Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1978547064', 'doi': 'https://doi.org/10.1053/hupa.2000.8227', 'title': 'Cell cycle regulators in bladder cancer: A multivariate survival study with emphasis, on p27Kip1', 'display_name': 'Cell cycle regulators in bladder cancer: A multivariate survival study with emphasis, on p27Kip1', 'publication_year': 2000, 'publication_date': '2000-06-01', 'ids': {'openalex': 'https://openalex.org/W1978547064', 'doi': 'https://doi.org/10.1053/hupa.2000.8227', 'mag': '1978547064', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10872671'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1053/hupa.2000.8227', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S63477337', 'display_name': 'Human Pathology', 'issn_l': '0046-8177', 'issn': ['0046-8177', '1532-8392'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023804098', 'display_name': 'Penelope Korkolopoulou', 'orcid': 'https://orcid.org/0000-0003-1883-3898'}, 'institutions': [{'id': 'https://openalex.org/I200777214', 'display_name': 'National and Kapodistrian University of Athens', 'ror': 'https://ror.org/04gnjpq42', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I200777214']}, {'id': 'https://openalex.org/I4210122732', 'display_name': 'General Hospital Asklepieio Voulas', 'ror': 'https://ror.org/036v5qv16', 'country_code': 'GR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210122732']}], 'countries': ['GR'], 'is_corresponding': True, 'raw_author_name': 'P KORKOLOPOULOU', 'raw_affiliation_strings': ['Department of Pathology, National University ofAthens, Greece', 'Departments of Pathology and Urology,Asklepeion Hospital, Voula, Athens, Greece'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, National University ofAthens, Greece', 'institution_ids': ['https://openalex.org/I200777214']}, {'raw_affiliation_string': 'Departments of Pathology and Urology,Asklepeion Hospital, Voula, Athens, Greece', 'institution_ids': ['https://openalex.org/I4210122732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021731465', 'display_name': 'Panagiota Christodoulou', 'orcid': 'https://orcid.org/0000-0001-5130-9938'}, 'institutions': [{'id': 'https://openalex.org/I200777214', 'display_name': 'National and Kapodistrian University of Athens', 'ror': 'https://ror.org/04gnjpq42', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I200777214']}, {'id': 'https://openalex.org/I4210122732', 'display_name': 'General Hospital Asklepieio Voulas', 'ror': 'https://ror.org/036v5qv16', 'country_code': 'GR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210122732']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'P CHRISTODOULOU', 'raw_affiliation_strings': ['Department of Pathology, National University ofAthens, Greece', 'Departments of Pathology and Urology,Asklepeion Hospital, Voula, Athens, Greece'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, National University ofAthens, Greece', 'institution_ids': ['https://openalex.org/I200777214']}, {'raw_affiliation_string': 'Departments of Pathology and Urology,Asklepeion Hospital, Voula, Athens, Greece', 'institution_ids': ['https://openalex.org/I4210122732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072710153', 'display_name': 'Anastasia Konstantinidou', 'orcid': 'https://orcid.org/0000-0002-2458-988X'}, 'institutions': [{'id': 'https://openalex.org/I200777214', 'display_name': 'National and Kapodistrian University of Athens', 'ror': 'https://ror.org/04gnjpq42', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I200777214']}, {'id': 'https://openalex.org/I4210122732', 'display_name': 'General Hospital Asklepieio Voulas', 'ror': 'https://ror.org/036v5qv16', 'country_code': 'GR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210122732']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'A KONSTANTINIDOU', 'raw_affiliation_strings': ['Department of Pathology, National University ofAthens, Greece', 'Departments of Pathology and Urology,Asklepeion Hospital, Voula, Athens, Greece'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, National University ofAthens, Greece', 'institution_ids': ['https://openalex.org/I200777214']}, {'raw_affiliation_string': 'Departments of Pathology and Urology,Asklepeion Hospital, Voula, Athens, Greece', 'institution_ids': ['https://openalex.org/I4210122732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081185528', 'display_name': 'Euphemia Thomas-Tsagli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200777214', 'display_name': 'National and Kapodistrian University of Athens', 'ror': 