Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1978272694', 'doi': 'https://doi.org/10.1096/fj.04-2126com', 'title': 'Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism', 'display_name': 'Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism', 'publication_year': 2004, 'publication_date': '2004-11-01', 'ids': {'openalex': 'https://openalex.org/W1978272694', 'doi': 'https://doi.org/10.1096/fj.04-2126com', 'mag': '1978272694', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15522912'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fj.04-2126com', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101638577', 'display_name': 'Tae‐Wook Chung', 'orcid': 'https://orcid.org/0000-0001-5243-5020'}, 'institutions': [{'id': 'https://openalex.org/I205490536', 'display_name': 'Dongguk University', 'ror': 'https://ror.org/057q6n778', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I205490536']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Tae‐Wook Chung', 'raw_affiliation_strings': ['National Research Laboratory for Glycobiology and Department of Biochemistry and Molecular Biology Dongguk University College of Oriental Medicine Kyungju Kyungbuk Korea'], 'affiliations': [{'raw_affiliation_string': 'National Research Laboratory for Glycobiology and Department of Biochemistry and Molecular Biology Dongguk University College of Oriental Medicine Kyungju Kyungbuk Korea', 'institution_ids': ['https://openalex.org/I205490536']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066587325', 'display_name': 'Sung‐Kwon Moon', 'orcid': 'https://orcid.org/0000-0002-0260-7231'}, 'institutions': [{'id': 'https://openalex.org/I205490536', 'display_name': 'Dongguk University', 'ror': 'https://ror.org/057q6n778', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I205490536']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Sung‐Kwon Moon', 'raw_affiliation_strings': ['Chunju National University Chungbuk Korea', 'National Research Laboratory for Glycobiology and Department of Biochemistry and Molecular Biology Dongguk University College of Oriental Medicine Kyungju Kyungbuk Korea'], 'affiliations': [{'raw_affiliation_string': 'National Research Laboratory for Glycobiology and Department of Biochemistry and Molecular Biology Dongguk University College of Oriental Medicine Kyungju Kyungbuk Korea', 'institution_ids': ['https://openalex.org/I205490536']}, {'raw_affiliation_string': 'Chunju National University Chungbuk Korea', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111519070', 'display_name': 'Young‐Chae Chang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39705031', 'display_name': 'Catholic University of Daegu', 'ror': 'https://ror.org/04fxknd68', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I39705031']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Young‐Chae Chang', 'raw_affiliation_strings': ['Department of Pathology, College of Medicine, Daegu Catholic University, Daegu, Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, College of Medicine, Daegu Catholic University, Daegu, Korea', 'institution_ids': ['https://openalex.org/I39705031']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104533276', 'display_name': 'Jeong‐Heon Ko', 'orcid': 'https://orcid.org/0000-0003-3349-2534'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jeong‐Heon Ko', 'raw_affiliation_strings': ['Proteome Research Korea Research Institute of Bioscience and Biotechnology Daejon Korea'], 'affiliations': [{'raw_affiliation_string': 'Proteome Research Korea Research Institute of Bioscience and Biotechnology Daejon Korea', 'institution_ids': ['https://openalex.org/I73616290']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044077275', 'display_name': 'Young‐Choon Lee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I51226738', 'display_name': 'Dong-A University', 'ror': 'https://ror.org/03qvtpc38', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I51226738']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Young‐Choon Lee', 'raw_affiliation_strings': ['Faculty of Biotechnology Dong-A University Pusan Korea'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Biotechnology Dong-A University Pusan Korea', 'institution_ids': ['https://openalex.org/I51226738']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023880471', 