Publication Information

{'id': 'https://openalex.org/W1981275174', 'doi': 'https://doi.org/10.1136/mp.50.2.77', 'title': 'Routine diagnosis of large granular lymphocytic leukaemia by Southern blot and polymerase chain reaction analysis of clonal T cell receptor gene rearrangement.', 'display_name': 'Routine diagnosis of large granular lymphocytic leukaemia by Southern blot and polymerase chain reaction analysis of clonal T cell receptor gene rearrangement.', 'publication_year': 1997, 'publication_date': '1997-04-01', 'ids': {'openalex': 'https://openalex.org/W1981275174', 'doi': 'https://doi.org/10.1136/mp.50.2.77', 'mag': '1981275174', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9231154', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/379587'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/mp.50.2.77', 'pdf_url': 'https://mp.bmj.com/content/molpath/50/2/77.full.pdf', 'source': {'id': 'https://openalex.org/S68106708', 'display_name': 'Molecular Pathology', 'issn_l': '1366-8714', 'issn': ['1366-8714', '1472-4154'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://mp.bmj.com/content/molpath/50/2/77.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111564194', 'display_name': 'Douglas Ryan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802808109', 'display_name': 'Belfast City Hospital', 'ror': 'https://ror.org/02405mj67', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289110261', 'https://openalex.org/I2802808109']}, {'id': 'https://openalex.org/I138801177', 'display_name': 'University of Ulster', 'ror': 'https://ror.org/01yp9g959', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I138801177']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'D K Ryan', 'raw_affiliation_strings': ['Department of Haematology, Balfast City Hospital.'], 'affiliations': [{'raw_affiliation_string': 'Department of Haematology, Balfast City Hospital.', 'institution_ids': ['https://openalex.org/I2802808109', 'https://openalex.org/I138801177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103634325', 'display_name': 'H. D. Alexander', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802808109', 'display_name': 'Belfast City Hospital', 'ror': 'https://ror.org/02405mj67', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289110261', 'https://openalex.org/I2802808109']}, {'id': 'https://openalex.org/I138801177', 'display_name': 'University of Ulster', 'ror': 'https://ror.org/01yp9g959', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I138801177']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'H D Alexander', 'raw_affiliation_strings': ['Department of Haematology, Balfast City Hospital.'], 'affiliations': [{'raw_affiliation_string': 'Department of Haematology, Balfast City Hospital.', 'institution_ids': ['https://openalex.org/I2802808109', 'https://openalex.org/I138801177']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5113592255', 'display_name': 'T C Morris', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802808109', 'display_name': 'Belfast City Hospital', 'ror': 'https://ror.org/02405mj67', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289110261', 'https://openalex.org/I2802808109']}, {'id': 'https://openalex.org/I138801177', 'display_name': 'University of Ulster', 'ror': 'https://ror.org/01yp9g959', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I138801177']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'T C Morris', 'raw_affiliation_strings': ['Department of Haematology, Balfast City Hospital.'], 'affiliations': [{'raw_affiliation_string': 'Department of Haematology, Balfast City Hospital.', 'institution_ids': ['https://openalex.org/I2802808109', 'https://openalex.org/I138801177']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.278, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.802902, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '50', 'issue': '2', 'first_page': '77', 'last_page': '81'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10185', 'display_name': 'Lymphoma Diagnosis and Treatment', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gene-rearrangement', 'display_name': 'Gene rearrangement', 'score': 0.6987074}, {'id': 'https://openalex.org/keywords/southern-blot', 'display_name': 'Southern blot', 'score': 0.64900076}, {'id': 