Publication Information

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1587, 1650, 1654, 1801, 1877, 1910], 'replace': [169, 689, 776, 822, 961, 1011, 1217, 1802], 'molecular': [173, 246, 693, 715, 830, 1667], 'multimodality': [174, 694], 'imaging': [175, 247, 695, 716, 831, 1043, 1450, 1553, 1612, 1668, 1717, 1735], 'platform': [176, 696], 'choice': [178, 828, 1917], 'topic': [181], 'debated': [182], "month's": [185], 'Point/Counterpoint.': [186], 'introduction': [189, 1112], 'considered': [194, 259], 'experts': [197], 'major': [201, 442, 635], 'breakthrough': [202], 'potentially': [205, 1731], 'lead': [206], 'paradigm': [209], 'shift': [210], 'healthcare': [212], 'revolutionize': [214], 'clinical': [215, 660, 836, 1146, 1283, 1337, 1395, 1430, 1542, 1615, 1671, 1854, 1887], 'practice.': [216, 1674], 'Several': [217], 'research': [218, 654, 840, 1178, 1339, 1673, 1868], 'groups': [219], 'academic': [221, 1357], 'corporate': [223], 'settings': [224, 655, 1340], 'focusing': [226], 'on': [227, 605, 842, 881, 1102, 1874], 'various': [231], 'configurations': [232, 603], 'MR-compatible': [234], 'inserts': [236], 'allow': [238], 'simultaneous': [239, 292, 303, 1513], 'scanning': [240, 256, 304, 311, 456, 483, 1474, 1517], 'using': [241, 459, 545, 1313, 1512], 'most': [243, 1297, 1829], 'highly': [244], 'sophisticated': [245], 'technologies': [248, 611], 'available': [249, 1863], 'today.1–6': [250], 'Compared': [251], 'PET/CT,': [253, 925, 972], 'where': [254, 435, 1192, 1404, 1409], 'was': [257], '(erroneously)': [258], 'ultimate': [263], 'solution': [264], 'for': [265, 299, 343, 427, 445, 462, 524, 544, 558, 628, 770, 816, 829, 898, 936, 951, 958, 991, 1003, 1008, 1072, 1227, 1272, 1328, 1466, 1555, 1575, 1584, 1614, 1658, 1850], 'image': [266, 981], 'coregistration': [267, 1526], 'correlate': [269], 'structural': [270, 324, 719], 'thus': [274, 346], 'allowing': [275], 'anatomic': [276], 'localization': [277], 'abnormal': [279, 290], 'tracer': [280], 'uptake': [281], 'or': [282, 355, 397, 877, 1061, 1093], 'facilitating': [283], 'process': [285], 'differentiating': [287], 'normal': [288, 484], 'uptake,': [291], 'additional': [296, 1163, 1494], 'features.': [297], 'First,': [298, 1436], 'small': [300, 487], 'animal': [301, 494], 'reduces': [305], 'time': [306, 457], 'under': [307, 312], 'anesthesia': [308], 'enables': [310, 450], 'identical': [313], 'physiological': [314], 'conditions.': [315], 'Second,': [316, 1534], 'high-field': [317], 'generates': [319], 'high': [320], 'resolution': [321, 330, 1566], 'offering': [326, 1482], 'soft-tissue': [328], 'contrast': [329, 728, 1565], 'large': [333, 1867], 'variety': [334], 'tissue': [336, 407, 1486, 1564], 'contrasts': [337], 'CT,': [340, 501], 'allows': [342, 897], 'enabling': [347], 'temporal': [348], 'correlation': [349], 'blood': [351], 'flow': [352], 'metabolism': [354], 'receptor': [356], 'expression': [357], 'brain': [359, 551, 952, 1647], 'studies': [360, 1391, 1543, 1872], 'and,': [361, 622, 1296, 1399, 1828], 'more': [362, 505, 519, 623, 1326, 1400, 1455], 'importantly,': [363, 1298, 1401, 1511, 1830], 'capable': [365], 'assessing': [367], 'flow,': [368], 'diffusion,': [369], 'perfusion,': [370], 'cardiac': [372], 'motion': [373], 'one': [375, 632], 'single': [376], 'examination.': [377], 'Third,': [378], 'MRS': [384, 1499], 'measure': [386], 'spatially': [387], 'matched': [388], 'regional': [389], 'biochemical': [390], 'content': [391], 'assess': [394, 1847], 'status': [396], 'presence': [399], 