Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1980878904', 'doi': 'https://doi.org/10.1016/j.cell.2007.07.003', 'title': 'Cellular Senescence in Cancer and Aging', 'display_name': 'Cellular Senescence in Cancer and Aging', 'publication_year': 2007, 'publication_date': '2007-07-01', 'ids': {'openalex': 'https://openalex.org/W1980878904', 'doi': 'https://doi.org/10.1016/j.cell.2007.07.003', 'mag': '1980878904', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17662938'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cell.2007.07.003', 'pdf_url': 'http://www.cell.com/article/S0092867407008902/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.cell.com/article/S0092867407008902/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5077962453', 'display_name': 'Manuel Collado', 'orcid': 'https://orcid.org/0000-0002-0330-0880'}, 'institutions': [{'id': 'https://openalex.org/I4210089594', 'display_name': 'Spanish National Cancer Research Centre', 'ror': 'https://ror.org/00bvhmc43', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210089594']}, {'id': 'https://openalex.org/I4210138819', 'display_name': 'Centro de Investigación del Cáncer', 'ror': 'https://ror.org/04rxrdv16', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I184999862', 'https://openalex.org/I4210138819']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Manuel Collado', 'raw_affiliation_strings': ['Spanish National Cancer Research Center (CNIO), Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Spanish National Cancer Research Center (CNIO), Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210089594', 'https://openalex.org/I4210138819']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085977927', 'display_name': 'Marı́a A. Blasco', 'orcid': 'https://orcid.org/0000-0002-4211-233X'}, 'institutions': [{'id': 'https://openalex.org/I4210138819', 'display_name': 'Centro de Investigación del Cáncer', 'ror': 'https://ror.org/04rxrdv16', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I184999862', 'https://openalex.org/I4210138819']}, {'id': 'https://openalex.org/I4210089594', 'display_name': 'Spanish National Cancer Research Centre', 'ror': 'https://ror.org/00bvhmc43', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210089594']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Maria A. Blasco', 'raw_affiliation_strings': ['Spanish National Cancer Research Center (CNIO), Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Spanish National Cancer Research Center (CNIO), Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210138819', 'https://openalex.org/I4210089594']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5061302501', 'display_name': 'Manuel Serrano', 'orcid': 'https://orcid.org/0000-0001-7177-9312'}, 'institutions': [{'id': 'https://openalex.org/I4210089594', 'display_name': 'Spanish National Cancer Research Centre', 'ror': 'https://ror.org/00bvhmc43', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210089594']}, {'id': 'https://openalex.org/I4210138819', 'display_name': 'Centro de Investigación del Cáncer', 'ror': 'https://ror.org/04rxrdv16', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I184999862', 'https://openalex.org/I4210138819']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Manuel Serrano', 'raw_affiliation_strings': ['Spanish National Cancer Research Center (CNIO), Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Spanish National Cancer Research Center (CNIO), Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210089594', 'https://openalex.org/I4210138819']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 10100, 'currency': 'USD', 'value_usd': 10100, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 12.934, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1580, 'citation_normalized_percentile': {'value': 0.998981, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '130', 'issue': '2', 'first_page': '223', 'last_page': '233'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10937', 'display_name': 'Cellular Senescence and Aging-Related Diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10937', 'display_name': 'Cellular Senescence and Aging-Related Diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10676', 'display_name': 'Molecular Mechanisms of Aging and Longevity', 'score': 0.9866, 'subfield': {'id': 'https://openalex.org/subfields/1302', 'display_name': 'Aging'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11013', 'display_name': 'Mechanisms of Skin Aging and Photodamage', 'score': 0.9785, 'subfield': {'id': 'https://openalex.org/subfields/2708', 'display_name': 'Dermatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cellular-senescence', 'display_name': 