Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1980935014', 'doi': 'https://doi.org/10.1111/j.1550-7408.1982.tb04018.x', 'title': 'Growth Cycle‐Dependent Overproduction and Accumulation of Protoporphyrin IX in <i>Tetrahymena</i>: Effect of Heavy Metals1', 'display_name': 'Growth Cycle‐Dependent Overproduction and Accumulation of Protoporphyrin IX in <i>Tetrahymena</i>: Effect of Heavy Metals1', 'publication_year': 1982, 'publication_date': '1982-05-01', 'ids': {'openalex': 'https://openalex.org/W1980935014', 'doi': 'https://doi.org/10.1111/j.1550-7408.1982.tb04018.x', 'mag': '1980935014', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6808123'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1550-7408.1982.tb04018.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210213139', 'display_name': 'The Journal of Protozoology', 'issn_l': '0022-3921', 'issn': ['0022-3921', '2375-0804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108492767', 'display_name': 'Larry Ruben', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'LARRY RUBEN', 'raw_affiliation_strings': ['Department of Genetics and Cell Biology, University of Minnesota, St. Paul, Minnesota 55108', 'Yale University School of Medicine, Department of Internal Medicine, 333 Cedar Street, New Haven, Connecticut 06510.'], 'affiliations': [{'raw_affiliation_string': 'Yale University School of Medicine, Department of Internal Medicine, 333 Cedar Street, New Haven, Connecticut 06510.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'Department of Genetics and Cell Biology, University of Minnesota, St. Paul, Minnesota 55108', 'institution_ids': ['https://openalex.org/I130238516']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073287347', 'display_name': 'Jean Lageson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'JEAN LAGESON', 'raw_affiliation_strings': ['Department of Genetics and Cell Biology, University of Minnesota, St. Paul, Minnesota 55108'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics and Cell Biology, University of Minnesota, St. Paul, Minnesota 55108', 'institution_ids': ['https://openalex.org/I130238516']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029448074', 'display_name': 'BOB HYZY', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'BOB HYZY', 'raw_affiliation_strings': ['Department of Genetics and Cell Biology, University of Minnesota, St. Paul, Minnesota 55108'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics and Cell Biology, University of Minnesota, St. Paul, Minnesota 55108', 'institution_ids': ['https://openalex.org/I130238516']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076388035', 'display_name': 'Alan B. Hooper', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'ALAN B. HOOPER', 'raw_affiliation_strings': ['Department of Genetics and Cell Biology, University of Minnesota, St. Paul, Minnesota 55108'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics and Cell Biology, University of Minnesota, St. Paul, Minnesota 55108', 'institution_ids': ['https://openalex.org/I130238516']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.392513, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 70, 'max': 72}, 'biblio': {'volume': '29', 'issue': '2', 'first_page': '233', 'last_page': '238'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase-1 and Carbon Monoxide', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase-1 and Carbon Monoxide', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12441', 'display_name': 'Porphyrin Metabolism and Disorders', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12094', 'display_name': 'Hemoglobin structure and function', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/protoporphyrin-ix', 'display_name': 'Protoporphyrin IX', 'score': 0.94465464}, {'id': 'https://openalex.org/keywords/overproduction', 'display_name': 'Overproduction', 'score': 0.9059313}, {'id': 'https://openalex.org/keywords/tetrahymena-pyriformis', 'display_name': 'Tetrahymena pyriformis', 'score': 0.7351562}, {'id': 'https://openalex.org/keywords/hematoporphyrin', 'display_name': 'Hematoporphyrin', 'score': 0.4498651}], 'concepts': [{'id': 'https://openalex.org/C2779671804', 'wikidata': 'https://www.wikidata.org/wiki/Q619815', 'display_name': 'Protoporphyrin IX', 'level': 3, 'score': 0.94465464}, {'id': 'https://openalex.org/C124420848', 'wikidata': 'https://www.wikidata.org/wiki/Q333076', 'display_name': 'Overproduction', 'level': 3, 'score': 0.9059313}, {'id': 'https://openalex.org/C2778417259', 'wikidata': 'https://www.wikidata.org/wiki/Q619815', 'display_name': 'Protoporphyrin', 'level': 3, 'score': 0.84980863}, {'id': 'https://openalex.org/C2991723024', 'wikidata': 'https://www.wikidata.org/wiki/Q3519169', 'display_name': 'Tetrahymena pyriformis', 'level': 3, 'score': 0.7351562}, {'id': 'https://openalex.org/C2776217839', 'wikidata': 'https://www.wikidata.org/wiki/Q189621', 'display_name': 'Heme', 'level': 3, 'score': 0.7062023}, {'id': 'https://openalex.org/C2779480358', 'wikidata': 'https://www.wikidata.org/wiki/Q422926', 'display_name': 'Porphyrin', 'level': 2, 'score': 0.6821438}, {'id': 'https://openalex.org/C2777166614', 'wikidata': 'https://www.wikidata.org/wiki/Q1198419', 'display_name': 'Tetrahymena', 'level': 2, 'score': 0.592043}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5264569}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5101078}, {'id': 