'https://ror.org/04gnjpq42', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I200777214']}, {'id': 'https://openalex.org/I4210122732', 'display_name': 'General Hospital Asklepieio Voulas', 'ror': 'https://ror.org/036v5qv16', 'country_code': 'GR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210122732']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'E THOMASTSAGLI', 'raw_affiliation_strings': ['Department of Pathology, National University ofAthens, Greece', 'Departments of Pathology and Urology,Asklepeion Hospital, Voula, Athens, Greece'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, National University ofAthens, Greece', 'institution_ids': ['https://openalex.org/I200777214']}, {'raw_affiliation_string': 'Departments of Pathology and Urology,Asklepeion Hospital, Voula, Athens, Greece', 'institution_ids': ['https://openalex.org/I4210122732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054183517', 'display_name': 'Panagiotis Kapralos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200777214', 'display_name': 'National and Kapodistrian University of Athens', 'ror': 'https://ror.org/04gnjpq42', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I200777214']}, {'id': 'https://openalex.org/I4210122732', 'display_name': 'General Hospital Asklepieio Voulas', 'ror': 'https://ror.org/036v5qv16', 'country_code': 'GR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210122732']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'P KAPRALOS', 'raw_affiliation_strings': ['Department of Pathology, National University ofAthens, Greece', 'Departments of Pathology and Urology,Asklepeion Hospital, Voula, Athens, Greece'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, National University ofAthens, Greece', 'institution_ids': ['https://openalex.org/I200777214']}, {'raw_affiliation_string': 'Departments of Pathology and Urology,Asklepeion Hospital, Voula, Athens, Greece', 'institution_ids': ['https://openalex.org/I4210122732']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5087880779', 'display_name': 'Panagiotis Davaris', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200777214', 'display_name': 'National and Kapodistrian University of Athens', 'ror': 'https://ror.org/04gnjpq42', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I200777214']}, {'id': 'https://openalex.org/I4210122732', 'display_name': 'General Hospital Asklepieio Voulas', 'ror': 'https://ror.org/036v5qv16', 'country_code': 'GR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210122732']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'P DAVARIS', 'raw_affiliation_strings': ['Department of Pathology, National University ofAthens, Greece', 'Departments of Pathology and Urology,Asklepeion Hospital, Voula, Athens, Greece'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, National University ofAthens, Greece', 'institution_ids': ['https://openalex.org/I200777214']}, {'raw_affiliation_string': 'Departments of Pathology and Urology,Asklepeion Hospital, Voula, Athens, Greece', 'institution_ids': ['https://openalex.org/I4210122732']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5023804098'], 'corresponding_institution_ids': ['https://openalex.org/I200777214', 'https://openalex.org/I4210122732'], 'apc_list': {'value': 3460, 'currency': 'USD', 'value_usd': 3460, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 9.468, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 94, 'citation_normalized_percentile': {'value': 0.927839, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '31', 'issue': '6', 'first_page': '751', 'last_page': '760'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10458', 'display_name': 'Diagnosis and Treatment of Bladder Cancer', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10458', 'display_name': 'Diagnosis and Treatment of Bladder Cancer', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Engineering Bacteria for Cancer Treatment', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/retinoblastoma-protein', 'display_name': 'Retinoblastoma protein', 'score': 0.65595996}, {'id': 'https://openalex.org/keywords/cell-cycle', 'display_name': 'Cell Cycle', 'score': 0.525645}, {'id': 'https://openalex.org/keywords/cyclin-e', 'display_name': 'Cyclin E', 'score': 0.5070486}, {'id': 'https://openalex.org/keywords/retinoblastoma', 'display_name': 'Retinoblastoma', 'score': 0.4575218}], 'concepts': [{'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.6754034}, {'id': 'https://openalex.org/C2776062698', 'wikidata': 'https://www.wikidata.org/wiki/Q21111463', 'display_name': 'Retinoblastoma protein', 'level': 4, 'score': 