'neoplasia': [401], 'other': [403, 433, 844, 1233, 1740], 'diseases': [404], 'specific': [406], 'regions.': [408], 'Finally,': [409], 'does': [411, 467], 'use': [413, 607, 933, 1187, 1333, 1351, 1888], 'any': [414, 1162, 1368], 'ionizing': [415], 'radiation': [416, 436, 1203, 1773], 'therefore': [418], 'used': [421, 990, 1071], 'restrictions': [423], 'serial': [425], 'pediatric': [428], 'cases,': [429], 'situations': [434], 'exposure': [437, 1774], 'concern.': [440], 'A': [441], 'advantage': [443, 793, 979, 1197, 1206, 1790], 'cited': [444], 'reduction': [452, 1229], 'overall': [455], 'attenuation': [463, 525, 548, 563, 937, 1532, 1726], 'correction.': [464, 1533, 1727], 'at': [469, 832, 949, 1442, 1769, 1807, 1864], 'expense': [471], 'substantial': [474], 'increase': [475], 'absorbed': [477], 'dose,': [478], 'issue': [481], 'when': [482, 754], 'subjects': [485], 'animals,': [488], 'change': [492, 1257], 'model': [495], 'studied.7': [497], 'In': [498, 767, 810, 1005, 1261, 1479, 1728], 'comparison': [499], 'typically': [503], 'expensive,': [506], 'involves': [507], 'longer': [508, 879], 'scan': [509, 1723], 'times,': [510], 'produces': [512], 'difficult': [520, 741], 'derive': [522], 'maps': [523], 'correction': [526, 564], 'emission': [530], 'data.': [531], 'some': [533, 672], 'solutions': [534], 'do': [535], 'exist': [536], 'demonstrated': [538], 'proof': [541], 'concept': [543], 'segmented': [546], 'MRI-guided': [547, 562], 'compensation': [549], 'PET,8': [552], 'plenty': [554], 'opportunities': [556], 'remain': [557], 'creative': [559], 'advances': [560], 'whole-body': [566, 661, 992], 'imaging.': [568, 737, 1026, 1147, 1260, 1315, 1838, 1922], 'Whereas': [569], 'technical': [571, 1343], 'have': [573, 616, 1181, 1222, 1265, 1287, 1820], 'been': [574, 617, 947, 1049, 1593, 1821], 'recently': [575, 637], 'solved,': [576], 'recognized': [579, 1608], 'implementation': [581], 'operation': [583], 'system': [588], 'still': [590, 757, 1625], 'facing': [591, 1691], 'important': [593], 'challenges': [594], 'must': [596], 'overcome': [598], 'through': [599, 1496], 'research.': [600], 'Many': [601], 'design': [602, 894], 'based': [604], 'detector': [609], 'readout': [610], 'insensitive': [612], 'fields': [615], 'proposed,': [618], 'including': [619, 1642], 'avalanche': [620], 'photodiodes': [621], 'recently,': [624], 'silicon': [625], 'photomultipliers,': [626], 'particularly': [627, 753, 1022, 1810], 'preclinical': [629], 'systems.': [630], 'Moreover,': [631], 'vendors': [636], 'married': [638], 'insert': [641], '3T': [644], 'head': [646], 'scanner,4': [647], 'making': [648], 'its': [649, 759, 780, 798, 802, 807, 1111, 1350, 1570, 1692], 'application': [650, 996], 'humans': [652], '(and': [656], 'possibly': [657], 'extension': [658], 'PET/MR)': [662], 'near': [664], 'certainty': [665], 'prototypes': [667], 'deployed': [670], 'European': [673], 'institutions.': [674], 'Weighing': [675], 'advantages': [677, 970, 1151, 1165, 1274, 1708, 1817], 'drawbacks': [679], 'each': [681], 'renders': [683], 'conclusion': [685], '"simultaneous': [686], 'choice"': [698], 'only': [700, 784, 889, 1786], 'plausible': [701], 'but': [702, 788, 1053, 1122, 1452], 'also': [703, 789, 942, 1365, 1440], 'obvious.': [704], 'likely': [708], 'succeed': [709], 'unifying': [711], 'four': [713], 'promising': [714], 'techniques': [717], 'PET,': [718], 'fMRI,': [721], 'MRS,': [723], 'sharp': [727], 'provided': [733, 1686, 1711], 'It': [738], 'always': [740], 'predict': [743, 1213], 