': 'Helicos Biosciences (United States)', 'ror': 'https://ror.org/044cqax96', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I908450791']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Philipp Kapranov', 'raw_affiliation_strings': ['Helicos BioSciences Corporation, Cambridge, USA'], 'affiliations': [{'raw_affiliation_string': 'Helicos BioSciences Corporation, Cambridge, USA', 'institution_ids': ['https://openalex.org/I908450791']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050437003', 'display_name': 'Mamta Tahiliani', 'orcid': 'https://orcid.org/0000-0003-0495-0620'}, 'institutions': [{'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}, {'id': 'https://openalex.org/I1288882113', 'display_name': "Boston Children's Hospital", 'ror': 'https://ror.org/00dvg7y05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1288882113']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mamta Tahiliani', 'raw_affiliation_strings': ['Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Boston, USA', 'Present address: Department of Biochemistry, New York University Langone Medical Centre, New York, New York 10016, USA.,'], 'affiliations': [{'raw_affiliation_string': 'Present address: Department of Biochemistry, New York University Langone Medical Centre, New York, New York 10016, USA.,', 'institution_ids': ['https://openalex.org/I57206974']}, {'raw_affiliation_string': 'Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Boston, USA', 'institution_ids': ['https://openalex.org/I1288882113']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059348374', 'display_name': 'George Q. Daley', 'orcid': 'https://orcid.org/0000-0002-6346-5919'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'George Q. Daley', 'raw_affiliation_strings': ['Division of Hematology/Oncology, Children’s Hospital Boston; Dana-Farber Cancer Institute; Harvard Stem Cell Institute,'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology/Oncology, Children’s Hospital Boston; Dana-Farber Cancer Institute; Harvard Stem Cell Institute,', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087113506', 'display_name': 'X. Shirley Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'X. Shirley Liu', 'raw_affiliation_strings': ['Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, USA#TAB#'], 'affiliations': [{'raw_affiliation_string': 'Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, USA#TAB#', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035293995', 'display_name': 'Joseph R. Ecker', 'orcid': 'https://orcid.org/0000-0001-5799-5895'}, 'institutions': [{'id': 'https://openalex.org/I1307098950', 'display_name': 'Salk Institute for Biological Studies', 'ror': 'https://ror.org/03xez1567', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1307098950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joseph R. Ecker', 'raw_affiliation_strings': ['Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, USA'], 'affiliations': [{'raw_affiliation_string': 'Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, USA', 'institution_ids': ['https://openalex.org/I1307098950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082097561', 'display_name': 'Patrice M. Milos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I908450791', 'display_name': 'Helicos Biosciences (United States)', 'ror': 'https://ror.org/044cqax96', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I908450791']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patrice M. Milos', 'raw_affiliation_strings': ['Helicos BioSciences Corporation, Cambridge, USA'], 'affiliations': [{'raw_affiliation_string': 'Helicos BioSciences Corporation, Cambridge, USA', 'institution_ids': ['https://openalex.org/I908450791']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060648430', 'display_name': 'Suneet Agarwal', 'orcid': 'https://orcid.org/0000-0003-4910-3118'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Suneet Agarwal', 'raw_affiliation_strings': ['Division of Hematology/Oncology, Children’s Hospital Boston; Dana-Farber Cancer Institute; Harvard Stem Cell Institute,'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology/Oncology, Children’s Hospital Boston; Dana-Farber Cancer Institute; Harvard Stem Cell Institute,', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5080472610', 'display_name': 'Anjana Rao', 'orcid': 'https://orcid.org/0000-0002-1870-1775'}, 