NF-κ B Promotes Breast Cancer Cell Migration and Metastasis by Inducing the Expression of the Chemokine Receptor CXCR4

Name: Work Video:
Duration: 3 min 30 s
Gregory M. Helbig; Kent W. Christopherson; Poornima Bhat‐Nakshatri; Suresh Kumar; Hiromitsu Kishimoto; Kathy D. Miller; Hal E. Broxmeyer; Harikrishna Nakshatri
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'https://openalex.org/W1995841674', 'https://openalex.org/W197389798', 'https://openalex.org/W101610969'], 'abstract_inverted_index': {'Metastasis': [0, 272, 571, 628], 'of': [1, 16, 68, 91, 116, 125, 128, 131, 146, 152, 158, 193, 208, 267, 273, 288, 340, 363, 388, 397, 400, 403, 418, 424, 430, 465, 480, 539, 558, 569, 585, 657, 677, 681, 693, 704, 829, 851, 889, 901, 936, 974, 986, 1026, 1050, 1062, 1103, 1114, 1209, 1242, 1253, 1261, 1287, 1296, 1309, 1329, 1340, 1363, 1388, 1409, 1445, 1450, 1608, 1728, 1847, 1857, 1887, 2063, 2080, 2124, 2164, 2338, 2367, 2380, 2414, 2416, 2466, 2498, 2503, 2579, 2720, 2751, 2813, 2822, 2830, 2859, 2901, 2908, 2960, 3119, 3160, 3185, 3194, 3219, 3233, 3290, 3323, 3346, 3437, 3452, 3486, 3495, 3505, 3552, 3555, 3564, 3569, 3597, 3605, 3630, 3639, 3649, 3664, 3672, 3705, 3784, 3806, 3817, 3855, 3873, 3893, 3918, 3927, 3933, 3950, 3972, 3978, 4039, 4058, 4063, 4092, 4111, 4121, 4129, 4156, 4172, 4187, 4195, 4203, 4209, 4316, 4332, 4354, 4389], 'cancer': [2, 17, 69, 103, 118, 136, 218, 247, 270, 274, 289, 341, 375, 390, 408, 490, 519, 542, 548, 564, 578, 601, 658, 668, 694, 732, 811, 823, 1040, 1063, 1082, 1615, 1722, 1741, 1858, 1902, 1915, 2480, 2911, 3249, 3373, 3411, 4174, 4298], 'cells': [3, 18, 70, 119, 137, 163, 219, 229, 248, 275, 290, 342, 391, 409, 435, 491, 501, 520, 565, 602, 669, 695, 711, 715, 733, 812, 824, 1041, 1064, 1083, 1255, 1310, 1616, 1859, 1872, 1903, 2085, 2158, 2371, 2447, 2490, 2511, 2606, 2747, 2831, 2912, 2951, 3065, 3071, 3145, 3152, 3223, 3250, 3257, 3296, 3302, 3352, 3360, 3374, 3412, 3478, 3659, 3946, 3958, 3965, 3980, 3987, 4004, 4045, 4060, 4094, 4097, 4123, 4153, 4211, 4299, 4312, 4334, 4349, 4362, 4383], 'is': [4, 276, 572, 661, 1098, 1238, 1247, 1292, 1351, 1356, 1403, 1604, 1733, 3180, 3313, 3375, 3501, 3518, 3622, 3848, 4124, 4166, 4197, 4221, 4290], 'a': [5, 36, 60, 149, 277, 308, 332, 421, 573, 697, 758, 1036, 1055, 1070, 1239, 1327, 1352, 1357, 1394, 1448, 1998, 2028, 2053, 2070, 2097, 2765, 2790, 2805, 2958, 3181, 3192, 3230, 3314, 3404, 3414, 3675, 3729, 3821, 3836, 3856, 3938, 3983, 4142, 4192, 4307, 4398], 'complex': [6, 278, 1241, 3748, 3758, 3794], 'process': [7, 279], 'involving': [8, 280], 'multiple': [9, 281], 'steps': [10, 282], 'including': [11, 283, 1120, 1439], 'invasion,': [12, 284], 'angiogenesis,': [13, 42, 285, 314], 'and': [14, 25, 33, 41, 50, 66, 76, 97, 148, 171, 181, 197, 210, 241, 263, 286, 297, 305, 313, 322, 338, 348, 369, 420, 443, 453, 469, 482, 513, 535, 545, 555, 576, 612, 673, 691, 724, 1020, 1042, 1060, 1117, 1133, 1289, 1314, 1322, 1354, 1366, 1610, 1717, 1896, 1919, 1926, 1939, 1987, 2011, 2023, 2039, 2050, 2083, 2092, 2102, 2106, 2117, 2167, 2243, 2345, 2358, 2365, 2392, 2441, 2478, 2533, 2574, 2594, 2619, 2639, 2654, 2793, 2844, 2868, 2883, 2956, 2964, 2966, 2970, 3057, 3067, 3135, 3150, 3175, 3187, 3282, 3319, 3427, 3464, 3490, 3499, 3542, 3544, 3666, 3767, 3803, 3831, 3843, 3944, 3963, 4095, 4140, 4151, 4215], 'trafficking': [15, 287], 'through': [19, 291, 1256, 3921, 4061], 'blood': [20, 292], 'vessels,': [21, 293], 'extravasations,': [22, 294], 'organ-specific': [23, 265, 295, 537, 553, 682, 709, 726, 1833], 'homing,': [24, 65, 296, 337], 'growth.': [26, 298], 'While': [27, 299, 644, 748], 'matrix': [28, 92, 300, 364, 868, 953, 1129], 'metalloproteinases,': [29, 93, 301, 365], 'urokinase-type': [30, 94, 302, 366, 864, 949, 1125], 'plasminogen': [31, 95, 303, 367, 865, 950, 1126], 'activator,': [32, 96, 304, 368], 'cytokines': [34, 98, 306, 370, 1315, 3384], 'play': [35, 59, 307, 331, 1054], 'major': [37, 309, 4193], 'role': [38, 62, 310, 334, 1056, 3289], 'in': [39, 63, 99, 134, 143, 155, 216, 231, 236, 260, 311, 335, 371, 406, 415, 427, 488, 503, 508, 532, 547, 650, 696, 730, 1023, 1057, 1069, 1080, 1100, 1217, 1359, 1405, 1447, 1613, 1735, 1739, 1860, 1864, 1882, 1893, 1901, 1928, 2120, 2400, 2411, 2433, 2439, 2443, 2475, 2484, 2527, 2566, 2576, 2599, 2611, 2621, 2637, 2674, 2732, 2748, 2798, 2802, 2818, 2832, 2856, 2866, 2972, 3062, 3121, 3143, 3148, 3162, 3197, 3221, 3292, 3350, 3358, 3371, 3408, 3447, 3476, 3514, 3549, 3579, 3683, 4002, 4100, 4131, 4149, 4169, 4181, 4206, 4294, 4306, 4336, 4358], 'invasion': [40, 312], 'chemokines': [43, 315], 'such': [44, 53, 316, 325, 1316, 4372], 'as': [45, 54, 317, 326, 1035, 1317, 1393, 2129, 2180, 2246, 2294, 2560, 2650, 2680, 2879, 3379, 3381, 3674, 4310, 4373], 'stromal': [46, 318, 830, 839, 924], 'derived': [47, 319, 831, 840, 925, 1944], 'factor-1α': [48, 320, 832], '(SDF-1α)': [49, 321], 'their': [51, 323, 722, 1880, 4341], 'receptors': [52, 324], 'CXCR4': [55, 147, 159, 195, 209, 237, 327, 419, 431, 467, 481, 509, 1015, 1051, 1078, 1104, 1384, 1410, 1875, 1894, 1991, 2066, 2470, 2499, 2504, 2520, 2902, 3120, 3138, 3163, 3220, 3236, 3293, 3299, 3317, 3325, 3338, 3347, 3369, 3392, 3399, 3439, 3473, 3496, 3516, 3585, 3632, 3651, 3673, 3746, 3755, 3792, 3812, 3895, 3922, 4112, 4130, 4136, 4157, 4190, 4302, 4326, 4339, 4355, 4364], 'are': [56, 214, 328, 486, 549, 684, 755, 1067, 1084, 1876, 1943, 2648, 2877], 'thought': [57, 329], 'to': [58, 185, 190, 251, 330, 457, 462, 523, 552, 561, 605, 642, 670, 701, 734, 820, 1110, 1214, 1250, 1311, 1344, 1401, 1828, 1851, 1862, 1906, 2518, 2717, 2755, 2804, 