Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1981377196', 'doi': 'https://doi.org/10.1016/j.neuro.2012.03.003', 'title': 'Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines', 'display_name': 'Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines', 'publication_year': 2012, 'publication_date': '2012-06-01', 'ids': {'openalex': 'https://openalex.org/W1981377196', 'doi': 'https://doi.org/10.1016/j.neuro.2012.03.003', 'mag': '1981377196', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22445961'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.neuro.2012.03.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S115834843', 'display_name': 'NeuroToxicology', 'issn_l': '0161-813X', 'issn': ['0161-813X', '1872-9711'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100664825', 'display_name': 'Shaowei Wang', 'orcid': 'https://orcid.org/0000-0002-1267-9554'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}, {'id': 'https://openalex.org/I21642278', 'display_name': 'Ningxia University', 'ror': 'https://ror.org/04j7b2v61', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I21642278']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shao-wei Wang', 'raw_affiliation_strings': ['School of Life Science, Ningxia University, Yinchuan 750021, China', 'Tsinghua University School of Medicine, Haidian District, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'Tsinghua University School of Medicine, Haidian District, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}, {'raw_affiliation_string': 'School of Life Science, Ningxia University, Yinchuan 750021, China', 'institution_ids': ['https://openalex.org/I21642278']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087423645', 'display_name': 'Yujiong Wang', 'orcid': 'https://orcid.org/0000-0003-2522-3043'}, 'institutions': [{'id': 'https://openalex.org/I21642278', 'display_name': 'Ningxia University', 'ror': 'https://ror.org/04j7b2v61', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I21642278']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yu-Jiong Wang', 'raw_affiliation_strings': ['School of Life Science, Ningxia University, Yinchuan 750021, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Science, Ningxia University, Yinchuan 750021, China', 'institution_ids': ['https://openalex.org/I21642278']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035641531', 'display_name': 'Yajing Su', 'orcid': 'https://orcid.org/0000-0003-0454-1405'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ya-jing Su', 'raw_affiliation_strings': ['Tsinghua University School of Medicine, Haidian District, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'Tsinghua University School of Medicine, Haidian District, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102764199', 'display_name': 'Weiwei Zhou', 'orcid': 'https://orcid.org/0000-0002-4065-3036'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}, {'id': 'https://openalex.org/I4210132375', 'display_name': 'First Affiliated Hospital of Chinese PLA General Hospital', 'ror': 'https://ror.org/039713658', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210132375']}, {'id': 'https://openalex.org/I4210160531', 'display_name': "Chinese People's Liberation Army", 'ror': 'https://ror.org/05tf9r976', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I4210160531']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei-wei Zhou', 'raw_affiliation_strings': ["First Hospital Affiliated to General Hospital of the Chinese People's Liberation Army, Beijing 100048, China", 'Tsinghua University School of Medicine, Haidian District, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'Tsinghua University School of Medicine, Haidian District, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}, {'raw_affiliation_string': "First Hospital Affiliated to General Hospital of the Chinese People's Liberation Army, Beijing 100048, China", 'institution_ids': ['https://openalex.org/I4210132375', 'https://openalex.org/I4210160531']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084566298', 'display_name': 'Shigao Yang', 'orcid': 'https://orcid.org/0000-0003-2717-6914'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shi-gao Yang', 'raw_affiliation_strings': ['Tsinghua University School of Medicine, Haidian District, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'Tsinghua University School of Medicine, Haidian District, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090458052', 'display_name': 'Ran Zhang', 'orcid': 'https://orcid.org/0000-0002-7630-1251'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ran Zhang', 'raw_affiliation_strings': ['Tsinghua University School of Medicine, Haidian District, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'Tsinghua