Publication Information

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301, 328, 358, 392, 415, 433, 536, 668, 678, 703, 920, 1056, 1191, 1278, 1349, 1380, 1641, 3497, 3564, 3580, 3914, 4056], 'caused': [3, 242], 'by': [4, 179, 243, 418, 542, 944, 1715, 1908, 1990, 2156, 2167, 2202, 2222, 2249, 2478, 2728, 2746, 2843, 2874, 2895, 2914, 3051, 3078, 3210, 3792, 3798, 3820], 'a': [5, 138, 220, 244, 377, 459, 636, 648, 719, 921, 1066, 1290, 1352, 1381, 1389, 1417, 1626, 1643, 1933, 1991, 2025, 2206, 2403, 2508, 2667, 2675, 2918, 3280, 3466, 3503], 'polyglutamine': [6, 245, 637, 670], 'expansion': [7, 246, 638, 671], 'in': [8, 46, 74, 156, 197, 208, 247, 285, 313, 395, 436, 447, 635, 639, 686, 701, 721, 766, 774, 942, 1065, 1159, 1239, 1509, 1565, 1630, 1827, 1832, 1878, 1902, 2050, 2297, 2361, 2391, 2495, 2507, 2625, 2737, 2785, 2793, 2817, 2879, 3020, 3037, 3070, 3087, 3124, 3157, 3223, 3239, 3247, 3310, 3342, 3371, 3407, 3450, 3473, 3499, 3531, 3555, 3570, 3614, 3642, 3668, 3676, 3737, 3870, 3890, 3917, 3957, 3980, 3987, 4032, 4079, 4093, 4101, 4131], 'the': [9, 36, 57, 164, 180, 209, 248, 275, 296, 403, 419, 448, 640, 644, 669, 673, 687, 690, 696, 709, 767, 928, 938, 1111, 1153, 1166, 1178, 1184, 1235, 1425, 1561, 1570, 1621, 1674, 1700, 1716, 1828, 1833, 1842, 1846, 1868, 1871, 1879, 1885, 1895, 1925, 2000, 2032, 2051, 2169, 2234, 2245, 2256, 2300, 2303, 2424, 2479, 2525, 2609, 2635, 2730, 2748, 2797, 2819, 2822, 2870, 2876, 2883, 2892, 3014, 3021, 3191, 3195, 3240, 3253, 3284, 3290, 3304, 3323, 3330, 3334, 3344, 3353, 3393, 3451, 3461, 3474, 3523, 3541, 3547, 3626, 3653, 3666, 3688, 3700, 3730, 3754, 3765, 3807, 3848, 3882, 3932, 3967, 4011, 4041, 4084, 4102, 4116], 'huntingtin': [10, 249, 645], 'protein': [11, 59, 192, 250, 298, 431, 654, 1231, 1383, 1647, 1654, 1899, 3005, 3406, 3471], '(Htt)': [12, 251, 646], 'and': [13, 35, 93, 226, 236, 252, 274, 332, 465, 475, 552, 651, 689, 733, 769, 880, 911, 916, 948, 1103, 1105, 1165, 1229, 1336, 1345, 1430, 1437, 1560, 1659, 1686, 1705, 1811, 1883, 1924, 1930, 1946, 1951, 1985, 2021, 2048, 2053, 2059, 2078, 2081, 2147, 2188, 2217, 2225, 2231, 2274, 2281, 2305, 2320, 2349, 2353, 2372, 2383, 2444, 2460, 2504, 2524, 2566, 2606, 2685, 2692, 2790, 2852, 2960, 2987, 3041, 3066, 3075, 3102, 3140, 3170, 3175, 3198, 3242, 3308, 3386, 3404, 3418, 3421, 3444, 3453, 3476, 3551, 3567, 3597, 3624, 3651, 3662, 3670, 3686, 3718, 3726, 3744, 3748, 3782, 3786, 3795, 3837, 3872, 3888, 3897, 3959, 3982, 3995, 4009, 4047, 4052, 4075, 4105], 'associated': [15, 150, 254, 389, 1279], 'with': [16, 56, 91, 125, 151, 255, 295, 330, 364, 390, 711, 1196, 1234, 1280, 1342, 1416, 1683, 1784, 1910, 1922, 2015, 2164, 2178, 2186, 2367, 2399, 2428, 2520, 2529, 2542, 2546, 2577, 2601, 2629, 2674, 2687, 2733, 2750, 2855, 3013, 3045, 3063, 3084, 3105, 3137, 3143, 3168, 3172, 3178, 3190, 3228, 3270, 3295, 3340, 3378, 3465, 3489, 3529, 3553, 3619, 3631, 3647, 3658, 3681, 3694, 3743, 3777, 3783, 3830, 3834, 3842, 3938, 3991, 4049, 4068, 4097], 'excitotoxic': [17, 256, 770, 939, 1062], 'death': [18, 257, 559, 685, 1064], 'of': [19, 38, 102, 173, 182, 258, 277, 341, 412, 421, 534, 544, 549, 629, 643, 672, 692, 699, 708, 924, 1071, 1113, 1155, 1168, 1181, 1186, 1283, 1295, 1351, 1354, 1392, 1419, 1427, 1515, 1518, 1676, 1681, 1870, 1881, 1884, 1894, 1935, 2055, 2227, 2237, 2242, 2244, 2290, 2481, 2538, 2573, 2608, 2690, 2796, 2824, 2829, 2847, 2858, 2882, 2925, 2974, 2980, 3001, 3185, 3194, 3207, 3244, 3286, 3293, 3306, 3314, 3325, 3333, 3337, 3349, 3357, 3402, 3410, 3431, 3455, 3463, 3478, 3482, 3511, 3519, 3526, 3543, 3549, 3574, 3582, 3595, 3716, 3735, 3758, 3764, 3767, 3771, 3775, 3811, 3817, 3825, 3852, 3885, 3893, 3928, 3935, 4015, 4044, 4058, 4072, 4086, 4107], 'striatal': [20, 106, 126, 198, 259, 345, 365, 437, 1286, 2378, 2930, 2969, 3874, 3899, 3947, 3961, 3984], 'neurons.': [21, 260], 'Group': [22, 261, 1139, 1644], 'I': [23, 262, 1140, 1645], 'metabotropic': [24, 263, 503, 881, 1141, 1337], 'glutamate': [25, 233, 264, 472, 504, 873, 909, 931, 1142, 1331], 'receptors': [26, 265, 871, 900, 950, 1143, 1149, 1338], '(mGluRs)': [27, 266], 'that': [28, 53, 61, 87, 94, 137, 202, 267, 292, 300, 326, 333, 376, 441, 677, 716, 905, 930, 1384, 1421, 1572, 1623, 1639, 1648, 1665, 1694, 1977, 3375], 'are': [29, 268, 874, 912, 1146, 1511, 3429, 3509, 3665, 3976, 4001], 'coupled': [30, 269], 'to': [31, 65, 80, 98, 148, 166, 168, 211, 270, 304, 319, 337, 387, 405, 407, 450, 558, 680, 761, 926, 1059, 1152, 1175, 1177, 1424, 1569, 1581, 1620, 1650, 1656, 1853, 1981, 2031, 2072, 2285, 2432, 2453, 2511, 3023, 3272, 3448, 3492, 3907, 3989, 4095], 'inositol': [32, 116, 271, 355, 500, 1161, 2887, 3218, 3366, 3609, 3639, 3865, 3954, 3977, 4088, 4128], '1,4,5-triphosphate': [33, 272, 1162], 'formation': [34, 118, 273, 357, 2911, 3220, 3368, 3611, 3641, 3867, 3956, 3979, 4090, 4130], 'release': [37, 276, 1167, 1277], 'intracellular': [39, 278, 1160, 1169], 'Ca2+': [40, 279, 1170, 1242, 1276], 'stores': [41, 280, 1171], 'play': [42, 281, 762], 'an': [43, 227, 282, 466, 537, 630, 763, 1690, 2448, 2805], 'important': [44, 283, 764], 'role': [45, 284, 720, 765], 'regulating': [47, 286, 722], 'neuronal': [48, 287, 684, 726, 771, 1633, 2621], 'function.': [49, 288], 'We': [50, 85, 289, 324], 'show': [51, 136, 290, 375, 1638, 1664], 'here': [52, 291], 'mGluRs': [54, 293, 1687], 'interact': [55, 294], 'Htt-binding': [58, 297], 'optineurin': [60, 78, 143, 161, 170, 203, 299, 317, 382, 400, 