0.65595996}, {'id': 'https://openalex.org/C2780352672', 'wikidata': 'https://www.wikidata.org/wiki/Q504775', 'display_name': 'Bladder cancer', 'level': 3, 'score': 0.6150014}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5986921}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.54515994}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.5126564}, {'id': 'https://openalex.org/C94561458', 'wikidata': 'https://www.wikidata.org/wiki/Q24724860', 'display_name': 'Cyclin E', 'level': 5, 'score': 0.5070486}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.49768546}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4685662}, {'id': 'https://openalex.org/C2776577112', 'wikidata': 'https://www.wikidata.org/wiki/Q500695', 'display_name': 'Retinoblastoma', 'level': 3, 'score': 0.4575218}, {'id': 'https://openalex.org/C199835354', 'wikidata': 'https://www.wikidata.org/wiki/Q15311861', 'display_name': 'Cyclin D1', 'level': 4, 'score': 0.45457408}, {'id': 'https://openalex.org/C120089663', 'wikidata': 'https://www.wikidata.org/wiki/Q59250999', 'display_name': 'Cyclin', 'level': 4, 'score': 0.4350226}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.34635693}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.34284675}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2364847}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.2139704}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.088288724}], 'mesh': [{'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D016213', 'descriptor_name': 'Cyclins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001749', 'descriptor_name': 'Urinary Bladder Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D001749', 'descriptor_name': 'Urinary Bladder Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019941', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p16', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D019941', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p16', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050759', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p21', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050760', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p27', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016213', 'descriptor_name': 'Cyclins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D016213', 'descriptor_name': 'Cyclins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019394', 'descriptor_name': 'Ki-67 Antigen', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D019394', 'descriptor_name': 'Ki-67 Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016160', 'descriptor_name': 'Retinoblastoma Protein', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D016160', 'descriptor_name': 'Retinoblastoma Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015996', 'descriptor_name': 'Survival Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001749', 'descriptor_name': 'Urinary Bladder Neoplasms', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001749', 'descriptor_name': 'Urinary Bladder Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1053/hupa.2000.8227', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S63477337', 'display_name': 'Human Pathology', 'issn_l': '0046-8177', 'issn': ['0046-8177', '1532-8392'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10872671', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.58, 'id': 'https://metadata.un.org/sdg/1', 'display_name': 'No poverty'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1496204824', 'https://openalex.org/W1507642320', 'https://openalex.org/W1536690700', 'https://openalex.org/W1567424149', 'https://openalex.org/W1571410968', 'https://openalex.org/W1876313598', 'https://openalex.org/W1965727118', 'https://openalex.org/W1971716928', 'https://openalex.org/W1977207625', 'https://openalex.org/W1983013270', 'https://openalex.org/W1983150121', 'https://openalex.org/W1996413533', 'https://openalex.org/W2001191224', 'https://openalex.org/W2005236535', 'https://openalex.org/W2014699175', 'https://openalex.org/W2015066175', 'https://openalex.org/W2015519364', 'https://openalex.org/W2019055238', 'https://openalex.org/W2029080338', 'https://openalex.org/W2030231219', 'https://openalex.org/W2040189858', 'https://openalex.org/W2061805562', 'https://openalex.org/W2065411915', 'https://openalex.org/W2066848701', 'https://openalex.org/W2086003985', 'https://openalex.org/W2087717687', 'https://openalex.org/W2091403769', 'https://openalex.org/W2092104789', 'https://openalex.org/W2099907467', 'https://openalex.org/W2102917490', 