2852, 3423, 3433, 3627, 3643, 3646, 3669, 3690, 3720, 3810, 3835, 3850, 3885, 3890, 3911, 4098, 4102, 4107, 4126, 4198, 4212, 4224, 4367], 'critical': [61, 333, 1853], 'motility,': [64, 336], 'proliferation': [67, 339, 692, 1061], 'at': [71, 343, 566, 675, 2397, 2426, 2596, 2815, 3992], 'specific': [72, 344, 735, 1071, 3183], 'metastatic': [73, 101, 268, 345, 373, 540, 809], 'sites.': [74, 346], 'We': [75, 200, 347, 472, 1087, 1597, 1839, 3634, 3968], 'others': [77, 349, 1718], 'have': [78, 350, 1211, 1304, 1441, 1598, 1719, 1948, 3265], 'previously': [79, 351, 1951, 2131, 2182, 2248, 2296, 2682, 2905], 'reported': [80, 352, 2904], 'that': [81, 111, 176, 203, 249, 353, 383, 448, 475, 521, 653, 666, 808, 1032, 1043, 1076, 1091, 1246, 1600, 1721, 1841, 1871, 1873, 1904, 2457, 3258, 3311, 3335, 3353, 3368, 3385, 3493, 3509, 3604, 3617, 3800, 3828, 3903, 4054, 4088, 4117, 4164, 4289, 4300, 4328, 4346, 4350, 4369], 'the': [82, 89, 114, 123, 129, 177, 188, 194, 204, 211, 252, 261, 264, 354, 361, 386, 395, 401, 449, 460, 466, 476, 483, 524, 533, 536, 556, 567, 606, 655, 664, 751, 764, 814, 1008, 1044, 1058, 1089, 1092, 1101, 1112, 1251, 1293, 1337, 1360, 1389, 1406, 1845, 1855, 1883, 1907, 1924, 2008, 2089, 2110, 2277, 2336, 2376, 2449, 2455, 2458, 2467, 2485, 2530, 2588, 2600, 2640, 2659, 2677, 2733, 2756, 2761, 2781, 2795, 2799, 2828, 2833, 2837, 2853, 2857, 2869, 2888, 2906, 2914, 3117, 3158, 3217, 3252, 3288, 3304, 3324, 3340, 3383, 3391, 3421, 3428, 3431, 3438, 3448, 3453, 3510, 3515, 3521, 3526, 3550, 3561, 3567, 3575, 3584, 3594, 3607, 3618, 3625, 3631, 3640, 3644, 3650, 3667, 3686, 3691, 3735, 3740, 3745, 3781, 3791, 3801, 3811, 3818, 3829, 3871, 3879, 3883, 3888, 3894, 3908, 3925, 3970, 3975, 4090, 4201, 4207, 4213, 4218, 4291, 4374, 4385, 4393], 'extracellular': [83, 355, 1093], 'signal-activated': [84, 356, 1094], 'transcription': [85, 357, 1074, 1095, 1368], 'factor': [86, 358, 895, 980, 1038, 1096, 1137, 1325, 1731, 3458], 'NF-κB': [87, 112, 140, 178, 259, 359, 384, 412, 450, 531, 1097, 1106, 1210, 1237, 1342, 1390, 1396, 1446, 1603, 1737, 1831, 1842, 2955, 3053, 3114, 3161, 3186, 3291, 3378, 3388, 3396, 3454, 3506, 3511, 3565, 3580, 3619, 3641, 3665, 3731, 3807, 3823, 3874, 3904, 3914, 3928, 3973, 3998, 4055, 4165], 'up-regulates': [88, 360], 'expression': [90, 124, 145, 207, 240, 362, 396, 417, 479, 512, 1079, 1102, 1113, 1846, 1895, 2025, 2045, 2067, 2093, 2099, 2165, 2337, 2471, 2502, 3059, 3118, 3218, 3322, 3345, 3370, 4202], 'highly': [100, 372], 'breast': [102, 117, 135, 217, 269, 374, 389, 407, 489, 541, 600, 810, 822, 1027, 1081, 1614, 1740, 1914, 2910, 3248, 3372, 3410, 4173], 'cell': [104, 205, 238, 376, 477, 510, 1301, 1916, 2169, 2775, 2796, 2806, 2839, 3263, 3320, 3341, 3707, 4295], 'lines.': [105, 377], 'In': [106, 378, 1206, 1714, 1866, 2702, 4087], 'this': [107, 379, 3612, 3721, 3815, 4378], 'report,': [108, 380], 'we': [109, 381, 1716, 1868, 3124, 3238, 3327, 3402, 3536, 3867, 3936, 4134, 4380], 'demonstrate': [110, 382, 1840], 'regulates': [113, 385, 1844, 3116, 3398, 4056], 'motility': [115, 387, 1856, 3953], 'by': [120, 392, 716, 1835, 1995, 2018, 2109, 2507, 2536, 2764, 2779, 2826, 2836, 2842, 3191, 3377, 3382, 3481, 3488, 3497, 3653, 3762, 3770, 3981, 4137], 'directly': [121, 184, 393, 456, 1843, 3397, 3808, 4115, 4167], 'up-regulating': [122, 394, 1837], 'CXCR4.': [126, 398, 817, 1011, 1838], 'Overexpression': [127, 399], 'inhibitor': [130, 402, 850, 888, 900, 935, 973, 985, 1260, 3184], 'κB': [132, 404, 1262], '(IκB)': [133, 405, 1263], 'with': [138, 227, 246, 410, 499, 518, 1052, 1259, 2088, 2096, 2161, 2240, 2285, 2429, 2454, 2514, 2529, 2676, 2683, 2727, 3070, 3073, 3130, 3171, 3244, 3287, 3301, 3303, 3332, 3413, 3420, 3430, 3661, 3685, 3728, 3941, 3947, 3956, 3961, 3986, 3989, 4044, 4047, 4322], 'constitutive': [139, 411, 1443, 1736, 3997], 'activity': [141, 413, 2116, 2119, 3056, 3444, 3469, 3475, 3548, 3568, 3596, 4001], 'resulted': [142, 414], 'reduced': [144, 416, 3216, 3480, 3744, 4108, 4118], 'corresponding': [150, 422], 'loss': [151, 423], 'SDF-1α-mediated': [153, 165, 212, 242, 425, 437, 484, 514, 1897, 3916, 3931, 4170], 'migration': [154, 213, 243, 262, 426, 485, 515, 534, 1898, 2776, 2823, 2847, 3932, 3977, 4041, 4057, 4120, 4146, 4171], 'vitro.': [156, 428, 1865], 'Introduction': [157, 429], 'cDNA': [160, 432, 4158], 'into': [161, 433, 2007, 2375, 4384], 'IκB-expressing': [162, 434], 'restored': [164, 436, 4148], 'migration.': [166, 438], 'Electrophoretic': [167, 439, 2153], 'mobility': [168, 440, 860, 945], 'shift': [169, 441, 861, 946], 'assays': [170, 174, 442, 446, 2666], 'transient': [172, 444, 3405, 4138], 'transfection': [173, 445, 2179, 3406, 4139], 'revealed': [175, 447, 4327], 'subunits': [179, 451, 1291, 3554, 3642, 3663, 3805, 3833, 3875], 'p65': [180, 452, 1290, 3558, 3608, 3687, 3766, 3804, 3832, 3844], 'p50': [182, 454, 1288, 3562, 3678, 3774, 3802, 3830, 3842], 'bind': [183, 455, 3809, 3834], 'sequences': [186, 458], 'within': [187, 459, 3624], '–66': [189, 461, 3626, 3645, 3668, 3884, 3910], '+7': [191, 463, 3424, 3434, 3628, 3647, 3670], 'region': [192, 464, 1362, 1408, 3425, 3435, 3648, 3671, 3722, 3816], 'promoter': [196, 468, 1361, 1407, 1992, 3400, 3474, 3517, 3652, 3737, 3819, 3896], 'activate': [198, 470, 4225], 'transcription.': [199, 471], 'also': [201, 473, 1869, 2016, 4222], 'show': [202, 474, 1870], 'surface': [206, 239, 478, 511, 2501, 3321, 3344], 'enhanced': [215, 487], 'isolated': [220, 492, 2453], 'from': [221, 493, 1923, 1945, 2031, 2056, 2073, 2448, 2489, 2760, 3132, 3173, 3246, 3520, 3525, 3657, 3734, 4217], 'mammary': [222, 494, 1884, 2377, 