409, 442], 'also': [63, 120, 302, 359, 1642, 2996], 'linked': [64, 303, 1151, 1341], 'normal': [66, 305, 1519], 'pressure': [67, 306], 'open': [68, 307], 'angled': [69, 308], 'glaucoma': [70, 152, 309, 391, 1521, 1566], 'and,': [71, 310], 'when': [72, 123, 311, 362], 'expressed': [73, 312, 650], 'HEK': [75, 314, 3008, 3224, 3248, 3298, 3315, 3372, 3422, 3483, 3532, 3556, 3575, 3615, 3643, 3677, 3738, 3826, 3920, 4080], '293': [76, 315, 2351, 3009, 3225, 3249, 3299, 3316, 3373, 3423, 3484, 3533, 3557, 3576, 3616, 3644, 3678, 3739, 3827, 3921, 4081], 'cells,': [77, 316, 2299], 'functions': [79, 97, 318, 336, 1649], 'antagonize': [81, 320], 'agonist-stimulated': [82, 321], 'mGluR1a': [83, 92, 103, 174, 322, 331, 342, 413, 2266, 2304, 3208, 3237, 3274, 3449, 3467, 3601, 3674, 3722, 3736], 'signaling.': [84, 104, 323, 343, 1661, 1678, 3275, 3602], 'find': [86, 325], 'Htt': [88, 96, 158, 327, 335, 397, 674, 700, 713, 717, 1228, 1343, 1668, 1672, 1685, 2144, 2149, 2170, 2385, 3446, 3599, 3720, 4034], 'co-precipitated': [90, 329], 'mutant': [95, 112, 157, 183, 334, 351, 396, 422, 1227, 1667, 2145, 2384, 3445, 3598, 3719, 4033, 4077], 'facilitate': [99, 338], 'optineurin-mediated': [100, 339], 'attenuation': [101, 172, 340, 411], 'In': [105, 133, 344, 372, 1053, 1225], 'cell': [107, 346, 772, 1063, 1634, 2379, 2513, 2884, 2893, 2970, 3003, 3049, 3317, 3424, 3485, 3723, 3727, 3732, 3818, 3875, 3985], 'lines': [108, 347, 2380, 3986], 'derived': [109, 128, 348, 367, 1288], 'from': [110, 129, 349, 368, 933, 1289, 1727, 1734, 1748, 1759, 1765, 1774, 1789, 1795, 1818, 1838, 1900, 2465, 2468, 2891, 2928, 2968, 3007, 3048, 3201, 3297, 3895, 3945], 'HttQ111/Q111': [111, 350], 'knock-in': [113, 131, 352, 370], 'mice': [114, 353, 1190], 'mGluR5-stimulated': [115, 354, 1241], 'phosphate': [117, 356, 2406, 2888, 2910, 3219, 3367, 3610, 3640, 3866, 3955, 3978, 4089, 4129], 'severely': [121, 360], 'impaired': [122, 155, 361, 394], 'compared': [124, 363, 3841], 'cells': [127, 366, 702, 1710, 2352, 2355, 2425, 2526, 2731, 2749, 2779, 2813, 2871, 2931, 3010, 3034, 3226, 3374, 3617, 3645, 3679, 3740, 3768, 3776, 3828, 3900, 3905, 3922, 4082], 'HttQ7/Q7': [130, 369], 'mice.': [132, 371], 'addition,': [134, 373, 1226], 'we': [135, 200, 374, 439, 1637, 1663], 'missense': [139, 378], 'single': [140, 379], 'nucleotide': [141, 380, 4027], 'polymorphism': [142, 381, 4028], 'H486R': [144, 162, 383, 401], 'variant': [145, 384, 4030], 'previously': [146, 385, 2087, 2697], 'identified': [147, 386, 1356, 1387], 'be': [149, 388, 1340], 'selectively': [154, 393], 'binding.': [159, 398, 4035], 'Although': [160, 399, 695], 'retains': [163, 402], 'capacity': [165, 404], 'bind': [167, 406], 'mGluR1a,': [169, 408], 'H486R-dependent': [171, 410], 'signaling': [175, 235, 414, 474, 1243, 1332, 3209, 3675], 'not': [177, 416, 704, 1670, 2617, 3915], 'enhanced': [178, 417], 'expression': [181, 193, 420, 432, 2289, 3246, 3288, 3305, 3401, 3496, 3545, 3569, 3725, 3734, 3884, 4078], 'Htt.': [184, 423, 535], 'Because': [185, 424], 'G': [186, 425, 489, 493, 1147, 1653], 'protein-coupled': [187, 426, 490, 494, 1148], 'receptor': [188, 234, 427, 473, 495, 1107, 1237, 2310], 'kinase': [189, 428], '2': [190, 429, 2547, 2579], '(GRK2)': [191, 430], 'relatively': [195, 434], 'low': [196, 435], 'tissue,': [199, 438], 'propose': [201, 440], 'may': [204, 443, 936, 1339, 1575, 1688, 1695], 'substitute': [205, 444], 'for': [206, 223, 445, 462, 872, 1513, 1876, 1890, 1965, 1987, 2255, 2434, 2447, 2498, 2782, 2804, 2831, 3216, 3257, 3364, 3397, 3607, 3637, 3704, 3952, 3971, 4120], 'GRK2': [207, 446, 2083, 3385, 3403], 'striatum': [210, 449, 691, 3416], 'mediate': [212, 451, 906], 'mGluR': [213, 224, 452, 463, 1652, 1677], 'desensitization.': [214, 453], 'Taken': [215, 454], 'together,': [216, 455], 'these': [217, 456, 3500], 'studies': [218, 457], 'identify': [219, 458], 'novel': [221, 460], 'mechanism': [222, 461], 'desensitization': [225, 464], 'additional': [228, 467, 1691, 2449, 2806], 'biochemical': [229, 468, 1692, 1814], 'link': [230, 469, 1422, 1556, 1693], 'between': [231, 470, 1557, 1702], 'altered': [232, 471, 1240], 'disease.': [238, 477], '(HD)': [480], '4The': [481], 'abbreviations': [482], 'used': [483, 1831], 'are:': [484], 'HD,': [485], 'disease;': [487], 'GPCR,': [488], 'receptor;': [491, 505], 'GRK,': [492], 'kinase;': [496], 'Htt,': [497], 'huntingtin;': [498], 'IP3,': [499], '1,4,5-triphosphate;': [501], 'mGluR,': [502], 'OPTN,': [506, 1558, 3383, 3623, 3650, 3684, 3746, 3784, 3835, 3886, 3909], 'optineurin;': [507], 'AMPA,': [508], 'α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic': [509], 'acid;': [510], 'NMDA,': [511], 'N-methyl-d-aspartate;': [512], 'HA,': [513], 'hemagglutinin;': [514], 'MTT,': [515], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [516], 'bromide;': [517], 'GST,': [518], 'glutathione': [519, 2292], 'S-transferase;': [520], 'HBSS,': [521, 2614], 'HEPES-buffered': [522, 2602], 'saline': [523, 2603, 3174], 'solution;': [524], 'PBS,': [525], 'phosphate-buffered': [526], 'saline;': [527], 'C-tail,': [528], 'carboxyl-terminal': [529, 2267, 2311], 'tail;': [530], 'N-Htt,': [531], 'amino-terminal': [532, 641, 2079, 2143, 2171, 2291], 'domain': [533, 1849, 1897], 'autosomal-dominant': [538], 'neurodegenerative': [539], 'disorder': [540], 'manifested': [541], 'symptoms': [543], 'involuntary': [545], 'body': [546, 923], 'movement,': [547], 'loss': [548, 773, 1583], 'cognitive': [550], 'function,': [551], 