Publication Information

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217, 236, 451, 523, 746, 748], 'entry': [2, 118, 218, 334, 434], '(SOCE)': [3, 219, 435], 'is': [4, 9, 50, 189, 220, 225, 266, 405, 493, 511, 527, 640, 752, 905, 909, 1478, 1749, 1757, 2092, 2313, 2330], 'a': [5, 65, 207, 221, 281, 423, 537, 1385, 1479, 1758, 1768, 2327, 2885, 3219, 3229, 3238, 3449, 3626, 3744, 3893, 4162, 4201, 4226, 4235, 4252, 4267, 4288, 4305], 'ubiquitous': [6, 222], 'mechanism': [7, 223, 1743], 'that': [8, 87, 168, 182, 224, 303, 384, 398, 941, 1270, 1388, 1482, 1762, 2076, 2090, 2242, 2295, 2308, 2323, 2347, 4345, 4371], 'mediated': [10, 226, 512], 'by': [11, 227, 631, 919, 1078, 1267, 1661, 1744, 2863, 3124, 3136, 3361, 3551, 3559, 3719, 3730, 4049, 4200, 4301], 'distinct': [12, 228], 'SOC': [13, 38, 57, 117, 194, 212, 229, 254, 273, 333, 410, 428, 650, 737, 811, 903, 963, 1278, 2098, 2343], 'channels,': [14, 230, 520, 651, 812], 'ranging': [15, 231, 542, 3212], 'from': [16, 232, 501, 543, 815, 1789, 2361, 2372, 2381, 2390, 2399, 2408, 2418, 2430, 2442, 2634, 2841, 3196, 3213, 3228, 3914, 4304], 'the': [17, 44, 132, 163, 233, 260, 348, 379, 506, 514, 624, 629, 633, 638, 643, 653, 657, 664, 679, 743, 806, 896, 920, 948, 1083, 1274, 1382, 1453, 1457, 1489, 1500, 1655, 1705, 1741, 1845, 2069, 2081, 2097, 2250, 2259, 2267, 2271, 2274, 2280, 2509, 2574, 2580, 2590, 2805, 2820, 2827, 2833, 2854, 2905, 2940, 2952, 3018, 3099, 3132, 3142, 3148, 3163, 3192, 3197, 3272, 3475, 3717, 3775, 3915, 3987, 4014, 4050, 4129, 4218, 4222, 4276, 4350, 4403, 4408], 'highly': [18, 234, 744], 'selective': [19, 235], 'release-activated': [21, 237, 452, 747], 'Ca2+': [22, 200, 238, 416, 433, 442, 500, 503, 636, 928, 934, 1080, 1275, 1846, 2268, 2335, 2983, 4340, 4365, 4406], '(CRAC)': [23, 239, 749], 'channel': [24, 195, 240, 411, 680, 738, 1459, 1850, 1971], 'in': [25, 40, 116, 121, 131, 148, 178, 191, 196, 241, 256, 332, 337, 347, 364, 394, 407, 412, 495, 530, 637, 669, 678, 754, 791, 902, 924, 1100, 1280, 1391, 1394, 1488, 1499, 1536, 1618, 1654, 1776, 1839, 2100, 2258, 2287, 2332, 2641, 2832, 2958, 3010, 3017, 3028, 3131, 3141, 3147, 3271, 3356, 3377, 3448, 3553, 3568, 3589, 3957, 3992, 4018, 4133, 4287, 4346, 4417], 'rat': [26, 242, 485], 'basophilic': [27, 243, 486], 'leukemia': [28, 244], 'and': [29, 59, 72, 89, 119, 138, 146, 181, 213, 245, 275, 288, 305, 335, 354, 362, 397, 429, 510, 534, 552, 560, 757, 800, 1070, 1115, 1287, 1475, 1541, 1786, 2065, 2285, 2344, 2353, 2356, 2377, 2414, 2421, 2424, 2437, 2448, 2453, 2541, 2583, 2628, 2645, 2708, 2723, 2731, 2812, 2850, 2903, 3205, 3235, 3256, 3261, 3278, 3286, 3359, 3363, 3405, 3474, 3479, 3557, 3591, 3603, 3606, 3611, 3623, 3762, 3765, 3833, 3883, 3897, 3955, 3967, 3990, 4011, 4013, 4035, 4058, 4062, 4067, 4125, 4142, 4147, 4224, 4321, 4360], 'other': [30, 41, 246, 257, 758, 792, 3592], 'hematopoietic': [31, 247, 759], 'cells': [32, 152, 180, 248, 368, 396, 760, 803, 1290, 1543, 1620, 2103, 2455, 2563, 2695, 2711, 2866, 3027, 3436, 3718, 4347, 4419], 'to': [33, 56, 77, 198, 249, 272, 293, 414, 497, 555, 642, 646, 739, 817, 911, 926, 1075, 1095, 1273, 1496, 1702, 1766, 1782, 2315, 2559, 2597, 2803, 2852, 2884, 2900, 2950, 3215, 3281, 4046, 4217, 4234, 4377], 'relatively': [34, 250, 818], 'Ca2+-selective': [35, 251, 819], 'or': [36, 101, 111, 252, 317, 327, 648, 931, 3135, 3443, 3543, 3700, 3702, 3795, 4150, 4317, 4329, 4335, 4354, 4388], 'non-selective': [37, 253, 816], 'channels': [39, 49, 58, 255, 265, 274, 658, 668, 904, 916, 956, 964, 1279, 2099, 2346], 'cells.': [42, 125, 160, 258, 341, 376, 2660, 2954], 'Although': [43, 259, 895, 1063], 'exact': [45, 261, 1742], 'composition': [46, 262], 'of': [47, 61, 64, 67, 98, 106, 136, 142, 176, 185, 193, 263, 277, 280, 283, 314, 322, 352, 358, 392, 401, 409, 499, 516, 539, 557, 635, 656, 666, 808, 899, 947, 955, 962, 1277, 1384, 1456, 1472, 1528, 1612, 1697, 1829, 1835, 1848, 1964, 2083, 2096, 2244, 2254, 2263, 2270, 2283, 2303, 2311, 2318, 2326, 2334, 2342, 2557, 2562, 2662, 2720, 2728, 2797, 2859, 2942, 2982, 3023, 3191, 3202, 3221, 3232, 3240, 3246, 3368, 3546, 3601, 3614, 3693, 3774, 3784, 3873, 3906, 3995, 4054, 4221, 4312, 4314, 4323, 4325, 4399], 'these': [48, 179, 204, 264, 395, 420, 667, 915], 'not': [51, 109, 267, 325, 906, 1750, 3252, 4368, 4392], 'yet': [52, 268, 660, 1751], 'established,': [53, 269], 'TRPC1': [54, 