Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1980866671', 'doi': 'https://doi.org/10.3164/jcbn.32.1', 'title': 'Up-Regulation of the Uncoupling Protein Family by Chronic Treatment with a .BETA.3-Adrenergic Receptor Agonist in Obese Yellow KK Mice', 'display_name': 'Up-Regulation of the Uncoupling Protein Family by Chronic Treatment with a .BETA.3-Adrenergic Receptor Agonist in Obese Yellow KK Mice', 'publication_year': 2002, 'publication_date': '2002-01-01', 'ids': {'openalex': 'https://openalex.org/W1980866671', 'doi': 'https://doi.org/10.3164/jcbn.32.1', 'mag': '1980866671'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3164/jcbn.32.1', 'pdf_url': 'https://www.jstage.jst.go.jp/article/jcbn1986/32/0/32_0_1/_pdf', 'source': {'id': 'https://openalex.org/S10422625', 'display_name': 'Journal of Clinical Biochemistry and Nutrition', 'issn_l': '0912-0009', 'issn': ['0912-0009', '1880-5086'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4353105724', 'host_organization_name': 'Society for Free Radical Research Japan', 'host_organization_lineage': ['https://openalex.org/P4353105724'], 'host_organization_lineage_names': ['Society for Free Radical Research Japan'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.jstage.jst.go.jp/article/jcbn1986/32/0/32_0_1/_pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110061241', 'display_name': 'Akinori Kogure', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I40677808', 'display_name': 'Kyoto Prefectural University of Medicine', 'ror': 'https://ror.org/028vxwa22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I40677808']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akinori KOGURE', 'raw_affiliation_strings': ['First Department of Internal Medicine, Kyoto, Prefectural University of Medicine'], 'affiliations': [{'raw_affiliation_string': 'First Department of Internal Medicine, Kyoto, Prefectural University of Medicine', 'institution_ids': ['https://openalex.org/I40677808']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101111285', 'display_name': 'Toshihide Yoshida', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I40677808', 'display_name': 'Kyoto Prefectural University of Medicine', 'ror': 'https://ror.org/028vxwa22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I40677808']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshihide YOSHIDA', 'raw_affiliation_strings': ['First Department of Internal Medicine, Kyoto, Prefectural University of Medicine'], 'affiliations': [{'raw_affiliation_string': 'First Department of Internal Medicine, Kyoto, Prefectural University of Medicine', 'institution_ids': ['https://openalex.org/I40677808']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108522725', 'display_name': 'Toshikazu Yoshikawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I40677808', 'display_name': 'Kyoto Prefectural University of Medicine', 'ror': 'https://ror.org/028vxwa22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I40677808']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshikazu YOSHIKAWA', 'raw_affiliation_strings': ['First Department of Internal Medicine, Kyoto, Prefectural University of Medicine'], 'affiliations': [{'raw_affiliation_string': 'First Department of Internal Medicine, Kyoto, Prefectural University of Medicine', 'institution_ids': ['https://openalex.org/I40677808']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 57}, 'biblio': {'volume': '32', 'issue': None, 'first_page': '1', 'last_page': '9'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11399', 'display_name': 'Muscle metabolism and nutrition', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10528', 'display_name': 'Adipokines, Inflammation, and Metabolic Diseases', 'score': 0.9887, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thermogenin', 'display_name': 'Thermogenin', 'score': 0.8155602}, {'id': 'https://openalex.org/keywords/ucp3', 'display_name': 