'institutions': [{'id': 'https://openalex.org/I1311191458', 'display_name': 'La Jolla Institute For Allergy & Immunology', 'ror': 'https://ror.org/05vkpd318', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1311191458']}, {'id': 'https://openalex.org/I1288882113', 'display_name': "Boston Children's Hospital", 'ror': 'https://ror.org/00dvg7y05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1288882113']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anjana Rao', 'raw_affiliation_strings': ['Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Boston, USA', 'La Jolla Institute for Allergy & Immunology, La Jolla, USA'], 'affiliations': [{'raw_affiliation_string': 'La Jolla Institute for Allergy & Immunology, La Jolla, USA', 'institution_ids': ['https://openalex.org/I1311191458']}, {'raw_affiliation_string': 'Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Boston, USA', 'institution_ids': ['https://openalex.org/I1288882113']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 46.78, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 767, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '473', 'issue': '7347', 'first_page': '394', 'last_page': '397'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9784, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11928', 'display_name': 'Genomic Imprinting and Parental Gene Expression Control', 'score': 0.9253, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/5-hydroxymethylcytosine', 'display_name': '5-Hydroxymethylcytosine', 'score': 0.7497151}, {'id': 'https://openalex.org/keywords/dna-methylation', 'display_name': 'DNA Methylation', 'score': 0.51623}, {'id': 'https://openalex.org/keywords/gene-expression-regulation', 'display_name': 'Gene Expression Regulation', 'score': 0.514005}, {'id': 'https://openalex.org/keywords/tet-proteins', 'display_name': 'TET Proteins', 'score': 0.507739}, {'id': 'https://openalex.org/keywords/chromatin-immunoprecipitation', 'display_name': 'Chromatin immunoprecipitation', 'score': 0.5011761}, {'id': 'https://openalex.org/keywords/h3k4me3', 'display_name': 'H3K4me3', 'score': 0.4826313}, {'id': 'https://openalex.org/keywords/genomic-dna', 'display_name': 'genomic DNA', 'score': 0.47323808}, {'id': 'https://openalex.org/keywords/genomic-imprinting', 'display_name': 'Genomic imprinting', 'score': 0.4480496}, {'id': 'https://openalex.org/keywords/5-methylcytosine', 'display_name': '5-Methylcytosine', 'score': 0.44572508}], 'concepts': [{'id': 'https://openalex.org/C2778901553', 'wikidata': 'https://www.wikidata.org/wiki/Q238535', 'display_name': '5-Hydroxymethylcytosine', 'level': 5, 'score': 0.7497151}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.60348237}, {'id': 'https://openalex.org/C64927066', 'wikidata': 'https://www.wikidata.org/wiki/Q36293', 'display_name': 'Histone', 'level': 3, 'score': 0.51387215}, {'id': 'https://openalex.org/C134320426', 'wikidata': 'https://www.wikidata.org/wiki/Q901026', 'display_name': 'Chromatin immunoprecipitation', 'level': 5, 'score': 0.5011761}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.48894277}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.48303375}, {'id': 'https://openalex.org/C2780914512', 'wikidata': 'https://www.wikidata.org/wiki/Q25323943', 'display_name': 'H3K4me3', 'level': 5, 'score': 0.4826313}, {'id': 'https://openalex.org/C83640560', 'wikidata': 'https://www.wikidata.org/wiki/Q180951', 'display_name': 'Chromatin', 'level': 3, 'score': 0.4815805}, {'id': 'https://openalex.org/C17757408', 'wikidata': 'https://www.wikidata.org/wiki/Q4135516', 'display_name': 'genomic DNA', 'level': 3, 'score': 0.47323808}, {'id': 'https://openalex.org/C201492766', 'wikidata': 'https://www.wikidata.org/wiki/Q84087', 'display_name': 'Genomic imprinting', 'level': 5, 'score': 0.4480496}, {'id': 'https://openalex.org/C2775926025', 'wikidata': 'https://www.wikidata.org/wiki/Q238563', 'display_name': '5-Methylcytosine', 'level': 5, 'score': 0.44572508}, {'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.43343502}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.41444564}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.40343052}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.3770735}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.37146878}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3419363}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.32638443}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.21738571}], 