143, 270, 359, 1271, 2091, 2245, 2255, 2594, 2663, 3615, 4380], 'contributes': [55, 271, 1272], 'regulation': [60, 276, 556, 2310, 2317, 2352], 'physiological': [62, 278, 897], 'function': [63, 279, 1393, 1703], 'variety': [66, 282, 538], 'cell': [68, 284, 532, 558, 671, 793, 1103, 1282, 3786, 4001], 'types.': [69, 285], 'Recently,': [70, 286], 'Orai1': [71, 88, 110, 147, 287, 304, 326, 363, 1777, 1830, 1836, 1965, 2064, 2286, 2438, 2806, 2855, 4330, 4336], 'STIM1': [73, 90, 102, 289, 306, 318, 1474, 1477, 1529, 1613, 1649, 1698, 1746, 1967, 2066, 2284, 2309, 2436, 4318, 4333], 'have': [74, 290, 659, 804, 957, 1072, 1263, 1467, 1778, 2087, 2278, 2909, 4414], 'been': [75, 291, 661, 958, 1073, 1093, 1264, 1494, 1700, 1779, 2074, 2666, 2910], 'suggested': [76, 292, 1701, 1765, 2075], 'be': [78, 294, 740, 1076, 1096, 1497, 1767, 2853], 'sufficient': [79, 295, 2079], 'for': [80, 94, 174, 211, 296, 310, 390, 427, 1088, 1098, 1773, 2080, 2301, 2543, 2564, 2589, 3268, 3445, 3471, 3481, 3736, 3862, 3978, 4008, 4023, 4037], 'generating': [81, 297], 'CRAC': [82, 214, 298, 430, 1392, 1458, 1849, 1970, 2345], 'channels.': [83, 96, 215, 299, 312, 431, 525, 945, 2305], 'Here': [84, 300], 'we': [85, 301, 2277, 2321, 4413], 'show': [86, 302, 2307], 'are': [91, 172, 307, 388, 673, 917, 1085, 1460, 2078, 2299, 3015, 3021, 3581], 'also': [92, 308], 'required': [93, 309, 1097, 2510, 4130, 4155], 'TRPC1-SOC': [95, 311, 2304, 2312], 'Knockdown': [97, 313, 1527, 1828, 4313], 'TRPC1,': [99, 107, 315, 323, 4315, 4327], 'Orai1,': [100, 316, 1756, 4316], 'attenuated,': [103, 319], 'whereas': [104, 320, 1833, 2252, 2823], 'overexpression': [105, 321, 1611, 2248], 'but': [108, 324], 'STIM1,': [112, 145, 328, 361, 4328], 'induced': [113, 329, 3706], 'an': [114, 330, 1484, 2093, 2868, 2877, 3554, 3569, 4189, 4212], 'increase': [115, 331], 'ISOC': [120, 177, 336, 393], 'human': [122, 149, 338, 365, 469, 2593, 2828], 'salivary': [123, 150, 339, 366, 470, 797, 1106, 1285, 2101], 'gland': [124, 151, 159, 340, 367, 375, 1286, 2102, 3918], 'All': [126, 342, 4041], 'three': [127, 170, 343, 386, 2297], 'proteins': [128, 171, 344, 387, 1466, 2298, 3778, 3866], 'were': [129, 345, 2359, 2370, 2380, 2428, 2440, 2456, 2506, 2553, 2569, 2595, 2696, 2712, 2734, 2808, 2861, 2956, 3259, 3284, 3370, 3437, 3465, 3477, 3549, 3566, 3594, 3616, 3633, 3705, 3713, 3779, 3867, 3890, 3900, 3912, 3951, 4016, 4030, 4043, 4065, 4140, 4159, 4167, 4176, 4261, 4285, 4299, 4391], 'co-localized': [130, 346], 'plasma': [133, 349, 518, 644, 1769], 'membrane': [134, 350, 519, 1657, 3288], 'region': [135, 351, 1658, 2262], 'cells,': [137, 353, 1114, 2944], 'thapsigargin': [139, 355, 1662, 2357], 'increased': [140, 356], 'co-immunoprecipitation': [141, 357], 'with': [144, 360, 1791, 1837, 1966, 2256, 2508, 2571, 2876, 2980, 3098, 3155, 3439, 3455, 3707, 3751, 3781, 3879, 3885, 3986, 4006, 4128, 4145, 4344, 4349, 4381, 4402], 'as': [153, 155, 369, 371, 796, 960, 1469, 1704, 2458, 2512, 2578, 2809, 2984, 3045, 3170, 3295, 3375, 3484, 3583, 3625, 3635, 3902, 3919, 4039, 4069, 4154, 4294, 4342], 'well': [154, 370], 'dispersed': [156, 372], 'mouse': [157, 373, 3916], 'submandibular': [158, 374, 3917, 3949], 'In': [161, 377, 1609, 2273, 2814, 2939], 'aggregate,': [162, 378], 'data': [164, 205, 380, 421, 1084, 2240, 2291, 2338], 'presented': [165, 381, 2292], 'here': [166, 382, 2293], 'reveal': [167, 383, 2294, 2339], 'all': [169, 385, 531, 914, 2296, 2565], 'essential': [173, 389, 2094, 2300], 'generation': [175, 391, 2302], 'dynamic': [183, 399, 2324], 'assembly': [184, 400, 2325], 'TRPC1-STIM1-Orai1': [186, 402, 2328], 'ternary': [187, 403], 'complex': [188, 404, 2329], 'involved': [190, 406, 2331], 'activation': [192, 408, 515, 2333], 'response': [197, 413, 496, 925], 'internal': [199, 415, 490, 927, 933, 1079], 'store': [201, 417, 929, 935, 1081], 'depletion.': [202, 418], 'Thus,': [203, 419], 'suggest': [206, 422], 'common': [208, 424, 2340], 'molecular': [209, 425, 654, 1454], 'basis': [210, 426], '6The': [436], 'abbreviations': [437], 'used': [438, 2542, 2584, 2802, 2899, 2949, 3154, 3267, 3480, 4036], 'are:': [439], 'SOCE,': [440, 1832, 2247], 'store-operated': [441, 445, 522, 4409], 'entry;': [443], 'SOC,': [444], 'Ca2+;': [446, 453], 'ER,': [447], 'endoplasmic': [448, 507], 'reticulum;': [449], 'CRAC,': [450], 'siRNA,': [454, 4334], 'small': [455], 'interference': [456], 