'UCP3', 'score': 0.75339437}, {'id': 'https://openalex.org/keywords/adrenergic-agonist', 'display_name': 'Adrenergic agonist', 'score': 0.60999274}], 'concepts': [{'id': 'https://openalex.org/C151279926', 'wikidata': 'https://www.wikidata.org/wiki/Q965695', 'display_name': 'Thermogenesis', 'level': 3, 'score': 0.84096915}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.8406554}, {'id': 'https://openalex.org/C2779406938', 'wikidata': 'https://www.wikidata.org/wiki/Q24720289', 'display_name': 'Uncoupling protein', 'level': 4, 'score': 0.82111657}, {'id': 'https://openalex.org/C81979416', 'wikidata': 'https://www.wikidata.org/wiki/Q419493', 'display_name': 'Thermogenin', 'level': 4, 'score': 0.8155602}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.812142}, {'id': 'https://openalex.org/C2780642333', 'wikidata': 'https://www.wikidata.org/wiki/Q901269', 'display_name': 'Brown adipose tissue', 'level': 3, 'score': 0.80132633}, {'id': 'https://openalex.org/C2779299233', 'wikidata': 'https://www.wikidata.org/wiki/Q7864100', 'display_name': 'UCP3', 'level': 5, 'score': 0.75339437}, {'id': 'https://openalex.org/C151955695', 'wikidata': 'https://www.wikidata.org/wiki/Q654528', 'display_name': 'White adipose tissue', 'level': 3, 'score': 0.68799675}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.64557874}, {'id': 'https://openalex.org/C2780013391', 'wikidata': 'https://www.wikidata.org/wiki/Q2496749', 'display_name': 'Adrenergic agonist', 'level': 4, 'score': 0.60999274}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4850263}, {'id': 'https://openalex.org/C169331234', 'wikidata': 'https://www.wikidata.org/wiki/Q4897175', 'display_name': 'Beta-3 adrenergic receptor', 'level': 4, 'score': 0.43722433}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4305261}, {'id': 'https://openalex.org/C171089720', 'wikidata': 'https://www.wikidata.org/wiki/Q193583', 'display_name': 'Adipose tissue', 'level': 2, 'score': 0.4027862}, {'id': 'https://openalex.org/C40465926', 'wikidata': 'https://www.wikidata.org/wiki/Q410568', 'display_name': 'Adrenergic receptor', 'level': 3, 'score': 0.29845524}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.20664379}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3164/jcbn.32.1', 'pdf_url': 'https://www.jstage.jst.go.jp/article/jcbn1986/32/0/32_0_1/_pdf', 'source': {'id': 'https://openalex.org/S10422625', 'display_name': 'Journal of Clinical Biochemistry and Nutrition', 'issn_l': '0912-0009', 'issn': ['0912-0009', '1880-5086'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4353105724', 'host_organization_name': 'Society for Free Radical Research Japan', 'host_organization_lineage': ['https://openalex.org/P4353105724'], 'host_organization_lineage_names': ['Society for Free Radical Research Japan'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3164/jcbn.32.1', 'pdf_url': 'https://www.jstage.jst.go.jp/article/jcbn1986/32/0/32_0_1/_pdf', 'source': {'id': 'https://openalex.org/S10422625', 'display_name': 'Journal of Clinical Biochemistry and Nutrition', 'issn_l': '0912-0009', 'issn': ['0912-0009', '1880-5086'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4353105724', 'host_organization_name': 'Society for Free Radical Research Japan', 'host_organization_lineage': ['https://openalex.org/P4353105724'], 'host_organization_lineage_names': ['Society for Free Radical Research Japan'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.77}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W109691321', 'https://openalex.org/W1550000221', 'https://openalex.org/W1900866157', 'https://openalex.org/W1915944311', 'https://openalex.org/W1924583624', 'https://openalex.org/W1965875712', 'https://openalex.org/W1972802538', 'https://openalex.org/W1975323382', 'https://openalex.org/W1977704859', 'https://openalex.org/W1979064868', 'https://openalex.org/W1984770162', 'https://openalex.org/W2021985872', 'https://openalex.org/W2023530279', 