Construction of Quaternary Stereocenters: New Perspectives through Enantioselective Michael Reactions

Name: Work Video:
Duration: 3 min 30 s
Description: PdII-catalyzed Michael reactions of β-dicarbonyl compounds 1 and enones 2 can generate quaternary stereocenters (shown in yellow) with selectivities of 90 % ee at relatively high temperatures (−10 °C). This method represents a breakthrough in enantioselective synthesis.
Jens Christoffers; Angelika Baro
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