'RNA;': [457], 'Tg,': [458], 'thapsigargin;': [459], 'TRITC,': [460], 'tetramethylrhodamine': [461], 'isothiocyanate;': [462], 'HA,': [463], 'hemagglutinin;': [464], 'GST,': [465], 'glutathione': [466], 'S-transferase;': [467], 'HSG,': [468], 'gland;': [471], 'TRPC,': [472], 'transient': [473, 949], 'receptor': [474, 950], 'potential': [475, 951, 3231, 3245], 'canonical;': [476], 'sh,': [477], 'short': [478], 'hairpin;': [479], 'IP,': [480], 'immunoprecipitation;': [481], 'IB,': [482], 'immunoblotting;': [483], 'RBL,': [484, 756], 'leukemia;': [487], 'TIRF,': [488], 'total': [489], 'reflection': [491], 'fluorescence.': [492], 'stimulated': [494], 'depletion': [498, 930, 936], 'intracellular': [502, 939], 'stores': [504], '(primarily': [505], 'reticulum': [508], '(ER))': [509], 'via': [513], 'specific': [517], 'termed': [521], '(SOC)': [524], 'SOCE': [526, 622, 1099, 1535, 1617, 1709, 1748, 3121, 4320], 'ubiquitously': [528], 'expressed': [529, 3582, 3624], 'types': [533, 672, 794, 810], 'critically': [535], 'regulates': [536, 1747], 'cellular': [540], 'functions': [541], 'T-lymphocyte': [544], 'activation,': [545], 'smooth': [546, 801, 1109, 1288], 'muscle': [547, 802, 1289], 'contraction,': [548], 'platelet': [549], 'aggregation,': [550], 'fluid': [551], 'protein': [553, 1091, 1481, 1761, 1772, 2265, 2552, 2947, 3369, 3704], 'secretion,': [554], 'growth': [559], 'proliferation': [561], '(1Berridge': [562], 'M.J.': [563, 2013], 'Bootman': [564], 'M.D.': [565, 1593, 1862], 'Roderick': [566], 'H.L.': [567], 'Nat.': [568, 607, 991, 2024], 'Rev.': [569, 587, 688, 764, 779, 826, 971, 1297, 1399, 1414], 'Mol.': [570], 'Cell': [571, 608, 992, 1599, 2025, 2400, 2446, 3726], 'Biol.': [572, 609, 726, 864, 993, 1181, 1246, 1352, 1438, 1560, 1600, 1680, 1726, 1918, 1989, 2026, 2048, 2123, 2145, 2224, 2469, 2526, 2609, 2676, 2924, 2993, 3056, 3076, 3309, 3337, 3390, 3419, 3498, 3526, 3649, 3675, 3818, 3847, 4428, 4444, 4466], '2003;': [573, 1354, 1440, 2147, 2678, 2995, 4446], '4:': [574, 611, 995], '517-529Crossref': [575], 'PubMed': [576, 591, 613, 692, 704, 730, 769, 783, 830, 842, 868, 890, 975, 997, 1009, 1031, 1049, 1124, 1146, 1191, 1234, 1256, 1301, 1313, 1331, 1362, 1376, 1404, 1418, 1448, 1522, 1569, 1604, 1643, 1689, 1735, 1823, 1867, 1888, 1927, 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[1116], '(4Beech': [1117], '12Brownlow': [1151], 'S.L.': [1152, 1591, 1854], 'Sage': [1153], 'S.O.': [1154], 'Thromb.': [1155], 'Haemost.': [1156], '94:': [1158], '839-845PubMed': [1159], '13Liu': [1162], 'Wang': [1164, 2106], 'W.': [1165, 1628, 1856, 2044, 2107, 2197, 2485, 2780, 4109], 'Singh': [1166, 1347, 2108, 2140, 2217, 2519, 2671, 2917, 2988, 3069, 3302, 3328, 3383, 3410, 3491, 3517, 3642, 3811, 3838, 4439], 'B.B.': [1167, 1348, 2109, 2141, 2161, 2218, 2520, 2672, 2918, 2989, 3070, 3303, 3329, 3384, 3411, 3492, 3518, 3643, 3665, 3812, 3839, 3923, 4073, 4440], 'Lockwich': [1168, 2110, 2166, 3928, 4078], 'T.': [1169, 1201, 1219, 1227, 1558, 1678, 1724, 2042, 2111, 2167, 2193, 2776, 3929, 4079, 4105], 'Jadlowiec': [1170, 2112, 3330, 3412, 3519, 3840], "O'Connell": [1172, 2114, 2188, 2771, 4100, 4461], 'B.': [1173, 1426, 1810, 1980, 2115, 2189, 2751, 2772, 4101], 'Wellner': [1174, 2116], 'Zhu': [1176, 2118, 2170, 2198, 2781, 3932, 4082, 4110], 'M.X.': [1177, 2119, 2171, 3933, 4083], 'Chem.': [1182, 1247, 1353, 1439, 1990, 2049, 2124, 2146, 2225, 2527, 2610, 2677, 2925, 2994, 3077, 3310, 3338, 3391, 3420, 3499, 3527, 3650, 3676, 3819, 3848, 4445, 4467], '2000;': [1183, 2125, 3339, 3421, 3528, 3849], '275:': [1184, 2126, 3340, 3422, 3529, 3850], '3403-3411Abstract': [1185, 2127], '(251)': [1193, 2135], '14Mori': [1196], 'Y.': [1197, 1205, 1802, 1858, 1877, 2743], 'Wakamori': [1198], 'M.': [1199, 1203, 1207, 1213, 1225, 1436, 1583, 1804, 1816, 1873, 1894, 1933, 1943, 2007, 2015, 2745, 2757], 'Miyakawa': [1200], 'Hermosura': [1202], 'Hara': [1204], 'Nishida': [1206], 'Hirose': [1208], 'Mizushima': [1210], 'A.': [1211, 1221, 1639, 1818, 1881, 1896, 1900, 1912, 1937, 1949, 2011, 2017, 2019, 2496, 2759, 4462], 'Kurosaki': [1212, 1226], 'Mori': [1214], 'E.': [1215], 'Gotoh': [1216], 'Okada': [1218], 'Fleig': [1220, 1911, 1948, 2018], 'Iino': [1224], 'Med.': [1230], '195:': [1232], '673-681Crossref': [1233], '(177)': [1236], '15Zagranichnaya': [1239], 'T.K.': [1240, 2603], 'Wu': [1241, 2604], 'Villereal': [1243, 2606], 'M.L.': [1244, 1547, 1667, 1713, 2607], '280:': [1249, 2227, 2529, 2612, 2927, 3079, 3312, 3393, 3501, 3652, 3821], '29559-29569Abstract': [1250, 2613], '(182)': [1258, 2621], 'These': [1261, 2337], 'findings': [1262], 'further': [1265], 'substantiated': [1266], 'studies': [1268, 1387], 'demonstrating': [1269], 'permeability': [1276, 2269], '16Liu': [1345, 2138, 4437], '278:': [1355, 1441, 2148, 2679, 2996, 4447], '11337-11343Abstract': [1356, 2149, 2680, 2997, 4448], '(164)': [1364, 2157, 2688, 3005, 4456], '17Xu': [1367], 'S.