Apoptosis Triggered by 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine Is Prevented by Increased Expression of CTP:Phosphocholine Cytidylyltransferase

Name: Work Video:
Duration: 3 min 30 s
Irina Baburina; Suzanne Jackowski
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3778, 3788, 3836, 3839, 3843, 3846, 3852, 3862, 3870, 3878, 3903, 3912, 3920, 3924, 3932, 3942, 3948, 3985, 3993, 4079, 4085, 4092, 4121, 4148, 4153, 4159, 4169, 4194, 4200, 4218, 4228, 4231, 4237, 4243, 4457, 4466, 4470, 4478, 4482, 4488, 4511, 4516, 4595, 4637, 4698, 4730, 4746, 4760, 4767, 4776, 4786, 4792, 4796, 4800, 4897, 4910, 4924, 4930, 4967, 4971, 4988, 5004, 5017, 5021, 5120, 5130, 5139, 5144, 5197, 5218, 5251, 5254, 5298, 5304, 5318, 5339, 5347, 5503, 5600], 'regulation': [8, 187], 'of': [9, 22, 29, 66, 77, 108, 125, 132, 136, 156, 176, 188, 201, 208, 245, 256, 287, 304, 311, 315, 335, 355, 377, 385, 419, 578, 585, 679, 761, 767, 1217, 1282, 1291, 1294, 1300, 1310, 1321, 1371, 1387, 1430, 1440, 1452, 1462, 1601, 1614, 1825, 1830, 1915, 1959, 1969, 2011, 2083, 2106, 2196, 2202, 2220, 2232, 2243, 2282, 2340, 2353, 2370, 2395, 2430, 2446, 2479, 2544, 2551, 2669, 2817, 2853, 2856, 2873, 2878, 2889, 2954, 2959, 2970, 3002, 3007, 3016, 3031, 3048, 3058, 3099, 3107, 3214, 3232, 3239, 3279, 3308, 3321, 3336, 3348, 3351, 3381, 3391, 3424, 3436, 3444, 3453, 3469, 3522, 3532, 3541, 3551, 3567, 3592, 3610, 3631, 3643, 3658, 3670, 3694, 3701, 3747, 3780, 3838, 3845, 3899, 3915, 3923, 3935, 3984, 3995, 4081, 4095, 4123, 4147, 4150, 4155, 4183, 4233, 4246, 4250, 4257, 4469, 4490, 4492, 4598, 4626, 4701, 4745, 4749, 4762, 4788, 4810, 4814, 4817, 4823, 4899, 4903, 4912, 4929, 4974, 4990, 4995, 5011, 5020, 5133, 5146, 5199, 5210, 5221, 5226, 5238, 5253, 5256, 5300, 5321, 5325, 5341, 5350, 5482, 5505, 5513, 5537, 5542, 5545, 5559, 5561, 5564, 5571, 5602], 'CTP:phosphocholine': [10, 189, 370], 'cytidylyltransferase': [11, 190], '(CCT)': [12, 191], 'expression': [13, 39, 72, 96, 192, 218, 251, 275, 3001, 3234, 3563, 3633, 3928, 3944, 4128, 4585, 5145, 5293, 5343, 5569], 'via': [14, 193, 4078], 'a': [15, 194, 374, 415, 1259, 1316, 1375, 1391, 1459, 1607, 1679, 1688, 1935, 2094, 2123, 2367, 2428, 2463, 2599, 2640, 2941, 2950, 2960, 3185, 3258, 3530, 3795, 4254, 4609, 4616, 4630, 4735, 5125, 5200, 5212, 5230, 5366, 5460, 5479, 5514], 'tetracycline-responsive': [16, 195, 3013], 'promoter': [17, 196, 2086, 3009], 'to': [18, 31, 91, 120, 149, 197, 210, 270, 299, 328, 381, 582, 589, 1238, 1254, 1267, 1327, 1445, 1448, 1609, 1721, 1844, 1924, 1933, 1965, 2093, 2225, 2443, 2585, 2631, 2738, 2784, 2814, 2883, 2911, 2919, 2965, 3021, 3041, 3044, 3051, 3110, 3168, 3345, 3458, 3486, 3526, 3545, 3570, 3580, 3777, 3814, 3841, 3969, 4068, 4112, 4213, 4501, 4603, 4633, 4894, 4992, 5196, 5245, 5315, 5365, 5502, 5580], 'test': [19, 198, 3546, 4612], 'role': [21, 200, 1290, 1937, 3435, 4618], 'CCT': [23, 38, 56, 71, 84, 95, 111, 161, 202, 217, 235, 250, 263, 274, 290, 340, 1383, 1463, 1538, 1615, 1665, 1692, 1894, 1939, 1951, 1961, 2028, 2074, 2197, 2221, 2263, 2334, 2562, 2588, 2740, 3059, 3100, 3123, 3206, 3233, 3309, 3325, 3437, 3470, 3552, 3562, 3632, 3734, 3867, 3909, 3927, 3943, 4088, 4113, 4127, 4184, 4219, 4238, 4476, 4504, 4584, 4599, 4620, 4641, 4740, 4753, 4793, 5292, 5342, 5572], 'in': [24, 40, 50, 103, 122, 203, 219, 229, 282, 301, 424, 592, 1263, 1297, 1532, 1539, 1669, 1691, 1827, 1922, 1940, 2150, 2229, 2294, 2366, 2598, 2615, 2639, 2666, 2870, 3053, 3102, 3127, 3236, 3268, 3292, 3311, 3324, 3374, 3386, 3396, 3407, 3438, 3464, 3538, 3587, 3605, 3678, 3705, 3719, 3744, 3753, 3861, 3885, 3902, 4110, 4131, 4163, 4481, 4506, 4588, 4622, 4743, 4772, 4923, 4938, 4979, 5000, 5205, 5250, 5317, 5328, 5338, 5369, 5478, 5507, 5599], 'apoptosis': [25, 204, 591, 1618, 1718, 2916, 3483, 3523, 3572], 'triggered': [26, 205], 'by': [27, 86, 163, 206, 265, 342, 1620, 1676, 1909, 1953, 2240, 2277, 2287, 2385, 2402, 2538, 2565, 2652, 2843, 2851, 3077, 3143, 3211, 3422, 3449, 3473, 3573, 3628, 3896, 4208, 4508, 4805, 4828], 'exposure': [28, 207, 3106, 3525], 'cells': [30, 53, 119, 209, 232, 298, 423, 594, 1312, 1534, 1761, 1826, 1908, 2065, 2113, 2165, 2228, 2266, 2827, 2840, 2861, 2893, 2897, 2908, 3050, 3081, 3150, 3198, 3384, 3414, 3429, 3481, 3537, 3569, 3579, 3603, 3621, 3646, 3659, 3673, 3703, 3740, 3768, 3799, 3812, 3824, 3840, 3857, 3973, 3997, 4143, 4170, 4260, 4921, 5332], 'antineoplastic': [33, 212, 587, 690, 1301, 5361], 'phospholipid': [34, 141, 213, 320, 1302], '1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine': [35, 214], '(ET-18-OCH3).': [36, 215], 'Basal': [37, 216], 'engineered': [42, 221], 'same': [48, 227, 2254, 2284, 3039, 3145, 3192, 3287, 3405, 3689, 4160, 4195], 'as': [49, 228, 389, 685, 2462, 3170, 3193, 3288, 3406, 3690, 3849, 3851, 4000, 4161, 4477, 5151], 'control': [51, 230, 2226, 2246, 2998, 3294, 3400, 3426, 3577, 3602, 3721, 3853, 3950], 'lines,': [54, 233], 'and': [55, 58, 93, 97, 234, 237, 272, 276, 379, 410, 427, 771, 961, 1232, 1279, 1324, 1353, 1381, 1389, 1442, 1526, 1535, 1616, 1755, 1973, 1976, 1984, 2100, 2119, 2169, 2191, 2234, 2275, 2325, 2382, 2391, 2437, 2532, 2567, 2610, 2634, 2664, 2691, 2705, 2736, 2765, 2801, 2823, 2834, 2868, 2886, 2891, 2913, 3085, 3094, 3129, 3199, 3204, 3221, 3342, 3441, 3461, 3467, 3506, 3514, 3518, 3543, 3576, 3727, 3787, 3811, 3855, 3876, 3947, 3962, 3979, 3987, 3992, 4089, 4126, 4152, 4734, 4752, 4759, 4779, 4890, 4926, 4933, 5153, 5308, 5330, 5465, 5469], 'activity': [57, 85, 236, 264, 1464, 1693, 2198, 2222, 2335, 2424, 3101, 3124, 3188, 3207, 3260, 3267, 3278, 3291, 3303, 3395, 3418, 4245, 4505, 4642], 'protein': [59, 238, 826, 1982, 2534, 2545, 2624, 3027, 3310, 3353], 'were': [60, 100, 239, 279, 2018, 2058, 2091, 2114, 2166, 2188, 2267, 2292, 2375, 2383, 2433, 2466, 2523, 2546, 2592, 2604, 2629, 2650, 2698, 2712, 2760, 2790, 2828, 2837, 2841, 2862, 2894, 2898, 3091, 3140, 3622, 3661, 3676, 3769, 3953, 3963, 3974, 4066], 'elevated': [61, 240, 3097, 3122, 3306, 3421, 5291, 