'Cellular senescence', 'score': 0.8045826}, {'id': 'https://openalex.org/keywords/cellular-aging', 'display_name': 'Cellular Aging', 'score': 0.6835581}, {'id': 'https://openalex.org/keywords/derepression', 'display_name': 'Derepression', 'score': 0.64967024}, {'id': 'https://openalex.org/keywords/aging', 'display_name': 'Aging', 'score': 0.54037}, {'id': 'https://openalex.org/keywords/senescence', 'display_name': 'Senescence', 'score': 0.500976}, {'id': 'https://openalex.org/keywords/epigenesis', 'display_name': 'Epigenesis', 'score': 0.4168982}], 'concepts': [{'id': 'https://openalex.org/C522857546', 'wikidata': 'https://www.wikidata.org/wiki/Q2070979', 'display_name': 'Senescence', 'level': 2, 'score': 0.89427364}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8923413}, {'id': 'https://openalex.org/C2779523775', 'wikidata': 'https://www.wikidata.org/wiki/Q9075999', 'display_name': 'Cellular senescence', 'level': 4, 'score': 0.8045826}, {'id': 'https://openalex.org/C177336024', 'wikidata': 'https://www.wikidata.org/wiki/Q14872779', 'display_name': 'Telomere', 'level': 3, 'score': 0.79871}, {'id': 'https://openalex.org/C2908780919', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Cellular Aging', 'level': 4, 'score': 0.6835581}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.6638226}, {'id': 'https://openalex.org/C73766848', 'wikidata': 'https://www.wikidata.org/wiki/Q5262529', 'display_name': 'Derepression', 'level': 5, 'score': 0.64967024}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.5782447}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5534287}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.41956738}, {'id': 'https://openalex.org/C179463898', 'wikidata': 'https://www.wikidata.org/wiki/Q10273301', 'display_name': 'Epigenesis', 'level': 5, 'score': 0.4168982}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.39446768}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.3420968}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.2605695}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.11559194}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.101587}, {'id': 'https://openalex.org/C186310378', 'wikidata': 'https://www.wikidata.org/wiki/Q941796', 'display_name': 'Psychological repression', 'level': 4, 'score': 0.08820054}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.06324381}], 'mesh': [{'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D016922', 'descriptor_name': 'Cellular Senescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019941', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p16', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019941', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p16', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016615', 'descriptor_name': 'Telomere', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016615', 'descriptor_name': 'Telomere', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cell.2007.07.003', 'pdf_url': 'http://www.cell.com/article/S0092867407008902/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17662938', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cell.2007.07.003', 'pdf_url': 'http://www.cell.com/article/S0092867407008902/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 116, 'referenced_works': ['https://openalex.org/W1481473039', 'https://openalex.org/W1499959019', 'https://openalex.org/W1612842202', 'https://openalex.org/W1676646253', 'https://openalex.org/W1944558458', 'https://openalex.org/W1970249544', 'https://openalex.org/W1970891016', 'https://openalex.org/W1973063382', 'https://openalex.org/W1975899243', 'https://openalex.org/W1979784082', 'https://openalex.org/W1980415043', 'https://openalex.org/W1981148605', 'https://openalex.org/W1982395176', 'https://openalex.org/W1983298684', 'https://openalex.org/W1983673827', 'https://openalex.org/W1984187829', 'https://openalex.org/W1986014209', 'https://openalex.org/W1986594019', 'https://openalex.org/W1986615467', 'https://openalex.org/W1986763150', 'https://openalex.org/W1988008469', 'https://openalex.org/W1991962444', 'https://openalex.org/W1993892315', 'https://openalex.org/W1995648202', 'https://openalex.org/W1995751421', 'https://openalex.org/W1995925983', 'https://openalex.org/W1997813173', 'https://openalex.org/W1998767677', 'https://openalex.org/W2001733842', 'https://openalex.org/W2002569327', 'https://openalex.org/W2003223749', 'https://openalex.org/W2004273407', 'https://openalex.org/W2004314923', 'https://openalex.org/W2010077871', 'https://openalex.org/W2012573722', 'https://openalex.org/W2017235640', 'https://openalex.org/W2018514685', 'https://openalex.org/W2020717634', 'https://openalex.org/W2022572059', 