Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1978695791', 'doi': 'https://doi.org/10.1021/bi100968m', 'title': 'Activation and Specificity of Human Caspase-10', 'display_name': 'Activation and Specificity of Human Caspase-10', 'publication_year': 2010, 'publication_date': '2010-08-26', 'ids': {'openalex': 'https://openalex.org/W1978695791', 'doi': 'https://doi.org/10.1021/bi100968m', 'mag': '1978695791', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20795673', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2943529'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi100968m', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2943529?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081903577', 'display_name': 'K. Wachmann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I40399489', 'display_name': 'Torrey Pines Institute For Molecular Studies', 'ror': 'https://ror.org/01grq2104', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I40399489']}, {'id': 'https://openalex.org/I182212641', 'display_name': 'University of Salzburg', 'ror': 'https://ror.org/05gs8cd61', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I182212641']}], 'countries': ['AT', 'US'], 'is_corresponding': False, 'raw_author_name': 'Katherine Wachmann', 'raw_affiliation_strings': ['Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria', 'Program in Apoptosis and Cell Death Research, Sanford-BurnhamMedical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.'], 'affiliations': [{'raw_affiliation_string': 'Program in Apoptosis and Cell Death Research, Sanford-BurnhamMedical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.', 'institution_ids': ['https://openalex.org/I40399489']}, {'raw_affiliation_string': 'Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria', 'institution_ids': ['https://openalex.org/I182212641']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037589339', 'display_name': 'Cristina Pop', 'orcid': 'https://orcid.org/0000-0002-9088-8589'}, 'institutions': [{'id': 'https://openalex.org/I4210112450', 'display_name': 'Toxicologie, Pharmacologie et Signalisation Cellulaire', 'ror': 'https://ror.org/021ryxk89', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210112450']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Cristina Pop', 'raw_affiliation_strings': ['Program in Apoptosis and Cell Death Research'], 'affiliations': [{'raw_affiliation_string': 'Program in Apoptosis and Cell Death Research', 'institution_ids': ['https://openalex.org/I4210112450']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058167126', 'display_name': 'Bram J. van Raam', 'orcid': 'https://orcid.org/0000-0002-6500-2731'}, 'institutions': [{'id': 'https://openalex.org/I4210112450', 'display_name': 'Toxicologie, Pharmacologie et Signalisation Cellulaire', 'ror': 'https://ror.org/021ryxk89', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210112450']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Bram J. van Raam', 'raw_affiliation_strings': ['Program in Apoptosis and Cell Death Research'], 'affiliations': [{'raw_affiliation_string': 'Program in Apoptosis and Cell Death Research', 'institution_ids': ['https://openalex.org/I4210112450']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000997540', 'display_name': 'Marcin Drąg', 'orcid': 'https://orcid.org/0000-0001-8510-1967'}, 'institutions': [{'id': 'https://openalex.org/I4210112450', 'display_name': 'Toxicologie, Pharmacologie et Signalisation Cellulaire', 'ror': 'https://ror.org/021ryxk89', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210112450']}, {'id': 'https://openalex.org/I11923345', 'display_name': 'Wrocław University of Science and Technology', 'ror': 'https://ror.org/008fyn775', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I11923345']}], 'countries': ['FR', 'PL'], 'is_corresponding': False, 'raw_author_name': 'Marcin Drag', 'raw_affiliation_strings': ['Division of Medicinal Chemistry and Microbiology, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland', 'Program in Apoptosis and Cell Death Research'], 'affiliations': [{'raw_affiliation_string': 'Program in Apoptosis and Cell Death Research', 'institution_ids': ['https://openalex.org/I4210112450']}, {'raw_affiliation_string': 'Division of Medicinal Chemistry and Microbiology, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland', 