5568], '25-fold': [62, 241, 3263], 'following': [63, 242, 2199, 3105, 3524, 3761], '48': [64, 243, 3244, 3584], 'h': [65, 244, 2812, 3245, 3585, 3775, 3961], 'induction': [67, 246, 2195, 3226, 3250, 3630, 4182], 'with': [68, 247, 1604, 1661, 1678, 1847, 1890, 2116, 2270, 2346, 2435, 2468, 2476, 2517, 2548, 2606, 2660, 2714, 2722, 2762, 2767, 2772, 2803, 2831, 2864, 3067, 3082, 3152, 3305, 3430, 3535, 3648, 3664, 3771, 3804, 3826, 3955, 3989, 4459, 5003, 5539, 5567], 'doxycycline.': [69, 248, 2203, 2244, 3113, 3392, 3474], 'Increased': [70, 249], 'prevented': [73, 252, 3736, 4020], 'ET-18-OCH3-induced': [74, 253, 1901, 4206, 4623], 'apoptosis.': [75, 254, 1671, 1902, 4624], 'Acylation': [76, 255, 4625], 'exogenous': [78, 257, 4082, 4627], 'lysophosphatidylcholine': [79, 98, 114, 258, 277, 293], 'circumvented': [80, 259, 4084], 'requirement': [82, 261, 4086, 4638], 'providing': [87, 266, 4071], 'an': [88, 267, 2338, 3171, 3754, 4072, 4104, 4210, 4763], 'alternate': [89, 268, 4073, 4211], 'route': [90, 269, 4212, 4632], 'phosphatidylcholine,': [92, 271], 'heightened': [94, 273], 'supplementation': [99, 115, 278, 294, 1757, 1818, 4019, 4125, 4141, 4179, 4204, 4751], 'equally': [101, 280], 'effective': [102, 281, 5562], 'reversing': [104, 283, 1911, 4756], 'cytotoxic': [106, 174, 285, 353, 417, 576, 1278, 3440, 3913, 4093, 4244, 4699], 'effect': [107, 138, 286, 317, 577, 1377, 1914, 3914, 4105, 4256, 4765], 'ET-18-OCH3.': [109, 288, 1283, 3527, 3748, 3936, 4096, 4247, 4806], 'Neither': [110, 289], 'overexpression': [112, 291, 3471, 3550, 3735, 3868, 3910, 4185, 4754, 5512], 'nor': [113, 292], 'allowed': [116, 295], 'proliferate': [121, 300, 3743], 'presence': [124, 303, 1829, 3055, 3238, 3347, 3388, 3466, 3540, 3589, 3607, 3746, 4149], 'ET-18-OCH3,': [126, 305, 363, 1231, 1831, 5565], 'indicating': [127, 306, 1832], 'that': [128, 153, 170, 307, 332, 349, 574, 1225, 1243, 1248, 1273, 1427, 1611, 1664, 1686, 1833, 1840, 1893, 1955, 2257, 2432, 2947, 3189, 3228, 3261, 3479, 3660, 3675, 3866, 3877, 3908, 4017, 4070, 4101, 4114, 4190, 4202, 4216, 4230, 4456, 4592, 4613, 4635, 4727, 4785, 4896, 4919, 4934, 4966, 5006, 5122, 5128, 5141, 5203, 5241, 5290, 5360, 5473, 5548], 'cytostatic': [130, 309, 1280, 1838, 3442, 3921, 3933, 4972, 5219], 'property': [131, 310, 4809], 'ET-18-OCH3': [133, 164, 312, 343, 358, 420, 579, 1441, 1525, 1622, 1916, 1966, 2912, 3052, 3445, 3487, 3544, 3598, 3651, 3665, 3762, 3783, 3817, 3831, 3875, 3916, 3986, 4021, 4134, 4145, 4258, 4479, 4497, 4601, 4702, 4733, 4757, 4811, 4975, 4991, 5123, 5142, 5222, 5246, 5295, 5458, 5506, 5538, 5555], 'independent': [135, 314, 1613, 4813, 5578], 'its': [137, 316, 1845, 4815], 'on': [139, 318, 1288, 1378, 1917, 2013, 2273, 2389, 2473, 2512, 2700, 4106, 4133, 4259, 4487, 4515, 4755, 4987, 5511], 'membrane': [140, 319, 1333, 1379], 'synthesis.': [142, 321, 1927], 'These': [143, 322, 403, 1454, 1885, 2185, 3905, 4064, 4197, 4606, 4963], 'data': [144, 323, 3906, 4065, 4198, 4781, 4964], 'provide': [145, 324, 1946, 4224, 4608, 4782], 'compelling': [146, 325, 4225], 'genetic': [147, 326, 1947, 4222, 4611, 4780], 'evidence': [148, 327, 1948, 4784], 'support': [150, 329, 4199, 4226], 'conclusion': [152, 331, 3750, 4201, 4229], 'interruption': [155, 334, 4232], 'phosphatidylcholine': [157, 336], 'synthesis': [158, 337, 963, 1296, 1373, 1432, 4077, 4215, 4235, 4252, 4790], 'at': [159, 338, 2379, 2528, 2595, 2612, 2642, 2654, 2693, 2792, 3784, 3976, 4236, 4791], 'step': [162, 341, 4239, 4794], 'is': [165, 344, 580, 1223, 1234, 1266, 1305, 1315, 1390, 1612, 1667, 1674, 1895, 2945, 3343, 4240, 4253, 4629, 4795, 4812, 4892, 4907, 5333, 5459], 'primary': [167, 346, 686], 'physiological': [168, 347, 762, 1241, 1460, 4824], 'imbalance': [169, 348], 'accounts': [171, 350], 'action': [175, 354, 418, 3443, 3922, 4973, 5220, 5255], 'drug.': [178, 357, 4471], '1The': [359], 'abbreviations': [360], 'used': [361, 2564, 2783, 3043, 3529, 4771], 'are:': [362], '1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine;': [364], 'PtdCho,': [365], 'phosphatidylcholine;': [366], 'LPC,': [367, 1458, 1523], 'lysophosphatidylcholine;': [368, 1997], 'CCT,': [369], 'cytidylyltransferase;': [371], 'bis-Tris,': [372], '2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-propane-1,3-diol.is': [373], 'nonmetabolizable': [375], 'analog': [376], 'LPC': [378, 1605, 1756, 1817, 1904, 2810, 4018, 4083, 4102, 4124, 4140, 4178, 4203, 4628, 4728, 4750, 4935], 'belongs': [380], 'first': [383], 'generation': [384], 'ether': [386, 5362], 'lipids': [387, 5363], 'tested': [388, 3448, 3752, 4137], 'growth': [390, 3379, 3459, 3533, 3758, 3894, 5001, 5206], 'inhibitors': [391], '(1Westphal': [392], 'O.': [393], 'Lipids.': [394, 530, 862, 1146, 4421, 5279, 5399], '1987;': [395, 839, 863], '22:': [396, 864, 5186], '787-788Crossref': [397], 'PubMed': [398, 461, 485, 505, 534, 552, 608, 627, 650, 672, 734, 753, 821, 845, 866, 889, 907, 921, 941, 956, 981, 1046, 1064, 1084, 1098, 1122, 1135, 1150, 1197, 1348, 1363, 1420, 1482, 1504, 1560, 1582, 1640, 1709, 1750, 1791, 1812, 1867, 2050, 2418, 2455, 2582, 2753, 2935, 2988, 3365, 3501, 4046, 4321, 4339, 4359, 4373, 4397, 4410, 4425, 4535, 4557, 4577, 4668, 4689, 4720, 4866, 4885, 4958, 5070, 5110, 5166, 5188, 5283, 5388, 5403, 5426, 5442, 5496, 5530], 'Scopus': [399, 486, 506, 535, 553, 609, 628, 651, 673, 719, 735, 754, 822, 867, 890, 908, 922, 957, 982, 1047, 1065, 1099, 1151, 1176, 1198, 1349, 1364, 1421, 1483, 1505, 1561, 1583, 1641, 1751, 1792, 1813, 1868, 2051, 2419, 2456, 2936, 2989, 3502, 4047, 4322, 4340, 4374, 4426, 4451, 4536, 4558, 4578, 4669, 4690, 4721, 4851, 4867, 4886, 4959, 5071, 5111, 5167, 5189, 5284, 5404, 5427, 5443, 5497, 5531], '(5)': [400], 'Google': [401, 449, 462, 488, 508, 537, 555, 568, 611, 630, 653, 675, 721, 737, 756, 791, 810, 824, 846, 869, 892, 910, 924, 942, 959, 984, 1001, 1012, 1027, 1049, 1067, 1085, 1101, 1123, 1136, 1153, 1178, 1200, 1351, 1366, 1423, 1485, 1507, 1563, 1585, 1643, 1710, 1753, 1794, 1815, 1870, 2053, 2421, 2458, 2583, 