'https://openalex.org/W2023990738', 'https://openalex.org/W2026711486', 'https://openalex.org/W2027779909', 'https://openalex.org/W2035532250', 'https://openalex.org/W2036198235', 'https://openalex.org/W2038076787', 'https://openalex.org/W2041036994', 'https://openalex.org/W2041156660', 'https://openalex.org/W2041198010', 'https://openalex.org/W2042000503', 'https://openalex.org/W2043204829', 'https://openalex.org/W2046589688', 'https://openalex.org/W2048755332', 'https://openalex.org/W2049085719', 'https://openalex.org/W2049151391', 'https://openalex.org/W2050166933', 'https://openalex.org/W2056495027', 'https://openalex.org/W2060632243', 'https://openalex.org/W2061440932', 'https://openalex.org/W2061619522', 'https://openalex.org/W2062759109', 'https://openalex.org/W2063269133', 'https://openalex.org/W2063914679', 'https://openalex.org/W2065220409', 'https://openalex.org/W2065564965', 'https://openalex.org/W2065891752', 'https://openalex.org/W2066848701', 'https://openalex.org/W2067117191', 'https://openalex.org/W2070193339', 'https://openalex.org/W2073429636', 'https://openalex.org/W2076328665', 'https://openalex.org/W2076984763', 'https://openalex.org/W2080370285', 'https://openalex.org/W2080769506', 'https://openalex.org/W2082122713', 'https://openalex.org/W2082399402', 'https://openalex.org/W2084289371', 'https://openalex.org/W2085786821', 'https://openalex.org/W2087404852', 'https://openalex.org/W2087849372', 'https://openalex.org/W2088566849', 'https://openalex.org/W2092476887', 'https://openalex.org/W2093958228', 'https://openalex.org/W2095370504', 'https://openalex.org/W2097529540', 'https://openalex.org/W2097852826', 'https://openalex.org/W2099021742', 'https://openalex.org/W2099956701', 'https://openalex.org/W2101370480', 'https://openalex.org/W2101446599', 'https://openalex.org/W2102801302', 'https://openalex.org/W2102922697', 'https://openalex.org/W2103235451', 'https://openalex.org/W2104908670', 'https://openalex.org/W2105571100', 'https://openalex.org/W2108482850', 'https://openalex.org/W2113724972', 'https://openalex.org/W2120923197', 'https://openalex.org/W2121371748', 'https://openalex.org/W2122342818', 'https://openalex.org/W2122740168', 'https://openalex.org/W2124621255', 'https://openalex.org/W2136840198', 'https://openalex.org/W2139712402', 'https://openalex.org/W2142020978', 'https://openalex.org/W2142205521', 'https://openalex.org/W2145357417', 'https://openalex.org/W2145859123', 'https://openalex.org/W2146143136', 'https://openalex.org/W2147991226', 'https://openalex.org/W2150740687', 'https://openalex.org/W2154799239', 'https://openalex.org/W2158491040', 'https://openalex.org/W2160185049', 'https://openalex.org/W2160840611', 'https://openalex.org/W2168395104', 'https://openalex.org/W2171317581'], 'related_works': ['https://openalex.org/W4379768574', 'https://openalex.org/W4379510564', 'https://openalex.org/W4361246758', 'https://openalex.org/W2387070056', 'https://openalex.org/W2371502216', 'https://openalex.org/W2366509794', 'https://openalex.org/W2161673543', 'https://openalex.org/W2150751047', 'https://openalex.org/W2005469667', 'https://openalex.org/W1828198099'], 'abstract_inverted_index': {'Cellular': [0], 'senescence,': [1], 'a': [2], 'state': [3, 39], 'of': [4, 20, 40, 46], 'irreversible': [5], 'growth': [6], 'arrest,': [7], 'can': [8], 'be': [9, 56], 'triggered': [10], 'by': [11], 'multiple': [12], 'mechanisms': [13, 29], 'including': [14], 'telomere': [15], 'shortening,': [16], 'the': [17, 21, 38, 44], 'epigenetic': [18], 'derepression': [19], '<i>INK4a</i>/<i>ARF</i>': [22], 'locus,': [23], 'and': [24, 36], 'DNA': [25], 'damage.': [26], 'Together': [27], 'these': [28], 'limit': [30], 'excessive': [31], 'or': [32], 'aberrant': [33], 'cellular': [34, 52], 'proliferation,': [35], 'so': [37], 'senescence': [41, 53], 'protects': [42], 'against': [43], 'development': [45], 'cancer.': [47], 'Recent': [48], 'evidence': [49], 'suggests': [50], 'that': [51], 'also': [54], 'may': [55], 'involved': [57], 'in': [58], 'aging.': [59]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1980878904', 'counts_by_year': [{'year': 2024, 'cited_by_count': 47}, {'year': 2023, 'cited_by_count': 73}, {'year': 2022, 'cited_by_count': 91}, {'year': 2021, 'cited_by_count': 94}, {'year': 2020, 'cited_by_count': 106}, {'year': 2019, 'cited_by_count': 96}, {'year': 2018, 'cited_by_count': 107}, {'year': 2017, 'cited_by_count': 83}, {'year': 2016, 'cited_by_count': 110}, {'year': 2015, 'cited_by_count': 87}, {'year': 2014, 'cited_by_count': 112}, {'year': 2013, 'cited_by_count': 116}, {'year': 2012, 'cited_by_count': 88}], 'updated_date': '2024-09-15T04:07:22.666709', 'created_date': '2016-06-24'}