'extent': [745], 'success': [747], 'achieve': [752], 'infancy': [760], 'case': [764, 908], 'PET/MR.': [766, 853, 1902], 'general': [768], 'however,': [769, 888, 1220], 'nascent': [772], 'successfully': [775], 'an': [777, 995, 1552, 1788], 'established': [778, 863], 'standard,': [779], 'capabilities': [781, 1507], 'should': [782, 804, 1014, 1207, 1371, 1618, 1860], 'emulate': [785], 'standard': [787, 1431, 1611, 1657], 'constitute': [790], 'demonstrable': [792], 'undeniably': [795], 'leads': [796], 'widespread': [799, 1383], 'use,': [800, 1107], 'while': [801], 'disadvantages': [803], 'offset': [806], 'potential': [808, 1269, 1684], 'benefits.': [809], 'regard': [812], 'I': [813, 1170, 1316, 1364, 1414, 1595, 1675, 1697, 1906], 'argue,': [815], 'now,': [817], 'modality': [826, 1554, 1859, 1915], 'least': [833, 950, 1865], 'evaluation': [837, 1309], 'standpoint.': [838], 'For': [839], 'applications': [841], 'hand,': [845], 'much': [846], 'said': [849], 'favor': [851], 'capability': [857], 'emulating': [859, 968], 'achievements': [861], 'already': [862, 1048], 'Scan': [866], 'duration': [867], 'anticipated': [871], 'similar': [874], 'slightly': [878], 'depending': [880], 'pulse': [883], 'sequence': [884], 'used.9': [885], 'can,': [887], 'achieved': [891], 'if': [892], 'concurrent': [899], 'rather': [900, 1054], 'acquisition,': [904, 982], 'Furthermore,': [911, 1762], 'instantaneous': [913], 'fusion': [914], 'data,': [919, 1064], 'facilitated': [921], 'acceptance': [923, 1384], 'accomplished': [928, 1050], 'PET/MR9–11': [930], 'correction,': [938], 'although': [939], 'challenging,': [940], 'presumably': [943], 'feasible': [944], 'shown': [948, 1822], 'imaging.8': [953], 'mentioned': [956, 1698], 'earlier,': [957], 'should,': [964], 'addition': [966, 1480], 'provide': [973, 1018, 1490, 1787, 1879], 'clinically': [975, 1825], 'practical': [976, 1827], 'tangible': [978], 'interpretation,': [983], 'diagnosis.': [985], 'currently': [988], 'mainly': [989, 1131, 1538], 'evaluations,': [994], 'comprising': [997], 'majority': [999], 'reimbursable': [1001], 'indications': [1002, 1577, 1641], 'PET/CT.12': [1004], 'regard,': [1007], 'able': [1016], 'alternative': [1021], 'whole': [1024, 1153, 1306, 1714, 1835, 1919], 'body': [1025, 1154, 1307, 1715, 1836, 1920], 'since': [1028, 1629, 1811], 'pairing': [1030, 1781], 'envisioned': [1037], 'further': [1039, 1602], 'improve': [1040], 'portion': [1044, 1451], 'what': [1046], 'augment': [1056, 1733], 'spectroscopic': [1062, 1746], '(MRS)': [1063], 'both': [1065], 'routinely': [1070], 'diagnostic': [1073, 1084, 1150, 1164, 1308, 1445, 1503], 'evaluation,': [1074, 1284], 'question': [1076, 1099], 'then': [1077, 1878], 'becomes:': [1078], 'Is': [1079], 'perspective': [1085], 'pair': [1087], 'scanner': [1090], 'MR?': [1094], 'answer': [1096], 'largely': [1100], 'depends': [1101], 'application,': [1104], 'ease': [1105, 1241], 'cost.': [1109], 'Since': [1110], 'early': [1115], '1980s,': [1116], 'steadily': [1119], 'gained': [1120], 'acceptance,': [1121], 'replaced': [1126], 'areas,': [1130], 'because': [1132], 'reasons': [1135], 'above.': [1136], 'same': [1138, 1707], 'applies': [1139], 'replacing': [1142, 1183, 1279], 'routine': [1145, 1282, 1305, 1834, 1886], 'Until': [1148, 1903], 'well': [1157, 1757], 'established,': [1158], 'reimbursable,': [1159], 'supersede': [1161], 'introduce,': [1169], 'believe': [1171, 1907], 'restricted': [1176], 'difficulty': [1182], 'widely': [1185], 'accepted': [1186], 'One': [1190, 1617], 'area': [1191], 