2754, 2938, 2991, 3366, 3504, 4049, 4276, 4287, 4302, 4324, 4342, 4360, 4376, 4398, 4411, 4428, 4453, 4538, 4560, 4580, 4671, 4692, 4723, 4853, 4869, 4888, 4961, 5040, 5059, 5073, 5090, 5113, 5169, 5191, 5286, 5389, 5406, 5429, 5445, 5456, 5499, 5533], 'Scholar).': [402, 569, 676, 757, 1214, 1367, 1424, 1521, 1599, 1711, 1816, 1884, 2054, 2160, 2422, 2939, 2992, 3367, 4063, 4581, 4724, 4962, 5114, 5287, 5457, 5500, 5534], 'compounds': [404, 1455], 'do': [405], 'not': [406, 1235, 1820, 1842, 3331, 3370, 3420, 3653, 3662, 3742, 3833, 3859, 3889, 3930, 4025, 4175, 4187, 5303, 5334, 5345, 5551], 'directly': [407, 3447], 'target': [408, 1899, 1921, 3033, 4109, 4480, 4737, 5215, 5573], 'DNA,': [409], 'numerous': [411], 'studies': [412, 5358], 'have': [413, 682], 'demonstrated': [414, 4016], 'selective': [416, 2176], 'against': [421, 2559], 'transformed': [422], 'whole': [425], 'animals': [426], 'tissue': [428, 2798], 'culture': [429, 1990, 2799], '(2Andreesen': [430], 'R.': [431, 452, 493, 598, 713, 876, 882, 989, 1052, 2139, 2925, 3491, 4264, 4327, 4845], 'Modolell': [432, 453, 470, 599, 2926, 3492, 5159], 'M.': [433, 454, 517, 600, 643, 711, 742, 835, 987, 1034, 1104, 1728, 1732, 1769, 1773, 1799, 2927, 2973, 3493, 4262, 4309, 4379, 4646, 4650, 4676, 4843, 4874, 5160, 5180, 5266, 5413, 5487, 5521], 'Weltzien': [434], 'H.U.': [435, 469], 'Eibl': [436, 524, 5273, 5395], 'H.': [437, 525, 529, 620, 872, 1030, 1038, 1734, 1775, 2133, 2983, 4305, 4313, 4567, 4652, 5274, 5278, 5396], 'Common': [438], 'H.H.': [439], 'Lohr': [440], 'G.W.': [441, 5448], 'Munder': [442, 455, 474, 496, 994, 4269], 'P.G.': [443, 456, 475, 497, 995, 4270], 'Cancer': [444, 500, 563, 703, 786, 805, 996, 4271, 4835, 5035, 5054, 5085, 5104, 5451], 'Res.': [445, 547, 564, 603, 748, 787, 806, 997, 1041, 1416, 2930, 3496, 4272, 4316, 4880, 5036, 5055, 5086, 5381, 5422, 5452], '1978;': [446], '38:': [447], '3894-3899PubMed': [448], 'Scholar,': [450, 463, 489, 509, 538, 556, 612, 631, 654, 709, 722, 738, 792, 811, 847, 870, 893, 911, 943, 985, 1002, 1013, 1028, 1050, 1068, 1086, 1102, 1124, 1137, 1154, 1179, 1201, 1411, 1486, 1508, 1564, 1586, 1795, 1871, 4050, 4277, 4288, 4303, 4325, 4343, 4361, 4377, 4399, 4412, 4429, 4539, 4561, 4672, 4841, 4854, 4870, 5041, 5060, 5074, 5091, 5170, 5390, 5407, 5430, 5446], '3Andreesen': [451], 'Blood.': [457], '1979;': [458, 998, 4273], '54:': [459], '519-523Crossref': [460], '4Berdel': [464], 'W.E.': [465, 523, 5272], 'Bausert': [466], 'W.R.E.': [467], 'Weltzein': [468], 'M.L.': [471], 'Sidman': [472], 'K.H.': [473], 'Eur.': [476, 1129, 1167, 4404, 4442], 'J.': [477, 498, 527, 621, 645, 661, 783, 831, 836, 855, 917, 932, 970, 1005, 1075, 1094, 1113, 1130, 1168, 1186, 1471, 1493, 1549, 1571, 1629, 1700, 1739, 1780, 1856, 2039, 2573, 2744, 3356, 4035, 4280, 4350, 4369, 4388, 4405, 4443, 4524, 4546, 4657, 4709, 4947, 5032, 5162, 5276, 5379], 'Cancer.': [478, 646, 1007, 1169, 4282, 4444], '1980;': [479, 502], '16:': [480], '1119-1204Abstract': [481], 'Full': [482, 667, 669, 842, 938, 976, 978, 1081, 1119, 1173, 1192, 1194, 1477, 1479, 1499, 1501, 1555, 1557, 1577, 1579, 1635, 1637, 1706, 1745, 1747, 1786, 1788, 1862, 1864, 2045, 2047, 2579, 2750, 3362, 4041, 4043, 4356, 4394, 4448, 4530, 4532, 4552, 4554, 4574, 4663, 4665, 4715, 4717, 4953, 4955, 5385], 'Text': [483, 668, 670, 843, 939, 977, 979, 1082, 1120, 1174, 1193, 1195, 1478, 1480, 1500, 1502, 1556, 1558, 1578, 1580, 1636, 1638, 1707, 1746, 1748, 1787, 1789, 1863, 1865, 2046, 2048, 2580, 2751, 3363, 4042, 4044, 4357, 4395, 4449, 4531, 4533, 4553, 4555, 4575, 4664, 4666, 4716, 4718, 4954, 4956, 5386], 'PDF': [484, 671, 844, 940, 980, 1083, 1121, 1175, 1196, 1481, 1503, 1559, 1581, 1639, 1708, 1749, 1790, 1866, 2049, 2581, 2752, 3364, 4045, 4358, 4396, 4450, 4534, 4556, 4576, 4667, 4719, 4957, 5387], '(10)': [487], '5Runge': [490], 'M.H.': [491, 1730, 1771, 4648], 'Andreesen': [492, 988, 4263], 'Pfleidrer': [494], 'A.': [495, 1141, 1344, 1808, 4416, 4565, 4685, 5078, 5101], 'Natl.': [499, 1006, 1339, 1803, 4281, 4680], 'Inst.': [501, 1008, 4283], '64:': [503], '1301-1306Crossref': [504], '(89)': [507], '6Vogler': [510], 'W.R.': [511, 1015, 4290, 5260], 'Olson': [512, 1020, 4295, 5261], 'A.C.': [513, 1021, 4296, 5262], 'Okamoto': [514, 5263], 'S.': [515, 614, 660, 857, 878, 969, 1185, 1207, 1343, 1470, 1492, 1514, 1548, 1570, 1592, 1628, 1652, 1807, 1855, 1877, 2038, 2411, 2743, 2975, 3355, 4034, 4056, 4523, 4545, 4684, 4708, 4946, 5097, 5264, 5485, 5519], 'Shoji': [516, 5265], 'Raynoe': [518, 5267], 'R.L.': [519, 5268], 'Kuo': [520, 5269], 'J.F.': [521, 5270], 'Berdel': [522, 5271], 'Hajdu': [526, 5275], 'Nomura': [528, 5277], '1991;': [531, 1043, 1061, 4318, 4336, 5280], '26:': [532, 5281], '1418-1423Crossref': [533, 5282], '(28)': [536, 2420, 5285], '7Vallari': [539], 'D.S.': [540], 'Smith': [541, 2146], 'Z.L.': [542], 'Snyder': [543, 561], 'F.': [544, 562, 596, 635, 639, 1032, 1738, 1779, 2923, 3489, 4307, 4656, 5156], 'Biochem.': [545, 601, 622, 816, 902, 916, 1039, 1093, 1131, 2413, 2451, 2928, 3494, 4314, 4368, 4406, 5065, 5161, 5437], 'Biophys.': [546, 602, 884, 1040, 1209, 1516, 1594, 1654, 1879, 2414, 2929, 3495, 4058, 4315], 'Commun.': [548, 604, 1042, 2931, 3497, 4317], '1988;': [549], '156:': [550], '1-8Crossref': [551], '(34)': [554, 823, 5072], '8Hoffman': [557], 'D.R.': [558, 1337, 1356], 'Hoffman': [559], 'L.H.': [560], '1986;': [565, 935], '46:': [566], '5803-5809PubMed': [567], 'Recent': [570], 'work': [571, 1285, 3476, 4474, 4917, 5598], 'has': [572, 1286, 1374, 1687, 1837, 4985], 'established': [573, 3478], 'due': [581, 1444, 3344], 'ability': [584, 1447, 4989], 'phospholipids': [588, 692], 'induce': [590], 'sensitive': [593, 2910, 5307, 5331], '(9Mollinedo': [595, 2922, 3488], 'Martinez-Dalmau': [597, 2924, 3490], '1993;': [605, 647, 818, 1095, 2415, 2932, 3498, 4370, 5067, 5087, 5185, 5400, 5423, 5439], '192:': [606, 2933, 3499], '603-609Crossref': [607, 2934, 3500], '(97)': [610, 2937, 3503], '10Araki': [613], 'Tsuna': [615], 'I.': [616, 798, 5047], 