4386], 'fat': [223, 495, 1885, 2378, 4387], 'pad': [224, 496, 1886, 2379, 4388], 'xenografts': [225, 497], 'compared': [226, 498, 3069, 3300], 'parental': [228, 500], 'grown': [230, 502, 1927, 4335], 'culture.': [232, 504], 'A': [233, 505, 1284, 1890, 3777], 'further': [234, 506, 1891, 3156], 'increase': [235, 507, 1892], 'was': [244, 516, 1826, 1899, 1993, 2005, 2069, 2238, 2274, 2292, 2472, 2505, 2559, 2715, 2777, 2824, 3169, 3348, 3445, 3479, 3599, 3954, 4042, 4147, 4345], 'observed': [245, 517, 1900, 3349, 3955, 4043], 'metastasized': [250, 522, 1905], 'lungs.': [253, 525, 1908, 4375], 'Taken': [254, 526, 3363], 'together,': [255, 527, 3364], 'these': [256, 528, 3122, 3365, 3533, 4003, 4132, 4311], 'results': [257, 529, 1030, 3366, 3615, 3698, 3798, 3854, 4162], 'implicate': [258, 530], 'homing': [266, 538, 731, 1037], 'cells.': [271, 543, 2481, 3137, 3178, 4175], 'Morbidity': [544], 'mortality': [546], 'mainly': [550], 'due': [551, 700, 4106, 4125], 'metastasis': [554, 586, 656, 683, 1022, 1216, 1834], 'failure': [557, 4091], 'chemotherapeutic': [559], 'drugs': [560], 'selectively': [562, 1836], 'kill': [563], 'sites': [568, 584, 676, 736, 819], 'metastasis.': [570, 678], 'non-random': [574], 'process,': [575], 'each': [577, 2632], 'type': [579, 2406], 'has': [580, 646, 1107, 3188], 'its': [581, 1257, 1345], 'own': [582], 'preferred': [583], '(1Liotta': [587, 614], 'L.A.': [588, 615, 4271], 'Nature.': [589, 616, 798], '2001;': [590, 617, 740, 799, 2547, 2694, 4280], '410:': [591, 618, 800], '24-25Crossref': [592, 619], 'PubMed': [593, 620, 633, 743, 802, 1148, 1167, 1191, 1279, 1379, 1432, 1480, 1498, 1537, 1556, 1592, 1635, 1662, 1695, 1711, 1760, 1779, 1803, 1818, 1980, 2150, 2201, 2232, 2267, 2325, 2550, 2697, 2945, 3000, 3033, 3049, 3106, 4033, 4082, 4257, 4283], 'Scopus': [594, 621, 634, 744, 803, 1149, 1168, 1192, 1280, 1380, 1433, 1481, 1499, 1557, 1593, 1663, 1696, 1761, 1780, 1804, 1819, 1981, 2233, 2326, 2551, 2698, 2946, 3001, 3034, 3107, 4034, 4083, 4258, 4284], '(163)': [595, 622], 'Google': [596, 623, 636, 746, 805, 1151, 1170, 1194, 1204, 1235, 1282, 1382, 1435, 1483, 1501, 1517, 1538, 1559, 1570, 1595, 1636, 1665, 1698, 1712, 1763, 1782, 1806, 1821, 1983, 2151, 2202, 2235, 2268, 2328, 2553, 2700, 2948, 3003, 3036, 3050, 3109, 3213, 4036, 4085, 4260, 4286], 'Scholar).': [597, 637, 747, 1205, 1236, 1283, 1383, 1436, 1596, 1713, 1822, 1984, 2152, 2236, 2269, 2329, 2554, 2701, 2949, 3051, 3110, 3214, 4037, 4086, 4287], 'For': [598], 'example,': [599], 'preferentially': [603], 'metastasize': [604, 641, 825, 4366], 'regional': [607], 'lymph': [608, 1018], 'nodes,': [609], 'lungs,': [610], 'liver,': [611], 'bone': [613], 'Scholar,': [624, 1152, 1171, 1195, 1484, 1502, 1518, 1539, 1560, 1571, 1637, 1666, 1699, 1764, 1783, 1807, 2203, 3004, 3037, 4261], '2Nicolson': [625], 'G.L.': [626], 'Cancer': [627, 1230, 1512, 1565, 1910, 2368], 'Rev.': [629, 1143, 1162, 1274, 1374], '1993;': [630, 1201], '12:': [631, 1146, 1377, 1554], '325-343Crossref': [632], '(127)': [635], 'Prostate': [638], 'cancers': [639, 1451], 'usually': [640], 'bone.': [643], 'there': [645, 3312], 'been': [647, 1108, 1212, 1305, 1949, 3189, 3266], 'considerable': [648], 'progress': [649], 'identifying': [651], 'genes': [652, 665, 1119, 1365, 1392, 1612, 2968], 'promote': [654], 'cells,': [659, 1941, 1947, 3123, 3935, 4133], 'little': [660], 'known': [662, 4223], 'about': [663], 'enable': [667], 'seed,': [671], 'survive,': [672], 'proliferate': [674], 'Three': [679, 2861], 'models': [680, 754, 1025, 1219], 'currently': [685, 1085], 'under': [686], 'consideration:': [687], '1)': [688], 'selective': [689], 'survival': [690, 1059], 'particular': [698], 'organ': [699], 'local': [702], 'production': [703], 'appropriate': [705, 718, 2589], 'growth': [706, 1136, 1312, 1319, 1730, 1881, 2444], 'factors,': [707], '2)': [708], 'endothelial': [710, 1135], 'trapping': [712], 'circulating': [713, 4317], 'tumor': [714, 893, 978, 1323, 3456], 'expressing': [717, 4363], 'adhesion': [719], 'molecules': [720, 728], 'on': [721, 2789, 3339, 3790, 3930, 4340], 'surface,': [723, 4342], '3)': [725], 'attractant': [727], 'helping': [729], '(3Moore': [737], 'M.A.': [738, 1573], 'Bioessays.': [739], '23:': [741], '674-676Crossref': [742], '(112)': [745], 'data': [749, 2641, 2870], 'supporting': [750, 763], 'first': [752, 2564], 'two': [753, 3534], 'still': [756, 3610], 'scanty,': [757], 'recent': [759], 'study': [760, 1825], 'provided': [761], 'evidence': [762], 'third': [765], 'model.': [766], 'Muller': [767], 'et': [768], 'al.': [769], '(4Muller': [770], 'A.': [771, 793, 797, 1412, 1469, 1564, 1756, 1799, 4275], 'Homey': [772], 'B.': [773, 1473], 'Soto': [774], 'H.': [775, 1197, 1520, 1618, 1650, 1690, 1701, 1771, 1792, 1813, 1975, 2133, 2184, 2227, 2250, 2320, 2940, 2988, 3028, 3039, 3101, 3274, 3277, 3283, 4028], 'Ge': [776], 'N.': [777], 'Catron': [778], 'D.': [779, 1457, 1545, 2058, 3272, 4066, 4070], 'Buchanan': [780], 'M.E.': [781], 'McClanahan': [782], 'T.': [783, 1141, 1372, 1508], 'Murphy': [784], 'E.': [785, 795, 1467, 1747], 'Yuan': [786], 'W.': [787, 1463, 2033, 3205, 4243], 'Wagner': [788], 'S.N.': [789], 'Barrera': [790], 'J.L.': [791, 1422], 'Mohar': [792], 'Verastegui': [794], 'Zlotnik': [796], '50-56Crossref': [801], '(4387)': [804], 'Scholar)': [806], 'demonstrated': [807, 1442], 'overexpress': [813, 3354], 'chemokine': [815, 844, 929], 'receptor': [816, 1732], 'Additionally': [818], 'which': [821, 1849, 1942], 'express': [826, 1874, 2957, 4301, 4338, 4351, 4370], 'abundant': [827], 'amounts': [828], '(SDF-1α,': [833], '1The': [834], 'abbreviations': [835, 