'clear': [1196], 'lower': [1201], 'exposure.': [1204], 'itself': [1209], 'sufficient': [1211, 1407], 'Unfortunately,': [1219], 'we': [1221], 'repeatedly': [1223], 'seen': [1224], 'efforts': [1226, 1346], 'dose': [1228], 'circumvented': [1231], 'dominating': [1234], 'factors': [1235], 'such': [1236, 1718, 1742, 1856], 'cost,': [1238], 'speed,': [1239], 'use13,14': [1243], 'suggesting': [1244, 1798], 'reasoning': [1247], 'strong': [1251], 'enough': [1252], 'induce': [1254], 'suggested': [1256, 1815], 'summary,': [1262], 'scanners': [1264], 'lot': [1267], 'advantages.': [1270], 'assist': [1276], 'they': [1285], 'first': [1286], 'cost': [1290, 1831, 1899], 'effective': [1291, 1832], 'easy': [1293], 'realize': [1295], 'become': [1299], 'necessary': [1301, 1881], 'component': [1302], 'cancer': [1311], 'patients': [1312, 1381], 'concur': [1317], 'my': [1319, 1600, 1700], 'colleague': [1320, 1601], 'current': [1322, 1688], 'comfortable': [1327], 'end-users': [1329], 'requires': [1341], 'extensive': [1342], 'organizational': [1345], 'may': [1348, 1749], 'restrict': [1349], 'short': [1354], 'term': [1355], 'centers': [1358], 'having': [1359, 1592], 'required': [1361], 'scientific': [1362], 'resources.': [1363], 'agree': [1366, 1676], 'assessed': [1373], 'carefully': [1374], 'respect': [1376], 'benefits': [1378, 1396], 'conveyed': [1379, 1550], 'before': [1382], 'adoption.': [1386], 'We': [1387], 'clearly': [1388], 'need': [1389, 1849], 'large-scale': [1390], 'demonstrate': [1393, 1545], 'define': [1403], 'needed.': [1412], 'disagree': [1415], 'main': [1418], 'arguments': [1419], 'raised': [1420], 'claim': [1422, 1632], 'is,': [1425], 'remain,': [1428], 'foreseeable': [1434], 'future.': [1435], 'aiming': [1441], 'improving': [1443, 1753], 'relevance': [1446], 'profound': [1456], 'way,': [1457], 'providing': [1463], 'mapping': [1467], 'abnormalities': [1470], 'shortening': [1472], 'transmission': [1473], 'time,': [1475], 'does.': [1478], 'diversity': [1484], 'contrasts,': [1487], 'wealth': [1492, 1738], 'fMRI': [1497], 'enhance': [1501], 'performance': [1504], 'quantitative': [1506], 'PET.': [1509], 'More': [1510], '(rather': [1514], 'sequential)': [1516], 'resolve': [1519], 'impediments': [1523], 'anatomo-molecular': [1528], 'accurate': [1531], 'reimbursement': [1535], 'issues': [1536], 'driven': [1539], 'prospective': [1541], 'improvements': [1546], 'health': [1548], 'outcomes': [1549], 'given': [1557, 1560], 'indication.': [1558], 'Therefore,': [1559], 'higher': [1562], 'soft': [1563], 'highest': [1571], 'sensitivity': [1572], 'specificity': [1574], '(e.g.,': [1578], 'detection': [1579], 'liver': [1581], 'metastases),9': [1582], 'coverage': [1583], 'scans': [1586], 'undoubtedly': [1588], 'expanded.': [1590], 'said,': [1594], 'like': [1597], 'challenge': [1599], 'asking:': [1604], '"Is': [1605], 'unanimously': [1607], 'oncology?"': [1616], 'bear': [1619], 'mind': [1621], 'controversial': [1627], 'issue,': [1628], 'investigators': [1631], 'role': [1638], 'lymphomas,': [1643], 'lung': [1644], 'nodules,': [1645], 'tumors.15': [1648], 'Time': [1649], 'dictate': [1651], 'whether': [1652], 'influence': [1655, 1670], 'future': [1659], 'instrumentation,': [1661], 'poised': [1664], 'advance': [1666], 'Dr.': [1678], 'Zaidi': [1679], 'advantages,': [1685], 'technological': [1689], 'barriers': [1690], 'resolved.': [1695], 'As': [1696], 'opening': [1701], 'statement,': [1702], 'theoretically': [1704], 'provides': [1705], 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