'display_name': 'Gun Rae Cho', 'orcid': 'https://orcid.org/0000-0002-8536-4844'}, 'institutions': [{'id': 'https://openalex.org/I4210139925', 'display_name': 'Korea Basic Science Institute', 'ror': 'https://ror.org/0417sdw47', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210139925']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Gun Cho', 'raw_affiliation_strings': ['Proteome Analysis Team Korea Basic Science Research Institute Daejon Korea'], 'affiliations': [{'raw_affiliation_string': 'Proteome Analysis Team Korea Basic Science Research Institute Daejon Korea', 'institution_ids': ['https://openalex.org/I4210139925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100379508', 'display_name': 'Soo‐Hyun Kim', 'orcid': 'https://orcid.org/0000-0002-9394-1437'}, 'institutions': [{'id': 'https://openalex.org/I4210139925', 'display_name': 'Korea Basic Science Institute', 'ror': 'https://ror.org/0417sdw47', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210139925']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Soo‐Hyun Kim', 'raw_affiliation_strings': ['Proteome Analysis Team Korea Basic Science Research Institute Daejon Korea'], 'affiliations': [{'raw_affiliation_string': 'Proteome Analysis Team Korea Basic Science Research Institute Daejon Korea', 'institution_ids': ['https://openalex.org/I4210139925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012371446', 'display_name': 'Jong‐Guk Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I31419693', 'display_name': 'Kyungpook National University', 'ror': 'https://ror.org/040c17130', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I31419693']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jong‐Guk Kim', 'raw_affiliation_strings': ['Department of Microbiology, Kyungpook National University, Daegu, Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Kyungpook National University, Daegu, Korea', 'institution_ids': ['https://openalex.org/I31419693']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074483970', 'display_name': 'Cheorl‐Ho Kim', 'orcid': 'https://orcid.org/0000-0002-6323-0714'}, 'institutions': [{'id': 'https://openalex.org/I205490536', 'display_name': 'Dongguk University', 'ror': 'https://ror.org/057q6n778', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I205490536']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Cheorl‐Ho Kim', 'raw_affiliation_strings': ['National Research Laboratory for Glycobiology and Department of Biochemistry and Molecular Biology Dongguk University College of Oriental Medicine Kyungju Kyungbuk Korea'], 'affiliations': [{'raw_affiliation_string': 'National Research Laboratory for Glycobiology and Department of Biochemistry and Molecular Biology Dongguk University College of Oriental Medicine Kyungju Kyungbuk Korea', 'institution_ids': ['https://openalex.org/I205490536']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.178, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 458, 'citation_normalized_percentile': {'value': 0.999979, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '18', 'issue': '14', 'first_page': '1670', 'last_page': '1681'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12685', 'display_name': 'Phytochemical compounds biological activities', 'score': 0.9935, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12685', 'display_name': 'Phytochemical compounds biological activities', 'score': 0.9935, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9851, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13817', 'display_name': 'Tannin, Tannase and Anticancer Activities', 'score': 0.9813, 'subfield': {'id': 'https://openalex.org/subfields/2402', 'display_name': 'Applied Microbiology and Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2776992468', 'wikidata': 'https://www.wikidata.org/wiki/Q15410860', 'display_name': 'Caffeic acid phenethyl ester', 'level': 4, 'score': 0.9090114}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.6443248}, {'id': 'https://openalex.org/C2778224086', 'wikidata': 'https://www.wikidata.org/wiki/Q414116', 'display_name': 'Caffeic acid', 'level': 3, 'score': 