920], 'used': [836, 921, 2558, 3190, 3710], 'are:': [837, 922], 'SDF-1α,': [838, 923, 4371], 'factor-1α;': [841, 926], 'CXCR,': [842, 927], 'CXC': [843, 928], 'receptor;': [845, 914, 930, 999], 'NF-κB,': [846, 931, 1297, 2242, 3234], 'nuclear': [847, 932, 1338, 2172, 3702], 'factor-κB;': [848, 933], 'IκB,': [849, 934], 'κB;': [852, 937], 'IκBαSR,': [853, 938], 'IκBα': [854, 939, 2896, 2915, 3063], 'super-repressor;': [855, 940], 'IL,': [856, 941], 'interleukin;': [857, 942], 'EMSA,': [858, 943], 'electrophoretic': [859, 944], 'assay;': [862, 947], 'uPA,': [863, 948], 'activator;': [866, 951], 'MMP,': [867, 952], 'metalloproteinase;': [869, 954], 'IKK,': [870, 955], 'IκB': [871, 956, 1333], 'kinase': [872, 957], 'complex;': [873, 958], 'NIK,': [874, 959, 2048], 'NF-κB-inducing': [875, 960], 'kinase;': [876, 961], 'CAT,': [877, 962], 'chloramphenicol': [878, 963], 'acetyltransferase;': [879, 964], 'RSV,': [880, 965], 'Rous': [881, 966], 'sarcoma': [882, 967], 'virus;': [883, 968], 'β-gal,': [884, 969], 'β-galactosidase;': [885, 970], 'XIAP,': [886, 971, 2351], 'X-linked': [887, 972], 'apoptosis': [890, 902, 975, 987], 'protein;': [891, 903, 976, 988], 'TRAF,': [892, 977], 'necrosis': [894, 979, 1324, 3457], 'receptor-associated': [896, 981], 'factor;': [897, 982], 'cIAP,': [898, 983], 'cellular': [899, 984], 'TRPM-2,': [904, 989], 'testosterone-repressed': [905, 990], 'prostatic': [906, 991], 'message-2;': [907, 992], 'SP-1,': [908, 993], 'specificity': [909, 994], 'protein-1;': [910, 995], 'BLR,': [911, 996], "Burkitt's": [912, 997], 'lymphoma': [913, 998], 'PBS,': [915, 1000, 2567, 2580, 2612, 2622], 'phosphate-buffered': [916, 1001], 'saline;': [917, 1002], 'TPA,': [918, 1003], '12-O-tetradecanoylphorbol-13-acetate.1The': [919], '12-O-tetradecanoylphorbol-13-acetate.': [1004], 'recently': [1005], 'renamed': [1006], 'CXCL12),': [1007], 'ligand': [1009], 'for': [1010, 1039, 1334, 1606, 1854, 2037, 2047, 2104, 2394, 2423, 2492, 2602, 2631, 2644, 2873, 3196, 3547, 3974], 'Moreover': [1012], 'antibodies': [1013, 2517], 'against': [1014, 3765, 3773, 4325], 'significantly': [1016], 'inhibited': [1017], 'node': [1019], 'lung': [1021], 'xenograft': [1024, 1218, 4308], 'cancer.': [1028], 'These': [1029, 3262, 3614, 3797, 4161], 'suggest': [1031, 3616], 'SDF-1α': [1033, 1053, 1863, 4103, 4196, 4220], 'serves': [1034], 'signaling': [1045, 1330, 4228], 'pathways': [1046, 4229], 'activated': [1047, 3583, 3591, 3611], 'upon': [1048, 4154], 'interaction': [1049, 1258], 'once': [1065], 'they': [1066], 'localized': [1068], 'organ.': [1072], 'The': [1073, 1823, 2020, 2044, 2065, 2114, 2281, 2330, 2347, 2555, 2605, 3557, 3677, 3754, 3840], 'factors': [1075, 1313], 'regulate': [1077], 'unknown.': [1086], 'considered': [1088], 'possibility': [1090], 'involved': [1099, 1734, 3578, 4168, 4205], 'because': [1105, 3853], 'shown': [1109, 1213, 1599, 1720], 'up-regulate': [1111, 4200], 'several': [1115, 1299], 'prometastatic': [1116, 1609, 2961], 'proangiogenic': [1118], 'interleukin': [1121], '6': [1122, 2389, 4396], '(IL-6),': [1123], 'IL-8,': [1124], 'activator': [1127], '(uPA),': [1128], 'metalloproteinase': [1130], '9': [1131], '(MMP-9),': [1132], 'vascular': [1134], '(5Baeuerle': [1138, 1369], 'P.A.': [1139, 1183, 1370], 'Henkel': [1140, 1371], 'Annu.': [1142, 1373], 'Immunol.': [1144, 1375, 3209], '1994;': [1145, 1376], '141-179Crossref': [1147, 1378], '(4563)': [1150, 1381], '6Karin': [1153], 'M.': [1154, 1181, 1199, 1266, 1414, 1424, 3280, 4265, 4267, 4273], 'Cao': [1155, 1267], 'Y.': [1156, 1268, 4239], 'Greten': [1157, 1269], 'F.R.': [1158, 1270], 'Li': [1159, 1271], 'Z.W.': [1160, 1272], 'Nat.': [1161, 1273], 'Cancer.': [1163, 1275, 1707, 3045], '2002;': [1164, 1276, 1708, 1815, 3046, 4074], '2:': [1165, 1277], '301-310Crossref': [1166, 1278], '(2224)': [1169, 1281], '7Hansen': [1172], 'S.K.': [1173], 'Nerlov': [1174], 'C.': [1175, 1471, 1511], 'Zabel': [1176], 'U.': [1177, 1754, 1797], 'Verde': [1178], 'P.': [1179, 1522, 1620, 1643, 1674, 1785, 1809, 1959, 2135, 2186, 2211, 2252, 2304, 2924, 2981, 3012, 3085, 4012, 4237], 'Johnsen': [1180], 'Baeuerle': [1182], 'Blasi': [1184], 'F.': [1185, 1420, 1426, 1455], 'EMBO': [1186], 'J.': [1187, 1418, 1474, 1586, 1651, 2989, 3208, 4071, 4235, 4246, 4263], '1992;': [1188], '11:': [1189], '205-213Crossref': [1190], '(135)': [1193], '8Sato': [1196], 'Seiki': [1198], 'Oncogene.': [1200, 1494, 1691, 1814, 1976, 2228, 2321, 2941, 3029, 3102, 4029], '8:': [1202], '395-405PubMed': [1203], 'addition,': [1207, 1715, 1867], 'inhibitors': [1208], 'reduce': [1215], '(9Andela': [1220], 'V.B.': [1221], 'Schwarz': [1222], 'E.M.': [1223], 'Puzas': [1224], 'J.E.': [1225, 4245], "O'Keefe": [1226], 'R.J.': [1227, 1527, 1625, 1648, 1685, 1704, 1970, 2140, 2191, 2222, 2257, 2315, 2935, 2986, 3023, 3042, 3096, 4023], 'Rosier': [1228], 'R.N.': [1229], 'Res.': [1231, 1513, 1566, 1774], '2000;': [1232, 1495, 1692, 1757, 1776, 1977, 2229, 2322, 2942, 3030, 3103, 4030], '60:': [1233], '6557-6562PubMed': [1234], 'heterodimeric': [1240], 'Rel': [1243], 'family': [1244], 'proteins': [1245, 1264], 'physically': [1248], 'confined': [1249], 'cytoplasm': [1252], 'normal': [1254], '(6Karin': [1265], 'heterodimer': [1285], 'composed': [1286], 'predominant': [1294], 'form': [1295], 'although': [1298], 'other': [1300, 3429, 4226], 'type-specific': [1302], 'heterodimers': [1303], 'identified.': [1306], 'Upon': [1307], 'exposure': [1308], 'epidermal': [1318, 1729], 'factor,': [1320], 'IL-1,': [1321], 'α,': [1326, 3459], 'series': [1328], 'events': [1331, 2628], 'target': [1332, 1364, 1391], 'degradation,': [1335], 'promoting': [1336], 