'Kaji': [617], 'K.': [618, 880], 'Hayashi': [619], '(Tokyo).': [623], '1994;': [624, 716, 904, 1116, 2747, 3359, 4391, 4848, 5107, 5163], '115:': [625], '245-247Crossref': [626], '(16)': [629, 5112], '11Diomede': [632], 'L.': [633], 'Colotta': [634], 'Piovani': [636], 'B.': [637], 'Re': [638], 'Modest': [640, 784, 801, 5033, 5050, 5081, 5377, 5433], 'E.J.': [641, 785, 802, 5034, 5051, 5082, 5378, 5434], 'Samona': [642], 'Int.': [644, 5184], '53:': [648, 5088], '124-130Crossref': [649], '(125)': [652], '12Boggs': [655], 'K.P.': [656, 965, 1181, 1203, 1466, 1488, 1510, 1544, 1566, 1588, 1624, 1648, 1851, 1873, 2036, 4030, 4052, 4519, 4541, 4704, 4942], 'Rock': [657, 966, 1182, 1204, 1467, 1489, 1511, 1545, 1567, 1589, 1625, 1649, 1852, 1874, 2408, 4031, 4053, 4520, 4542, 4705, 4943], 'C.O.': [658, 967, 1183, 1205, 1468, 1490, 1512, 1546, 1568, 1590, 1626, 1650, 1853, 1875, 2409, 4032, 4054, 4521, 4543, 4706, 4944], 'Jackowski': [659, 968, 1184, 1206, 1469, 1491, 1513, 1547, 1569, 1591, 1627, 1651, 1854, 1876, 2037, 2410, 4033, 4055, 4522, 4544, 4707, 4945], 'Biol.': [662, 837, 933, 971, 1076, 1187, 1472, 1494, 1550, 1572, 1630, 1701, 1740, 1781, 1857, 2040, 2574, 2745, 3357, 4036, 4351, 4525, 4547, 4658, 4710, 4948], 'Chem.': [663, 838, 934, 972, 1077, 1188, 1473, 1495, 1551, 1573, 1631, 1702, 1741, 1782, 1858, 2041, 2575, 2746, 3358, 4037, 4352, 4526, 4548, 4659, 4711, 4949], '1995;': [664, 731, 750, 973, 1132, 1147, 1170, 1189, 1474, 1496, 1552, 1574, 1632, 1859, 2042, 2985, 4038, 4407, 4422, 4445, 4527, 4549, 4712, 4863, 4882, 4950, 5382], '270:': [665, 974, 1190, 1475, 1497, 1553, 1575, 1633, 1860, 2043, 4039, 4528, 4550, 4713, 4951], '11612-11618Abstract': [666, 975, 1476, 1554, 1634, 1861, 4040, 4529, 4714, 4952], '(82)': [674, 983, 1484, 1562, 1642, 1869, 4048, 4537, 4722, 4960], 'plethora': [678], 'biological': [680, 1322, 4467], 'processes': [681], 'been': [683], 'suggested': [684, 3731], 'targets': [687, 1229, 4906, 4969], 'ether-linked': [691], '(for': [693], 'reviews,': [694], 'see': [695], 'Refs.': [696], '13Daniel': [697], 'L.W.': [698, 833, 849, 4830], 'Hickman': [699, 4831], 'J.A.': [700, 2147, 4832], 'Tritton': [701, 4833], 'T.R.': [702, 4834], 'Chemotherapy.': [704, 4836], 'Blackwell': [705, 4837], 'Scientific,': [706, 4838], 'Oxford1993:': [707, 4839], '146-178Google': [708, 4840], '14Lohmeyer': [710, 4842], 'Bittman': [712, 881, 4844], 'Drugs': [714, 4846], 'Future.': [715, 4847], '19:': [717, 4849], '1021-1037Crossref': [718, 4850], '(81)': [720, 4852], '15Principe': [723, 4855], 'P.': [724, 726, 744, 874, 4856, 4858, 4876, 5491, 5525], 'Braquet': [725, 4857], 'Crit.': [727, 4859], 'Rev.': [728, 749, 4860, 4881], 'Oncol.': [729, 4861], 'Hematol.': [730, 1023, 4298, 4862], '18:': [732, 4864], '155-178Crossref': [733, 4865], '(26)': [736, 909, 4868], '16Houlihan': [739, 4871], 'W.J.': [740, 4872], 'Lohmeyer': [741, 4873], 'Workman': [743, 4875], 'Cheon': [745, 4877], 'S.H.': [746, 4878], 'Med.': [747, 4879], '15:': [751, 4883], '157-223Crossref': [752, 4884], '(122)': [755, 4887], 'The': [758, 1712, 2027, 2110, 2161, 2289, 2332, 2373, 2520, 2555, 2590, 2622, 2648, 2696, 2710, 2758, 2859, 3070, 3276, 3300, 3319, 3393, 3434, 3639, 3668, 3937, 3972, 4248, 4582, 4725, 4807, 5208, 5236, 5535], 'long': [759], 'list': [760], 'imbalances': [763, 1242, 4825], 'includes': [764], 'inhibition': [766, 1293, 1429, 1666, 3460, 4249, 4621, 4787, 4898], 'phosphatidylinositol': [768], 'phospholipase': [769], 'C': [770, 3615], 'calcium': [772], 'movements': [773], '(17Powis': [774, 5023], 'G.': [775, 804, 901, 915, 1036, 1128, 2977, 2979, 4311, 4403, 5024, 5053, 5084, 5093, 5103, 5176, 5420], 'Seewald': [776, 5025], 'M.J.': [777, 794, 5026, 5043], 'Gratas': [778, 5027], 'C.': [779, 861, 1162, 1413, 2572, 4437, 5028, 5158, 5178, 5398], 'Melder': [780, 799, 5029, 5048], 'D.': [781, 1156, 4431, 5030, 5394], 'Riebow': [782, 5031], '1992;': [788, 886, 1078, 2576, 4353, 5037], '52:': [789, 5038], '2835-2840PubMed': [790, 5039], '18Seewald': [793, 5042], 'Olsen': [795, 5044], 'R.A.': [796, 5045, 5374], 'Sehgal': [797, 5046], 'D.C.': [800, 5049], 'Powis': [803, 5052, 5083, 5102], '1990;': [807, 1417, 5056, 5453], '50:': [808, 5057, 5454], '4458-4463PubMed': [809, 5058], '19Pawelczyk': [812, 5061], 'T.': [813, 1054, 1072, 1088, 1108, 1139, 4329, 4347, 4363, 4383, 4414, 5062], 'Lowenstein': [814, 5063], 'J.M.': [815, 5064], 'Pharmacol.': [817, 903, 5066, 5106, 5438], '45:': [819, 4572, 5068, 5440], '493-497Crossref': [820, 5069], 'Scholar),': [825, 925, 960, 1659, 1754, 3505, 4454, 4889], 'kinase': [827], 'C-regulated': [828], 'functions': [829], '(20Parker': [830], 'Daniel': [832], 'Waite': [834], '262:': [840], '5385-5393Abstract': [841], '21Daniel': [848], 'Etkin': [850], 'L.A.': [851, 5080], 'Morrison': [852], 'B.T.': [853], 'Parker': [854], 'Morris-Natschke': [856], 'Surles': [858], 'J.R.': [859], 'Piantadosi': [860], '851-855Crossref': [865], '(54)': [868], '22Salari': [871], 'Dryden': [873], 'Davenport': [875], 'Howard': [877], 'Kones': [879], 'Biochim.': [883, 1208, 1515, 1593, 1653, 1878, 4057], 'Acta.': [885, 1210, 1517, 1595, 1655, 1880, 4059], '1134:': [887], '81-88Crossref': [888], '(36)': [891], '23Heesbeen': [894], 'E.C.': [895, 5409], 'Verdonck': [896, 5410], 'L.F.': [897, 5411], 'Staal': [898, 5417], 'G.E.': [899], 'Rijksen': [900], '47:': [905], '1481-1488Crossref': [906], '24Zhou': [912], 'X.': [913, 1126, 4401], 'Arthur': [914, 1127, 4402], '1997;': [918, 1211, 1518, 1596, 1656, 1881, 4060, 5493, 5527], '324:': [919], '897-902Crossref': [920], '(18)': [923], 'lysophospholipid': [926], 'metabolism': [927, 4461], '(25Herrmann': [928], 'D.B.J.': [929, 1004, 4279], 'Neumann': [930], 'H.A.': [931], '261:': [936], '7742-7747Abstract': [937], '26Surette': [944], 'M.E.': [945], 'Winkler': [946], 'J.D.': [947, 1695, 1797, 2570, 4674], 'Fonteh': [948], 'A.N.': [949], 'Chilton': [950], 'F.H.': [951], 'Biochemistry.': [952, 1359, 5492, 5526], '1996;': [953, 1742, 1783, 4571, 4660], '35:': [954, 