'https://openalex.org/keywords/lymphocytosis', 'display_name': 'Lymphocytosis', 'score': 0.5299904}, {'id': 'https://openalex.org/keywords/clone', 'display_name': 'clone (Java method)', 'score': 0.41159514}], 'concepts': [{'id': 'https://openalex.org/C19317047', 'wikidata': 'https://www.wikidata.org/wiki/Q412037', 'display_name': 'T-cell receptor', 'level': 4, 'score': 0.92262113}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.71043605}, {'id': 'https://openalex.org/C2992511266', 'wikidata': 'https://www.wikidata.org/wiki/Q1093098', 'display_name': 'Gene rearrangement', 'level': 3, 'score': 0.6987074}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6676826}, {'id': 'https://openalex.org/C49105822', 'wikidata': 'https://www.wikidata.org/wiki/Q176996', 'display_name': 'Polymerase chain reaction', 'level': 3, 'score': 0.6619837}, {'id': 'https://openalex.org/C133307689', 'wikidata': 'https://www.wikidata.org/wiki/Q48749', 'display_name': 'Southern blot', 'level': 3, 'score': 0.64900076}, {'id': 'https://openalex.org/C114684123', 'wikidata': 'https://www.wikidata.org/wiki/Q419458', 'display_name': 'CD3', 'level': 4, 'score': 0.62112963}, {'id': 'https://openalex.org/C2780126324', 'wikidata': 'https://www.wikidata.org/wiki/Q612345', 'display_name': 'Lymphocytosis', 'level': 2, 'score': 0.5299904}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.5210782}, {'id': 'https://openalex.org/C163864487', 'wikidata': 'https://www.wikidata.org/wiki/Q6901461', 'display_name': 'Monoclonal', 'level': 4, 'score': 0.50944954}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.4878657}, {'id': 'https://openalex.org/C81089528', 'wikidata': 'https://www.wikidata.org/wiki/Q5134986', 'display_name': 'clone (Java method)', 'level': 3, 'score': 0.41159514}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.3437833}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.326993}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.20486632}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.20386735}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.19526029}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.1408633}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.052675575}], 'mesh': [{'descriptor_ui': 'D015333', 'descriptor_name': 'Gene Rearrangement, beta-Chain T-Cell Antigen Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015334', 'descriptor_name': 'Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007945', 'descriptor_name': 'Leukemia, Lymphoid', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D015139', 'descriptor_name': 'Blotting, Southern', 'qualifier_ui': 'Q000592', 'qualifier_name': 'standards', 'is_major_topic': False}, {'descriptor_ui': 'D015139', 'descriptor_name': 'Blotting, Southern', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007945', 'descriptor_name': 'Leukemia, Lymphoid', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007945', 'descriptor_name': 'Leukemia, Lymphoid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': 'Q000592', 'qualifier_name': 'standards', 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012680', 'descriptor_name': 'Sensitivity and Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/mp.50.2.77', 'pdf_url': 'https://mp.bmj.com/content/molpath/50/2/77.full.pdf', 'source': {'id': 'https://openalex.org/S68106708', 'display_name': 'Molecular Pathology', 'issn_l': '1366-8714', 'issn': ['1366-8714', '1472-4154'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc379587', 'pdf_url': 'https://europepmc.org/articles/pmc379587?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC379587', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://mp.bmj.com/cgi/content/short/50/2/77', 'pdf_url': 'http://mp.bmj.com/content/50/2/77.full.pdf', 'source': {'id': 'https://openalex.org/S128516502', 'display_name': 'Notes and Queries', 'issn_l': '0029-3970', 'issn': ['0029-3970', '1471-6941'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9231154', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/mp.50.2.77', 'pdf_url': 'https://mp.bmj.com/content/molpath/50/2/77.full.pdf', 'source': {'id': 'https://openalex.org/S68106708', 'display_name': 'Molecular Pathology', 'issn_l': '1366-8714', 'issn': ['1366-8714', '1472-4154'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 