'mesh': [{'descriptor_ui': 'D003596', 'descriptor_name': 'Cytosine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D053595', 'descriptor_name': 'Embryonic Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016678', 'descriptor_name': 'Genome', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D017422', 'descriptor_name': 'Sequence Analysis, DNA', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D044503', 'descriptor_name': '5-Methylcytosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044503', 'descriptor_name': '5-Methylcytosine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019921', 'descriptor_name': 'Biotinylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003596', 'descriptor_name': 'Cytosine', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D003596', 'descriptor_name': 'Cytosine', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D003596', 'descriptor_name': 'Cytosine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003596', 'descriptor_name': 'Cytosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053595', 'descriptor_name': 'Embryonic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005091', 'descriptor_name': 'Exons', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005091', 'descriptor_name': 'Exons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016678', 'descriptor_name': 'Genome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010504', 'descriptor_name': 'Periodic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010504', 'descriptor_name': 'Periodic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017422', 'descriptor_name': 'Sequence Analysis, DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024363', 'descriptor_name': 'Transcription Initiation Site', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nature10102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137773608', 'display_name': 'Nature', 'issn_l': '0028-0836', 'issn': ['0028-0836', '1476-4687'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124347', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21552279', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124347', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1968931043', 'https://openalex.org/W1974646727', 'https://openalex.org/W1981030303', 'https://openalex.org/W1981463058', 'https://openalex.org/W1989457196', 'https://openalex.org/W2000875411', 'https://openalex.org/W2005458309', 'https://openalex.org/W2009903752', 'https://openalex.org/W2011181841', 'https://openalex.org/W2017840637', 'https://openalex.org/W2059099579', 'https://openalex.org/W2059198040', 'https://openalex.org/W2069428487', 'https://openalex.org/W2070542863', 'https://openalex.org/W2096153482', 'https://openalex.org/W2097743943', 'https://openalex.org/W2108664872', 'https://openalex.org/W2121090755', 'https://openalex.org/W2123960992', 'https://openalex.org/W2137505881', 'https://openalex.org/W2138472595', 'https://openalex.org/W2143798330', 'https://openalex.org/W2149206894', 'https://openalex.org/W2152451432', 'https://openalex.org/W2153424791', 'https://openalex.org/W2158610627', 'https://openalex.org/W2158668089', 'https://openalex.org/W2161224111'], 'related_works': ['https://openalex.org/W4225912813', 'https://openalex.org/W3156691351', 'https://openalex.org/W2977288015', 'https://openalex.org/W2476700496', 'https://openalex.org/W2091059103', 'https://openalex.org/W2074779733', 'https://openalex.org/W1997453048', 'https://openalex.org/W1995259616', 'https://openalex.org/W1984130135', 'https://openalex.org/W1965501136'], 'abstract_inverted_index': {'The': [0, 204, 232], 'modified': [1, 137], 'DNA': [2, 128, 223, 247, 256, 267], 'base': [3, 138], '5-hydroxymethylcytosine': [4, 133], '(5hmC),': [5], 'sometimes': [6], 'called': [7], 'the': [8, 14, 26, 32, 41, 51, 64, 99, 121, 153, 182, 199, 289, 333], 'sixth': [9], 'base,': [10], 'is': [11, 19, 135, 150, 187], 'present': [12, 139], 'in': [13, 37, 58, 126, 143, 147, 173, 321, 328, 341], 'mammalian': [15], 'genome': [16], 'where': [17], 'it': [18], 'generated': [20, 151], 'by': [21, 29, 152, 243, 252], 'oxidation': [22, 162], 'of': [23, 31, 54, 123, 156, 163, 185, 202, 216, 237, 245, 254, 265, 292], '5-methylcytosine': [24, 164], '(5mC;': [25], 'fifth': [27], 'base)': [28], 