Publication Information

{'id': 'https://openalex.org/W1980362697', 'doi': 'https://doi.org/10.4161/auto.21795', 'title': 'Deprive to kill', 'display_name': 'Deprive to kill', 'publication_year': 2012, 'publication_date': '2012-08-29', 'ids': {'openalex': 'https://openalex.org/W1980362697', 'doi': 'https://doi.org/10.4161/auto.21795', 'mag': '1980362697', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22932475', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3541294'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/auto.21795', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.4161/auto.21795?needAccess=true', 'source': {'id': 'https://openalex.org/S102544370', 'display_name': 'Autophagy', 'issn_l': '1554-8627', 'issn': ['1554-8627', '1554-8635'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.tandfonline.com/doi/pdf/10.4161/auto.21795?needAccess=true', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5085072211', 'display_name': 'Simone Cardaci', 'orcid': 'https://orcid.org/0000-0002-5955-3422'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Simone Cardaci', 'raw_affiliation_strings': ['Department of Biology', 'Rome, Italy', 'University of Rome “Tor Vergata”'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology', 'institution_ids': []}, {'raw_affiliation_string': 'University of Rome “Tor Vergata”', 'institution_ids': ['https://openalex.org/I116067653']}, {'raw_affiliation_string': 'Rome, Italy', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5007336855', 'display_name': 'Maria Rosa Ciriolo', 'orcid': 'https://orcid.org/0000-0002-7863-9029'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}, {'id': 'https://openalex.org/I4210133214', 'display_name': 'IRCCS Ospedale San Raffaele', 'ror': 'https://ror.org/039zxt351', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210133214', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4387155925', 'display_name': 'Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele', 'ror': 'https://ror.org/006x48140', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I4387155925']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Maria Rosa Ciriolo', 'raw_affiliation_strings': ['Department of Biology', 'IRCCS San Raffaele Pisana', 'Rome, Italy', 'University of Rome “Tor Vergata”'], 'affiliations': [{'raw_affiliation_string': 'Rome, Italy', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Biology', 'institution_ids': []}, {'raw_affiliation_string': 'University of Rome “Tor Vergata”', 'institution_ids': ['https://openalex.org/I116067653']}, {'raw_affiliation_string': 'IRCCS San Raffaele Pisana', 'institution_ids': ['https://openalex.org/I4210133214', 'https://openalex.org/I4387155925']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5007336855'], 'corresponding_institution_ids': ['https://openalex.org/I116067653', 'https://openalex.org/I4210133214', 'https://openalex.org/I4387155925'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.356, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 6, 'citation_normalized_percentile': {'value': 0.70805, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 81, 'max': 82}, 'biblio': {'volume': '8', 'issue': '12', 'first_page': '1830', 'last_page': '1832'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Enzymes and Metabolism', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2779349466', 'wikidata': 'https://www.wikidata.org/wiki/Q181619', 'display_name': 'Glutamine', 'level': 3, 'score': 0.7895887}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.73741364}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.69985175}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.63131464}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.59082025}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.5371142}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.53253603}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.52726257}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5126259}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.4238993}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.41405386}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.38086128}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.365175}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.2261154}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.21323264}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.21315014}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0934934}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D005973', 'descriptor_name': 'Glutamine', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': True}, {'descriptor_ui': 'D011773', 'descriptor_name': 'Pyruvates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005973', 'descriptor_name': 'Glutamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005973', 'descriptor_name': 'Glutamine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027501', 'descriptor_name': 'Monocarboxylic Acid Transporters', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D027501', 'descriptor_name': 'Monocarboxylic Acid Transporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011773', 'descriptor_name': 'Pyruvates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027981', 'descriptor_name': 'Symporters', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D027981', 'descriptor_name': 'Symporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/auto.21795', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.4161/auto.21795?needAccess=true', 'source': {'id': 'https://openalex.org/S102544370', 'display_name': 'Autophagy', 'issn_l': '1554-8627', 'issn': ['1554-8627', '1554-8635'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3541294', 'pdf_url': 'https://europepmc.org/articles/pmc3541294?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541294', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22932475', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/auto.21795', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.4161/auto.21795?needAccess=true', 'source': {'id': 'https://openalex.org/S102544370', 'display_name': 'Autophagy', 'issn_l': '1554-8627', 'issn': ['1554-8627', '1554-8635'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.85, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3149757538', 'https://openalex.org/W2912385559', 'https://openalex.org/W2890156259', 'https://openalex.org/W2757612808', 'https://openalex.org/W2505176208', 'https://openalex.org/W2084880710', 'https://openalex.org/W2081413935', 'https://openalex.org/W2055507365', 'https://openalex.org/W2012224340', 'https://openalex.org/W2006416158'], 'abstract_inverted_index': {'Killing': [0], 'properties': [1], 'of': [2, 13, 23, 33, 37, 46, 58, 89, 112, 116, 123], 'antitumor': [3, 31], 'drugs': [4, 125], 'can': [5, 119], 'be': [6], 'enhanced': [7], 'by': [8, 50, 64], 'strategies': [9], 'targeting': [10, 106], 'biochemical': [11], 'adaptations': [12], 'cancer': [14, 21], 'cells.': [15], 'Recently,': [16], 'we': [17], 'reported': [18], 'that': [19, 114], 'depriving': [20], 'cells': [22], 'glutamine': [24, 75, 117], 'is': [25, 55, 71], 'a': [26, 97, 110], 'feasible': [27], 'approach': [28], 'to': [29, 85], 'enhance': [30], 'effects': [32], 'the': [34, 44, 56, 65, 81, 87, 121], 'alkylating': [35], 'analog': [36], 'pyruvic': [38], 'acid,': [39], '3-bromopyruvate,': [40], 'which': [41], 'rely': [42], 'on': [43], 'induction': [45], 'autophagic': [47], 'cell': [48], 'death': [49], 'metabolic-oxidative': [51], 'stress.': [52], '3-bromopyruvate': [53, 90], 'chemopotentiation': [54], 'result': [57], 'its': [59, 100], 'increased': [60, 73], 'intracellular': [61], 'uptake': [62], 'mediated': [63], 'monocarboxylate': [66], 'transporter': [67], '1,': [68], 'whose': [69], 'expression': [70], 'post-transcriptionally': [72], 'upon': [74], 'withdrawal.': [76], 'Overall,': [77], 'our': [78], 'results': [79], 'identified': [80], 'metabolic': [82], 'condition': [83], 'able': [84], 'increase': [86], 'selectivity': [88], 'targets': [91], 'in': [92, 102], 'neoplastic': [93], 'tissues,': [94], 'thereby': [95], 'providing': [96], 'stage': [98], 'for': [99, 105], 'use': [101], 'clinical': [103], 'settings': [104], 'malignancies': [107], 'and': [108], 'represent': [109], 'proof': [111], 'principle': [113], 'modulation': [115], 'availability': [118], 'influence': [120], 'delivery': [122], 'monocarboxylic': [124], 'into': [126], 'tumors.': [127]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1980362697', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-15T11:34:22.812269', 'created_date': '2016-06-24'}