'translocation': [1339], 'NF-κB.': [1341, 3387, 3556], 'binds': [1343], 'response': [1346, 1861, 3620, 3824, 3838, 4101], 'elements': [1347], '(5′-GGGPuNNNPyPyCC-3′': [1348], 'where': [1349], 'Pu': [1350], 'purine': [1353], 'Py': [1355], 'pyrimidine)': [1358], 'activates': [1367], 'may': [1385], 'be': [1386, 1852, 3141, 3760, 3851, 4105], 'one': [1387, 3419], 'putative': [1395, 3522], 'binding': [1397, 3055, 3512, 3638, 3732, 3742, 3845, 3872, 3906, 4000, 4208], 'site': [1398, 3513, 3523, 3733, 3743, 3846], '(5′-GAGGCATTTCC-3′,': [1399], '–230': [1400], '–240)': [1402], 'present': [1404, 1824], '(10Caruz': [1411], 'Samsom': [1413], 'Alonso': [1415], 'J.M.': [1416], 'Alcami': [1417], 'Baleux': [1419], 'Virelizier': [1421], 'Parmentier': [1423], 'Arenzana-Seisdedos': [1425], 'FEBS': [1427], 'Lett.': [1428], '1998;': [1429, 1553, 1800, 4249], '426:': [1430], '271-278Crossref': [1431], '(93)': [1434], 'Several': [1437], 'laboratories,': [1438], 'ours,': [1440], 'activation': [1444, 1738, 3507], 'variety': [1449], '(11Bargou': [1452], 'R.C.': [1453], 'Emmerich': [1454], 'Krappmann': [1456], 'Bommert': [1458], 'K.': [1459, 3271], 'Mapara': [1460], 'M.Y.': [1461], 'Arnold': [1462], 'Royer': [1464], 'H.D.': [1465], 'Grinstein': [1466], 'Greiner': [1468], 'Scheidereit': [1470], 'Dorken': [1472], 'Clin.': [1475, 1587], 'Investig.': [1476, 1588], '1997;': [1477, 1534, 1567, 1589, 1632, 2147, 2198, 2264], '100:': [1478, 1590], '2961-2969Crossref': [1479], '(689)': [1482], '12Cogswell': [1485], 'P.C.': [1486], 'Guttridge': [1487], 'D.C.': [1488], 'Funkhouser': [1489], 'W.K.': [1490], 'Baldwin': [1491, 1548], 'Jr.,': [1492, 1526, 1529, 1549, 1624, 1627, 1647, 1684, 1687, 1703, 1768, 1789, 1969, 1972, 2139, 2142, 2190, 2193, 2221, 2224, 2256, 2259, 2314, 2317, 2934, 2937, 2985, 3022, 3025, 3041, 3095, 3098, 4022, 4025], 'A.S.': [1493, 1550], '19:': [1496, 1693, 1978, 2230, 2323, 2943, 3031, 3104, 4031, 4281], '1123-1131Crossref': [1497], '(377)': [1500], '13Dong': [1503], 'G.': [1504, 2075], 'Chen': [1505], 'Z.': [1506], 'Kato': [1507], 'Van': [1509], 'Waes': [1510], '1999;': [1514, 1654, 2992, 3210], '59:': [1515], '3495-3504PubMed': [1516], '14Nakshatri': [1519], 'Bhat-Nakshatri': [1521, 1619, 1642, 1673, 1958, 2134, 2185, 2210, 2251, 2303, 2923, 2980, 3011, 3084, 4011], 'Martin': [1523, 1621, 2136, 2187, 2253], 'D.A.': [1524, 1622, 2137, 2188, 2254], 'Goulet': [1525, 1623, 1646, 1683, 1702, 1788, 1968, 2138, 2189, 2220, 2255, 2313, 2933, 2984, 3021, 3040, 3094, 4021], 'Sledge': [1528, 1626, 1686, 1767, 1971, 2141, 2192, 2223, 2258, 2316, 2936, 3024, 3097, 4024], 'G.W.': [1530, 1543, 1628, 1688, 1769, 1973, 2143, 2194, 2225, 2260, 2318, 2938, 3026, 3099, 4026], 'Mol.': [1531, 1629, 2144, 2195, 2261], 'Cell.': [1532, 1630, 2145, 2196, 2262], 'Biol.': [1533, 1631, 1652, 2146, 2197, 2263, 2990, 4072, 4247], '17:': [1535, 1633, 2148, 2199, 2265], '3629-3639Crossref': [1536, 1634, 2149, 2200, 2266], '15Reuther': [1540], 'J.Y.': [1541], 'Reuther': [1542], 'Cortez': [1544], 'Pendergast': [1546], 'A.M.': [1547, 1583], 'Genes': [1551], 'Dev.': [1552], '968-981Crossref': [1555], '(350)': [1558], '16Shattuck-Brandt': [1561], 'R.L.': [1562], 'Richmond': [1563], '57:': [1568], '3032-3039PubMed': [1569], '17Sovak': [1572], 'Bellas': [1574], 'R.E.': [1575], 'Kim': [1576], 'D.W.': [1577], 'Zanieski': [1578], 'G.J.': [1579], 'Rogers': [1580], 'A.E.': [1581], 'Traish': [1582], 'Sonenshein': [1584], 'G.E.': [1585], '2952-2960Crossref': [1591], '(641)': [1594], 'constitutively': [1601, 2953], 'active': [1602, 2954], 'responsible': [1605], 'overexpression': [1607, 1727], 'antiapoptotic': [1611, 2967], '(14Nakshatri': [1617, 2132, 2183, 2249], '18Newton': [1638], 'T.R.': [1639, 1676, 1787, 1961, 2213, 2306, 2926, 2977, 3014, 3087, 4014], 'Patel': [1640, 2978], 'N.M.': [1641, 1668, 1953, 2205, 2298, 2918, 2979, 3006, 3079, 4006], 'Stauss': [1644, 2982], 'C.R.': [1645, 2983], 'Nakshatri': [1649, 1689, 1770, 1791, 1812, 1974, 2226, 2319, 2939, 2987, 3027, 3100, 4027], 'Chem.': [1653, 2991, 4073, 4248], '274:': [1655, 2993], '18827-18835Abstract': [1656, 2994], 'Full': [1657, 1659, 2995, 2997, 4077, 4079, 4252, 4254], 'Text': [1658, 1660, 2996, 2998, 4078, 4080, 4253, 4255], 'PDF': [1661, 2999, 4081, 4256], '(59)': [1664, 3002], '19Patel': [1667, 2204, 3005], 'Nozaki': [1669, 1954, 2206, 2299, 2919, 3007, 3080, 4007], 'S.': [1670, 1678, 1755, 1766, 1798, 1955, 1963, 2207, 2215, 2300, 2308, 2920, 2928, 3008, 3016, 3081, 3089, 4008, 4016, 4241], 'Shortle': [1671, 1956, 2208, 2301, 2921, 3009, 3082, 4009], 'N.H.': [1672, 1957, 2209, 2302, 2922, 3010, 3083, 4010], 'Newton': [1675, 1786, 1960, 2212, 2305, 2925, 3013, 3086, 4013], 'Rice': [1677, 1962, 2214, 2307, 2927, 3015, 3088, 4015], 'Gelfanov': [1679, 1964, 2216, 2309, 2929, 3017, 3090, 4017], 'V.': [1680, 1965, 2217, 2310, 2930, 3018, 3091, 4018], 'Boswell': [1681, 1966, 2218, 2311, 2931, 3019, 3092, 4019], 'S.H.': [1682, 1967, 2219, 2312, 2932, 3020, 3093, 4020], '4159-4169Crossref': [1694, 1979, 2231, 2324, 2944, 3032, 3105, 4032], '(271)': [1697, 1982, 2234, 2327, 2947, 3035, 3108, 4035], '20Nakshatri': [1700, 3038], 'Curr.': [1705, 3043], 'Probl.': [1706, 3044], '26:': [1709, 3047], '282-309Crossref': [1710, 3048], 'cell-derived': [1723], 'heregulin,': [1724], 'IL-1α,': [1725, 3229, 3460], 'and/or': [1726], '(21Biswas': [1742], 'D.K.': [1743], 'Cruz': [1744], 'A.P.': [1745], 'Gansberger': [1746], 'Pardee': [1748], 'A.B.': [1749], 'Proc.': [1750, 1793], 'Natl.': [1751, 1794], 'Acad.': [1752, 1795], 'Sci.': [1753, 1796], '97:': [1758], '8542-8547Crossref': [1759], '(306)': [1762], '22Nozaki': [1765], 