'https://openalex.org/C2777334866', 'wikidata': 'https://www.wikidata.org/wiki/Q106345', 'display_name': 'Ciliate', 'level': 2, 'score': 0.490284}, {'id': 'https://openalex.org/C2780699678', 'wikidata': 'https://www.wikidata.org/wiki/Q908742', 'display_name': 'Hematoporphyrin', 'level': 3, 'score': 0.4498651}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.41046685}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.40382674}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37689793}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.3028381}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.1172902}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07158467}, {'id': 'https://openalex.org/C2781323092', 'wikidata': 'https://www.wikidata.org/wiki/Q1428072', 'display_name': 'Photodynamic therapy', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003035', 'descriptor_name': 'Cobalt', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011166', 'descriptor_name': 'Porphyrins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011524', 'descriptor_name': 'Protoporphyrins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013769', 'descriptor_name': 'Tetrahymena pyriformis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014001', 'descriptor_name': 'Tin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000624', 'descriptor_name': '5-Aminolevulinate Synthetase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000624', 'descriptor_name': '5-Aminolevulinate Synthetase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003035', 'descriptor_name': 'Cobalt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006418', 'descriptor_name': 'Heme', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006418', 'descriptor_name': 'Heme', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011166', 'descriptor_name': 'Porphyrins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011524', 'descriptor_name': 'Protoporphyrins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013769', 'descriptor_name': 'Tetrahymena pyriformis', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D013769', 'descriptor_name': 'Tetrahymena pyriformis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014001', 'descriptor_name': 'Tin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1550-7408.1982.tb04018.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210213139', 'display_name': 'The Journal of Protozoology', 'issn_l': '0022-3921', 'issn': ['0022-3921', '2375-0804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6808123', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 18, 'referenced_works': ['https://openalex.org/W1560388838', 'https://openalex.org/W157272645', 'https://openalex.org/W1574786078', 'https://openalex.org/W1594873397', 'https://openalex.org/W1967528101', 'https://openalex.org/W1987794485', 'https://openalex.org/W2003896806', 'https://openalex.org/W2019003542', 'https://openalex.org/W2066313956', 'https://openalex.org/W2143834288', 'https://openalex.org/W2255672572', 'https://openalex.org/W2314782572', 'https://openalex.org/W2316941233', 'https://openalex.org/W2317534488', 'https://openalex.org/W2487798569', 'https://openalex.org/W2734405269', 'https://openalex.org/W77696615', 'https://openalex.org/W97799595'], 'related_works': ['https://openalex.org/W384619142', 'https://openalex.org/W2379117224', 'https://openalex.org/W2377050941', 'https://openalex.org/W2370980546', 'https://openalex.org/W2328594492', 'https://openalex.org/W2109867925', 'https://openalex.org/W2031867342', 'https://openalex.org/W2003982711', 'https://openalex.org/W1980935014', 'https://openalex.org/W1850189838'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Cells': [1], 'of': [2, 13, 29, 58, 71, 92, 98], 'the': [3, 14, 33, 41, 54, 68, 81, 115], 'ciliate': [4], 'Tetrahymena': [5], 'pyriformis': [6], 'GL': [7], 'overproduce': [8], 'and': [9], 'accumulate': [10], 'massive': [11], 'quantities': [12], 'heme': [15], 'intermediate,': [16], 'protoporphyrin': [17, 59, 85, 99, 111], 'IX.': [18], 'Protoporphyrin': [19], 'is': [20, 46], 'localized': [21], 'intracellularly': [22], 'in': [23, 32, 67, 80, 101, 114], 'discrete': [24], 'membranous': [25], 'compartments.': [26], 'The': [27, 90], 'amount': [28], 'porphyrin': [30], 'stored': [31], 'cell': [34], 'changes': [35], 'dramatically': [36], 'as': [37], 'cells': [38], 'progress': [39], 'through': [40], 'growth': [42, 69], 'cycle.': [43], 'Porphyrin': [44], 'overproduction': [45], 'stimulated': [47], 'by': [48, 83, 105], 'δ‐aminolevulinic': [49, 75, 106], 'acid,': [50], 'but': [51], 'only': [52], 'during': [53], 'mid‐stationary': [55], 'phase.': [56], 'Overproduction': [57], 'IX': [60, 86, 100, 112], 'apparently': [61], 'results': [62], 'from': [63], 'an': [64], 'increase,': [65], 'late': [66], 'cycle,': [70], 'activities': [72], 'subsequent': [73], 'to': [74], 'acid': [76], 'synthetase.': [77], 'Feedback': [78], 'inhibition': [79], 'pathway': [82], 'accumulated': [84], 'does': [87], 'not': [88], 'occur.': [89], 'presence': [91], 'Co': [93], '2+': [94], 'completely': [95], 'inhibits': [96], 'accumulation': [97, 113], 'a': [102], 'manner': [103], 'reversed': [104], 'acid.': [107], 'Sn': [108], '4+': [109], 'stimulates': [110], 'culture.': [116]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1980935014', 'counts_by_year': [{'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-14T07:04:01.802603', 'created_date': '2016-06-24'}