'psychiatric': [553], 'disturbance,': [554], 'which': [555, 712, 1145, 2615], 'inevitably': [556], 'leads': [557], '(1Cell.': [560, 655], '1993;': [561, 656], '72:': [562, 657], '971-983Abstract': [563, 658], 'Full': [564, 581, 583, 614, 616, 659, 746, 748, 783, 842, 844, 958, 1022, 1024, 1093, 1095, 1264, 1266, 1369, 1371, 1473, 1475, 2106, 2108, 2132, 2134, 2712, 2714], 'Text': [565, 582, 584, 615, 617, 660, 747, 749, 784, 843, 845, 959, 1023, 1025, 1094, 1096, 1265, 1267, 1370, 1372, 1474, 1476, 2107, 2109, 2133, 2135, 2713, 2715], 'PDF': [566, 585, 618, 661, 750, 785, 846, 960, 1026, 1097, 1268, 1373, 1477, 2110, 2136, 2716], 'PubMed': [567, 586, 599, 619, 662, 751, 786, 804, 822, 847, 865, 893, 961, 979, 997, 1027, 1048, 1098, 1132, 1220, 1269, 1325, 1374, 1409, 1459, 1478, 1503, 1550, 1612, 2111, 2137, 2342, 2657, 2717], 'Scopus': [568, 587, 600, 620, 663, 752, 787, 823, 848, 866, 894, 962, 998, 1028, 1049, 1099, 1133, 1221, 1270, 1326, 1375, 1410, 1460, 1479, 1504, 1551, 1613, 2112, 2138, 2343, 2658, 2718], '(7281)': [569, 664], 'Google': [570, 589, 602, 622, 665, 754, 789, 805, 825, 850, 868, 896, 964, 980, 1000, 1030, 1051, 1101, 1135, 1223, 1272, 1328, 1377, 1412, 1462, 1481, 1506, 1553, 1615, 2114, 2140, 2345, 2418, 2660, 2720], 'Scholar,': [571, 590, 603, 790, 806, 826, 851, 965, 981, 1001, 1031, 1463, 1482, 2115], '2Li': [572], 'S.H.': [573], 'Li': [574], 'X.J.': [575], 'Trends': [576, 608, 740, 778, 837, 953, 1363], 'Genet.': [577, 1455], '2004;': [578, 1217, 2103, 2415, 2654, 2709], '20:': [579], '146-154Abstract': [580], '(449)': [588], '3Young': [591], 'A.B.': [592], 'J.': [593, 799, 974, 1041, 1125, 1200, 1400, 1446, 1448, 1467, 2100, 2126, 2652, 2706], 'Clin.': [594], 'Investig.': [595], '2003;': [596, 611, 743, 1261, 1366], '111:': [597], '299-302Crossref': [598], '(92)': [601, 2139], '4Harjes': [604], 'P.': [605, 737, 853, 1013, 1084, 1360], 'Wanker': [606, 738, 1361], 'E.E.': [607, 739, 1362], 'Biochem.': [609, 741, 1364], 'Sci.': [610, 742, 1318, 1365], '28:': [612, 744, 1367, 1501], '425-433Abstract': [613, 745, 1368], '(433)': [621, 753, 1376], 'Scholar).': [623, 666, 755, 869, 897, 1052, 1136, 1224, 1273, 1329, 1378, 1413, 1507, 1554, 1616, 2141, 2346, 2419, 2661, 2721], 'The': [624, 870, 898, 1555, 1679, 1778, 1855, 1958, 2180, 2190, 2239, 2253, 2264, 2376, 2778, 2812, 2837, 2865, 3033, 3057, 3080, 3131, 3389, 3427, 3578, 3660, 3696, 3751, 3804, 3823, 3845, 3963, 4054, 4112], 'HD': [625, 693, 775, 943, 1072, 1114, 1188, 1296], 'gene': [626, 1108, 1863], 'mutation': [627], 'consists': [628], 'unstable': [631], 'CAG': [632], 'repeat': [633], 'resulting': [634], 'region': [642], 'protein,': [647], 'ubiquitously': [649], 'evolutionary': [652], 'conserved': [653], 'It': [667], 'amino': [675], 'terminus': [676], 'proposed': [679, 1174], 'cause': [681], 'progressive': [682], 'widespread': [683], 'neocortex': [688], 'patients.': [694], 'precise': [697], 'function': [698, 1344], 'completely': [705], 'understood,': [706], 'analysis': [707, 3199, 3332], 'proteins': [710, 1358, 1420, 2296, 2927, 3067], 'interacts': [714, 1415], 'suggests': [715], 'plays': [718], 'clathrin-coated': [723], 'vesicle-mediated': [724], 'endocytosis,': [725], 'survival,': [727], 'vesicle': [728], 'transport,': [729], 'morphogenesis,': [730], 'calcium': [731, 2405], 'homeostasis,': [732], 'transcriptional': [734], 'regulation': [735, 1426], '(4Harjes': [736, 1359], 'Glutamate-mediated': [756], 'neurotoxicity': [757, 1704], 'has': [758, 1567, 1618], 'been': [759, 1173], 'postulated': [760], 'pathogenesis': [768], '(5DiFiglia': [776, 951], 'M.': [777, 952, 1306, 1533, 1545, 1595, 1607, 2639], 'Neurosci.': [779, 800, 838, 954, 975, 2653], '1990;': [780, 955], '13:': [781, 956], '286-289Abstract': [782, 957], '(421)': [788, 963], '6Beal': [791, 966], 'M.F.': [792, 814, 816, 967, 989, 991], 'Ferrante': [793, 968], 'R.J.': [794, 969, 1484], 'Swartz': [795, 970], 'K.J.': [796, 971], 'Kowall': [797, 809, 972, 984], 'N.W.': [798, 810, 973, 985], '1991;': [801, 976], '11:': [802, 977], '1649-1659Crossref': [803, 978], '7Storey': [807, 982], 'E.': [808, 983, 1210, 1300, 1535, 1597], 'Finn': [811, 986], 'S.F.': [812, 987], 'Mazurek': [813, 988], 'Beal': [815, 990], 'Ann.': [817, 992], 'Neurol.': [818, 861, 993], '1992;': [819, 994], '32:': [820, 995], '526-534Crossref': [821, 996], '(55)': [824, 999], '8Nicoletti': [827], 'F.': [828], 'Bruno': [829], 'V.': [830, 1212, 1302], 'Copani': [831], 'A.': [832, 857, 1202, 1208, 1251, 1321, 1525, 1587], 'Casabona': [833], 'G.': [834, 859, 1529, 1591], 'Knopfel': [835], 'T.': [836, 1523, 1537, 1585, 1599], '1996;': [839], '19:': [840, 2340], '267-271Abstract': [841], '(406)': [849], '9Calabresi': [852], 'Centonze': [854], 'D.': [855, 1541, 1603], 'Pisani': [856], 'Bernardi': [858], 'Exp.': [860], '1999;': [862, 2339], '158:': [863], '97-108Crossref': [864], '(98)': [867], 'classified': [875], 'into': [876, 914, 2173, 2195, 2233, 2276, 2316, 2438, 2869], 'two': [877, 1861, 2599, 3690], 'types:': [878], 'ionotropic': [879, 899, 1335], '(10Conn': [882], 'P.J.': [883], 'Pin': [884], 'J.