University School of Medicine, Haidian District, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033289971', 'display_name': 'Min Zhao', 'orcid': 'https://orcid.org/0000-0003-1779-8111'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Min Zhao', 'raw_affiliation_strings': ['Tsinghua University School of Medicine, Haidian District, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'Tsinghua University School of Medicine, Haidian District, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100372466', 'display_name': 'Yanan Li', 'orcid': 'https://orcid.org/0000-0002-6321-2567'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ya-nan Li', 'raw_affiliation_strings': ['Tsinghua University School of Medicine, Haidian District, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'Tsinghua University School of Medicine, Haidian District, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073885433', 'display_name': 'Ziping Zhang', 'orcid': 'https://orcid.org/0000-0003-2802-1586'}, 'institutions': [{'id': 'https://openalex.org/I21642278', 'display_name': 'Ningxia University', 'ror': 'https://ror.org/04j7b2v61', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I21642278']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zi-ping Zhang', 'raw_affiliation_strings': ['School of Life Science, Ningxia University, Yinchuan 750021, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Science, Ningxia University, Yinchuan 750021, China', 'institution_ids': ['https://openalex.org/I21642278']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091361638', 'display_name': 'Daqian Zhan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210132375', 'display_name': 'First Affiliated Hospital of Chinese PLA General Hospital', 'ror': 'https://ror.org/039713658', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210132375']}, {'id': 'https://openalex.org/I4210160531', 'display_name': "Chinese People's Liberation Army", 'ror': 'https://ror.org/05tf9r976', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I4210160531']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Da-wei Zhan', 'raw_affiliation_strings': ["First Hospital Affiliated to General Hospital of the Chinese People's Liberation Army, Beijing 100048, China"], 'affiliations': [{'raw_affiliation_string': "First Hospital Affiliated to General Hospital of the Chinese People's Liberation Army, Beijing 100048, China", 'institution_ids': ['https://openalex.org/I4210132375', 'https://openalex.org/I4210160531']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5034198553', 'display_name': 'Rui‐tian Liu', 'orcid': 'https://orcid.org/0000-0002-4297-4765'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Rui-tian Liu', 'raw_affiliation_strings': ['Tsinghua University School of Medicine, Haidian District, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'Tsinghua University School of Medicine, Haidian District, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5091361638', 'https://openalex.org/A5034198553'], 'corresponding_institution_ids': ['https://openalex.org/I4210132375', 'https://openalex.org/I4210160531', 'https://openalex.org/I99065089'], 'apc_list': {'value': 3800, 'currency': 'USD', 'value_usd': 3800, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 7.8, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 187, 'citation_normalized_percentile': {'value': 0.999948, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '33', 'issue': '3', 'first_page': '482', 'last_page': '490'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11266', 'display_name': 'Role of Microglia in Neurological Disorders', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12023', 'display_name': 'Cholinesterase Inhibitors in Neurodegenerative Diseases', 'score': 0.9891, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proinflammatory-cytokine', 'display_name': 'Proinflammatory cytokine', 'score': 0.69099927}, {'id': "https://openalex.org/keywords/alzheimer's-disease", 'display_name': "Alzheimer's Disease", 'score': 0.472467}, {'id': 'https://openalex.org/keywords/neurotoxicity', 'display_name': 'Neurotoxicity', 'score': 0.45797938}, {'id': 'https://openalex.org/keywords/malondialdehyde', 'display_name': 'Malondialdehyde', 'score': 0.4430191}], 'concepts': [{'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.7908772}, {'id': 'https://openalex.org/C2775963812', 'wikidata': 'https://www.wikidata.org/wiki/Q407857', 'display_name': 'Rutin', 'level': 3, 'score': 0.73726034}, {'id': 'https://openalex.org/C538909803', 'wikidata': 'https://www.wikidata.org/wiki/Q116907', 'display_name': 'Glutathione', 'level': 3, 'score': 0.7273625}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.71222687}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.692698}, {'id': 