'enzymes': [30, 160], 'Tet': [33, 124], 'family.': [34], 'Four': [35], 'papers': [36, 118], 'this': [38], 'issue,': [39], 'from': [40, 268], 'Helin,': [42], 'Zhang,': [43], 'Rao': [44, 82], 'and': [45, 70, 76, 83, 106, 115, 130, 158, 167, 177, 194, 218, 279, 304, 324], 'Reik': [46], 'laboratories,': [47], 'respectively,': [48], 'report': [49], 'on': [50, 181], 'genome-wide': [52, 183], 'distribution': [53, 184], 'Tet1': [55, 69], 'and/or': [56], '5hmC': [57, 96, 149, 166, 186, 238, 284, 316, 330], 'mouse': [59, 269], 'embryonic': [60, 270], 'stem': [61, 174, 271], 'cells': [62, 273], 'using': [63], 'ChIP-seq': [65], 'technique.': [66], 'Links': [67], 'between': [68], 'transcription': [71], 'regulation': [72], '—': [73, 78], 'both': [74], 'activation': [75], 'repression': [77], 'are': [79], 'revealed.': [80], 'Anjana': [81], 'colleagues': [84], 'also': [85], 'describe': [86, 191], 'two': [87, 192], 'alternative': [88], 'methods': [89], 'with': [90, 248, 257], 'increased': [91], 'sensitivity': [92], 'for': [93], 'mapping': [94], 'single': [95, 230], 'bases.': [97], 'In': [98], 'associated': [100], 'News': [101], '&': [102], 'Views,': [103], 'Nathalie': [104], 'Véron': [105], 'Antoine': [107], 'H.': [108], 'F.': [109], 'M.': [110], 'Peters': [111], 'discuss': [112], 'what': [113], 'these': [114], 'other': [116], 'recent': [117], 'reveal': [119], 'about': [120], 'role': [122, 320], 'proteins': [125, 169], 'regulating': [127], 'methylation': [129], 'gene': [131], 'expression.': [132], '(5hmC)': [134], 'a': [136, 214, 229, 258, 318, 326], 'at': [140, 288, 338], 'low': [141], 'levels': [142], 'diverse': [144], 'cell': [145, 175], 'types': [146], 'mammals1,2,3,4,5.': [148], 'TET': [154, 168], 'family': [155], 'Fe(II)': [157], '2-oxoglutarate-dependent': [159], 'through': [161], '(5mC)1,2,4,5,6,7.': [165], 'have': [170], 'been': [171], 'implicated': [172], 'biology': [176], 'cancer1,4,5,8,9,': [178], 'but': [179], 'information': [180], 'limited.': [188], 'Here': [189], 'we': [190], 'novel': [193], 'specific': [195, 259], 'approaches': [196], 'to': [197, 221, 239, 261, 332], 'profile': [198], 'genomic': [200, 246], 'localization': [201], '5hmC.': [203, 231], 'first': [205], 'approach,': [206], 'termed': [207], 'GLIB': [208], '(glucosylation,': [209], 'periodate': [210], 'oxidation,': [211], 'biotinylation)': [212], 'uses': [213], 'combination': [215], 'enzymatic': [217], 'chemical': [219], 'steps': [220], 'isolate': [222], 'fragments': [224], 'containing': [225], 'as': [226, 228], 'few': [227], 'second': [233], 'approach': [234], 'involves': [235], 'conversion': [236], 'cytosine': [240], '5-methylenesulphonate': [241], '(CMS)': [242], 'treatment': [244], 'sodium': [249], 'bisulphite,': [250], 'followed': [251], 'immunoprecipitation': [253], 'CMS-containing': [255], 'antiserum': [260], 'CMS5.': [262], 'High-throughput': [263], 'sequencing': [264], '5hmC-containing': [266], '(ES)': [272], 'showed': [274], 'strong': [275], 'enrichment': [276], 'within': [277], 'exons': [278], 'near': [280], 'transcriptional': [281, 322], 'start': [282, 290], 'sites.': [283], 'was': [285], 'especially': [286], 'enriched': [287], 'sites': [291], 'genes': [293, 340], 'whose': [294], 'promoters': [295], 'bear': [296], 'dual': [297], 'histone': [298, 305], '3': [299, 306], 'lysine': [300, 307], '27': [301], 'trimethylation': [302, 309], '(H3K27me3)': [303], '4': [308], '(H3K4me3)': [310], 'marks.': [311], 'Our': [312], 'results': [313], 'indicate': [314], 'that': [315], 'has': [317], 'probable': [319], 'regulation,': [323], 'suggest': [325], 'model': [327], 'which': [329], 'contributes': [331], '‘poised’': [334], 'chromatin': [335], 'signature': [336], 'found': [337], 'developmentally-regulated': [339], 'ES': [342], 'cells.': [343]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1981543052', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 23}, {'year': 2022, 'cited_by_count': 30}, {'year': 2021, 'cited_by_count': 31}, {'year': 2020, 'cited_by_count': 24}, {'year': 2019, 'cited_by_count': 42}, {'year': 2018, 'cited_by_count': 46}, {'year': 2017, 'cited_by_count': 62}, {'year': 2016, 'cited_by_count': 74}, {'year': 2015, 'cited_by_count': 70}, {'year': 2014, 'cited_by_count': 83}, {'year': 2013, 'cited_by_count': 119}, {'year': 2012, 'cited_by_count': 98}], 'updated_date': '2024-09-08T18:36:24.251288', 'created_date': '2016-06-24'}