-Z.': [1368], 'Beech': [1369], 'Circ.': [1371], 'Res.': [1372], '88:': [1374], '84-87Crossref': [1375], '(294)': [1378], 'With': [1381], 'exception': [1383], 'few': [1386], 'implicate': [1389], 'TRPCs': [1390], 'lymphocytes': [1395], '18Philipp': [1423], 'S.': [1424, 1585, 1638, 1800, 1806, 1875, 1879, 1902, 1945, 2495, 2741, 2747, 3333, 3415, 3522, 3843], 'Strauss': [1425], 'Hirnett': [1427], 'D.': [1428, 1941, 2169, 3671, 3931, 4081], 'Wissenbach': [1429], 'U.': [1430, 1637, 2494], 'Mery': [1431], 'L.': [1432, 1509, 2173, 2201, 2784, 3935, 4085, 4113], 'Flockerzi': [1433], 'V.': [1434], 'Hoth': [1435], '26629-26638Abstract': [1442], '(124)': [1450, 1524], 'Scholar)': [1452, 2540, 3540, 3861, 4124], 'largely': [1461], 'unknown.': [1462], 'Recently': [1463], 'new': [1465], 'emerged': [1468], 'candidate': [1470], 'SOCE:': [1473], 'Orai1.': [1476], 'single-transmembrane': [1480], 'unpaired': [1485], 'EF-hand': [1486, 1695], 'domain': [1487, 1696, 1760], 'N': [1490, 3610], 'terminus,': [1491], 'predicted': [1495], 'localized': [1498], 'lumen': [1502], '(19Williams': [1503], 'R.T.': [1504], 'Senior': [1505], 'P.V.': [1506], 'Van': [1507], 'Stekelenburg': [1508], 'Layton': [1510], 'J.E.': [1511, 1556, 1676, 1722], 'Smith': [1512], 'P.J.': [1513, 1577], 'Dziadek': [1514, 1629, 2486], 'M.A.': [1515, 1622, 1630, 2038, 2479, 2487], 'Biochim.': [1516], 'Biophys.': [1517], 'Acta.': [1518], '1596:': [1520], '131-137Crossref': [1521], 'expression': [1530, 1834, 2253], 'using': [1531, 2573, 2736, 2867, 3039, 3541, 3575, 3596, 3767, 3790, 3870, 4161, 4169, 4188, 4266, 4275, 4331], 'siRNA': [1532, 2600, 4337, 4355], 'significantly': [1533], 'reduced': [1534, 3770, 4338], 'SH-SY5Y,': [1538], 'Jurkat': [1539], 'T,': [1540], 'HeLa': [1542], '(20Liou': [1544, 1664, 1710], 'Kim': [1546, 1666, 1712], 'Heo': [1548, 1668, 1714], 'W.D.': [1549, 1669, 1715], 'Jones': [1550, 1670, 1716], 'J.T.': [1551, 1671, 1717, 1978], 'Myers': [1552, 1672, 1718], 'Ferrell': [1554, 1674, 1720], 'Meyer': [1557, 1677, 1723], 'Curr.': [1559, 1679, 1725, 1917], '15:': [1562, 1682, 1728, 2179, 3941, 4091], '1235-1241Abstract': [1563, 1683, 1729], '(1753)': [1571, 1691, 1737], '21Roos': [1574], 'DiGregorio': [1576], 'Yeromin': [1578], 'A.V.': [1579, 1852], 'Ohlsen': [1580], 'Lioudyno': [1582], 'Zhang': [1584, 1853], 'Safrina': [1586, 1859], 'O.': [1587, 1860], 'Kozak': [1588], 'J.A.': [1589], 'Wagner': [1590], 'Cahalan': [1592, 1861], 'Velicelebi': [1594], 'G.': [1595], 'Stauderman': [1596], 'K.A.': [1597], '169:': [1602], '435-445Crossref': [1603], '(1519)': [1606], 'contrast,': [1610], 'only': [1614], 'modestly': [1615], 'enhanced': [1616], 'HEK293': [1619], '(22Spassova': [1621], 'Soboloff': [1623, 1907, 2480], 'He': [1625, 2482], 'L.P.': [1626, 2483], 'Xu': [1627, 2043, 2484], 'Proc.': [1633, 2490], 'Natl.': [1634, 2491], 'Acad.': [1635, 2492], '103:': [1641, 2498], '4040-4045Crossref': [1642, 2499], '(277)': [1645, 2502], 'Additionally,': [1648], 'relocalized': [1651], 'into': [1652, 2647, 2658, 3618, 4211], 'punctae': [1653], 'subplasma': [1656], 'following': [1659, 3100], 'stimulation': [1660], '(Tg)': [1663, 2358], 'ER-Ca2+': [1706], 'sensor': [1707], 'regulating': [1708], 'known.': [1752], 'second': [1754], 'protein,': [1755], 'four-transmembrane': [1759], 'initially': [1764], 'membrane-localized': [1770], 'regulatory': [1771], 'ICRAC.': [1774, 2319], 'Mutations': [1775], 'genetically': [1780], 'linked': [1781], 'severe': [1783, 1792], 'combined': [1784, 1793], 'immunodeficiency,': [1785], 'T-lymphocytes': [1787], 'isolated': [1788], 'patients': [1790], 'immunodeficiency': [1794], 'displayed': [1795], 'decreased': [1796], 'ICRAC': [1797, 2070], 'activity': [1798, 1972], '(23Feske': [1799, 2740], 'Gwack': [1801, 1876, 2742], 'Prakriya': [1803, 2744], 'Srikanth': [1805, 1878, 2746], 'Puppel': [1807, 2748], 'S.H.': [1808, 