'https://openalex.org/C164027704', 'wikidata': 'https://www.wikidata.org/wiki/Q3491837', 'display_name': 'Proinflammatory cytokine', 'level': 3, 'score': 0.69099927}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.6090683}, {'id': 'https://openalex.org/C2775838275', 'wikidata': 'https://www.wikidata.org/wiki/Q410776', 'display_name': 'Superoxide dismutase', 'level': 3, 'score': 0.5336175}, {'id': 'https://openalex.org/C2777622882', 'wikidata': 'https://www.wikidata.org/wiki/Q417619', 'display_name': 'Nitric oxide synthase', 'level': 3, 'score': 0.5296823}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.51077485}, {'id': 'https://openalex.org/C2778760513', 'wikidata': 'https://www.wikidata.org/wiki/Q24773045', 'display_name': 'Glutathione peroxidase', 'level': 4, 'score': 0.46562192}, {'id': 'https://openalex.org/C2779491297', 'wikidata': 'https://www.wikidata.org/wiki/Q3338704', 'display_name': 'Neurotoxicity', 'level': 3, 'score': 0.45797938}, {'id': 'https://openalex.org/C2778401633', 'wikidata': 'https://www.wikidata.org/wiki/Q418661', 'display_name': 'Malondialdehyde', 'level': 3, 'score': 0.4430191}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.43669078}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.42807743}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.40021244}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.261698}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.19408509}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1842697}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.16601256}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.060524285}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.04711628}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000975', 'descriptor_name': 'Antioxidants', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012431', 'descriptor_name': 'Rutin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000975', 'descriptor_name': 'Antioxidants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002374', 'descriptor_name': 'Catalase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002374', 'descriptor_name': 'Catalase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019610', 'descriptor_name': 'Cytoprotection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005979', 'descriptor_name': 'Glutathione Peroxidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005979', 'descriptor_name': 'Glutathione Peroxidase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053583', 'descriptor_name': 'Interleukin-1beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053583', 'descriptor_name': 'Interleukin-1beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008315', 'descriptor_name': 'Malondialdehyde', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008315', 'descriptor_name': 'Malondialdehyde', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052247', 'descriptor_name': 'Nitric Oxide Synthase Type II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052247', 'descriptor_name': 'Nitric Oxide Synthase Type II', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012431', 'descriptor_name': 'Rutin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.neuro.2012.03.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S115834843', 'display_name': 'NeuroToxicology', 'issn_l': '0161-813X', 'issn': ['0161-813X', '1872-9711'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22445961', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81171014'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '30971012'}], 'datasets': [], 'versions': [], 'referenced_works_count': 81, 'referenced_works': ['https://openalex.org/W1450506488', 'https://openalex.org/W1484591758', 'https://openalex.org/W1487727801', 'https://openalex.org/W1503983308', 'https://openalex.org/W1505775618', 'https://openalex.org/W1513568277', 'https://openalex.org/W1520113561', 'https://openalex.org/W1547195205', 'https://openalex.org/W1570513132', 'https://openalex.org/W1570574272', 'https://openalex.org/W1945940080', 'https://openalex.org/W1965919419', 'https://openalex.org/W1966195914', 'https://openalex.org/W1967840782', 'https://openalex.org/W1969418637', 'https://openalex.org/W1969863703', 'https://openalex.org/W1974305753', 'https://openalex.org/W1979414792', 'https://openalex.org/W1981458288', 'https://openalex.org/W1986772003', 'https://openalex.org/W1986837175', 'https://openalex.org/W1987946727', 'https://openalex.org/W1992176243', 'https://openalex.org/W1992512542', 'https://openalex.org/W1993993136', 'https://openalex.org/W1998149522', 'https://openalex.org/W2002013328', 'https://openalex.org/W2008156058', 'https://openalex.org/W2013815976', 'https://openalex.org/W2016298044', 'https://openalex.org/W2017115444', 