0.6204114}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.59097445}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.50783426}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4935075}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.48673606}, {'id': 'https://openalex.org/C109523444', 'wikidata': 'https://www.wikidata.org/wiki/Q424216', 'display_name': 'Matrix metalloproteinase', 'level': 2, 'score': 0.4748043}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4659202}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.44641507}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.42097312}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.41170877}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.40804985}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3129933}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2965317}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.2424399}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.20904756}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.17539981}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.13553289}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06570345}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D002109', 'descriptor_name': 'Caffeic Acids', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002109', 'descriptor_name': 'Caffeic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002109', 'descriptor_name': 'Caffeic Acids', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002109', 'descriptor_name': 'Caffeic Acids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020780', 'descriptor_name': 'Matrix Metalloproteinase 9', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020780', 'descriptor_name': 'Matrix Metalloproteinase 9', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020780', 'descriptor_name': 'Matrix Metalloproteinase 9', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061965', 'descriptor_name': 'Matrix Metalloproteinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010626', 'descriptor_name': 'Phenylethyl Alcohol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010626', 'descriptor_name': 'Phenylethyl Alcohol', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fj.04-2126com', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15522912', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.79, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 69, 'referenced_works': ['https://openalex.org/W1521352631', 'https://openalex.org/W1530156780', 'https://openalex.org/W1585873539', 'https://openalex.org/W1623264536', 'https://openalex.org/W1812116884', 'https://openalex.org/W1841699403', 'https://openalex.org/W1886431664', 'https://openalex.org/W1964596759', 'https://openalex.org/W1965769122', 'https://openalex.org/W1968842030', 'https://openalex.org/W1969803272', 'https://openalex.org/W1972071205', 'https://openalex.org/W1977320698', 'https://openalex.org/W1978764552', 'https://openalex.org/W1981281538', 'https://openalex.org/W1981584534', 'https://openalex.org/W1982473504', 'https://openalex.org/W1983398917', 'https://openalex.org/W1984584032', 'https://openalex.org/W1986884128', 'https://openalex.org/W1987577564', 'https://openalex.org/W1989411463', 'https://openalex.org/W1989825919', 'https://openalex.org/W1995184275', 'https://openalex.org/W1995363528', 'https://openalex.org/W1996165453', 'https://openalex.org/W1996610886', 'https://openalex.org/W2008346295', 'https://openalex.org/W2009836750', 'https://openalex.org/W2018682845', 'https://openalex.org/W2022518765', 'https://openalex.org/W2025930815', 'https://openalex.org/W2029842272', 'https://openalex.org/W2030429605', 'https://openalex.org/W2035088045', 'https://openalex.org/W2038186927', 'https://openalex.org/W2038890616', 'https://openalex.org/W2040365742', 'https://openalex.org/W2040794484', 'https://openalex.org/W2043186800', 'https://openalex.org/W2053701209', 'https://openalex.org/W2061822462', 'https://openalex.org/W2066315131', 'https://openalex.org/W2068514940', 'https://openalex.org/W2071531606', 'https://openalex.org/W2081120437', 'https://openalex.org/W2083623093', 'https://openalex.org/W2090784980', 'https://openalex.org/W2093629370', 'https://openalex.org/W2101960107', 'https://openalex.org/W2106835194', 'https://openalex.org/W2109658199', 'https://openalex.org/W2118986158', 