'institution_ids': ['https://openalex.org/I11923345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026934240', 'display_name': 'Peter D. Mace', 'orcid': 'https://orcid.org/0000-0003-2175-9537'}, 'institutions': [{'id': 'https://openalex.org/I4210112450', 'display_name': 'Toxicologie, Pharmacologie et Signalisation Cellulaire', 'ror': 'https://ror.org/021ryxk89', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210112450']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Peter D. Mace', 'raw_affiliation_strings': ['Program in Apoptosis and Cell Death Research'], 'affiliations': [{'raw_affiliation_string': 'Program in Apoptosis and Cell Death Research', 'institution_ids': ['https://openalex.org/I4210112450']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087149939', 'display_name': 'Scott J. Snipas', 'orcid': 'https://orcid.org/0000-0002-4239-6862'}, 'institutions': [{'id': 'https://openalex.org/I4210112450', 'display_name': 'Toxicologie, Pharmacologie et Signalisation Cellulaire', 'ror': 'https://ror.org/021ryxk89', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210112450']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Scott J. Snipas', 'raw_affiliation_strings': ['Program in Apoptosis and Cell Death Research'], 'affiliations': [{'raw_affiliation_string': 'Program in Apoptosis and Cell Death Research', 'institution_ids': ['https://openalex.org/I4210112450']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079950186', 'display_name': 'Christian M. Zmasek', 'orcid': 'https://orcid.org/0000-0002-7933-2424'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Christian Zmasek', 'raw_affiliation_strings': ['Program for Bioinformatics and Systems Biology'], 'affiliations': [{'raw_affiliation_string': 'Program for Bioinformatics and Systems Biology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036828158', 'display_name': 'Robert Schwarzenbacher', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I182212641', 'display_name': 'University of Salzburg', 'ror': 'https://ror.org/05gs8cd61', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I182212641']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Robert Schwarzenbacher', 'raw_affiliation_strings': ['Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria.', 'institution_ids': ['https://openalex.org/I182212641']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087530743', 'display_name': 'Guy S. Salvesen', 'orcid': 'https://orcid.org/0000-0002-7933-6732'}, 'institutions': [{'id': 'https://openalex.org/I4210112450', 'display_name': 'Toxicologie, Pharmacologie et Signalisation Cellulaire', 'ror': 'https://ror.org/021ryxk89', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210112450']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Guy S. Salvesen', 'raw_affiliation_strings': ['Program in Apoptosis and Cell Death Research'], 'affiliations': [{'raw_affiliation_string': 'Program in Apoptosis and Cell Death Research', 'institution_ids': ['https://openalex.org/I4210112450']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5032790946', 'display_name': 'Stefan J. Riedl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210112450', 'display_name': 'Toxicologie, Pharmacologie et Signalisation Cellulaire', 'ror': 'https://ror.org/021ryxk89', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210112450']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Stefan J. Riedl', 'raw_affiliation_strings': ['Program in Apoptosis and Cell Death Research'], 'affiliations': [{'raw_affiliation_string': 'Program in Apoptosis and Cell Death Research', 'institution_ids': ['https://openalex.org/I4210112450']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.266, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 73, 'citation_normalized_percentile': {'value': 0.912218, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '49', 'issue': '38', 'first_page': '8307', 'last_page': '8315'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11075', 'display_name': 'Insect Resistance and Genetics', 'score': 0.9698, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12254', 'display_name': 'Machine Learning in Bioinformatics', 'score': 0.941, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cleavage', 'display_name': 'Cleavage (geology)', 'score': 