'https://openalex.org/W2017889639', 'https://openalex.org/W2019256890', 'https://openalex.org/W2021683757', 'https://openalex.org/W2027046018', 'https://openalex.org/W2028483346', 'https://openalex.org/W2035612133', 'https://openalex.org/W2040536037', 'https://openalex.org/W2041515345', 'https://openalex.org/W2043460971', 'https://openalex.org/W2044386512', 'https://openalex.org/W2048301110', 'https://openalex.org/W2051214521', 'https://openalex.org/W2054874422', 'https://openalex.org/W2055676865', 'https://openalex.org/W2058472591', 'https://openalex.org/W2064119008', 'https://openalex.org/W2068318042', 'https://openalex.org/W2069027667', 'https://openalex.org/W2074948025', 'https://openalex.org/W2076537472', 'https://openalex.org/W2079158266', 'https://openalex.org/W2080683779', 'https://openalex.org/W2085278496', 'https://openalex.org/W2086847915', 'https://openalex.org/W2091711919', 'https://openalex.org/W2113655852', 'https://openalex.org/W2114684542', 'https://openalex.org/W2120591996', 'https://openalex.org/W2131628920', 'https://openalex.org/W2131819352', 'https://openalex.org/W2132573038', 'https://openalex.org/W2138057278', 'https://openalex.org/W2140449315', 'https://openalex.org/W2142038032', 'https://openalex.org/W2144049496', 'https://openalex.org/W2144539581', 'https://openalex.org/W2144868623', 'https://openalex.org/W2147700603', 'https://openalex.org/W2153621974', 'https://openalex.org/W2154508412', 'https://openalex.org/W2164216733', 'https://openalex.org/W2165092386', 'https://openalex.org/W2168025729', 'https://openalex.org/W2168190728', 'https://openalex.org/W2169152986', 'https://openalex.org/W2170755337', 'https://openalex.org/W2401476466', 'https://openalex.org/W4247759744', 'https://openalex.org/W4251884284', 'https://openalex.org/W97354292'], 'related_works': ['https://openalex.org/W4361002699', 'https://openalex.org/W3142754484', 'https://openalex.org/W2385227795', 'https://openalex.org/W2382512754', 'https://openalex.org/W2352851082', 'https://openalex.org/W2066852536', 'https://openalex.org/W2060672425', 'https://openalex.org/W2041265148', 'https://openalex.org/W2028249799', 'https://openalex.org/W2012125107'], 'abstract_inverted_index': {"Alzheimer's": [0], 'disease': [1], '(AD)': [2], 'is': [3, 18], 'a': [4, 19], 'complex,': [5], 'multi-factorial': [6], 'neurodegenerative': [7], 'disease.': [8], 'The': [9, 24], 'aggregation': [10], 'of': [11, 22, 43, 72, 102, 117, 132, 146], 'soluble': [12], 'β-amyloid': [13], '(Aβ)': [14], 'into': [15], 'fibrillar': [16], 'deposits': [17], 'pathological': [20], 'hallmark': [21], 'AD.': [23, 44, 147], 'Aβ': [25], 'aggregate-induced': [26], 'neurotoxicity,': [27], 'inflammatory': [28], 'reactions,': [29], 'oxidative': [30], 'stress,': [31], 'and': [32, 59, 81, 109, 113, 123, 144], 'nitric': [33, 86], 'oxide': [34, 87, 104], '(NO)': [35], 'generation': [36, 125], 'are': [37], 'strongly': [38], 'linked': [39], 'to': [40], 'the': [41, 49, 70, 95, 100, 115, 130, 142], 'etiology': [42], 'Here,': [45], 'we': [46], 'show': [47], 'that': [48], 'common': [50], 'dietary': [51], 'flavonoid,': [52], 'rutin,': [53], 'can': [54], 'dose-dependently': [55], 'inhibit': [56], 'Aβ42': [57], 'fibrillization': [58], 'attenuate': [60], 'Aβ42-induced': [61], 'cytotoxicity': [62], 'in': [63, 126], 'SH-SY5Y': [64], 'neuroblastoma': [65], 'cells.': [66], 'Moreover,': [67], 'rutin': [68, 133], 'decreases': [69], 'formation': [71], 'reactive': [73], 'oxygen': [74], 'species': [75], '(ROS),': [76], 'NO,': [77], 'glutathione': [78, 96, 110], 'disulfide': [79], '(GSSG),': [80], 'malondialdehyde': [82], '(MDA),': [83], 'reduces': [84], 'inducible': [85], 'synthase': [88], '(iNOS)': [89], 'activity,': [90], 'attenuates': [91], 'mitochondrial': [92], 'damage,': [93], 'increases': [94], '(GSH)/GSSG': [97], 'ratio,': [98], 'enhances': [99], 'activities': [101], 'super': [103], 'dismutase': [105], '(SOD),': [106], 'catalase': [107], '(CAT)': [108], 'peroxidase': [111], '(GPx),': [112], 'modulates': [114], 'production': [116], 'proinflammatory': [118], 'cytokines': [119], 'by': [120], 'decreasing': [121], 'TNF-α': [122], 'IL-1β': [124], 'microglia.': [127], 'Taken': [128], 'together,': [129], 'actions': [131], 'on': [134], 'multiple': [135], 'pathogenic': [136], 'factors': [137], 'deserves': [138], 'further': [139], 'investigation': [140], 'for': [141], 'prevention': [143], 'treatment': [145]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1981377196', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 24}, {'year': 2022, 'cited_by_count': 18}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 17}, {'year': 2017, 'cited_by_count': 17}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-13T02:25:36.128833', 'created_date': '2016-06-24'}