'Biochem.': [1772], 'Biophys.': [1773], 'Commun.': [1775], '275:': [1777], '60-62Crossref': [1778], '(60)': [1781], '23Bhat-Nakshatri': [1784], 'R.': [1790, 3279, 4269], '95:': [1801], '6971-6976Crossref': [1802], '(80)': [1805], '24Bhat-Nakshatri': [1808], 'Sweeney': [1810], 'C.J.': [1811], '21:': [1816], '2066-2078Crossref': [1817], '(104)': [1820], 'initiated': [1827], 'determine': [1829, 3112, 3227, 3394, 3924], 'whether': [1830, 3113, 3228, 3395], 'promotes': [1832], 'CXCR4,': [1848, 2241, 2342], 'appears': [1850, 3827, 3902], 'clonally': [1877], 'selected': [1878], 'during': [1879], 'nude': [1888, 2382, 4359, 4390], 'mice.': [1889, 2383, 4360], 'Breast': [1909], 'Cell': [1911, 2418, 2435, 2495, 3343, 4188], 'Lines—The': [1912], 'human': [1913], 'lines': [1917, 3264], 'MCF-7': [1918, 2082, 2105, 3247, 3351, 3409], 'MDA-MB-231': [1920, 1946, 2084, 2370, 2510, 2893, 2909, 2950, 3177, 3222, 3477, 3919, 3934, 3979, 4059, 4176, 4333, 4382], 'were': [1921, 2015, 2027, 2052, 2086, 2127, 2159, 2174, 2373, 2386, 2420, 2437, 2451, 2460, 2487, 2512, 2563, 2592, 2607, 2629, 2635, 2642, 2656, 2667, 2753, 2863, 2871, 2885, 3060, 3441, 3699, 3709, 3861], 'obtained': [1922, 2488, 2778, 3700], 'ATCC': [1925], 'minimum': [1929], 'essential': [1930], 'medium': [1931, 2725, 2752], '+': [1932], '10%': [1933, 2728, 4331], 'fetal': [1934, 2729], 'calf': [1935], 'serum.': [1936], 'LxSN11,': [1937, 3133], 'IκBαSR6,': [1938, 3134, 3943], 'IκBαSR10': [1940, 3136, 3151, 3945, 3964], 'described': [1950, 2130, 2181, 2247, 2295, 2681, 3267], '(19Patel': [1952, 2297, 2917, 3078, 4005], 'Plasmid': [1985], 'Constructs': [1986], 'Transient': [1988], 'Transfection': [1989], 'Assays—The': [1990], 'recloned': [1994], 'PCR': [1996], 'using': [1997, 2276, 2658, 2669, 2887, 3655, 3876], 'Genome': [1999], 'Walker': [2000], 'kit': [2001, 2279], '(Clontech).': [2002], 'PCR-amplified': [2003], 'DNA': [2004, 3054, 3756, 3905, 3999], 'cloned': [2006], 'pBL-CAT3': [2009], 'vector': [2010, 2068, 2100, 3075, 3254, 3306], 'sequenced.': [2012], 'Deletion': [2013], 'mutants': [2014, 3540], 'generated': [2017, 3537], 'PCR.': [2019], 'p65,': [2021], 'p50,': [2022], 'Bcl-3': [2024, 3718], 'vectors': [2026, 2046, 2094], 'generous': [2029, 2054], 'gift': [2030, 2055, 2072], 'Dr.': [2032, 2057, 2074], 'Greene': [2034], '(Gladstone': [2035], 'Institute': [2036], 'Virology': [2038], 'Immunology,': [2040], 'San': [2041], 'Francisco,': [2042], 'CA).': [2043], 'IKKα,': [2049], 'IKKβ': [2051, 3590], 'Donner': [2059], '(Indiana': [2060, 2077], 'University': [2061, 2078], 'School': [2062, 2079], 'Medicine).': [2064, 2081], 'kind': [2071], 'Alkhatib': [2076], 'transfected': [2087, 2160, 3660], 'CXCR4/CAT': [2090, 3415, 3467], 'reporter': [2091, 3468], 'along': [2095], 'β-galactosidase': [2098, 2115, 2125], '(RSVβ-gal': [2101], 'pcH110': [2103], 'MDA-MB-231,': [2107], 'respectively)': [2108], 'calcium': [2111], 'phosphate': [2112], 'method.': [2113], 'CAT': [2118], 'an': [2121, 2522, 2973, 3126, 3165, 3240, 3333, 3502, 3763, 3771, 4323], 'equal': [2122], 'number': [2123, 2797, 2807, 2829, 2959, 3193], 'units': [2126], 'measured': [2128, 2473, 2506, 3446], 'Mobility': [2154], 'Shift': [2155], 'Assay': [2156], '(EMSA)—COS-1': [2157], '10': [2162, 2412], 'μg': [2163], 'vectors,': [2166], 'whole': [2168, 3706], 'extracts': [2170, 2173, 3656, 3703, 3708], 'or': [2171, 2287, 2521, 2711, 3256, 3450, 3461, 3508, 3682, 3887], 'prepared': [2175, 2275], '48': [2176], 'h': [2177, 2396, 2812], 'after': [2178, 2388, 2464, 2810, 4179, 4395], 'EMSA': [2237, 3877], 'performed': [2239, 2293, 2668, 3125, 3170, 3239, 3328, 3403, 3937, 4141], 'SP-1': [2244, 3741], 'probes': [2245, 2289], 'RNase': [2270, 2282, 3127, 3166, 3241], 'Protection': [2271], 'Assay—Total': [2272], 'RNA': [2273, 3131, 3172, 3245], 'RNeasy': [2278], '(Qiagen).': [2280], 'protection': [2283, 3128, 3167, 3242], 'assay': [2284, 3129, 3168, 3243, 3407, 3860, 3940, 3985], 'hCR6': [2286, 2331], 'hAPO-5': [2288, 2348], '(BD': [2290, 2525], 'Pharmingen)': [2291, 2526], 'probe': [2332, 2349, 3692, 3880], 'set': [2333], 'simultaneously': [2334], 'measures': [2335, 2350], 'CXCR1,': [2339], 'CXCR2,': [2340], 'CXCR3,': [2341], 'BLR-1,': [2343], 'BLR-2,': [2344], 'V28.': [2346], 'TRAF-1,': [2352], 'TRAF-2,': [2353], 'TRAF-3,': [2354], 'TRAF-4,': [2355], 'cIAP-1,': [2356], 'cIAP-2,': [2357], 'TRPM-2.': [2359], 'Mouse': [2360], 'Mammary': [2361, 2384], 'Fat': [2362], 'Pad': [2363], 'Injection': [2364], 'Isolation': [2366], 'Cells—': [2369], '(106)': [2372], 'injected': [2374], '7-week-old': [2381], 'tumors': [2385, 4394], 'resected': [2387, 4392], 'weeks,': [2390, 4397], 'minced,': [2391], 'digested': [2393, 2421], '1': [2395, 2408, 2493], '37': [2398, 2427, 2816], '°C': [2399, 2428, 2598, 2817], 'digestion': [2401], 'buffer': [2402], '(2': [2403], 'mg/ml': [2404, 2409, 2432], 'collagenase': [2405], '3,': [2407], 'hyaluronidase': [2410], 'ml': [2413], 'PBS/g': [2415], 'tumor).': [2417], 'pellets': [2419, 2436], 'again': [2422], '20': [2424], 'min': [2425], 'protease': [2430], '(12.5': [2431], 'PBS).': [2434], 'washed': [2438, 2565, 2609], 'PBS': [2440], 'plated': [2442], 'medium.': [2445], 'Metastatic': [2446], 'lungs': [2450, 2459], 'similarly': [2452, 3115], 'exception': [2456], 'collected': [2461], '8': [2462], 'weeks': [2463], 'removal': [2465], 'primary': [2468], 'tumor.': [2469], 'periodically': [2474], 'cultured': [2476, 2491], 'tumor-': [2477], 'metastasis-derived': [2479], 'Data': [2482, 2647, 2876], 'presented': [2483, 2649, 2878], 'text': [2486], 'month.': [2494], 'Surface': [2496, 4189], 'Expression': [2497], '—Cell': [2500], 'flow': [2508, 