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[17], 'mutation': [18], 'in': [19, 38, 66, 84, 101, 167, 171, 203], 'cystic': [21, 113], 'fibrosis': [22, 114], 'transmembrane': [23], 'conductance': [24], 'regulator': [25], '(CFTR)': [26], 'gene.': [27], 'In': [28], 'heterologous': [29], 'cells,': [30], 'defective': [31], 'processing': [32, 61], 'ΔF508': [35, 64, 82, 109, 135, 147, 172, 188], 'protein': [36, 65, 83, 164], 'results': [37], 'endoplasmic': [39, 192], 'reticulum': [40, 193], 'retention,': [41], 'proteolytic': [42], 'degradation,': [43], 'and': [44, 71, 79, 98, 108, 123, 159, 185], 'absence': [45], 'adenosine': [47], '3′,5′-cyclic': [48], 'monophosphate': [49], '(cAMP)-dependent': [50], 'plasma': [51], 'membrane': [52, 152, 197], 'Cl−': [53, 91, 125, 201], 'conductance.': [54], 'However,': [55], 'data': [56, 178], 'with': [57, 112, 138], 'respect': [58], 'to': [59, 194, 198], 'block': [62], 'native': [67, 86], 'epithelia': [68], 'are': [69], 'limited': [70], 'conflicting.': [72], 'Methods:': [73], 'To': [74], 'characterize': [75], 'both': [76], 'fate': [78], 'function': [80], 'a': [85], 'epithelium,': [87], 'we': [88, 142], 'measured': [89], 'CFTR-mediated': [90, 200], 'secretion,': [92], 'localization': [93], 'CFTR': [96, 99, 148, 163, 189], 'protein,': [97], 'maturation': [100, 184], 'rectal': [102, 130], 'biopsy': [103], 'specimens': [104], 'from': [105, 129, 134, 190], 'normal': [106, 168], 'individuals': [107], 'homozygous': [110, 136, 173], 'patients': [111, 137], '(CF).': [115], 'Results:': [116], 'Ussing': [117], 'chamber': [118], 'studies': [119], 'showed': [120], 'that': [121, 180], 'cAMP-dependent': [122], 'cholinergic': [124], 'secretion': [126, 202], 'was': [127, 165], 'absent': [128], 'tissues': [131], 'freshly': [132], 'excised': [133], 'CF.': [139], 'By': [140, 156], 'immunohistochemistry,': [141], 'detected': [143, 166], 'wild-type': [144], 'but': [145, 169], 'not': [146, 170], 'luminal': [151], 'crypt': [154], 'colonocytes.': [155], 'sequential': [157], 'immunoprecipitation': [158], 'immunoblotting': [160], 'analyses,': [161], 'mature': [162], 'tissues.': [174], 'Conclusions:': [175], 'Collectively,': [176], 'these': [177], 'show': [179], 'there': [181], 'insufficient': [183], 'transport': [186], 'apical': [196], 'support': [199], 'CF': [205], 'colon.': [206]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1980592570', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-09-24T18:00:15.741778', 'created_date': '2016-06-24'}