5108], '9187-9196Crossref': [955], '(86)': [958], 'PtdCho': [962, 1295, 1304, 1372, 1396, 1431, 1610, 1848, 1926, 4076, 4214, 4234, 4251, 4460, 4483, 4634, 4789, 4818], '(12Boggs': [964, 1465, 1543, 1623, 1850, 4029, 4518, 4703, 4941], '27Modolell': [986], 'Pahlke': [990, 4265], 'W.': [991, 1058, 1074, 1092, 1112, 1160, 1164, 2034, 2981, 4266, 4333, 4349, 4367, 4387, 4435, 4439, 5489, 5523], 'Brugger': [992, 4267], 'U.': [993, 1158, 1342, 1806, 4268, 4433, 4683], '39:': [999, 4274], '4681-4686PubMed': [1000, 4275], '28Herrmann': [1003, 4278], '1985;': [1009, 1024, 4284, 4299], '75:': [1010, 4285], '423-430PubMed': [1011, 4286], '29Vogler': [1014, 4289], 'Whigham': [1016, 4291], 'E.': [1017, 4292], 'Bennett': [1018, 4293], 'W.D.': [1019, 4294], 'Exp.': [1022, 4297], '13:': [1025, 4300], '629-633PubMed': [1026, 4301], '30Tronchère': [1029, 4304], 'Tercé': [1031, 1737, 1778, 4306, 4655], 'Record': [1033, 1731, 1772, 4308, 4649], 'Ribbes': [1035, 4310], 'Chap': [1037, 1733, 1774, 4312, 4651], '176:': [1044, 4319], '157-165Crossref': [1045, 4320], '(21)': [1048, 4323], '31Haase': [1051, 4326], 'Wieder': [1053, 1071, 1107, 4328, 4346, 4382], 'Geilen': [1055, 1089, 1105, 1142, 4330, 4364, 4380, 4417], 'C.C.': [1056, 1070, 1090, 1106, 1143, 4331, 4345, 4365, 4381, 4418], 'Reutter': [1057, 1073, 1091, 1111, 4332, 4348, 4366, 4386], 'FEBS': [1059, 4334], 'Lett.': [1060, 4335], '288:': [1062, 4337], '129-132Crossref': [1063, 4338], '(66)': [1066, 4341], '32Geilen': [1069, 4344], '267:': [1079, 2577, 4354], '6719-6724Abstract': [1080, 4355], '33Wieder': [1087, 4362], '291:': [1096, 4371], '561-567Crossref': [1097, 4372], '(31)': [1100, 4375], '34Detmar': [1103, 4378], 'Orfanos': [1109, 1144, 4384, 4419], 'C.E.': [1110, 1145, 4385, 4420], 'Invest.': [1114, 4389], 'Dermatol.': [1115, 4390], '102:': [1117, 4392], '490-494Abstract': [1118, 4393], '35Zhou': [1125, 4400], '232:': [1133, 4408], '881-888Crossref': [1134, 4409], '36Wieder': [1138, 4413], 'Haase': [1140, 4415], '30:': [1148, 4423], '389-393Crossref': [1149, 4424], '(37)': [1152, 4427], '37Berkovic': [1155, 4430], 'Grunwald': [1157, 4432], 'Menzel': [1159, 4434], 'Unger': [1161, 4436, 5397], 'Hiddemann': [1163, 4438], 'Fleer': [1165, 4440], 'E.A.M.': [1166, 4441], '31:': [1171, 4446], '2080-2085Abstract': [1172, 4447], '(35)': [1177, 4452, 5498, 5532], '38Boggs': [1180, 1487, 1565, 4540], '7757-7764Abstract': [1191, 1498, 1576, 4551], '(147)': [1199, 1506, 1584, 4559], '39Boggs': [1202, 1509, 1587, 1872, 4051], '(in': [1212, 1519, 1597, 1657, 1882, 4061], 'press)Google': [1213, 1520, 1598, 1658, 1883, 4062], 'Although': [1215], 'some': [1216, 3897], 'results': [1219, 4937, 5204], 'are': [1220, 1227, 1244, 1249, 1274, 1841, 1887, 1931, 2909, 4770, 4826, 5242, 5550], 'contradictory,': [1221], 'it': [1222, 1233, 1314, 3183, 4098, 4891], 'clear': [1224], 'there': [1226], 'multiple': [1228, 3322], 'yet': [1236], 'possible': [1237, 4100], 'distinguish': [1239], 'causative': [1245, 1668], 'from': [1246, 1762, 2020, 2066, 2211, 2427, 3147, 3178, 3254, 3398, 3409, 3624, 3655, 3874, 3891, 4144], 'those': [1247], 'either': [1250, 1621, 2021, 3586, 3604], 'derivative': [1251], 'or': [1252, 1645, 2023, 2061, 3056, 3378, 3389, 3427, 3590, 3608, 3802, 3967, 4130, 4901, 5009, 5302, 5556], 'unrelated': [1253], 'main': [1256], 'event.': [1257], 'Thus,': [1258, 1368, 1928], 'major': [1260, 1317, 5231], 'contemporary': [1261], 'focus': [1262], 'field': [1265], 'identify': [1268], 'critical': [1270, 1897, 4610], 'cellular': [1271, 1898, 1920, 1960, 4108, 4596, 4640, 4736, 5214, 5319, 5581], 'target(s)': [1272], 'responsible': [1275, 4116, 4464, 4908, 5216], 'actions': [1281], 'Our': [1284, 4013, 4221, 4472, 4915, 5288], 'focused': [1287, 4986], 'mechanism': [1299], 'action.': [1303], 'essential': [1306, 4241], 'survival': [1309], 'cultured': [1311], 'because': [1313, 2216, 3182, 3205], 'structural': [1318], 'building': [1319], 'block': [1320], 'membranes': [1323, 2711], 'precursor': [1326], 'other': [1329, 2056, 3519, 4738, 5470], 'two': [1330, 2904, 4768], 'most': [1331], 'abundant': [1332], 'phospholipids,': [1334], 'phosphatidylethanolamine': [1335], '(40Voelker': [1336], 'Proc.': [1338, 1802, 4679], 'Acad.': [1340, 1804, 4681], 'Sci.': [1341, 1805, 4682], '1984;': [1345], '81:': [1346], '2669-2673Crossref': [1347], '(158)': [1350], 'Scholar)': [1352, 1644, 2459, 2584, 2755, 4693, 5192], 'sphingomyelin': [1354], '(41Voelker': [1355], 'Kennedy': [1357], 'E.P.': [1358], '1982;': [1360, 1809, 4686], '21:': [1361], '2753-2759Crossref': [1362], '(166)': [1365], 'cessation': [1370, 4911], 'global': [1376], 'structure': [1380], 'function.': [1382], 'catalyzes': [1384], 'formation': [1386, 1451, 1531, 2399], 'CDP-choline': [1388, 1530], 'key': [1392], 'enzyme': [1393, 4517], 'controlling': [1394], 'biosynthetic': [1397, 4484], 'pathway': [1398, 1608, 4485, 4494], '(42Vance': [1399], 'D.E.': [1400, 1402, 1736, 1777, 4654], 'Vance': [1401, 1735, 1776, 4653], 'Phosphatidylcholine': [1403], 'Metabolism.': [1404, 4570], 'CRC': [1405], 'Press,': [1406], 'Boca': [1407], 'Raton,': [1408], 'FL1989:': [1409], '225-239Google': [1410], '43Kent': [1412], 'Prog.': [1414], 'Lipid': [1415, 5380], '29:': [1418], '87-105Crossref': [1419], '(167)': [1422], 'We': [1425, 3368, 3528, 5584, 5592], 'proposed': [1426], 'underlying': [1435, 4797], 'cause': [1436, 4798], 'cytotoxicity': [1439, 4022, 4135, 4207, 4758], 'hexadecylphosphocholine': [1443, 1527, 1646], 'their': [1446], 'limit': [1449], 'CDP-choline.': [1453], 'effectively': [1456, 3599], 'mimic': [1457], 'regulator': [1461, 2952], 'Like': [1522], 'both': [1524, 4167, 4191], 'reduce': [1528], 'intact': [1533], 'inhibit': [1536, 4502, 4993], 'purified': [1537, 4503], 'anin': [1540], 'vitro': [1541, 4507], 'assay': [1542, 2336], 'Supplementation': [1600], 'medium': [1603], 'provides': [1606], 'prevents': [1617, 4205, 4697], 'induced': [1619, 3210, 3472], '(39Boggs': [1647], 'consistent': [1660], 'idea': [1663, 1673, 5005], 'initiating': [1670], 'This': [1672, 2993, 3035, 3729, 3749, 