2537, 3329, 4320], 'cytometry.': [2509], 'stained': [2513], 'fluorochrome-conjugated': [2515], 'monoclonal': [2516], 'either': [2519, 3680], 'isotype': [2523], 'control': [2524], 'accordance': [2528, 2675], "manufacturer's": [2531, 2678], 'specifications': [2532], 'then': [2534, 2608], 'analyzed': [2535, 2636, 2864], 'cytometry': [2538, 4321], '(25Christopherson': [2539, 2686], 'II,': [2540, 2687], 'K.W.': [2541, 2688], 'Campbell': [2542, 2689], 'J.J.': [2543, 2690], 'Hromas': [2544, 2691], 'R.A.': [2545, 2692], 'Blood.': [2546, 2693], '98:': [2548, 2695], '3562-3568Crossref': [2549, 2696], '(24)': [2552, 2699], 'staining': [2556], 'protocol': [2557], 'follows.': [2561], 'Cells': [2562, 2894, 3920, 4177], 'penicillin,': [2568, 2581, 2613], 'streptomycin,': [2569, 2582, 2614], '1%': [2570, 2583, 2615, 2623], 'bovine': [2571, 2584, 2616, 2730], 'serum': [2572, 2585, 2617, 2731], 'albumin': [2573, 2586, 2618], 'resuspended': [2575], '100': [2577, 2843], 'μl': [2578, 2719, 2750], 'containing': [2587, 3251], 'antibody.': [2590], 'Samples': [2591, 2634], 'mixed': [2593], 'incubated': [2595], '4': [2597], 'dark': [2601], '40': [2603], 'min.': [2604], 'twice': [2610], 'fixed': [2620], 'paraformaldehyde.': [2624], 'One': [2625], 'hundred': [2626], 'thousand': [2627, 2737], 'accumulated': [2630], 'analysis.': [2633, 2646, 2875], 'triplicate,': [2638, 2867], 'averaged': [2643, 2872], 'statistical': [2645, 2874], 'means': [2651, 2880], '±': [2652, 2881], 'S.E.,': [2653, 2882], 'comparisons': [2655, 2884], 'made': [2657, 2886], 'two-tailed': [2660, 2889], "Student's": [2661, 2890], 't': [2662, 2891], 'test.': [2663, 2892], 'Chemotaxis': [2664], 'Assay—Chemotaxis': [2665], '96-well': [2670], 'chemotaxis': [2671, 3939, 3984, 4143], 'chambers': [2672], '(NeuroProbe)': [2673], 'instructions': [2679], 'minor': [2684], 'variations': [2685], 'brief,': [2703], '0,': [2704], '12.5,': [2705], '25,': [2706], '50,': [2707], '100,': [2708], '200,': [2709], '400,': [2710], '800': [2712], 'ng/ml': [2713], 'CXCL12/SDF-1α': [2714], 'added': [2716, 2754], '300': [2718], 'phenol': [2721], 'red-free': [2722], 'RPMI': [2723], '1640': [2724], 'supplemented': [2726], 'lower': [2734, 2762, 2800, 2834, 2854, 3061, 3602, 4127], 'chamber.': [2735], 'Twenty-five': [2736], 'fluorescent-tagged': [2738], '(4': [2739], 'μg/ml': [2740], 'calcein': [2741], 'AM,': [2742], 'Molecular': [2743], 'Probes,': [2744], 'Eugene,': [2745], 'OR)': [2746], '50': [2749], 'upper': [2757], 'chamber,': [2758], 'separated': [2759], 'chamber': [2763, 2801, 2835, 2855], 'membrane': [2766], '(5.7-mm': [2767], 'diameter,': [2768], '5-μm': [2769], 'pore': [2770], 'size,': [2771], 'polycarbonate': [2772], 'membrane).': [2773], 'Total': [2774], 'measuring': [2780], 'fluorescence': [2782], '(excitation,': [2783], '485': [2784], 'nm;': [2785], 'emission,': [2786], '530': [2787], 'nm)': [2788], 'microplate': [2791], 'spectrofluorometer': [2792], 'calculating': [2794], 'comparison': [2803], 'standard': [2808], 'curve': [2809], '2': [2811], 'incubation': [2814], '5%': [2819], 'CO2.': [2820], 'Percentage': [2821], 'calculated': [2825], 'dividing': [2827], 'total': [2838], 'input': [2840], 'multiplied': [2841], 'subtracting': [2845], 'random': [2846], '(always': [2848], 'less': [2849, 4329], 'than': [2850, 3603, 4330], '7%)': [2851], 'absence': [2858, 3449], 'SDF-1α.': [2860, 3951, 4318], 'samples': [2862], 'separately': [2865], 'Overexpressing': [2895], 'Super-repressor': [2897], 'Display': [2898], 'Lower': [2899], 'Levels': [2900, 4186], 'mRNA—We': [2903], 'generation': [2907], 'overexpressing': [2913], 'super-repressor': [2916], 'contain': [2952], '(uPA,': [2962], 'IL-6,': [2963], 'IL-8)': [2965], '(cIAP-2': [2969], 'TRAF-1)': [2971], 'NF-κB-dependent': [2974], 'manner': [2975], '(18Newton': [2976], 'Constitutive': [3052, 3472], 'cIAP-2': [3058], 'super-repressor-expressing': [3064], '(IκBαSR6': [3066], 'IκBαSR10)': [3068], 'transduced': [3072], 'retrovirus': [3074], 'alone': [3076, 3681], '(LxSN11)': [3077], 'To': [3111, 3155, 3226, 3309, 3530, 4114, 4376], 'transcripts': [3139], 'could': [3140, 3759, 4104], 'detected': [3142], 'LxSN11': [3144, 3957], 'but': [3146, 3356, 3559, 3588, 3738, 3959], 'not': [3147, 3357, 3560, 3589, 3724, 3739, 3864, 3869, 3898, 3960], 'IκBαSR6': [3149, 3962, 4150], '(Fig.': [3153, 3224, 3307, 3361, 3470, 3483, 3572, 3693, 3711, 3750, 3966, 4049, 4159], '1A).': [3154], 'confirm': [3157, 4163], 'involvement': [3159], 'expression,': [3164, 3237, 3294], 'untreated': [3174], 'parthenolide-treated': [3176], 'Parthenolide': [3179, 3215, 3991], 'relatively': [3182], 'investigators': [3195], 'vitro': [3198], 'studies': [3199, 4052], '(26Hehner': [3200], 'S.P.': [3201], 'Hofmann': [3202], 'T.G.': [3203], 'Droge': [3204], 'Schmitz': [3206], 'M.L.': [3207], '163:': [3211], '5617-5623PubMed': [3212], '1B).': [3225], 'potent': [3231], 'inducer': [3232], 'alters': [3235], 'empty': [3253], '(pcDNA3)': [3255], 'stably': [3259], 'overproduce': [3260], 'IL-1α.': [3261], 'elsewhere.': [3268], '2S.': [3269], 'Kumar,': [3270], 'Miller,': [3273], 'L.': [3275], 'Chua,': [3276], 'Kishimoto,': [3278], 'Bigsby,': [3281], 'Nakshatri,': [3284], 'submitted.': [3285], 'Consistent': [3286], 'IL-1α-overproducing': [3295], 'displayed': [3297], 'elevated': [3298], 'pcDNA3': [3305], '1C).': [3308], 'ensure': [3310], 'correlation': [3315], 'between': [3316, 3532], 'mRNA': [3318], 'protein,': [3326], 'cytometric': [3330], 'analysis': [3331], 'antibody': [3334, 3764, 3772, 3779, 4324], 'specifically': [3336], 'recognizes': [3337], 'surface.': [3342], 'IL-1α': [3355, 3463, 3489, 3498], 'MCF-7-pcDNA3': [3359], '2).': [3362], 