-P.': [885], 'Annu.': [886], 'Rev.': [887], 'Pharmacol.': [888], 'Toxicol.': [889], '1997;': [890], '37:': [891], '205-237Crossref': [892], '(2748)': [895], 'comprise': [901], 'cation-specific': [902], 'ion': [903], 'channels': [904], 'fast': [907], 'excitatory': [908], 'responses': [910, 3215, 3363, 3606, 3636], 'subdivided': [913], 'AMPA/kainate': [915, 949], 'NMDA': [917, 947, 1060], 'receptors.': [918], 'There': [919], 'considerable': [922], 'evidence': [925, 3770], 'support': [927], 'idea': [929], 'released': [932], 'cortical': [934], 'afferents': [935], 'regulate': [937], 'damage': [940], 'observed': [941, 1564], 'activating': [945], 'both': [946, 1334, 1684], '11Zeron': [1002], 'M.M.': [1003, 1074], 'Hansson': [1004, 1075], 'O.': [1005, 1076], 'Chen': [1006, 1077, 1447], 'N.': [1007, 1078], 'Wellington': [1008, 1079, 1254], 'C.L.': [1009, 1080, 1255], 'Leavitt': [1010, 1081], 'B.R.': [1011, 1082], 'Brundin': [1012, 1083], 'Hayden': [1014, 1085, 1256, 1311], 'M.R.': [1015, 1086, 1257, 1312], 'Raymond': [1016, 1087], 'L.A.': [1017, 1088], 'Neuron.': [1018, 1089, 1260], '2002;': [1019, 1090, 1547, 1609, 2129], '33:': [1020, 1091], '849-860Abstract': [1021, 1092], '(522)': [1029, 1100], '12Arning': [1032], 'L.': [1033, 1117, 1531, 1593], 'Kraus': [1034, 1118], 'P.H.': [1035, 1119, 2093, 2119, 2325, 2645], 'Valentin': [1036, 1120], 'S.': [1037, 1121, 1320], 'Saft': [1038, 1122], 'C.': [1039, 1123, 1204, 2643], 'Andrich': [1040, 1124], 'Epplen': [1042, 1126], 'J.T.': [1043, 1127], 'Neurogenetics.': [1044, 1128], '2005;': [1045, 1129, 1322], '6:': [1046, 1130], '25-28Crossref': [1047, 1131], '(82)': [1050, 1134], 'particular,': [1054], 'there': [1055], 'increased': [1057, 1193, 1275, 1281], 'sensitivity': [1058], 'receptor-mediated': [1061], 'YAC128': [1067, 1291], 'transgenic': [1068, 1189, 1292], 'mouse': [1069, 1293, 1806, 2377], 'model': [1070, 1294], '(11Zeron': [1073], 'Scholar)': [1102], 'NR2A': [1104], 'NR2B': [1106], 'variations': [1109], 'modify': [1110], 'age': [1112], 'onset': [1115], '(12Arning': [1116], 'More': [1137], 'recently,': [1138], '(mGluRs),': [1144], '(GPCRs)': [1150], 'activation': [1154, 1439], 'phospholipase': [1156, 1657], 'C,': [1157, 3400, 3537, 3672, 3815, 3949], 'increase': [1158, 4005], '(IP3)': [1163], 'formation,': [1164], 'have': [1172], 'contribute': [1176], 'underlying': [1179], 'pathophysiology': [1180], 'HD.': [1182, 1346, 1706], 'Specifically,': [1183], 'survival': [1185], 'R6/2': [1187], 'significantly': [1192], 'following': [1194, 2634, 3741, 3773], 'treatment': [1195, 4096], 'mGluR5': [1197, 2965, 2981, 3937], 'antagonists': [1198], '(13Schiefer': [1199], 'Sprunken': [1201], 'Puls': [1203], 'Luesse': [1205], 'H.G.': [1206], 'Milkereit': [1207, 1209], 'Johann': [1211], 'Kosinski': [1213], 'C.M.': [1214], 'Brain': [1215], 'Res.': [1216, 1499], '1019:': [1218], '246-254Crossref': [1219], '(97)': [1222], 'Htt-associated': [1230], '1': [1232, 2734, 2783], 'interactions': [1233, 1866], 'IP3': [1236, 1660], 'result': [1238], '(14Tang': [1244], 'T.S.': [1245, 1298], 'Tu': [1246], 'H.': [1247], 'Chan': [1248], 'E.Y.': [1249], 'Maximov': [1250], 'Wang': [1252], 'Z.': [1253], 'Bezprozvanny': [1258, 1313], 'I.': [1259, 1314], '39:': [1262], '227-239Abstract': [1263], '(411)': [1271], 'This': [1274, 1617], 'apoptosis': [1282, 1396, 3772], 'medium': [1284, 1725, 1943, 2043, 2365, 2497, 2516, 2530, 2536, 2541, 2571, 2575], 'spiny': [1285], 'neurons': [1287, 2596], '(15Tang': [1297], 'Slow': [1299], 'Lupu': [1301], 'Stavrovskaya': [1303], 'I.G.': [1304], 'Sugimori': [1305], 'Llinas': [1307], 'R.': [1308, 1527, 1539, 1589, 1601, 2097, 2123], 'Kristal': [1309], 'B.S.': [1310], 'Proc.': [1315], 'Natl.': [1316], 'Acad.': [1317], 'U.': [1319], '102:': [1323], '2602-2607Crossref': [1324], '(319)': [1327], 'Thus,': [1330], 'via': [1333], 'Optineurin': [1347], '(OPTN)': [1348], 'one': [1350], 'number': [1353], 'recently': [1355], 'Htt-interacting': [1357], 'OPTN': [1379, 1414, 1510, 1573, 1624, 1640, 1682, 2199, 2216, 2229, 2989, 3245, 3271, 3387, 3405, 3495, 3663, 4029, 4074], 'coiled-coiled': [1382], 'was': [1385, 1726, 1732, 1763, 1772, 1787, 1793, 1836, 1906, 1920, 2200, 2247, 2260, 2272, 2517, 2664, 2744, 2839, 2872, 2889, 2912, 2932, 2966, 3790, 3796, 3840], 'first': [1386], 'as': [1388, 2262, 2695, 3018, 3112, 3114, 3901, 3903, 4003], 'positive': [1390], 'regulator': [1391], 'tumor': [1393], 'necrosis': [1394], 'factor-α-mediated': [1395], '(16Li': [1397], 'Y.': [1398], 'Kang': [1399], 'Horwitz': [1401], 'M.S.': [1402], 'Mol.': [1403, 1454, 2336, 2413], 'Cell.': [1404, 2337], 'Biol.': [1405, 1469, 2101, 2127, 2338, 2414, 2707], '1998;': [1406, 1456], '18:': [1407], '1601-1610Crossref': [1408], '(180)': [1411], 'variety': [1418], 'it': [1423], 'cellular': [1428], 'morphogenesis': [1429], 'membrane': [1431], 'trafficking': [1432, 1435], '(Rab8),': [1433], 'vesicular': [1434], '(Htt),': [1436], 'transcription': [1438, 1869], '(TFIIIA)': [1440], '(17Faber': [1441], 'P.W.': [1442], 'Barnes': [1443], 'G.T.': [1444], 'Srinidhi': [1445], 'Gusella': [1449], 'J.F.': [1450], 'MacDonald': [1451], 'M.E.': [1452, 1486], 'Hum.': [1453], '7:': [1457], '1463-1474Crossref': [1458], '(333)': [1461], '18Hattula': [1464], 'K.': [1465], 'Peranen': [1466], 'Curr.': [1468], '2000;': [1470, 1500], '10:': [1471], '1603-1606Abstract': [1472], '(189)': [1480], '19Moreland': [1483], 'Dresser': [1485], 'Rodgers': [1487], 'J.S.': [1488, 1496], 'Roe': [1489], 'B.A.': [1490], 'Conaway': [1491, 1493], 'J.W.': [1492], 'R.C.': [1494], 'Hanas': [1495], 'Nucleic': [1497], 'Acids': [1498], '1986-1993Crossref': [1502], '(49)': [1505], 'Mutations': [1508], 'responsible': [1512], '∼17%': [1514], 'hereditary': [1516], 'forms': [1517], 'tension': [1520], '(20Rezaie': [1522, 1584], 'Child': [1524, 1586], 'Hitchings': [1526, 1588], 'Brice': [1528, 1590], 'Miller': [1530, 