2749], 'Tanasa': [1809, 2750], 'Hogan': [1811, 1882, 2752], 'P.G.': [1812, 1883, 2753], 'Lewis': [1813, 2754], 'Daly': [1815, 2756], 'Rao': [1817, 1880, 2758], 'Nature.': [1819, 1863, 1884, 2760], '441:': [1821, 2762], '179-185Crossref': [1822, 2763], '(1854)': [1825, 2766], 'decreases': [1831, 2246], 'mutations': [1838, 2257], 'conserved': [1840], 'negatively': [1841], 'charged': [1842], 'residues': [1843], 'changes': [1844, 3009, 4298], 'selectivity': [1847], '(24Yeromin': [1851], 'Jiang': [1855], 'Yu': [1857], '443:': [1865, 1886], '226-229Crossref': [1866], '(693)': [1869], '25Prakriya': [1872], 'Feske': [1874], '230-233Crossref': [1887], '(1111)': [1890], '26Vig': [1893], 'Beck': [1895, 1936, 2010], 'Billingsley': [1897], 'J.M.': [1898], 'Lis': [1899, 2016], 'Parvez': [1901], 'Peinelt': [1903, 1934], 'Koomoa': [1905, 1938, 2008], 'Kinet': [1913, 1952, 2022], 'J.P.': [1914, 1953, 2023], '16:': [1920], '2073-2079Abstract': [1921], '(485)': [1929], '27Vig': [1932], 'Rabah': [1940], 'Koblan-Huberson': [1942, 2014], 'Kraft': [1944], 'Turner': [1946], 'H.': [1947], 'Science.': [1954], '312:': [1956], '1220-1223Crossref': [1957], '(1153)': [1960], 'Co-expression': [1963], 'greatly': [1968], 'enhances': [1969], '(28Mercer': [1973], 'J.C.': [1974], 'Dehaven': [1975], 'W.I.': [1976], 'Smyth': [1977], 'Wedel': [1979], 'Boyles': [1981], 'R.R.': [1982], 'Bird': [1983], 'G.S.': [1984], '281:': [1992, 2051], '24979-24990Abstract': [1993], '(475)': [2001], '29Peinelt': [2004], 'Vig': [2006], 'Nadler': [2012], '8:': [2028], '771-773Crossref': [2029], '(515)': [2032], '30Soboloff': [2035], 'Spassova': [2037], 'Tang': [2039], 'X.D.': [2040], 'Hewavitharana': [2041], '20661-20665Abstract': [2052], '(483)': [2060], 'Because': [2063], 'can': [2067], 'reconstitute': [2068], 'current,': [2071, 4410], 'they': [2077], 'formation': [2082], 'this': [2084, 2264, 3590], 'channel.': [2085, 2272], 'We': [2086, 2306], 'previously': [2088, 2460, 2514, 2598, 2739, 3047, 3297, 3486, 3637, 3921, 4071, 4415], 'component': [2095], '(13Liu': [2104], '31Singh': [2160], 'Zheng': [2162, 3924, 4074], 'Liu': [2164, 3326, 3408, 3515, 3836, 3926, 4076], 'Liao': [2168, 3930, 4080], 'Birnbaumer': [2172, 2200, 2783, 3934, 4084, 4112], 'FASEB': [2176, 3938, 4088], '1652-1654Crossref': [2180, 3942, 4092], '(63)': [2183, 3945, 4095], '32Wang': [2186, 2769, 4098], 'W.C.': [2187, 2770, 4099], 'Dykeman': [2190, 2773, 4102], 'Sakai': [2192, 2775, 4104], 'Delporte': [2194, 2777, 4106], 'Swaim': [2196, 2779, 4108], 'Am.': [2204, 2787, 4116], '1999;': [2207, 2790, 3677, 4119], '276:': [2208, 2791, 4120], 'C969-C979Crossref': [2209, 2792, 4121], '33Liu': [2213, 3065, 3379, 3807], 'Bandyopadhyay': [2215, 2517, 2915, 3067, 3300, 3381, 3489, 3640, 3809], 'B.C.': [2216, 2518, 2916, 3068, 3301, 3382, 3490, 3641, 3810], '21600-21606Abstract': [2228, 2530, 2928, 3080, 3313, 3394, 3502, 3653, 3822], 'Our': [2239], 'knockdown': [2243], 'increases': [2249], 'activity,': [2251], 'pore': [2261], 'alters': [2266], 'present': [2275], 'study,': [2276], 'investigated': [2279], 'possible': [2281], 'role': [2282], 'TRPC1-dependent': [2288], 'SOCE.': [2289], 'its': [2316], 'Further,': [2320], 'report': [2322], 'entry.': [2336], 'contribute': [2348], 'toward': [2349], 'their': [2350], 'store-dependent': [2351], 'function.': [2354], 'Materials—Fura-2AM': [2355], 'obtained': [2360, 2371, 2389, 2429, 2441, 2633, 4031], 'Calbiochem': [2362], '(San': [2363, 2393], 'Diego,': [2364], 'CA).': [2365, 2892], 'Glass-bottomed': [2366], '35-mm': [2367], 'Petri': [2368], 'dishes': [2369], 'MatTek': [2373, 2700], 'Corp.': [2374], '(Ashland,': [2375], 'MA),': [2376, 2404], 'glass': [2378, 2715], 'coverslips': [2379], 'Fischer': [2382], 'Scientific': [2383], '(Pittsburgh,': [2384], 'PA).': [2385, 2435], 'Anti-STIM1': [2386], 'antibody': [2387, 2397, 2406, 2416, 4131], 'BD': [2391], 'Biosciences': [2392], 'Jose,': [2394], 'CA),': [2395], 'anti-Myc': [2396], 'Signaling': [2401], 'Technology': [2402], '(Danvers,': [2403], 'anti-HA': [2405], 'Roche': [2409, 2842], 'Applied': [2410, 2843], 'Science': [2411], '(Indianapolis,': [2412], 'IN),': [2413], 'anti-FLAG': [2415], 'Sigma-Aldrich.': [2419], 'Cy5-': [2420, 4146], 'fluorescein': [2422, 4148], 'isothiocyanate-': [2423, 4149], 'TRITC-tagged': [2425, 4151], 'secondary': [2426, 4152], 'antibodies': [2427, 4153], 'Jackson': [2431], 