17, 'referenced_works': ['https://openalex.org/W106878149', 'https://openalex.org/W1480061065', 'https://openalex.org/W158539629', 'https://openalex.org/W161786533', 'https://openalex.org/W1970687636', 'https://openalex.org/W1989261632', 'https://openalex.org/W1990841938', 'https://openalex.org/W2002752140', 'https://openalex.org/W2014326940', 'https://openalex.org/W2017774102', 'https://openalex.org/W2063450941', 'https://openalex.org/W2092594443', 'https://openalex.org/W2101960111', 'https://openalex.org/W2167439560', 'https://openalex.org/W2316119724', 'https://openalex.org/W3026456586', 'https://openalex.org/W4250889214'], 'related_works': ['https://openalex.org/W2799628826', 'https://openalex.org/W2791161545', 'https://openalex.org/W2418074846', 'https://openalex.org/W2143088715', 'https://openalex.org/W2079884654', 'https://openalex.org/W2057166411', 'https://openalex.org/W2040053783', 'https://openalex.org/W2001217486', 'https://openalex.org/W1982307020', 'https://openalex.org/W111039888'], 'abstract_inverted_index': {'AIMS:': [0], 'To': [1], 'compare': [2], 'the': [3, 16, 34, 39, 48, 51, 72, 93, 157, 202, 220], 'polymerase': [4], 'chain': [5], 'reaction': [6], '(PCR)': [7], 'assay': [8], 'with': [9, 62, 66, 80], 'standard': [10], 'Southern': [11], 'blot': [12], '(SB)': [13], 'hybridisation': [14, 79, 147, 204, 218], 'for': [15, 41, 219, 251], 'detection': [17], 'of': [18, 38, 50, 71, 90, 92, 164, 173, 201, 209, 223, 226], 'clonal': [19, 142, 182, 256], 'T': [20], 'cell': [21, 183], 'receptor': [22], '(TCR)': [23], 'gene': [24, 74, 104, 134, 245], 'rearrangements': [25, 70, 105, 143], 'in': [26, 108, 167, 184, 232, 259], 'large': [27], 'granular': [28], 'lymphocyte': [29], '(LGL)': [30], 'proliferations;': [31], 'to': [32, 46, 213, 216, 237], 'evaluate': [33], 'reliability': [35], 'and': [36, 45, 86, 96, 115, 255], 'practicality': [37], 'methods': [40], 'routine': [42, 221, 261], 'diagnostic': [43, 262], 'use;': [44], 'determine': [47], 'sensitivity': [49, 194], 'PCR': [52, 88, 113, 122, 160, 210], 'method.': [53], 'METHODS:': [54], 'Blood': [55], 'lymphocytes': [56], 'were': [57, 75, 106, 148, 235], 'isolated': [58], 'from': [59], '12': [60], 'patients': [61, 110, 117, 128, 230], 'persistent': [63], 'CD3+CD8+': [64], 'lymphocytosis': [65], 'LGL': [67, 227, 257], 'morphology.': [68], 'Clonal': [69], 'TCR': [73, 82, 94, 97, 102, 132, 140, 158, 176, 239, 242], 'demonstrated': [76], 'by': [77, 87, 112, 119, 145, 151], 'SB': [78, 120, 146, 203, 217], 'a': [81, 193, 260], 'beta': [83, 95, 103, 141, 159, 177, 240], 'constant': [84], 'probe,': [85], 'amplification': [89], 'portions': [91], 'gamma': [98, 133, 243], 'genes.': [99], 'RESULTS:': [100], 'Monoclonal': [101], 'detected': [107], 'eight': [109], '(67%)': [111], 'analysis': [114, 123], 'five': [116], '(42%)': [118], 'hybridisation.': [121], 'also': [124], 'showed': [125], 'that': [126, 156, 196, 200], 'seven': [127], '(58%)': [129], 'had': [130, 139], 'monoclonal': [131, 244], 'rearrangements.': [135, 246], 'All': [136], 'cases': [137, 225], 'which': [138], 'shown': [144], 'similarly': [149], 'identified': [150], 'PCR.': [152], 'Sensitivity': [153], 'tests': [154], 'suggested': [155], 'technique': [161], 'was': [162], 'capable': [163], 'detecting': [165], 'clonality': [166], 'as': [168, 170], 'little': [169], '50': [171], 'pg': [172], 'DNA.': [174], 'The': [175, 207], 'primers': [178], 'could': [179], 'detect': [180], 'one': [181], 'approximately': [185], '200': [186], 'or': [187], 'more': [188], 'normal': [189], 'cells': [190], '(<': [191], '0.5%),': [192], 'level': [195], 'at': [197], 'least': [198], 'doubles': [199], 'technique.': [205], 'CONCLUSIONS:': [206], 'use': [208], 'technology': [211], 'proved': [212], 'be': [214], 'superior': [215], 'investigation': [222], 'suspected': [224], 'leukaemia.': [228], 'Nine': [229], '(75%)': [231], 'this': [233], 'study': [234], 'found': [236], 'have': [238], 'and/or': [241], 'This': [247], 'approach': [248], 'is': [249], 'ideal': [250], 'distinguishing': [252], 'between': [253], 'reactive': [254], 'proliferation': [258], 'laboratory.': [263]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1981275174', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2025-01-02T23:30:58.272161', 'created_date': '2016-06-24'}