0.7783625}, {'id': 'https://openalex.org/keywords/caspase-2', 'display_name': 'Caspase 2', 'score': 0.510878}, {'id': 'https://openalex.org/keywords/nlrp1', 'display_name': 'NLRP1', 'score': 0.4961494}, {'id': 'https://openalex.org/keywords/caspase-9', 'display_name': 'Caspase-9', 'score': 0.46354574}, {'id': 'https://openalex.org/keywords/wild-type', 'display_name': 'Wild type', 'score': 0.43703496}], 'concepts': [{'id': 'https://openalex.org/C98424977', 'wikidata': 'https://www.wikidata.org/wiki/Q25805', 'display_name': 'Caspase', 'level': 4, 'score': 0.866189}, {'id': 'https://openalex.org/C175156509', 'wikidata': 'https://www.wikidata.org/wiki/Q1990218', 'display_name': 'Cleavage (geology)', 'level': 3, 'score': 0.7783625}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.67692506}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6435986}, {'id': 'https://openalex.org/C2776714187', 'wikidata': 'https://www.wikidata.org/wiki/Q212410', 'display_name': 'Protease', 'level': 3, 'score': 0.58732283}, {'id': 'https://openalex.org/C12519072', 'wikidata': 'https://www.wikidata.org/wiki/Q14914370', 'display_name': 'Caspase 3', 'level': 4, 'score': 0.58453566}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.54185796}, {'id': 'https://openalex.org/C125209161', 'wikidata': 'https://www.wikidata.org/wiki/Q422816', 'display_name': 'Enzyme activator', 'level': 3, 'score': 0.51503134}, {'id': 'https://openalex.org/C155863897', 'wikidata': 'https://www.wikidata.org/wiki/Q14913269', 'display_name': 'Caspase 2', 'level': 5, 'score': 0.510878}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.5063149}, {'id': 'https://openalex.org/C176912530', 'wikidata': 'https://www.wikidata.org/wiki/Q18036542', 'display_name': 'NLRP1', 'level': 5, 'score': 0.4961494}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.4699393}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4686415}, {'id': 'https://openalex.org/C2775998712', 'wikidata': 'https://www.wikidata.org/wiki/Q14907714', 'display_name': 'Caspase-9', 'level': 5, 'score': 0.46354574}, {'id': 'https://openalex.org/C207583985', 'wikidata': 'https://www.wikidata.org/wiki/Q128723', 'display_name': 'Wild type', 'level': 4, 'score': 0.43703496}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38970983}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.38499433}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.2503096}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C43369102', 'wikidata': 'https://www.wikidata.org/wiki/Q2307625', 'display_name': 'Fracture (geology)', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D053455', 'descriptor_name': 'Caspase 10', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D051023', 'descriptor_name': 'BH3 Interacting Domain Death Agonist Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051023', 'descriptor_name': 'BH3 Interacting Domain Death Agonist Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053455', 'descriptor_name': 'Caspase 10', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019281', 'descriptor_name': 'Dimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010450', 'descriptor_name': 'Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010450', 'descriptor_name': 'Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi100968m', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2943529', 'pdf_url': 'https://europepmc.org/articles/pmc2943529?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943529', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20795673', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2943529', 'pdf_url': 'https://europepmc.org/articles/pmc2943529?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.42, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 63, 'referenced_works': ['https://openalex.org/W107210068', 'https://openalex.org/W110317239', 'https://openalex.org/W1492587973', 'https://openalex.org/W1967894078', 'https://openalex.org/W1969281441', 'https://openalex.org/W1969893319', 'https://openalex.org/W1972263342', 'https://openalex.org/W1975435080', 'https://openalex.org/W1976141746', 'https://openalex.org/W1978525280', 'https://openalex.org/W1985529376', 'https://openalex.org/W1986978728', 'https://openalex.org/W1992637685', 'https://openalex.org/W1993129579', 'https://openalex.org/W1994362040', 