3864], 'corroborated': [1675], 'experiments': [1677, 1886, 1930, 2210, 3136, 3534, 4015, 4223, 4607], 'mutant': [1680, 1684, 1713, 1760, 2961, 3023], 'CHO': [1681], 'line,': [1683, 2248], '58,': [1685], 'temperature-sensitive': [1689], 'defect': [1690], '(44Esko': [1694], 'Wermuth': [1696], 'M.M.': [1697, 2407, 2449], 'Raetz': [1698, 1800, 4677], 'C.R.H.': [1699, 1801, 4678], '1981;': [1703], '256:': [1704], '7388-7393Abstract': [1705], '58': [1714], 'undergoes': [1717], 'when': [1719, 2917, 3125, 3484, 4766], 'shifted': [1720], 'nonpermissive': [1723], 'temperature': [1724], '(45Cui': [1725, 1766, 4643], 'Z.': [1726, 1767, 4644], 'Houweling': [1727, 1768, 4645], 'Chen': [1729, 1770, 2130, 4647], '271:': [1743, 1784, 4661], '14668-14671Abstract': [1744, 1785, 4662], '(182)': [1752, 1793, 4670], 'rescues': [1758], 'programmed': [1763, 3555, 4801], 'death': [1765, 3463, 3627, 3901, 4803], '46Esko': [1796, 4673], 'Nishijima': [1798, 4675], '79:': [1810, 4687], '1698-1702Crossref': [1811, 4688], '(61)': [1814, 4691], 'does': [1819], 'allow': [1821], 'continued': [1823, 3808, 3892], 'proliferation': [1824, 4028], 'drug': [1835, 2921, 5022, 5258, 5351, 5476], 'also': [1836, 3141, 4498, 4696, 5118, 5593], 'properties': [1839], 'related': [1843], 'interference': [1846, 4458], 'biosynthesis': [1849], 'completely': [1888], 'concordant': [1889], 'hypothesis': [1892, 1952], 'However,': [1903, 3698, 4097, 5115], 'could': [1905], 'possibly': [1906], 'rescue': [1907, 4157, 4936], 'competitively': [1910], 'inhibitory': [1913], 'another': [1918, 4107], 'important': [1919], 'addition': [1923, 2201, 2242, 2816, 2852, 3213, 3779, 3983, 4111], 'restoring': [1925], 'additional': [1929], 'required': [1932, 3133], 'verify': [1934], 'specific': [1936, 1957, 3549, 5552], 'ET-18-OCH3action.': [1941], 'In': [1942, 3617, 3821, 4166, 5136], 'this': [1943, 2235, 2901, 3334, 4138, 4589, 5137, 5224, 5257, 5543], 'report': [1944, 4590], 'we': [1945, 3559, 5116], 'demonstrating': [1954], 'elevation': [1958], 'content': [1962], 'confers': [1963], 'resistance': [1964, 4602, 5296, 5477, 5582], 'cytotoxicity.': [1967], 'Sources': [1968], 'supplies': [1970], 'were:CLONTECH,': [1971], 'pTRE,': [1972], 'pTK-Hyg': [1974, 2120, 3086, 3160], 'vectors,': [1975], 'Tet-OnTM': [1978], 'cells;': [1979], 'Sigma,': [1980], 'doxycycline,': [1981, 4151], 'A-Sepharose,': [1983], 'chromatography': [1985, 2004, 2405], 'standards;': [1986], 'Life': [1987], 'Technologies,': [1988], 'media;': [1991], 'Calbiochem,': [1992], 'ET-18-OCH3;': [1993], 'Avanti': [1994], 'Polar': [1995], 'Lipids,': [1996], 'American': [1998], 'Radiolabeled': [1999], 'Chemicals,': [2000], 'phospho[methyl-14C]choline;': [2001], 'Analtech,': [2002], 'thin-layer': [2003], 'plates;': [2005], 'Amersham,': [2006], 'ECL': [2007, 2779], 'kit': [2008, 2781], 'detection': [2010, 2780, 3320], 'proteins': [2012, 5546], 'immunoblots.': [2014], 'Molecular': [2015, 2151], 'biology': [2016], 'reagents': [2017], 'purchased': [2019], 'Promega': [2022], 'New': [2024, 2157], 'England': [2025], 'Biolabs.': [2026], 'cDNA': [2029, 2075], 'described': [2031, 2620, 4001], 'previously': [2032, 3341], '(47Yang': [2033], 'Boggs': [2035], '23951-23957Abstract': [2044], '(67)': [2052], 'All': [2055], 'materials': [2057], 'reagent': [2059], 'grade': [2060], 'better.': [2062], 'Tet-On': [2064, 2112, 3080, 3149, 3197, 3413], 'CLONTECHlaboratories': [2067], 'express': [2068], 'regulatory': [2070], 'Tet-responsive': [2071], 'transcription': [2072, 3030], 'factor.': [2073], 'cloned': [2077, 3005], 'into': [2078, 2102, 2171, 2279], 'pTRE': [2080, 2108, 2259, 3155], 'vector': [2081, 2260, 3156, 3202, 3945, 3949], 'downstream': [2082, 3006], 'Tet-regulated': [2085], 'elements.': [2087], 'Briefly,': [2088], 'XbaI': [2089, 2104], 'linkers': [2090], 'added': [2092, 2630, 2882], 'fragment': [2095], 'containing': [2096, 2173], 'CCT-coding': [2098], 'sequence': [2099, 2563], 'ligated': [2101], 'site': [2105, 4514], 'vector.': [2109, 3161], 'co-transfected': [2115], 'pTRE-CCT': [2118, 3084], 'vectors': [2121], 'using': [2122, 2252, 2460], 'calcium-phosphate': [2124], 'DNA': [2125, 2956], 'precipitation': [2126, 2481, 2608, 2618, 2662], 'technique': [2127], '(48Kingston': [2128], 'R.E.': [2129, 2141], 'C.A.': [2131], 'Okayama': [2132], 'Rose': [2134], 'J.K.': [2135], 'Ausubel': [2136], 'F.M.': [2137], 'Brent': [2138], 'Kingston': [2140], 'Moore': [2142], 'D.D.': [2143], 'Seidman': [2144], 'J.G.': [2145], 'Current': [2148, 4983], 'Protocols': [2149], 'Biology.': [2152], 'John': [2153], 'Wiley': [2154], '&': [2155], 'Sons,': [2156], 'York1994:': [2158], '9.1.1-9.1.11Google': [2159], 'next': [2162], 'day,': [2163], 'split': [2167], '1/10': [2168], 'seeded': [2170, 2791], 'dishes': [2172], 'hygromycin': [2175], 'medium.': [2177, 2858, 2875], 'Several': [2178, 5356], 'weeks': [2179], 'later,': [2180], 'individual': [2181], 'hygromycin-resistant': [2182, 3089, 3117], 'colonies': [2183, 2187, 3090], 'appeared.': [2184], 'clonal': [2186, 3068, 5603], 'isolated,': [2189, 3092], 'expanded,': [2190, 3093], 'screened': [2192, 3095], 'Clone': [2204, 3174], 'CCT.12': [2205, 3071, 3175, 3256, 3282, 3315, 3383, 3455, 3536, 3575, 3620, 3645, 3739, 3767, 3823], 'selected': [2207, 2899, 3167, 3177], 'our': [2209, 3135, 3507], '32': [2213, 3116], 'clones': [2214, 3109, 3118], 'examined': [2215], 'basal': [2218, 3186], 'level': [2219, 2236, 5340], 'identical': [2224, 4747], 'absence': [2231, 3057, 3390, 3468, 3591, 3609, 4761], 'inducer,': [2233, 3112], 'significantly': [2238], 'increased': [2239, 3301], 'CCT.00,': [2249], 'procedure': [2255, 3146], 'except': [2256], 'lacked': [2261], 'insert.': [2264], 'washed': [2268, 2467, 2657, 2721, 2761, 2829], 'twice': [2269, 2830], 'phosphate-buffered': [2271, 2470, 2832], 'saline': [2272, 2724, 2764, 2865], 'ice': [2274, 2390, 2513], 'harvested': [2276, 3975], 'scraping': [2278], '1': [2280, 2305, 2310, 2316, 2355, 2505, 2646, 2719, 2775, 2846, 2854, 3274, 3298, 3317, 3328], 'ml': [2281, 2855, 2872], 'buffer': [2285, 