'indicate': [3367, 3799], 'regulated': [3376], 'well': [3380, 4305], 'induce': [3386], 'Directly': [3389], 'Regulates': [3390, 3915], 'Promoter—To': [3393], 'activity,': [3401], 'reporter.': [3416, 3613], 'Two': [3417], 'reporters,': [3418], '–897': [3422], '(CXCR4(–897)/CAT)': [3426], '–209': [3432], '(CXCR4(–209)/CAT)': [3436], 'promoter,': [3440], 'used.': [3442], 'Reporter': [3443], 'presence': [3451, 3551], 'inducers': [3455], 'TPA.': [3462], 'TPA': [3465, 3491, 3500], 'induced': [3466], '3A).': [3471], 'IκBαSR': [3482, 4093, 4122], '3B).': [3484], 'Induction': [3485], 'CXCR4(–209)/CAT': [3487], 'suggests': [3492], 'induction': [3494], 'indirect': [3503], 'effect': [3504, 3789], 'distinct': [3519], 'predicted': [3524], 'TFSEARCH': [3527], 'computer': [3528], 'program.': [3529], 'distinguish': [3531], 'possibilities,': [3535], 'additional': [3538], 'deletion': [3539], '(CXCR4(–121)/CAT': [3541], 'CXCR4(–66)/CAT)': [3543], 'tested': [3545], 'them': [3546], 'various': [3553, 3662], 'subunit': [3563, 3609, 3783], 'increased': [3566], 'both': [3570], 'reporters': [3571], '3C).': [3573], 'Among': [3574], 'upstream': [3576], 'kinases': [3577], 'activation,': [3581], 'NIK': [3582], 'promoter.': [3586, 3633, 3813], 'IKKα': [3587], 'CXCR4(–897)/CAT.': [3592], 'Although': [3593], 'basal': [3595], 'CXCR4(–66)/CAT': [3598], '5': [3600, 3993], 'times': [3601], 'CXCR4(–121)/CAT,': [3606], 'element': [3621], 'located': [3623], 'sequence': [3629, 3847], 'next': [3635], 'determined': [3636, 3852], 'direct': [3637], 'EMSAs': [3654], 'COS-1': [3658], 'probe.': [3676], 'subunit,': [3679, 3688], 'combination': [3684], 'bound': [3689, 3719], '4,': [3694, 3712, 3751], 'lanes': [3695, 3713, 3752], '1–4).': [3696], 'Similar': [3697], 'when': [3701, 3878], 'instead': [3704, 4110], '5–7).': [3714], 'Neither': [3715], 'c-Rel': [3716], 'nor': [3717], '(data': [3723, 3863, 3897], 'shown).': [3725, 3865, 3899], 'Unlabeled': [3726], 'oligonucleotide': [3727], 'classical': [3730, 3822], 'immunoglobulin': [3736], 'probe·protein': [3747, 3757, 3793], 'formation': [3749], '8–10).': [3753], 'disrupted': [3761], 'supershifted': [3768], 'partially': [3769], '(lanes': [3775], '11–14).': [3776], 'nonspecific': [3778], '(against': [3780], 'p110': [3782], 'phosphatidylinositol': [3785], '3-kinase)': [3786], 'had': [3787], 'no': [3788], '(lane': [3795], '14).': [3796], 'Because': [3814, 4319], 'lacks': [3820], 'element,': [3825], 'it': [3826, 3901], 'non-classical': [3837], 'element.': [3839], 'exact': [3841], 'yet': [3849], 'DNase': [3857], 'I': [3858], 'footprinting': [3859], 'inconclusive': [3862], 'Also': [3866], 'did': [3868], 'detect': [3870], 'contained': [3881], 'only': [3882, 4347], '–33': [3886], '–32': [3889], '+1': [3891, 3912], 'regions': [3892], 'Thus,': [3900], 'requires': [3907], 'entire': [3909], 'region.': [3913], 'Migration': [3917], '—To': [3923], 'consequence': [3926], 'inhibition': [3929], 'LXSN11,': [3942], 'increasing': [3948], 'concentrations': [3949], 'SDF-1α-induced': [3952, 3976], '5A).': [3967], 'confirmed': [3969], 'requirement': [3971], 'performing': [3982], 'pretreated': [3988, 4046], 'parthenolide.': [3990], 'μm': [3994], 'completely': [3995], 'inhibits': [3996], 'Inhibition': [4038], 'SDF-1α-dependent': [4040, 4119, 4145], 'parthenolide': [4048], '5B).': [4050], 'Recent': [4051], 'indicated': [4053], 'up-regulation': [4062], 'uPA': [4064, 4109], '(27Sliva': [4065], 'Rizzo': [4067], 'M.T.': [4068], 'English': [4069], '277:': [4075], '3150-3157Abstract': [4076], '(133)': [4084], 'case,': [4089, 4292], 'parthenolide-pretreated': [4096], 'migrate': [4099], 'expression.': [4113], 'prove': [4116], 'levels': [4128, 4353], 'reintroduced': [4135], 'assay.': [4144], 'IκBα10': [4152], 'reintroduction': [4155], '5C).': [4160], 'Selected': [4178], 'Growth': [4180], 'Nude': [4182], 'Mice': [4183], 'Express': [4184], 'Higher': [4185], '—Although': [4191], 'function': [4194], 'transiently': [4199], 'integrins': [4204], 'CXCR4-expressing': [4210], 'endothelium': [4214], 'egression': [4216], 'circulation,': [4219], 'growth-promoting': [4227], '(28Ganju': [4230], 'R.K.': [4231], 'Brubaker': [4232], 'S.A.': [4233], 'Meyer': [4234], 'Dutt': [4236], 'Yang': [4238], 'Qin': [4240], 'Newman': [4242], 'Groopman': [4244], '273:': [4250], '23169-23175Abstract': [4251], '(558)': [4259], '29Kijowski': [4262], 'Baj-Krzyworzeka': [4264], 'Majka': [4266], 'Reca': [4268], 'Marquez': [4270], 'Christofidou-Solomidou': [4272], 'Janowska-Wieczorek': [4274], 'Ratajczak': [4276], 'M.Z.': [4277], 'Stem': [4278], 'Cells.': [4279], '453-466Crossref': [4282], '(201)': [4285], 'If': [4288], 'unlike': [4293], 'culture': [4296, 4337], 'models,': [4297], 'should': [4303, 4356, 4365], 'grow': [4304, 4357], 'model': [4309], 'can': [4313], 'take': [4314], 'advantage': [4315], 'our': [4343], 'hypothesis': [4344], 'those': [4348], 'higher': [4352], 'Furthermore': [4361], 'organs': [4368], 'test': [4377], 'possibility,': [4379], 'implanted': [4381], 'mice,': [4391]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1980790180', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 18}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 21}, {'year': 2019, 'cited_by_count': 20}, {'year': 2018, 'cited_by_count': 31}, {'year': 2017, 'cited_by_count': 28}, {'year': 2016, 'cited_by_count': 35}, {'year': 2015, 'cited_by_count': 29}, {'year': 2014, 'cited_by_count': 35}, {'year': 2013, 'cited_by_count': 47}, {'year': 2012, 'cited_by_count': 17}], 'updated_date': '2025-01-04T04:47:03.629482', 'created_date': '2016-06-24'}
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