'ImmunoResearch': [2432], '(West': [2433], 'Grove,': [2434], 'siRNAs': [2439, 2572], 'Dharmacon': [2443], '(Lafayette,': [2444], 'CO).': [2445], 'Culture': [2447], 'Transient': [2449], 'Transfection—HSG,': [2450], 'RBL-2H3,': [2451], 'HEK-293,': [2452], 'A7r5': [2454], 'cultured': [2457], 'described': [2459, 2513, 2599, 2738, 3046, 3296, 3376, 3485, 3636, 3903, 3920, 4070, 4295, 4416], '(6Liu': [2461, 3048, 4420], '22Spassova': [2478], 'Cells': [2505, 2568, 4284], 'transfected': [2507, 2570, 2657, 2943, 2953, 4348], 'vector': [2511, 2649, 3622, 4353], '(33Liu': [2515, 2913, 3298, 3487, 3638], 'experiments': [2544, 3593, 4175], 'after': [2545, 2585, 3715, 4032, 4396], '48': [2546, 2586], 'h.': [2547, 2587], 'Vectors': [2548], 'encoding': [2549], 'green': [2550, 2945], 'fluorescent': [2551, 2946], 'co-transfected': [2554], '(1:5': [2555], 'ratio': [2556], 'cDNA)': [2558], 'allow': [2560], 'selection': [2561], 'functional': [2566], 'experiments.': [2567], 'DharmaFECT': [2575], 'transfection': [2576], 'reagent': [2577], 'per': [2579, 3372], "manufacturer's": [2581], 'instructions': [2582], 'Sequences': [2588, 2796], 'shRNA': [2591], 'targeting': [2592], 'sequence': [2601, 2626, 2630], '(15Zagranichnaya': [2602], 'sense': [2625], '(5′-CACCGGGTGACTTTATATGGTTCGAAAACCATATAATAGTCACCC-3′)': [2627], 'antisense': [2629], '(5′-AAAAGGGTGACTATTATATGGTTTTCGAACCATATAATAGTCACCC-3′)': [2631], 'Integrated': [2635], 'DNA': [2636, 2800], 'Technologies': [2637], '(Coralville,': [2638], 'IA),': [2639], 'hybridized': [2640], 'equal': [2642], 'molar': [2643], 'ratio,': [2644], 'ligated': [2646], 'pENTR/U6': [2648], '(Invitrogen).': [2650], '1': [2651, 2968, 3222, 3241, 3440], 'μg/ml': [2652], 'TRPC1-shRNA': [2653], '(shTRPC1)': [2654], 'plasmid': [2655], 'HSG': [2659, 3785, 4418], 'Construction': [2661], 'mutants': [2664], 'earlier': [2668], '(16Liu': [2669, 2986], 'For': [2691, 2704, 3159], 'live': [2692], 'cell-imaging': [2693], 'experiments,': [2694], 'plated': [2697, 2713], 'glass-bottomed': [2699], 'tissue': [2701], 'culture': [2702], 'dishes.': [2703], 'patch': [2705, 3034], 'clamp': [2706, 3035], 'measurement': [2707, 3036], 'TIRF': [2709, 4181, 4214], 'microscopy,': [2710], 'coverslips.': [2716], 'RNA': [2717], 'Isolation,': [2718], 'Synthesis': [2719], 'First-strand': [2721], 'cDNA,': [2722, 2730], 'RT-PCR': [2724, 2732, 2834], 'Analysis—RNA': [2725], 'isolation,': [2726], 'synthesis': [2727], 'first-strand': [2729], 'analysis': [2733], 'conducted': [2735, 3634, 4187], 'methods': [2737], 'primers': [2798], '(Integrated': [2799], 'Technologies),': [2801], 'detect': [2804], 'transcript,': [2807], 'follows:': [2810, 3171], '5′-CAGCAGCCAACGTCAGCACCA-3′': [2811], '3′-CAGCTGGTCCTGTAAGCGGGCAAA-5′.': [2813], 'Fig.': [2815], '1,': [2816, 4357], '-ve': [2817], 'control': [2818, 2825, 4352], 'indicates': [2819, 2826], 'buffer': [2821, 3358, 3459, 3794, 3961, 4022], 'control,': [2822], '+ve': [2824], 'cDNA': [2829], 'aliquot': [2830], 'provided': [2831, 2911, 4199], 'kit,': [2835], 'FastStart': [2836], 'High': [2837], 'Fidelity': [2838], 'PCR': [2839, 2846], 'system': [2840], 'Sciences.': [2844], 'product': [2847], 'sequenced': [2849], 'confirmed': [2851], 'transcript.': [2856], '[Ca2+]i': [2857, 2860], 'Measurements—Measurements': [2858], 'performed': [2862, 3038, 3901], 'imaging': [2864, 4185, 4279], 'Fura-2AM-loaded': [2865], 'Olympus': [2869, 4190, 4213, 4237], '50×': [2870], 'microscope': [2871, 4194, 4223], '(Olympus,': [2872], 'Center': [2873], 'Valley,': [2874], 'PA),': [2875], 'ORCA-ER': [2878], 'camera': [2879, 4272], '(Hamamatsu,': [2880], 'Tokyo,': [2881], 'Japan)': [2882], 'attached': [2883, 4216], 'Polychrome': [2886], 'IV': [2887], '(Till': [2888], 'Photonics': [2889], 'LLC,': [2890], 'Pleasanton,': [2891], 'MetaFluor': [2893], '(Molecular': [2894, 3043, 4172], 'Devices,': [2895], 'Downingtown,': [2896], 'PA)': [2897], 'acquire': [2901], 'images': [2902], 'processing': [2904], 'data.': [2906], 'Other': [2907], 'details': [2908, 3374], 'elsewhere': [2912], 'case': [2941], 'select': [2951], 'Measurements': [2955], 'made': [2957], 'standard': [2959, 3451, 3958, 3996, 4290], 'extracellular': [2960, 3452, 3959, 3997, 4291], 'solution': [2961, 3134, 3144, 3152, 3165, 3960, 3998, 4292], '(145': [2962], 'mm': [2963, 2966, 2969, 2972, 2975, 3103, 3107, 3110, 3113, 3116, 3157, 3173, 3176, 3179, 3182, 3185, 3709, 3758, 3769, 3799], 'NaCl,': [2964, 