Publication Information

{'id': 'https://openalex.org/W1979409476', 'doi': 'https://doi.org/10.1073/pnas.73.11.4187', 'title': 'beta-Endorphin: cross tolerance to and cross physical dependence on morphine.', 'display_name': 'beta-Endorphin: cross tolerance to and cross physical dependence on morphine.', 'publication_year': 1976, 'publication_date': '1976-11-01', 'ids': {'openalex': 'https://openalex.org/W1979409476', 'doi': 'https://doi.org/10.1073/pnas.73.11.4187', 'mag': '1979409476', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/186788', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/431379'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.73.11.4187', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc431379?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5112157592', 'display_name': 'L F Tseng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L F Tseng', 'raw_affiliation_strings': ['University of California at San Francisco,'], 'affiliations': [{'raw_affiliation_string': 'University of California at San Francisco,', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014354004', 'display_name': 'Horace H. Loh', 'orcid': 'https://orcid.org/0000-0002-3409-4100'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'H H Loh', 'raw_affiliation_strings': ['University of California at San Francisco,'], 'affiliations': [{'raw_affiliation_string': 'University of California at San Francisco,', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5091382715', 'display_name': 'C H Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'C H Li', 'raw_affiliation_strings': ['University of California at San Francisco,'], 'affiliations': [{'raw_affiliation_string': 'University of California at San Francisco,', 'institution_ids': ['https://openalex.org/I180670191']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.448, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 78, 'citation_normalized_percentile': {'value': 0.819532, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '73', 'issue': '11', 'first_page': '4187', 'last_page': '4189'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10196', 'display_name': 'Pain Mechanisms and Treatments', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/beta-endorphin', 'display_name': 'beta-Endorphin', 'score': 0.79616654}, {'id': 'https://openalex.org/keywords/physical-dependence', 'display_name': 'Physical dependence', 'score': 0.75109315}, {'id': 'https://openalex.org/keywords/cross-tolerance', 'display_name': 'Cross-tolerance', 'score': 0.4582431}, {'id': 'https://openalex.org/keywords/beta', 'display_name': 'BETA (programming language)', 'score': 0.42397475}, {'id': 'https://openalex.org/keywords/endorphins', 'display_name': 'Endorphins', 'score': 0.41845345}], 'concepts': [{'id': 'https://openalex.org/C2777389121', 'wikidata': 'https://www.wikidata.org/wiki/Q81225', 'display_name': 'Morphine', 'level': 2, 'score': 0.9350506}, {'id': 'https://openalex.org/C2777557602', 'wikidata': 'https://www.wikidata.org/wiki/Q2993328', 'display_name': 'beta-Endorphin', 'level': 2, 'score': 0.79616654}, {'id': 'https://openalex.org/C2778195246', 'wikidata': 'https://www.wikidata.org/wiki/Q2622112', 'display_name': 'Physical dependence', 'level': 3, 'score': 0.75109315}, {'id': 'https://openalex.org/C2779897013', 'wikidata': 'https://www.wikidata.org/wiki/Q1151752', 'display_name': 'Jumping', 'level': 2, 'score': 0.75022066}, {'id': 'https://openalex.org/C15490471', 'wikidata': 'https://www.wikidata.org/wiki/Q2734305', 'display_name': 'Nociception', 'level': 3, 'score': 0.59924585}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4815774}, {'id': 'https://openalex.org/C946728', 'wikidata': 'https://www.wikidata.org/wiki/Q746408', 'display_name': 'Cross-tolerance', 'level': 3, 'score': 0.4582431}, {'id': 'https://openalex.org/C2780820201', 'wikidata': 'https://www.wikidata.org/wiki/Q173235', 'display_name': 'Analgesic', 'level': 2, 'score': 0.43193352}, {'id': 'https://openalex.org/C2776174256', 'wikidata': 'https://www.wikidata.org/wiki/Q830842', 'display_name': 'BETA (programming language)', 'level': 2, 'score': 0.42397475}, {'id': 'https://openalex.org/C2778680817', 'wikidata': 'https://www.wikidata.org/wiki/Q190528', 'display_name': 'Endorphins', 'level': 2, 'score': 0.41845345}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.39791557}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.38679898}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3758322}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.36813927}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3173116}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.118970215}, {'id': 'https://openalex.org/C42407357', 'wikidata': 'https://www.wikidata.org/wiki/Q521', 'display_name': 'Physiology', 'level': 1, 'score': 0.07177344}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C199360897', 'wikidata': 'https://www.wikidata.org/wiki/Q9143', 'display_name': 'Programming language', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D009021', 'descriptor_name': 'Morphine Dependence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000698', 'descriptor_name': 'Analgesia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004361', 'descriptor_name': 'Drug Tolerance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009021', 'descriptor_name': 'Morphine Dependence', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013375', 'descriptor_name': 'Substance Withdrawal Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013375', 'descriptor_name': 'Substance Withdrawal Syndrome', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.73.11.4187', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc431379', 'pdf_url': 'https://europepmc.org/articles/pmc431379?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC431379', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/186788', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc431379', 'pdf_url': 'https://europepmc.org/articles/pmc431379?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.68, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 10, 'referenced_works': ['https://openalex.org/W1981728064', 'https://openalex.org/W2022304550', 'https://openalex.org/W2036609848', 'https://openalex.org/W2041935994', 'https://openalex.org/W2051612811', 'https://openalex.org/W2054951528', 'https://openalex.org/W2088637181', 'https://openalex.org/W2089462923', 'https://openalex.org/W2097088407', 'https://openalex.org/W2211878186'], 'related_works': ['https://openalex.org/W4237617264', 'https://openalex.org/W3037926329', 'https://openalex.org/W2416435043', 'https://openalex.org/W2407662096', 'https://openalex.org/W2404703847', 'https://openalex.org/W2133591619', 'https://openalex.org/W2091241147', 'https://openalex.org/W2032307762', 'https://openalex.org/W1999838949', 'https://openalex.org/W1979409476'], 'abstract_inverted_index': {'The': [0, 34], 'effects': [1], 'of': [2, 24, 55], 'beta-endorphin': [3, 38, 66], 'on': [4], 'the': [5, 51], 'antinociceptive': [6, 53], 'responses': [7], 'and': [8], 'abrupt': [9, 68, 83], 'withdrawal': [10, 69, 84], 'jumping': [11], 'in': [12, 50, 73], 'morphine-dependent': [13], 'mice': [14], 'were': [15, 18], 'studied.': [16], 'Mice': [17], 'rendered': [19], 'morphine': [20, 26, 41, 56], 'dependent': [21], 'by': [22, 46], 'implantation': [23], 'a': [25], 'pellet': [27, 42], '(75': [28], 'mg': [29], 'base)': [30], 'for': [31], '3': [32], 'days.': [33], 'analgesic': [35], 'response': [36], 'to': [37], 'decreased': [39], 'after': [40], 'implantation,': [43], 'as': [44], 'evidenced': [45], 'an': [47], 'eight-fold': [48], 'increase': [49], 'median': [52], 'dose': [54], 'was': [57], 'found.': [58], 'In': [59], 'small': [60], 'doses': [61, 75], '(0.09-0.17': [62], 'mug': [63, 77], 'per': [64, 78], 'mouse),': [65, 79], 'suppressed': [67], 'jumping.': [70, 85], 'Met-enkephalin,': [71], 'even': [72], 'high': [74], '(200': [76], 'did': [80], 'not': [81], 'suppress': [82]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1979409476', 'counts_by_year': [{'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-07T15:29:53.124933', 'created_date': '2016-06-24'}