1592], 'Coca-Prados': [1532, 1594], 'Heon': [1534, 1596], 'Krupin': [1536, 1598], 'Ritch': [1538, 1600], 'Kreutzer': [1540, 1602], 'Crick': [1542, 1604], 'R.P.': [1543, 1605], 'Sarfaraz': [1544, 1606], 'Science.': [1546, 1608, 1751], '295:': [1548, 1610], '1077-1079Crossref': [1549, 1611], '(944)': [1552, 1614], 'apoptosis,': [1559], 'retinal': [1562], 'degeneration': [1563], 'lead': [1568, 1619], 'suggestion': [1571, 1622], 'mutants': [1574], 'directly': [1576], 'induce': [1577], 'optic': [1578], 'neuropathy': [1579], 'leading': [1580], 'visual': [1582], 'represents': [1625], 'common': [1627], 'factor': [1628], 'involved': [1629], 'protection': [1631], 'against': [1632], 'death.': [1635], 'Here': [1636], 'mGluR-interacting': [1646], 'inhibit': [1651], 'coupling': [1655], 'C': [1658], 'Moreover,': [1662], 'polyglutamine-expanded': [1666], 'but': [1669, 1953], 'wild-type': [1671, 2082, 2148, 2215, 2382, 3596, 3717, 4045, 4073], 'potentiates': [1673], 'inhibition': [1675], 'association': [1680], 'provide': [1689], 'help': [1696], 'shed': [1697], 'light': [1698], 'upon': [1699], 'relationship': [1701], 'glutamate-induced': [1703], 'Materials—Human': [1707], 'embryonic': [1708, 2469], 'kidney': [1709], '(HEK': [1711], '293)': [1712], 'were': [1713, 1746, 1758, 1816, 1960, 1974, 1979, 1997, 2037, 2069, 2085, 2154, 2183, 2193, 2220, 2314, 2356, 2386, 2397, 2426, 2463, 2476, 2488, 2527, 2597, 2611, 2627, 2726, 2780, 2814, 2995, 3035, 3043, 3059, 3068, 3082, 3133, 3165, 3176, 3188, 3376, 3487], 'provided': [1714], 'American': [1717], 'Type': [1718], 'Culture': [1719, 2348, 2570], 'Collection': [1720], '(Manassas,': [1721], 'VA).': [1722], 'Tissue': [1723], 'culture': [1724, 2522], 'Invitrogen.': [1728], 'Bovine': [1729], 'serum': [1730, 2371], 'albumin': [1731], 'obtained': [1733, 2467], 'Bioshop': [1735], 'Canada': [1736], 'Inc.': [1737, 1768], '(Mississauga,': [1738], 'Ontario,': [1739], 'Canada)': [1740], 'Mouse': [1741], 'anti-HA': [1742], '(12CA5)': [1743], 'monoclonal': [1744, 1809, 3120], 'antibodies': [1745, 1757, 1912, 3121, 3944], 'purchased': [1747, 1764, 1788, 1794, 1817, 1837], 'Roche': [1749], 'Applied': [1750], 'Horseradish': [1752], 'peroxidase-conjugated': [1753, 3146], 'anti-mouse': [1754, 1803, 3151], 'IgG': [1755, 3149, 3152], 'secondary': [1756, 1804, 3144], 'Amersham': [1760], 'Biosciences.': [1761], 'Quisqualate': [1762], 'Tocris': [1766], 'Cookson': [1767], '(Ellisville,': [1769], 'MO).': [1770], '[3H]myo-Inositol': [1771], 'acquired': [1773], 'PerkinElmer': [1775], 'Life': [1776], 'Sciences.': [1777], 'Dowex': [1779, 2900], '1-X8': [1780, 2901], '(formate': [1781, 2902], 'form)': [1782, 2903], 'resin': [1783], '200-400': [1785, 2904], 'mesh': [1786, 2905], 'Bio-Rad.': [1790], 'LysoTracker': [1791], 'Red': [1792], 'Molecular': [1796], 'Probes': [1797], '(Eugene,': [1798], 'OR).': [1799], 'Fluorescein': [1800], 'isothiocyanate-conjugated': [1801], 'goat': [1802], 'antibody,': [1805, 1810], 'anti-FLAG': [1807], 'M2': [1808], 'all': [1812, 2607], 'other': [1813], 'reagents': [1815], 'Sigma.': [1819], 'Yeast': [1820, 1994], 'Two-hybrid': [1821, 1865], 'Screening—A': [1822], 'human': [1823, 2198, 2228], 'brain': [1824, 1927], 'cDNA': [1825, 1928, 2230, 2301, 3016], 'library': [1826, 1929], 'pGAD10': [1829, 1840], 'vector,': [1830, 3649, 3683, 3779], 'two-hybrid': [1834, 1995, 2258], 'screen,': [1835], 'Clontech.': [1839], 'contains': [1841], 'ADH': [1843], 'promoter': [1844], 'expressing': [1845, 2381], 'GAL4': [1847], 'transactivation': [1848], '(amino': [1850, 2017, 2151, 2269], 'acids': [1851, 2152, 2270], '768': [1852], '881).': [1854], 'yeast': [1856, 1903, 1972, 2001, 2041, 2257], 'reporter': [1857, 1862, 2002], 'strain': [1858, 1904, 2003], 'Y190': [1859, 1905, 1919, 2004], 'harbors': [1860], 'constructs.': [1864, 3750, 3788], 'activate': [1867], 'HIS3': [1872], 'gene,': [1873, 1887], 'allowing': [1874, 1888], 'screening': [1875, 1889], 'growth': [1877], 'absence': [1880, 2054, 2820, 3243, 3345, 3452, 3475, 4103], 'histidine,': [1882], 'lacZ': [1886], 'β-galactosidase': [1891, 1988, 2067], 'activity.': [1892], 'Expression': [1893], 'mGluR1-Ct-GAL4-binding': [1896], 'fusion': [1898, 2295, 3470], 'pAS2-mGluR1-Ct': [1901, 1923], 'verified': [1907], 'immunoblotting': [1909], 'anti-mGluR1a': [1911], '(Upstate': [1913, 2985], 'Biotechnology,': [1914], 'Inc.,': [1915], 'Lake': [1916], 'Placid,': [1917], 'NY).': [1918], 'cotransformed': [1921, 2014], 'pGAD10-human': [1926], 'plated': [1931, 2038, 2489], 'at': [1932, 1962, 2063, 2358, 2388, 2501, 2787, 2809, 2834, 3054], 'density': [1934], '5': [1936, 2761], '×': [1937, 1970], '104': [1938], 'colonies/plate': [1939], 'on': [1940, 2039, 2490, 2841, 3289, 3546, 3600, 3721, 4083], 'synthetic': [1941, 2040], 'minimal': [1942], 'lacking': [1944, 2044], 'leucine': [1945], 'tryptophan': [1947], '(for': [1948], 'plasmid': [1949, 2400], 'selection)': [1950], 'histidine': [1952, 2049], 'containing': [1954, 2800, 3127, 3160], '25': [1955, 2056, 2567, 2591], 'mm': [1956, 2057, 2548, 2568, 2580, 2592, 2753, 2756, 2759, 2762, 2765, 2768, 2771, 2774, 2802, 2938, 2943, 2946, 2949, 3092, 3095], '3-aminotriazole.': [1957], 'plates': [1959, 1984], 'incubated': [1961, 2060, 2427, 2816, 3104, 3142, 3177, 3488], '30': [1963, 2064, 2832, 3992, 3996, 4098], '°C': [1964, 2360, 2390, 2503, 2789], '5-7': [1966], 'days.': [1967, 2534], 'Approximately': [1968], '2.5': [1969, 2767], '106': [1971], 'transformants': [1973, 2036], 'screened.': [1975], 