3108, 3174], '5': [2965, 3175, 3757, 3993], 'KCl,': [2967], 'MgCl2,': [2970, 3111], '10': [2971, 2974, 3109, 3112, 3115, 3156, 3178, 3181, 3184, 3737, 3768, 4232], 'HEPES,': [2973, 3114, 3183], 'glucose,': [2976, 3186], 'pH': [2977, 3118, 3187], '7.4': [2978, 3188], '(NaOH))': [2979], 'additions': [2981], 'indicated': [2985, 3146], 'Relative': [3008], '340/380': [3011], 'ratios': [3012], '(representing': [3013], '[Ca2+]i)': [3014], 'figures': [3019], '(traces': [3020], 'average': [3022], 'at': [3024, 3200, 3237, 3467, 3722, 3732, 3981, 4026, 4136], 'least': [3025], '50-100': [3026], 'each': [3029, 4134], 'experiment).': [3030], 'Electrophysiological': [3031], 'Measurements—Whole': [3032], 'cell-attached': [3033], 'Axopatch': [3040], '200B': [3041], 'amplifier': [3042], 'Devices)': [3044], 'Patch': [3091], 'pipette': [3092, 3133], 'resistance': [3093, 3258], '3-6': [3095], 'mΩ': [3096], 'filled': [3097], 'solution:': [3101], '145': [3102], 'cesium': [3104], 'methanesulfonate,': [3105], '8': [3106, 3249], 'EGTA,': [3117], '7.2': [3119], '(CsOH).': [3120], 'either': [3125, 3698, 3789, 4385], 'inositol': [3127], '1,4,5-trisphosphate': [3128], '(10': [3129], 'μm)': [3130, 3140], 'Tg': [3138, 3442, 4007], '(1': [3139], 'external': [3143, 3151, 3164, 3988], '(as': [3145], 'figures).': [3149], 'Standard': [3150], 'CaCl2.': [3158], 'Na+': [3160], 'current': [3161, 3193, 3198, 3274], '(divalent': [3166], 'cation-free)': [3167], 'composed': [3169], '165': [3172], 'CsCl,': [3177], 'EDTA,': [3180, 3759], '(NaOH).': [3189], 'Development': [3190], 'assessed': [3195], 'amplitudes': [3199], 'potentials': [3201], '-80': [3203], 'mV': [3204, 3207, 3217, 3250], '+80': [3206], 'recorded': [3208], 'during': [3209], 'voltage': [3210], 'ramps': [3211], '-90': [3214], '90': [3216], '(over': [3218], 'period': [3220], 's,': [3223], 'imposed': [3224], 'every': [3225, 4263], '4': [3226, 4027], 's)': [3227], 'holding': [3230], '0': [3233], 'mV,': [3234], 'digitized': [3236], 'rate': [3239], 'kHz.': [3242], 'A': [3243], 'liquid-junction': [3244], 'less': [3247], 'than': [3248], 'corrected,': [3253], 'capacitative': [3254], 'currents': [3255], 'series': [3257], 'determined': [3260], 'minimized.': [3262], 'ramp': [3265], 'leak': [3269], 'subtraction': [3270], 'subsequent': [3273], 'records.': [3275], 'Western': [3276, 3364, 3560, 3898], 'Blotting': [3277], 'Immunoprecipitation—Cells,': [3279], 'grown': [3280], '80%': [3282], 'confluence,': [3283], 'harvested,': [3285], 'crude': [3287], 'fraction': [3289], '(used': [3290], 'where': [3291], 'indicated)': [3292], 'prepared': [3294, 3913], '34Lockwich': [3324, 3406, 3513, 3834], 'T.P.': [3325, 3407, 3514, 3835], 'Weiland': [3332, 3414, 3521, 3842], '11934-11942Abstract': [3341, 3423, 3530, 3851], '(359)': [3349, 3431, 3538, 3859], 'preparation': [3353], 'solubilized': [3355, 4017], 'SDS-sample': [3357], 'analyzed': [3360, 4168], 'SDS-PAGE': [3362, 3895], 'blotting': [3365], '(25-50': [3366], 'μg': [3367, 3783], 'loaded': [3371, 3742], 'lane;': [3373], 'Refs.': [3378, 3806], 'Scholar': [3404, 3832], 'Where': [3434, 3562], 'indicated,': [3435, 3563], 'treated': [3438, 4005, 4127, 4144], 'μm': [3441, 3773], 'vehicle': [3444], '3': [3446], 'min': [3447, 3980, 4025], 'Ca2+-containing': [3450, 4289], 'solution,': [3453, 3989], 'lysed': [3454], 'radioimmune': [3456, 3791, 4019], 'precipitation': [3457, 3792, 4020], 'assay': [3458, 3793, 4021], 'containing': [3460, 3753, 3802, 3962, 3972], 'proteolytic': [3461, 3803], 'inhibitors.': [3462], 'lysates': [3464, 3787], 'centrifuged': [3466], '50,000': [3468], '×': [3469, 3734], 'g': [3470, 3735], '30': [3472, 4024], 'min,': [3473], 'supernatants': [3476], 'precleared': [3478], 'immunoprecipitation': [3482, 4038], '(IP)': [3483], '1:100': [3542, 4137], '1:200': [3544], 'dilution': [3545], 'antibodies.': [3547], 'Immunoprecipitates': [3548], 'released': [3550], 'solubilization': [3552], 'SDS': [3555, 3886], 'sample': [3556, 3887], 'resolved': [3558, 3891], 'blotting.': [3561], 'band': [3564, 4228, 4254], 'intensities': [3565], 'quantified': [3567], 'image': [3570], 'analyzer,': [3571], 'Gel': [3572], 'Doc™': [3573], 'XR,': [3574], 'Quality': [3576], 'One': [3577], 'software': [3578, 4171, 4280], '(Bio-Rad).': [3579], 'Results': [3580], 'means': [3584], '±': [3585], 'S.E.': [3586], 'Statistical': [3587], 'analyses': [3588], 'done': [3595, 