2296, 2482, 2609, 2619, 2672], 'followed': [2286], 'centrifugation.': [2288], 'pellets': [2291], 'resuspended': [2293, 2611, 2665, 2869], 'lysis': [2295], '(10': [2297], 'mm': [2298, 2303, 2306, 2311, 2320, 2358, 2487, 2500, 2503, 2506, 2680, 2726, 2729], 'HEPES,': [2299], 'pH': [2300, 2349, 2489, 2682, 2731], '7.4,': [2301], '10': [2302, 2377, 2509, 2526, 2689, 2728], 'NaCl,': [2304, 2485, 2727], 'EDTA,': [2307, 2504], '2': [2308, 2357, 2804, 3240, 3593, 3805, 3956], 'mmdithiothreitol,': [2309, 2678], 'phenylmethylsulfonyl': [2312, 2507], 'fluoride,': [2313, 2508], '2%': [2314], 'aprotinin,': [2315], 'μg/ml': [2317, 2510, 2805, 3241, 3594, 3806, 3957], 'leupeptin,': [2318], '50': [2319, 2362, 2486, 2667, 2808], 'NaF,': [2321, 2501], '100': [2322, 2677], 'μm': [2323, 2363, 2809, 3782, 3816, 3830], 'Na3VO4)': [2324], 'sonicated': [2326], 'three': [2327, 2658, 3120, 3180], 'times': [2328, 2659], '30': [2330, 2515], 's.': [2331], 'standard': [2333], 'contained': [2337], 'aliquot': [2339], 'lysate': [2344], 'mixed': [2345], '125': [2347], 'mmbis-Tris-HCl,': [2348], '6.5,': [2350], '0.5': [2351], 'μCi': [2352], 'phospho[methyl-14C]choline,': [2354], 'mmphosphocholine,': [2356], 'CTP,': [2359], '20': [2360], 'mmMgCl2,': [2361], 'PtdCho/18:1': [2364], '(1:1)': [2365], 'final': [2368], 'volume': [2369], '40': [2371], 'μl.': [2372], 'incubations': [2374], 'min': [2378, 2516, 2527], '37': [2380], '°C': [2381, 2597, 2644], 'stopped': [2384, 2850], 'placing': [2386], 'samples': [2388, 2591], 'adding': [2392], '5': [2393, 3774, 3960], 'μl': [2394, 2478, 2668], '0.5m': [2396], 'EDTA.': [2397], 'CDP-[14C]choline': [2398], 'determined': [2401, 2441, 2537, 3560, 3793], 'thin': [2403], 'layer': [2404], '(49Luche': [2406], 'Arch.': [2412], '301:': [2416], '114-118Crossref': [2417], 'CCT-specific': [2423, 3187, 3259, 3277, 3290, 3302, 3394, 3417, 5326], 'calculated': [2426], 'series': [2429, 3531], 'assays': [2431], 'linear': [2434], 'time': [2436, 3223, 3785], 'protein.': [2438], 'Protein': [2439, 2601], 'according': [2442], 'method': [2445], 'Bradford': [2447, 2540], '(50Bradford': [2448], 'Anal.': [2450], '1976;': [2452], '72:': [2453], '248-254Crossref': [2454], '(222135)': [2457], 'γ-globulin': [2461], 'standard.': [2464], 'Cells': [2465, 2789], 'cold': [2469], 'saline,': [2471, 2833], 'lysed': [2472], 'plate': [2475, 2800], '400': [2477], 'radioimmune': [2480, 2607, 2617, 2661], '(0.15': [2483], 'm': [2484], 'Tris,': [2488, 2681], '8.0,': [2490, 2732], '1%': [2491, 2715], 'Nonidet': [2492], 'P-40,': [2493], '0.5%': [2494], 'deoxycholic': [2495], 'acid,': [2496], '0.1%': [2497, 2733], 'SDS,': [2498, 2674], '33': [2499], '3.3': [2502], 'leupeptin)': [2511], 'occasional': [2518], 'rocking.': [2519], 'lysates': [2522], 'centrifuged': [2524, 2692], '230': [2529], '×': [2530, 2795], 'g,': [2531], 'concentration': [2535, 4597], 'method.': [2541], 'Equivalent': [2542], 'amounts': [2543], 'immunoprecipitated': [2547], '15': [2549], 'μg': [2550], 'affinity-purified': [2552], 'anti-peptide': [2553], 'antibody.': [2554, 2788], 'antibody': [2556, 2741, 2770], 'raised': [2558], 'N-terminal': [2561], 'Watkins': [2566], 'Kent': [2568, 2571], '(51Watkins': [2569], '5686-5692Abstract': [2578], 'generate': [2586], 'immunoprecipitating': [2587], 'antisera.': [2589], 'incubated': [2593, 2638, 2766], 'overnight': [2594], '4': [2596, 2643, 2655, 2811, 2818, 3581, 3781, 3815, 3829, 3970], 'rotator.': [2600], 'A-Sepharose': [2602, 2625], 'beads': [2603, 2626, 2649], 'prewashed': [2605], '10%': [2613, 2675, 2701], '(v/v)': [2614], 'above.': [2621], 'suspended': [2623], '(100': [2627], 'μl)': [2628], 'each': [2632, 2884, 5576], 'sample': [2633, 2671, 3682], 'mixture': [2636], 'rotator': [2641], 'h.': [2647, 2776], 'collected': [2651], 'centrifugation': [2653], '°C,': [2656], 'buffer,': [2663], 'SDS': [2670], '(2%': [2673], 'glycerol,': [2676], '60': [2679], '6.8,': [2683], '0.001%': [2684], 'bromphenol': [2685], 'blue),': [2686], 'boiled': [2687], 'min,': [2690], 'room': [2694], 'temperature.': [2695], 'supernatants': [2697], 'loaded': [2699], 'SDS-polyacrylamide': [2702], 'gel': [2703], 'electrophoresis': [2704], 'electroblotted': [2706], 'onto': [2707], 'nitrocellulose': [2708], 'membranes.': [2709], 'blocked': [2713], 'dry': [2716], 'milk': [2717], 'h,': [2720, 3981], 'Tris-buffered': [2723, 2763], '(150': [2725], 'Tris-HCl': [2730], 'Triton': [2734], 'X-100),': [2735], 'exposed': [2737, 2918, 3485, 3813, 3968], 'anti-recombinant': [2739], '(52Jackowski': [2742, 3354], '269:': [2748, 3360], '3858-3867Abstract': [2749, 3361], 'diluted': [2756], '1/200.': [2757], 'blots': [2759], 'secondary': [2769, 2787], 'conjugated': [2771], 'peroxidase': [2773], 'An': [2777], 'Amersham': [2778], 'localize': [2785], 'densities': [2793], '2.5': [2794], '105': [2796], 'cells/10-cm': [2797], 'treated': [2802, 3647, 3663, 3770, 3803, 3825, 3954], 'doxycycline': [2806, 3128, 3215, 3218, 3242, 3431, 3542, 3595, 3611, 3649, 3707, 3772, 3807, 3827, 3958, 4181], 'and/or': [2807], 'prior': [2813, 3776], 'μmET-18-OCH3.': [2819, 3971], 'At': [2820], '24-,': [2821], '48-,': [2822], '72-h': [2824], 'intervals,': [2825], 'washes': [2836], 'collected.': [2838], 'Adherent': [2839], 'removed': [2842], 'trypsinization': [2844], 'min.': [2847], 'Trypsinization': [2848], 'complete': [2857, 2874], 'trypsinized': [2860], 'combined': [2863], 'washes,': [2866], 'centrifuged,': [2867], '1–2': [2871], 'One': [2876, 3162], 'drop': [2877], 'trypan': [2879, 3990], 'blue': [2880], 'sample,': [2885], 'numbers': [2888], 'total': [2890, 3672], 'viable': [2892, 3677, 3702, 3789, 3881, 3996], 'counted.': [2895], 'study': [2902], 'reasons.': [2905], 'First,': [2906, 3558], 'rapidly': [2914, 3511], 'undergo': [2915, 3482], 'Second,': [2940], 'available': [2946], 'stably': [2948], 'expresses': [2949], 'transcriptional': [2951, 2967, 3014], 'consisting': [2953], 'binding': [2957, 3020], 'domain': [2958, 2969], 'Tet': [2962, 3024], 'repressor': [2963, 3015], 'fused': [2964], 'activation': [2968, 5198], 