'Colonies': [1976], 'grew': [1978], 'transferred': [1980], 'fresh': [1982, 2429], 'selective': [1983], 'assayed': [1986], 'activity': [1989, 3238], 'filter': [1992], 'assay.': [1993, 3822], 'backcrosses': [1996], 'performed': [1998, 2612, 2665, 2933, 2997], 'using': [1999, 2024, 2205, 2279, 2318, 2402, 2613, 2666, 2899, 2917, 2934, 2977, 2998, 3502], '(MATa,': [2005], 'leu2-3,': [2006], '112': [2007], 'ura': [2008], '3-5,': [2009], 'trp1-901,': [2010], 'his3-D200,': [2011], 'ade': [2012], '2-101)': [2013], 'pGAD-OPTN': [2016], 'acid': [2018, 2851], 'residues': [2019], '202-246),': [2020], 'pAS2': [2022], 'mGluR1a-Ct': [2023], 'modified': [2026, 2363, 2393, 2404, 2739], 'lithium': [2027], 'acetate': [2028], 'method': [2029, 2407], 'according': [2030, 2071], "manufacturer's": [2033, 2636], 'instructions.': [2034], 'Double': [2035], 'drop-out': [2042], 'leucine,': [2045], 'tryptophan,': [2046], 'uracyl,': [2047], 'presence': [2052, 2823, 3241, 3348, 3454, 3477, 4106], '3-aminotriazol': [2058], '3-5': [2061], 'days': [2062, 2624], '°C.': [2065, 2811, 2836, 3056], 'Liquid': [2066], 'assays': [2068], 'conducted': [2070], 'standard': [2073], 'procedures.': [2074], 'Plasmid': [2075], 'Construction—The': [2076], 'FLAG-mGluR1a': [2077, 3040, 3296, 3341, 3530, 3554, 3780, 3831], 'myc-tagged': [2080, 2142], 'constructs': [2084, 2182, 2246, 3017, 3839], 'described': [2086, 2696, 3019], '(21Dhami': [2088], 'G.K.': [2089, 2117], 'Dale': [2090, 2120, 2646], 'L.B.': [2091, 2121, 2647, 2699], 'Anborgh': [2092, 2118, 2644], "O'Connor-Halligan": [2094], 'K.E.': [2095], 'Sterne-Marr': [2096, 2122], 'Ferguson': [2098, 2124, 2650, 2704], 'S.S.G.': [2099, 2125, 2409, 2651, 2705], 'Chem.': [2102, 2128, 2708], '279:': [2104, 2710], '16614-16620Abstract': [2105], '(68)': [2113], '22Dhami': [2116], '277:': [2130], '25266-25272Abstract': [2131], '(Q138)': [2146], '(Q15)': [2150], '1-704)': [2153], 'constructed': [2155, 2221, 2261], 'digesting': [2157], 'pEGFP-N1-Htt-Q138': [2158], '1-704': [2159], 'or': [2160, 2213, 2441, 2678, 2821, 3109, 3118, 3150, 3233, 3347, 3384, 3630, 3657, 3693, 3833, 3911, 3919, 3941, 4110], 'peGFP-N1-Htt-Q15': [2161], '1-704,': [2162], 'respectively,': [2163], 'BspEI': [2165], 'followed': [2166], 'cloning': [2168], 'fragments': [2172, 2192], 'pGEX4T1': [2174], '(Amersham': [2175, 3153], 'Biosciences)': [2176, 3154], 'digested': [2177, 2185], 'XmaI.': [2179], 'pGEX4T-Htt': [2181], 'then': [2184, 2445, 2791, 2815, 2853, 3076, 3103, 3141], 'BamHI': [2187, 2280, 2319], 'NotI.': [2189], 'Htt-containing': [2191], 'cloned': [2194, 2201, 2275, 2315], 'pcDNA3myc.': [2196], 'Full-length': [2197], 'PCR': [2203, 2223], 'amplification': [2204, 2224], 'Quick': [2207], 'Clone': [2208], 'kit': [2209], '(Clontech).': [2210], 'Amino-terminal': [2211], 'myc-': [2212], 'HA-tagged': [2214, 2218], 'OPTN-H486R': [2219, 4066, 4076], 'mutagenesis': [2226], 'inserted': [2232], 'BamHI/EcoRI': [2235], 'sites': [2236, 2284, 2323], 'pcDNA3.': [2238], 'sequence': [2240], 'integrity': [2241], 'each': [2243, 3561], 'confirmed': [2248], 'automated': [2250], 'DNA': [2251], 'sequencing.': [2252], 'bait': [2254], 'screen': [2259], 'follows.': [2263], 'rat': [2265, 2471, 3411], 'tail': [2268], '841-1199)': [2271], 'PCR-amplified': [2273], 'pAS2-1': [2277], '(Clontech)': [2278], 'EcoRI': [2282], 'restriction': [2283, 2322], 'generate': [2286], 'pAS2-mGluR1-Ct.': [2287], 'For': [2288], 'S-transferase': [2293], '(GST)': [2294], 'mammalian': [2298], 'encoding': [2302], 'angiotensin': [2306], 'II': [2307], 'type': [2308], '1A': [2309], 'tails': [2312], '(C-tails)': [2313], 'pEBG': [2317], 'NotI': [2321], '(23Anborgh': [2324], 'Qian': [2326], 'X.': [2327], 'Papageorge': [2328], 'A.G.': [2329], 'Vass': [2330], 'W.C.': [2331], 'DeClue': [2332], 'J.E.': [2333], 'Lowy': [2334], 'D.R.': [2335], '4611-4622Crossref': [2341], '(70)': [2344], 'Cell': [2347, 2457], 'Transfection—HEK': [2350], 'COS7': [2354, 3904, 3918], 'grown': [2357, 2387, 2446], '37': [2359, 2502, 2788, 2810, 2835], "Dulbecco's": [2362, 2392, 2738], "Eagle's": [2364, 2394, 2540, 2740], 'supplemented': [2366, 2545, 2576], '10%': [2368, 2550, 3085], 'fetal': [2369], 'bovine': [2370], '100': [2373, 3408], 'μg/μl': [2374], 'gentamicin.': [2375], '33': [2389], 'medium.': [2395, 2741], 'Cells': [2396, 2487], 'transfected': [2398, 2628, 3012, 3829, 3906], 'cDNAs': [2401], '(24Ferguson': [2408], 'Caron': [2410], 'M.G.': [2411], 'Methods': [2412], '237:': [2416], '121-126PubMed': [2417], 'After': [2420], 'transfection': [2421, 3742, 3774], '(18': [2422], 'h),': [2423], 'medium,': [2430, 2523], 'allowed': [2431], 'recover': [2433], '6-8': [2435], 'h,': [2436], 'reseeded': [2437], '6-,': [2439], '12-,': [2440], '24-well': [2442], 'dishes,': [2443], '18': [2450], 'h': [2451, 2500, 2784], 'prior': [2452], 'experimentation.': [2454], 'Primary': [2455, 2620], 'Neuronal': [2456], 'Culture,': [2458], 'Immunostaining,': [2459], 'Transfection—Neuronal': [2461], 'cultures': [2462, 2622], 'prepared': [2464], 'cortex': [2466, 3414], 'day-20': [2470], 'embryos.': [2472], 'All': [2473], 'animal': [2474], 'procedures': [2475], 'approved': [2477], 'University': [2480], 'Western': [2482, 3180], 'Ontario': [2483], 'Animal': [2484], 'Care': [2485], 'Committee.': [2486], 'poly-d-lysine-coated': [2491], '50-mm': [2492], 'glass': [2493], 'coverslips': [2494], 'isolation': [2496], '4': [2499, 2623, 3055], '5%': [2505], 'CO2': [2506], 'humidified': [2509], 'incubator': [2510], 'permit': [2512], 