4177], "Student's": [3597], 't': [3598], 'test.': [3599], 'Purification': [3600], 'GST-N-': [3602], 'GST-C-TRPC1': [3604, 3703], 'Proteins': [3605, 3712, 3889], 'GST': [3607, 3627, 3630, 3699, 3874], 'Pull-down': [3608], 'Assays—The': [3609], 'C': [3612], 'termini': [3613], 'cloned': [3617], 'pGEX5.1': [3619], '(Amersham': [3620], 'Biosciences)': [3621], 'fusion': [3628], 'protein.': [3629], 'pull-down': [3631], 'assays': [3632], '35Singh': [3664], 'Patel': [3666], 'H.H.': [3667], 'Roepman': [3668], 'Schick': [3670], 'Ferreira': [3672], 'P.A.': [3673], '274:': [3678], '37370-37378Abstract': [3679], '(77)': [3687], 'Briefly,': [3690, 3948], '500': [3691, 3782, 3798], 'ml': [3692, 3994], 'Escherichia': [3694], 'coli': [3695], '(BL-21)': [3696], 'expressing': [3697], 'GST-N-TRPC1': [3701], '0.2': [3708], 'isopropyl': [3710], '1-thio-β-d-galactopyranoside.': [3711], 'purified': [3714], 'lysing': [3716], 'French': [3720], 'press': [3721], '1200': [3723], 'pounds/square': [3724], 'inch.': [3725], 'debris': [3727], 'removed': [3729], 'centrifugation': [3731], '10,000': [3733], 'min.': [3738, 3864], 'supernatant': [3740], 'onto': [3743], 'GST-agarose': [3745], 'affinity': [3746], 'column,': [3747], 'washed': [3748, 3876, 3984, 4141], 'five': [3749, 3877], 'times': [3750, 3878], 'PBS': [3752], '1%': [3754], 'Triton': [3755], 'X-100,': [3756], '0.01%': [3760], 'β-mercaptoethanol,': [3761], 'protease': [3763], 'inhibitors,': [3764], 'eluted': [3766], 'glutathione.': [3771], '2.2': [3772], 'individual': [3776], 'GST-purified': [3777], 'incubated': [3780, 3884], '(lysed': [3788], 'octylglucoside': [3796], 'plus': [3797], 'potassium': [3800], 'iodide': [3801], 'inhibitors;': [3804], 'see': [3805], '60': [3863, 4009], 'Interacting': [3865], 'pulled': [3868], 'down': [3869, 4379], '100': [3871], 'μl': [3872], 'beads,': [3875], 'high': [3880], 'salt': [3881], 'buffer,': [3882], 'buffer.': [3888, 3999], '10%': [3894], 'gel,': [3896], 'blots': [3899], 'above.': [3904, 4040], 'Preparation': [3905], 'Dispersed': [3907], 'Mouse': [3908], 'Submandibular': [3909], 'Gland': [3910], 'Cells—Cells': [3911], '(31Singh': [3922, 4072], 'glands': [3950], 'removed,': [3952], 'cleaned,': [3953], 'minced,': [3954], 'digested': [3956], '0.02%': [3963], 'soybean': [3964], 'trypsin': [3965], 'inhibitor': [3966], '0.1%': [3968], 'bovine': [3969], 'serum': [3970], 'albumin': [3971], 'collagenase': [3973], 'P': [3974], '(2.5': [3975], 'mg/8': [3976], 'ml)': [3977], '15-20': [3979], '37': [3982], '°C,': [3983], 'twice': [3985], 'resuspended': [3991], 'suspension': [4002], 'then': [4004, 4126, 4143], 's': [4010, 4265], 'centrifuged,': [4012], 'pellets': [4015], '°C.': [4028], 'Lysates': [4029], 'centrifugation,': [4033], 'precleared,': [4034], 'mice': [4042], 'maintained': [4044], 'according': [4045], 'guidelines': [4047], 'approved': [4048], 'NIDCR,': [4051], 'National': [4052], 'Institutes': [4053], 'Health,': [4055], 'Animal': [4056], 'Care': [4057], 'Use': [4059], 'Committee.': [4060], 'Immunofluorescence': [4061], 'Confocal': [4063], 'Microscopy—Cells': [4064], 'fixed': [4066], 'permeabilized': [4068], '(indicated': [4132], 'case)': [4135], 'dilution.': [4138], 'Samples': [4139], '(1:100': [4156], 'dilution).': [4157], 'Images': [4158, 4166, 4260], 'collected': [4160, 4250, 4262], 'Leica': [4163], 'confocal': [4164], 'microscope.': [4165], 'MetaMorph': [4170], 'Devices).': [4173], 'Control': [4174], 'without': [4178], 'primary': [4179], 'antibody.': [4180], 'Microscopy': [4182], 'Imaging—TIRF': [4183], 'microscopy': [4184], 'IX81': [4191], 'motorized': [4192], 'inverted': [4193], '(Olympus).': [4195], 'Excitation': [4196], 'light': [4197, 4248], '20-milliwatt': [4202], 'argon-krypton': [4203], 'laser.': [4204], '488': [4206, 4227], 'nm': [4207], 'laser': [4208], 'directed': [4210], 'illuminator': [4215], 'rear': [4219], 'port': [4220], 'through': [4225, 4251], 'pass': [4229, 4255], 'filter': [4230, 4256], '(BP': [4231, 4257], 'nm)': [4233], 'TIRF-optimized': [4236], 'Plan': [4238], 'APO': [4239], '×60': [4240], '(1.45': [4241], 'numerical': [4242], 'aperture)': [4243], 'oil': [4244], 'immersion': [4245], 'objective.': [4246], 'Emitted': [4247], '525': [4253], '50': [4258], 'nm).': [4259], '0.5': [4264], 'Hamamatsu': [4268], 'EM': [4269], 'C9100': [4270], 'back-thinned': [4271], '(Hamamatsu)': [4273], 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