'VP16': [2971], '(53Gossen': [2972], 'Freundieb': [2974], 'Bender': [2976], 'Müller': [2978], 'Hillen': [2980], 'Bujard': [2982], 'Science.': [2984], '268:': [2986], '1766-1769Crossref': [2987], '(2075)': [2990], 'affords': [2996], 'tight': [2997], 'over': [2999, 3794], 'introduced': [3003], 'genes': [3004, 5149], 'elements': [3010], 'Escherichia': [3017], 'coli.': [3018], 'Doxycycline': [3019], 'repressor-VP16': [3025], 'fusion': [3026], 'potently': [3028], 'activates': [3029, 5124], 'gene.': [3034], 'approach': [3036], 'allows': [3037], 'clone': [3040, 3163, 3255, 3314, 3401], 'be': [3042, 4463, 4977, 5194, 5229, 5313], 'determine': [3045], 'sensitivity': [3047, 3452, 5352], 'overexpression,': [3060], 'thus': [3061, 4090], 'avoiding': [3062], 'inherent': [3064], 'problems': [3065], 'associated': [3066], 'variation.': [3069], 'co-transfecting': [3078], 'vectors.': [3087], 'Individual': [3088], 'levels': [3098, 3231, 3307, 5570], 'extracts': [3104, 3253, 3272, 3397, 3408], 'Of': [3114], 'examined,': [3119], 'showed': [3121, 3227], 'grown': [3126, 3385], 'possessed': [3130, 3184], 'characteristics': [3132], '(see': [3137], 'below).': [3138], 'Clones': [3139], 'isolated': [3142], 'cotransfected': [3151], 'empty': [3154, 3201], 'plus': [3157, 3650, 3708, 3828, 4180], 'selectable': [3159], '(CCT.00)': [3164, 3402, 3578, 3952], 'randomly': [3166], 'serve': [3169], 'experimental': [3172], 'control.': [3173], 'candidates': [3181, 5227], 'parental': [3195, 3411, 3428], 'controls,': [3203], 'strongly': [3209, 4614], '(Fig.1).': [3216], 'dose-response': [3219], 'experiment': [3220, 3755], 'course': [3224], 'highest': [3230], 'occurred': [3235], '(not': [3246, 3415, 3432], 'shown).': [3247, 3416, 3433], 'Under': [3248], 'these': [3249, 4118, 4904, 5012], 'conditions,': [3251], 'cell-free': [3252], 'exhibited': [3257, 3515], 'higher': [3264], 'than': [3265, 3718, 4739], 'uninduced': [3270, 3281], '(Fig.': [3273, 3297, 3316, 3327, 3596, 3612, 3634, 3666, 3683, 3711, 3723], 'B).': [3275, 3299, 3728], 'clone,': [3295], 'CCT.00': [3296], 'correlated': [3304], 'doxycycline-induced': [3313, 3680], 'A).': [3318], 'bands': [3323], 'immunoblots': [3326], 'B)': [3329], 'unexpected': [3332], 'since': [3333], 'type': [3335], 'banding': [3337], 'pattern': [3338, 4489], 'observed': [3340, 4162], 'phosphorylated': [3349], 'isoforms': [3350], 'did': [3369, 3741, 3832, 3858, 3888, 3929, 4024, 4174], 'observe': [3371], 'any': [3372], 'differences': [3373, 5305], 'morphology': [3377], 'rate': [3380], 'treatment': [3423, 3763], 'comparing': [3450], 'Previous': [3475], 'had': [3477, 4103], 'populations': [3510], 'lost': [3512], 'viability': [3513, 3693, 3844], 'condensed': [3516], 'nuclei': [3517], 'morphological': [3520, 3641], 'features': [3521], 'whether': [3547, 3561, 5301], 'would': [3553], 'prevent': [3554], 'death.': [3557], 'altered': [3564], 'response': [3566], 'ET-18-OCH3-triggered': [3571], 'exposing': [3574], 'μmET-18-OCH3': [3582], '2).': [3597, 3667], 'killed': [3600], '2,': [3613, 3635, 3684, 3712, 3724], 'panels': [3614, 3636, 3725], 'andE).': [3616], 'sharp': [3618], 'contrast,': [3619, 3822], 'protected': [3623], 'ET-18-OCH3-dependent': [3625], 'D': [3637], 'andF).': [3638], 'gross': [3640], 'appearance': [3642, 3657], 'distinguishable': [3654], 'percentage': [3669], 'present': [3674], 'ET-18-OCH3-treated': [3681, 3709], 'panel': [3685, 3713], 'F)': [3686, 3714], 'percent': [3692], 'untreated': [3696, 3801, 3966], 'controls.': [3697], 'number': [3700, 3791, 3994, 4822], 'recovered': [3704], 'group': [3710, 5544], 'consistently': [3716], 'lower': [3717], 'groups': [3722], 'result': [3730, 5289], 'that,': [3732], 'while': [3733], 'apoptosis,': [3737], 'where': [3756], 'measured': [3760], '(Fig.3).': [3764], 'Exponentially': [3765], 'growing': [3766], '0,': [3786], '3-day': [3796], 'period.': [3797], 'Control': [3798], 'left': [3800, 3965], 'exponential': [3809], 'growth,': [3810], 'alone': [3818, 4129], 'died': [3819], 'rapidly.': [3820], 'proliferate.': [3834, 4176], 'Despite': [3835], 'inability': [3837], 'divide,': [3842], 'population': [3847, 3873], 'remained': [3848, 4171], 'high': [3850], 'groups,': [3854], 'dead': [3856], 'accumulate': [3860, 5364], 'culture.': [3863], 'indicated': [3865], 'rescued': [3869, 4142], 'entire': [3871], 'relatively': [3879, 5243], 'constant': [3880], 'count': [3883], 'displayed': [3884], 'Fig.': [3886], '3': [3887], 'arise': [3890], 'accompanied': [3895], 'degree': [3898], 'population.': [3904], 'show': [3907], 'overrides': [3911], 'but': [3917, 4023, 4173, 5336], 'cannot': [3918], 'overcome': [3919], 'drug.Figure': [3925], '3Elevated': [3926], 'override': [3931], 'effects': [3934, 4094, 4468, 4700, 4748, 5019, 5504], 'harboring': [3941], '(CCT.12)': [3946], 'then': [3964], '24,': [3977], '48,': [3978], '72': [3980], 'after': [3982], 'stained': [3988], 'blue,': [3991], 'counted': [3999], 'under': [4002], '“Experimental': [4003], 'Procedures.”View': [4004], 'Large': [4005], 'Image': [4006], 'Figure': [4007], 'ViewerDownload': [4008], 'Hi-res': [4009], 'image': [4010], 'Download': [4011], '(PPT)': [4012], 'previous': [4014, 4473, 4916], 'permit': [4026], 'interpreted': [4067], 'mean': [4069], 'source': [4074], 'acylation': [4080], 'reversed': [4091], 'results.': [4119], 'Comparing': [4120], 'effectiveness': [4122], 'combination': [4132], '(Fig.4)': [4136], 'point.': [4139], 'regardless': [4146], 'extent': [4154, 5368], 'doxycycline-treated': [4164], 'cells.': [4165, 4605], 'cases,': [4168], 'viable,': [4172], 'Importantly,': [4177], 'additive,': [4188], 'suggesting': [4189, 4455], 'treatments': [4192, 4769], 'targeted': [4193], 'process.': [4196], 'supplying': [4209], 'circumvents': [4217, 4636], 'step.': [4220], 'universal': [4255], '(27Modolell': [4261], 'may': [4462, 5014, 5193, 5344, 5575], 'identified': [4475], 'based': [4486], 'accumulation': [4491, 5560], 'choline-derived': [4493], 'intermediatesin': [4495], 'vivo.': [4496], 'able': [4500], 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