'attachment.': [2514], 'Isolation': [2515, 2535], 'subsequently': [2518], 'replaced': [2519], 'serum-free': [2521], 'cultured': [2528], 'replenished': [2531], 'every': [2532], '3': [2533], 'consisted': [2537, 2572], 'minimum': [2539], "Earle's": [2543], 'salts': [2544], 'Glutamax/glutamine,': [2549, 2581], 'heat-inactivated': [2551], 'horse': [2552], 'serum,': [2553], '6': [2554], 'mg/ml': [2555, 2955, 2958], 'glucose,': [2556, 2760], '0.5': [2557, 2560, 2582, 2585], 'units/ml': [2558, 2583], 'penicillin,': [2559, 2584], 'μg/ml': [2561, 2586, 2962], 'streptomycin,': [2562, 2587], '10': [2563, 2588, 2801, 2807, 3094], 'μm': [2564, 2589, 3993, 3997, 4099], 'MK-801,': [2565, 2590], 'KCl.': [2569, 2593], 'neurobasal': [2574], 'B-27,': [2578], 'Before': [2594], 'experimentation,': [2595], 'washed': [2598, 3060], 'times': [2600, 3062, 3136], 'solution': [2604], '(HBSS),': [2605], 'experiments': [2610, 2994, 3501, 3521, 3930], 'does': [2616], 'contain': [2618], 'glutamate.': [2619], 'vitro': [2626], 'Effectene': [2630], '(Qiagen,': [2631], 'Hilden,': [2632], 'Germany)': [2633], 'instructions': [2637], '(25Bhattacharya': [2638], 'Babwah': [2640, 2702], 'A.V.': [2641, 2703], 'Godin': [2642], 'Poulter': [2648], 'M.O.': [2649], '24:': [2655], '8752-8761Crossref': [2656], '(80)': [2659], 'Confocal': [2662], 'microscopy': [2663], 'Zeiss': [2668, 2676], 'LSM-510': [2669], 'META': [2670], 'laser': [2671], 'scanning': [2672], 'microscope': [2673], '63X': [2677], '100X': [2679], 'NA': [2680], '1.4': [2681], 'oil': [2682], 'immersion': [2683], 'lens': [2684], 'filters': [2686], 'emission': [2688], 'wavelengths': [2689], '488': [2691], '514': [2693], 'nm': [2694], '(26Dale': [2698], 'Seachrist': [2700], 'J.L.': [2701], '13110-13118Abstract': [2711], '(101)': [2719], 'Inositol': [2722], 'Phosphate': [2723], 'Formation—Inositol': [2724], 'lipids': [2725], 'radiolabeled': [2727], 'incubating': [2729], 'overnight': [2732, 3052], 'μCi/ml': [2735], '[3H]myo-inositol': [2736, 2743], 'Unincorporated': [2742], 'removed': [2745], 'washing': [2747], 'HBSS': [2751, 2786], '(116': [2752], 'NaCl,': [2754, 2944, 3093], '20': [2755, 2954, 2957, 2961], 'HEPES,': [2757, 2939], '11': [2758], 'NaHCO3,': [2763], '4.7': [2764], 'KCl,': [2766], 'CaCl2,': [2769], '1.3': [2770], 'MgSO4,': [2772], '1.2': [2773], 'KH2PO4,': [2775], 'pH': [2776, 2940, 3097], '7.4).': [2777], 'preincubated': [2781, 2792], '500': [2794, 2845, 2999, 3480], 'μl': [2795, 2846, 2857, 2881], 'same': [2798, 3667], 'buffer': [2799, 2936, 3074, 3089, 3126, 3139, 3159], 'LiCl': [2803], 'min': [2808, 2833], 'either': [2818, 3229, 3343, 3628, 3655, 3691, 3939, 4108], 'increasing': [2825], 'concentrations': [2826], '(0-30': [2827], 'mm)': [2828], 'quisqualate': [2830, 3213, 3361, 3604, 3634, 4100], 'reaction': [2838], 'stopped': [2840], 'ice': [2842], 'adding': [2844], '0.8': [2848], 'm': [2849, 2860, 2863], 'perchloric': [2850], 'neutralized': [2854], '400': [2856], '0.72': [2859], 'KOH,': [2861], '0.6': [2862], 'KHCO3.': [2864], 'total': [2866, 2975, 3002], '[3H]inositol': [2867], 'incorporated': [2868], 'determined': [2873, 2913, 3189], 'counting': [2875], 'radioactivity': [2877], 'present': [2878], '50': [2880, 3891], 'lysate.': [2885], 'Total': [2886], 'purified': [2890], 'extracts': [2894], 'anion': [2896, 2906], 'exchange': [2897, 2907], 'chromatography': [2898], 'resin.': [2908], '[3H]Inositol': [2909], 'liquid': [2915], 'scintillation': [2916, 2922], 'Beckman': [2919], 'LS': [2920], '6500': [2921], 'system.': [2923], 'Co-immunoprecipitation—Co-immunoprecipitation': [2924], 'endogenous': [2926, 3936], 'HdhQ7/Q7': [2929, 3871, 3896, 3946, 3958, 3981], 'lysis': [2935, 3038, 3064], '(25': [2937], '7.5,': [2941], '300': [2942], '1.5': [2945, 2978], 'MgCl2,': [2947], '0.2': [2948], 'EDTA,': [2950], '0.1%': [2951], 'Triton': [2952], 'X-100,': [2953], 'leupeptin,': [2956], 'aprotonin,': [2959], 'phenylmethylsulfonyl': [2963], 'fluoride).': [2964], 'immunoprecipitated': [2967, 3044], 'supernatant': [2971], '(500': [2972], 'μg': [2973, 3000, 3409, 3481, 3892], 'protein)': [2976], 'mg': [2979], 'rabbit': [2982, 2990, 3106, 3504], 'polyclonal': [2983, 2991, 3505, 3943], 'antibody': [2984], 'Biotechnology)': [2986], '1:75': [2988], 'antibody.': [2992, 3507], 'Co-immunoprecipitation': [2993], 'lysate': [3004], 'solubilized': [3006, 3036], 'transiently': [3011], 'various': [3015], 'legends': [3022], 'Figs.': [3024], '1,': [3025], '2,': [3026], '3,': [3027], '4,': [3028], '5,': [3029], '6,': [3030], '7,': [3031], '8.': [3032], 'buffer.': [3039], 'FLAG-mGluR5a': [3042], 'FLAG-Sepharose': [3046], 'beads': [3047, 3058], 'lysates': [3050, 3486, 3894], 'rotation': [3053], 'four': [3061, 3398, 3705, 3759, 4121], 'buffer,': [3065], 'eluted': [3069], '3×': [3071], 'SDS': [3072], 'sample': [3073], 'separated': [3077], 'SDS-PAGE.': [3079], 'membranes': [3081, 3132], 'blocked': [3083], 'milk': [3086], 'wash': [3088, 3125, 3138, 3158], '(TBS-T)': [3090], '(150': [3091], 'Tris-HCl,': [3096], '7.0,': [3098], '0.05%': [3099], 'Tween': [3100], '20)': [3101], 'GRK2-,': [3107], 'OPTN-,': [3108], 'mGluR5-specific': [3110, 3942], 'antibodies,': [3111], 'well': [3113, 3902], 'Htt-,': [3115], 'myc-,': [3116], 'FLAG-,': [3117], 'HA-specific': [3119], 'diluted': [3122, 3155], '1:1000': [3123], '3%': [3128, 3161], 'skim': [3129], 'milk.': [3130, 3163], 'rinsed': [3134, 3166], 'three': [3135, 3358, 3432, 3512, 3520, 3583, 3812, 3853, 3929, 3972, 4016, 4059], 'horseradish': [3145], 