'https://openalex.org/W2006131891', 'https://openalex.org/W2006981341', 'https://openalex.org/W2008880656', 'https://openalex.org/W2011950893', 'https://openalex.org/W2012173926', 'https://openalex.org/W2022068602', 'https://openalex.org/W2025044046', 'https://openalex.org/W2025128734', 'https://openalex.org/W2027021865', 'https://openalex.org/W2032417513', 'https://openalex.org/W2032437043', 'https://openalex.org/W2033682281', 'https://openalex.org/W2036505974', 'https://openalex.org/W2040642461', 'https://openalex.org/W2048795742', 'https://openalex.org/W2052842511', 'https://openalex.org/W2056155809', 'https://openalex.org/W2059444339', 'https://openalex.org/W2062853648', 'https://openalex.org/W2062949984', 'https://openalex.org/W2065540065', 'https://openalex.org/W2068627962', 'https://openalex.org/W2075477970', 'https://openalex.org/W2075733006', 'https://openalex.org/W2076104002', 'https://openalex.org/W2078202890', 'https://openalex.org/W2079689456', 'https://openalex.org/W2086389810', 'https://openalex.org/W2086925846', 'https://openalex.org/W2088569816', 'https://openalex.org/W2092415563', 'https://openalex.org/W2094334993', 'https://openalex.org/W2094869832', 'https://openalex.org/W2103699489', 'https://openalex.org/W2108307486', 'https://openalex.org/W2110077740', 'https://openalex.org/W2110173959', 'https://openalex.org/W2135450099', 'https://openalex.org/W2141456617', 'https://openalex.org/W2151501496', 'https://openalex.org/W2152276217', 'https://openalex.org/W2156179144', 'https://openalex.org/W2156412351', 'https://openalex.org/W2157321507', 'https://openalex.org/W2166219468', 'https://openalex.org/W2316070165', 'https://openalex.org/W2883755802', 'https://openalex.org/W4239718055'], 'related_works': ['https://openalex.org/W3149175423', 'https://openalex.org/W2984141991', 'https://openalex.org/W2891027352', 'https://openalex.org/W2160035242', 'https://openalex.org/W2119683782', 'https://openalex.org/W2066782359', 'https://openalex.org/W2044252588', 'https://openalex.org/W2029377139', 'https://openalex.org/W1993888620', 'https://openalex.org/W1979154669'], 'abstract_inverted_index': {'Two': [0], 'apical': [1, 70], 'caspases,': [2], 'caspase-8': [3, 20], 'and': [4, 24, 45, 77, 95, 111, 145], '-10,': [5], 'are': [6], 'involved': [7], 'in': [8, 14, 21, 56], 'the': [9, 46, 49, 65, 75, 80, 108, 112, 119, 133], 'extrinsic': [10], 'death': [11], 'receptor': [12], 'pathway': [13], 'humans,': [15], 'but': [16, 129], 'it': [17], 'is': [18], 'mainly': [19], 'its': [22, 41], 'apoptotic': [23], 'nonapoptotic': [25], 'functions': [26], 'that': [27, 62, 118], 'has': [28, 123], 'been': [29], 'an': [30], 'intense': [31], 'research': [32], 'focus.': [33], 'In': [34], 'this': [35], 'study': [36], 'we': [37, 73], 'concentrate': [38], 'on': [39, 126, 132], 'caspase-10,': [40], 'mechanism': [42], 'of': [43, 48, 79, 87, 97], 'activation,': [44], 'role': [47, 141], 'intersubunit': [50], 'cleavage.': [51], 'Our': [52], 'data': [53], 'obtained': [54], 'through': [55], 'vitro': [57], 'dimerization': [58, 67], 'assays': [59], 'strongly': [60], 'suggest': [61], 'caspase-10': [63], 'follows': [64], 'proximity-induced': [66], 'model': [68], 'for': [69, 142], 'caspases.': [71], 'Furthermore,': [72], 'compare': [74], 'specificity': [76], 'activity': [78, 125, 131], 'wild-type': [81], 'protease': [82], 'with': [83], 'a': [84, 104, 139], 'mutant': [85], 'incapable': [86], 'autoprocessing': [88], 'by': [89], 'using': [90], 'positional': [91], 'scanning': [92], 'substrate': [93], 'analysis': [94], 'cleavage': [96], 'natural': [98], 'protein': [99, 135], 'substrates.': [100], 'These': [101], 'experiments': [102], 'reveal': [103], 'striking': [105], 'difference': [106], 'between': [107], 'wild': [109], 'type': [110], 'mutant,': [113], 'leading': [114], 'us': [115], 'to': [116], 'hypothesize': [117], 'single': [120], 'chain': [121], 'enzyme': [122], 'restricted': [124], 'most': [127], 'proteins': [128], 'high': [130], 'proapoptotic': [134], 'Bid,': [136], 'potentially': [137], 'supporting': [138], 'prodeath': [140], 'both': [143], 'cleaved': [144], 'uncleaved': [146], 'caspase-10.': [147]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1978695791', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2025-01-05T11:02:29.682130', 'created_date': '2016-06-24'}