'https://openalex.org/W2128846890', 'https://openalex.org/W2131954674', 'https://openalex.org/W2138852914', 'https://openalex.org/W2160115028', 'https://openalex.org/W2260430648', 'https://openalex.org/W2275614507', 'https://openalex.org/W2318856916', 'https://openalex.org/W2412406914', 'https://openalex.org/W2414222796', 'https://openalex.org/W297761204', 'https://openalex.org/W37569660'], 'related_works': ['https://openalex.org/W4211046008', 'https://openalex.org/W3092184089', 'https://openalex.org/W2187684008', 'https://openalex.org/W2107866180', 'https://openalex.org/W2099925982', 'https://openalex.org/W2078990441', 'https://openalex.org/W2063780942', 'https://openalex.org/W2025982955', 'https://openalex.org/W2023204707', 'https://openalex.org/W1621533677'], 'abstract_inverted_index': {'Cyclin-dependent': [0], 'kinase': [1], 'inhibitors': [2], '(CKIs)': [3], 'prevent': [4], 'cyclin-dependent': [5], 'kinases': [6], 'from': [7, 64], 'phosphorylating': [8], 'critical': [9], 'substrates': [10], 'such': [11], 'as': [12], 'retinoblastoma': [13], 'gene': [14], 'protein': [15], '(pRb),': [16], 'hence': [17], 'blocking': [18], 'the': [19, 28, 65, 88, 205, 209, 247], 'cascade': [20], 'of': [21, 30, 90, 106, 212], 'events': [22], 'leading': [23], 'to': [24, 59, 61, 114, 186], 'cell': [25, 66, 108, 239, 262], 'proliferation.': [26], 'Currently,': [27], 'list': [29], 'CKIs': [31], 'includes': [32], 'p21WAF1/Cip1,': [33], 'p27Kip1,': [34], 'p57Kip2': [35], '(the': [36, 45], 'Cip/Kip': [37], 'family),': [38], 'p15/': [39], 'INK4b,': [40], 'p16/INK4a,': [41], 'p18/INK4c,': [42], 'and': [43, 71, 76, 92, 111, 119, 140, 177, 193, 233], 'p19/INK4d': [44], 'INK4': [46], 'family).': [47], 'Among': [48], 'them,': [49], 'p27': [50, 91, 121, 150, 167, 223], 'plays': [51], 'a': [52, 235], 'crucial': [53], 'role': [54], 'linking': [55], 'extracellular': [56], 'growth-regulatory': [57], 'signals': [58], 'progression': [60], 'or': [62, 260], 'exit': [63], 'cycle.': [67], 'Unlike': [68], 'p53,': [69], 'p16,': [70, 99], 'Rb,': [72], 'mutations': [73], 'in': [74, 82, 102, 126, 199, 228, 238, 242, 268], 'Kip1': [75], 'WAF1': [77], 'genes': [78], 'are': [79], 'distinctly': [80], 'rare': [81], 'bladder': [83], 'cancer.': [84], 'We': [85], 'analyzed': [86], 'immunohistochemically': [87], 'expression': [89, 156, 168, 189, 224, 250], 'other': [93, 261], 'interacting': [94], 'G1': [95], 'proteins': [96], '(ie,': [97], 'p21,': [98], 'pRb,': [100], 'p53)': [101], '120': [103], 'consecutive': [104], 'cases': [105], 'transitional': [107], 'carcinomas': [109], '(TCCs)': [110], 'related': [112], 'it': [113], 'proliferation': [115], 'rate,': [116], 'clinicopathologic': [117], 'parameters,': [118], 'survival.': [120], 'levels': [122], 'were': [123], 'significantly': [124], 'higher': [125], 'low-grade': [127], '(P': [128, 133, 137, 174, 179, 190, 215], '=': [129, 134, 145, 148, 158, 161, 175, 180, 191, 195, 216], '.001),': [130, 135, 139], 'superficial': [131], '(Ta-T1)': [132], 'papillary': [136], '<': [138], 'slowly': [141], 'proliferating': [142], 'TCCs': [143, 214, 232], '(rs': [144, 157], '-0.235,': [146], 'P': [147, 160, 194], '.05).': [149, 162], 'also': [151], 'positively': [152], 'correlated': [153], 'with': [154, 171], 'p16': [155], '0.212,': [159], 'In': [163], 'univariate': [164], 'analysis,': [165, 201], 'decreased': [166], 'was': [169], 'associated': [170], 'poor': [172], 'overall': [173, 210, 266], '.0109)': [176], 'postrelapse': [178], '.0344)': [181], 'survival,': [182], 'especially': [183], 'if': [184], 'combined': [185, 248], 'increased': [187], 'Ki-67': [188], '.0004': [192], '.036,': [196], 'respectively).': [197], 'Furthermore,': [198], 'multivariate': [200], 'Ki-67/p27': [202, 249], 'status': [203], 'had': [204], 'strongest': [206], 'bearing': [207], 'on': [208], 'survival': [211, 267], 'muscle-invasive': [213, 231, 269], '.0019).': [217], 'Our': [218], 'results': [219], 'indicate': [220], 'that': [221, 255], 'low': [222], 'is': [225, 234], 'more': [226], 'common': [227], 'poorly': [229], 'differentiated': [230], 'major': [236], 'player': [237], 'cycle': [240], 'control': [241], 'these': [243], 'neoplasms.': [244], 'More': [245], 'importantly,': [246], 'provides': [251], 'prognostic': [252], 'information': [253], 'beyond': [254], 'provided': [256], 'by': [257], 'conventional': [258], 'parameters': [259], 'cycle-related': [263], 'proteins,': [264], 'concerning': [265], 'TCCs.': [270]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1978547064', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-08-15T04:03:23.060912', 'created_date': '2016-06-24'}