'donkey': [3147], 'anti-rabbit': [3148], '1:2500': [3156], 'skimmed': [3162], 'Membranes': [3164], 'twice': [3167, 3171], 'TBS-T': [3169], 'Tris-buffered': [3173], 'ECL': [3179], 'blotting': [3181], 'detection': [3182], 'reagents.': [3183], 'Intensities': [3184], 'immunoblot': [3186, 3282, 3321, 3459, 3517, 3539, 3579, 3927, 4038, 4055], 'signals': [3187], 'β4.0.2': [3192], 'version': [3193], 'data': [3196, 3390, 3428, 3697, 3752, 3805, 3846, 3964, 4113], 'acquisition': [3197], 'software': [3200], 'Scion': [3202], 'Corp.': [3203], '(Frederick,': [3204], 'MD).FIGURE': [3205], '2Inhibition': [3206], 'OPTN.': [3211, 3234, 3456, 3632, 3659, 3695], 'A,': [3212, 3276, 3457, 3603, 3729, 3877, 4036], 'dose': [3214, 3362, 3605, 3635, 3950], 'FLAG-mGluR1a-stimulated': [3217, 3365, 3608, 3638, 4087, 4127], '(IP': [3221, 3369, 3612, 3868, 4091], 'Formation)': [3222, 3370, 3613, 3869, 4092], 'cotransfected': [3227, 3377, 3618, 3646, 3680], 'empty': [3230, 3379, 3620, 3648, 3682, 3778], 'vector': [3231, 3380, 3621], '(Control)': [3232, 4104], 'B,': [3235, 3360, 3515, 3633, 3762, 3925, 4070], 'basal': [3236, 3673, 4007], 'cells.': [3250, 3300, 3534, 3558, 3844, 3948, 3962], 'Data': [3251, 3351, 3508, 4000], 'represent': [3252, 3352, 3392, 3699, 3753, 3806, 3847, 3966, 4010, 4115], 'mean': [3254, 3354, 3394, 3701, 3731, 3755, 3808, 3849, 3968, 4012, 4117], '±': [3255, 3355, 3395, 3702, 3756, 3809, 3850, 3969, 4013, 4118], 'S.E.': [3256, 3396, 3703, 3970, 4014, 4119], 'five': [3258], 'experiments.View': [3259, 3434, 3585, 3706, 3855, 4017], 'Large': [3260, 3435, 3586, 3707, 3856, 4018], 'Image': [3261, 3436, 3587, 3708, 3857, 4019], 'Figure': [3262, 3437, 3588, 3709, 3858, 4020], 'ViewerDownload': [3263, 3438, 3589, 3710, 3859, 4021], 'Hi-res': [3264, 3439, 3590, 3711, 3860, 4022], 'image': [3265, 3440, 3591, 3712, 3861, 4023], 'Download': [3266, 3441, 3592, 3713, 3862, 4024], '(PPT)FIGURE': [3267, 3442, 3593, 3714, 3863, 4025], '3GRK2': [3268], 'competes': [3269], 'attenuate': [3273], 'top': [3277], 'panel': [3278, 3302], 'shows': [3279, 3303, 3322, 3329], 'representative': [3281, 3430, 3458, 3510, 3516, 3538, 3581, 3878, 3926, 4037, 4057], 'showing': [3283, 3460, 3522, 3540, 3881, 3931, 4040], 'effect': [3285, 3542, 4071], 'myc-GRK2': [3287, 3307], 'co-immunoprecipitation': [3291, 3524, 3548, 3562, 3933, 4042], '(IP)': [3292, 3525, 3934, 4043], 'myc-OPTN': [3294, 3309, 3338, 3544], 'Middle': [3301], 'corresponding': [3311, 3571], '50-μg': [3312, 3572], 'aliquots': [3313, 3573], 'lysates.': [3318, 3426, 3577], 'Bottom': [3319], 'panel,': [3320], 'immunoprecipitation': [3324], 'FLAG-mGluR1a.': [3326], 'Bar': [3327], 'graph': [3328], 'densitometric': [3331], 'relative': [3335, 3883], 'amount': [3336], 'co-immunoprecipitated': [3339, 4067], '(control)': [3346], 'GRK2.': [3350], 'S.D.': [3356, 3757, 3810, 3851], 'experiments.': [3359, 3399, 3514, 3761, 3814, 3973, 4060, 4122], '(Control),': [3381, 3622], 'GRK2,': [3382], 'together.': [3388], 'points': [3391, 3698, 3965, 4114], 'cerebellum': [3412], '(Cb),': [3413], '(Cx),': [3415], '(Str),': [3417], 'hippocampal': [3419], '(Hip)': [3420], '(293)': [3425], 'independent': [3433, 3760, 3813, 3854], '4Wild-type': [3443], 'binding': [3447], 'co-precipitation': [3462], 'myc-N-HttQ15': [3464, 3550, 4109], 'C-tail': [3468], 'GST': [3469], '(GST-mGlu-Ct)': [3472], 'HA-OPTN.': [3479], 'GST-mGlu-Ct': [3490], 'bound': [3491], 'glutathione-Sepharose': [3493], 'beads.': [3494], 'detected': [3498], 'anti-OPTN': [3506], 'individual': [3513, 3584], '(IB)': [3518, 3880, 4039], 'full-length': [3527], 'HttQ15': [3528], 'NT,': [3535], 'nontransfected.': [3536], 'myc-N-HttQ138': [3552, 3568, 3749, 3787, 3838], 'Shown': [3559], 'below': [3560], 'blot': [3563], 'myc-OPTN,': [3565], 'myc-N-HttQ15,': [3566, 3625, 3685, 3747, 3785, 3836, 4051], '5Effect': [3594], 'latter': [3627, 3654, 3689], 'alone': [3629, 3656, 3692, 3781, 3832], 'myc-N-HttQ138,': [3652, 3687], 'control': [3661], 'curves': [3664], 'A': [3669], 'B.': [3671], '6Effect': [3715], 'surface': [3724, 3733], 'viability.': [3728], 'without': [3745], 'quantification': [3763, 3816], 'fraction': [3766], 'exhibiting': [3769, 3801], 'Apoptosis': [3789], 'measured': [3791], 'Hoechst': [3793], 'stain': [3794], 'defined': [3797], 'pyknotic': [3799], 'nuclei': [3800], 'condensed': [3802], 'chromatin.': [3803], 'viability': [3819, 3824], 'MTT': [3821], 'nontransfected': [3843], '7Quisqualate-stimulated': [3864], 'HdhQ111/Q111': [3873, 3898, 3960, 3983], 'lines.': [3876], 'immunoblots': [3879], 'mGluR5,': [3887], 'mGluR1': [3889], 'overexpress': [3908], 'mGluR5a,': [3910], 'mGluR1a.': [3912], '(OPTN': [3913], 'detectable': [3916], 'unless': [3923], 'overexpressed.)': [3924], 'OPTN-': [3940], 'response': [3951, 3988, 4094], 'quisqualate-stimulated': [3953], 'D,': [3974], 'shown': [3975], 'stimulation': [3990], 'phenylepherine': [3994], '5-hydroxytryptamine': [3998], '(serotonin).': [3999], 'presented': [4002], 'fold': [4004], 'above': [4006], 'values': [4008], '8Single': [4026], 'defective': [4031], 'HA-OPTN': [4046], 'HA-OPTN-H486R': [4048], 'FLAG-mGluR1a,': [4050], 'myc-N-HttQ138.': [4053, 4111], '*,': [4061, 4123], 'p': [4062, 4124], '<': [4063], '0.05': [4064], 'versus': [4065, 4126], 'myc-N-HttQ15.': [4069], 'antagonism': [4085], '<0.05': [4125]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1978849123', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2025-01-11T00:44:17.336481', 'created_date': '2016-06-24'}