'https://openalex.org/W2025487501', 'https://openalex.org/W2032814494', 'https://openalex.org/W2057498089', 'https://openalex.org/W2069957423', 'https://openalex.org/W2070543019', 'https://openalex.org/W2072678001', 'https://openalex.org/W2072919666', 'https://openalex.org/W2077150958', 'https://openalex.org/W2083385526', 'https://openalex.org/W2084384561', 'https://openalex.org/W2092823267', 'https://openalex.org/W2095793148', 'https://openalex.org/W2096712675', 'https://openalex.org/W2130394237', 'https://openalex.org/W2131538153', 'https://openalex.org/W2131589770', 'https://openalex.org/W2139002144', 'https://openalex.org/W2168299913'], 'related_works': ['https://openalex.org/W3014004894', 'https://openalex.org/W2160085280', 'https://openalex.org/W2099479611', 'https://openalex.org/W2081562544', 'https://openalex.org/W2077150958', 'https://openalex.org/W2027741102', 'https://openalex.org/W2019019494', 'https://openalex.org/W1980866671', 'https://openalex.org/W1972421172', 'https://openalex.org/W1968385601'], 'abstract_inverted_index': {'Chronic': [0], 'stimulation': [1], 'of': [2, 18, 23, 67, 80, 102, 158, 166, 173, 187, 254], 'the': [3, 16, 21, 30, 57, 60, 78, 99, 184, 239, 252], 'β3-adrenergic': [4, 69, 82, 113, 214, 256], 'receptor': [5, 70, 83, 114, 215, 257], 'in': [6, 10, 37, 75, 92, 127, 133, 141, 156, 161, 170, 181, 183, 189, 196, 201, 206, 222, 234], 'obese': [7, 106], 'mice': [8, 109], 'resulted': [9, 169], 'a': [11, 68, 81, 112, 171, 213, 255], 'reduced': [12], 'adiposity': [13], 'associated': [14], 'with': [15, 111], 'promotion': [17], 'lipolysis': [19], 'and': [20, 51, 65, 88, 98, 105, 135, 138, 144, 150, 176, 180, 192, 198, 203, 225, 231, 236, 238, 248], 'increase': [22], 'non-shivering': [24, 48], 'thermogenesis.': [25, 49], 'It': [26], 'is': [27, 42, 72], 'known': [28], 'that': [29, 212], 'mitochondrial': [31], 'uncoupling': [32], 'protein': [33], '1': [34], '(UCP': [35], '1)': [36], 'brown': [38], 'adipose': [39, 95], 'tissue': [40, 96], '(BAT)': [41], 'an': [43], 'important': [44], 'key': [45], 'molecule': [46], 'for': [47, 118], 'UCP2': [50, 148, 195, 230], 'UCP3': [52, 89, 151, 200, 232], 'were': [53, 153], 'recently': [54], 'cloned,': [55], 'but': [56, 129, 228], 'effect': [58, 79], 'on': [59, 85], 'UCP': [61, 241], 'family': [62, 242], '(UCP1,': [63], 'UCP2,': [64, 87], 'UCP3)': [66], 'agonist': [71, 84, 216], 'unclear.': [73], 'Therefore,': [74], 'this': [76], 'study,': [77], 'UCP1,': [86], 'was': [90, 124], 'investigated': [91], 'BAT,': [93, 128, 190, 223], 'white': [94, 177], '(WAT)': [97], 'gastrocnemius': [100, 139, 193, 226], 'muscle': [101, 140], 'C57BL': [103, 143], 'control': [104], 'yellow': [107, 145], 'KK': [108, 146], 'administered': [110], 'agonist,': [115], 'CL316,': [116, 167], '243': [117, 168], 'two': [119], 'weeks': [120], 'subcutaneously.': [121], 'UCP1': [122, 188, 220], 'mRNA': [123, 149, 152, 185, 221, 233], 'found': [125, 155], 'abundantly': [126], 'detected': [130], 'only': [131, 219], 'slightly': [132], 'subcutaneous': [134], 'perimetric': [136, 204], 'WAT': [137, 205], 'both': [142, 162, 207], 'mice.': [147, 163], 'also': [154, 229], 'all': [157], 'tissues': [159], 'examined': [160], 'Daily': [164], 'injections': [165], 'reduction': [172], 'body': [174], 'weight': [175], 'pad': [178], 'weight,': [179], 'increases': [182], 'levels': [186], 'WAT,': [191, 199, 224, 237], 'muscle,': [194, 227], 'BAT': [197, 202, 235], 'groups.': [208], 'These': [209], 'results': [210], 'suggest': [211], 'up-regulates': [217], 'not': [218], 'whole': [240], 'may': [243], 'contribute': [244], 'to': [245], 'increased': [246], 'thermogenesis': [247], 'anti-obesity': [249], 'action': [250], 'following': [251], 'administration': [253], 'agonist.': [258]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1980866671', 'counts_by_year': [], 'updated_date': '2024-12-14T07:04:36.839071', 'created_date': '2016-06-24'}