'https://openalex.org/W2139303048', 'https://openalex.org/W2147160932', 'https://openalex.org/W2150441492', 'https://openalex.org/W2159611626', 'https://openalex.org/W2159818315', 'https://openalex.org/W2161892290', 'https://openalex.org/W2167150493', 'https://openalex.org/W2169496763', 'https://openalex.org/W2324677651', 'https://openalex.org/W2329029967', 'https://openalex.org/W2416632722', 'https://openalex.org/W2999065750', 'https://openalex.org/W3216484931', 'https://openalex.org/W4240409061', 'https://openalex.org/W57236300', 'https://openalex.org/W90378718'], 'related_works': ['https://openalex.org/W4381848605', 'https://openalex.org/W3003204623', 'https://openalex.org/W2930398136', 'https://openalex.org/W2362714471', 'https://openalex.org/W2325532288', 'https://openalex.org/W2188083249', 'https://openalex.org/W2159787186', 'https://openalex.org/W2085125278', 'https://openalex.org/W2040369700', 'https://openalex.org/W2005896413'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Our': [1], 'previous': [2], 'studies': [3], 'have': [4, 31, 51, 64], 'clearly': [5], 'shown': [6], 'that': [7, 26, 59, 63, 191, 232], 'the': [8, 27, 41, 80, 97, 112, 130, 182, 196, 218, 224, 228, 233, 245, 256], 'angiogenic': [9], 'enzymes,': [10], 'matrix': [11], 'metalloproteinase': [12], '(MMP)': [13], '‐2/9,': [14], 'are': [15, 242], 'directly': [16], 'involved': [17], 'in': [18, 202, 205], 'human': [19], 'hepatic': [20], 'tumorigenesis': [21], 'and': [22, 24, 38, 55, 69, 93, 104, 108, 120, 124, 134, 145, 150, 168, 193, 209, 214, 230, 235, 240, 252, 285, 291, 304], 'metastasis': [23, 305], 'suggest': [25, 231], 'MMP‐2/9': [28], 'inhibitors,': [29], 'which': [30], 'dual': [32, 98, 257, 307], 'inhibitory': [33, 99], 'activi¬ties': [34], 'on': [35, 296], 'enzyme': [36, 106, 250], 'activity': [37, 123, 251], 'transcription,': [39], 'represent': [40], 'best': [42], 'candidates': [43], 'for': [44], 'achieving': [45], 'tumor': [46, 91, 200], 'regression.': [47], 'Many': [48], 'anti‐cancer': [49, 61, 87], 'drugs': [50, 62, 88], 'strong': [52, 60, 119], 'cellular': [53], 'cytotoxicity': [54, 68], 'side': [56, 70], 'effects,': [57], 'indicating': [58], 'no': [65], 'or': [66, 157], 'minimal': [67], 'effects': [71, 237], 'need': [72], 'to': [73, 84], 'be': [74], 'developed.': [75], 'The': [76, 207], 'specific': [77, 90, 102], 'aim': [78], 'of': [79, 101, 161, 184, 198, 212, 227, 238, 248, 259, 288, 301], 'present': [81], 'study': [82], 'was': [83, 127, 142], 'develop': [85], 'powerful': [86], 'with': [89, 164], 'regression': [92, 300], 'anti‐metastatic': [94], 'potential': [95, 226], 'having': [96], 'activities': [100, 107], 'MMP‐2': [103, 149], '‐9': [105, 151], 'gene': [109], 'transcription': [110, 125], 'at': [111], 'molecular': [113], 'level.': [114], 'Caffeic': [115], 'acid': [116, 138, 290, 293], '(CA),': [117], 'a': [118], 'selective': [121, 246], 'MMP‐9': [122, 178, 249, 264], 'inhibitor,': [126], 'isolated': [128], 'from': [129], 'plant': [131], 'Euonymus': [132], 'alatus': [133], 'its': [135], 'derivative,': [136], 'caffeic': [137, 289, 292], 'phenethyl': [139], 'ester': [140, 295], '(CAPE),': [141], 'synthesized.': [143], 'CA': [144, 165, 192, 213, 239], 'CAPE': [146, 169, 194, 215, 241], 'selectively': [147], 'inhibited': [148], 'but': [152, 186], 'not': [153, 187], '‐1,': [154], '‐3,': [155], '‐7,': [156], 'cathepsin': [158], 'K.': [159], 'Treatment': [160], 'HepG2': [162, 199], 'cells': [163], '(100': [166], 'μg/mL)': [167, 171], '(5': [170], 'suppressed': [172, 195], 'phorbol': [173], '12‐myristate': [174], '13‐acetate': [175], '(PMA)': [176], '‐in¬duced': [177], 'expression': [179], 'by': [180, 255, 306], 'inhibiting': [181], 'function': [183], 'NF‐κB,': [185], 'AP‐1.': [188], 'We': [189], 'confirmed': [190], 'growth': [197, 303], 'xenografts': [201], 'nude': [203], 'mice': [204], 'vivo.': [206], 'subcutaneous': [208], 'oral': [210], 'administrations': [211], 'significantly': [216], 'reduced': [217], 'liver': [219], 'metastasis.': [220], 'These': [221], 'results': [222], 'confirm': [223], 'therapeutic': [225, 286], 'compounds': [229], 'antimetastatic': [234], 'anti‐tumor': [236], 'mediated': [243], 'through': [244], 'suppression': [247], 'transcriptional': [253], 'down‐regulation': [254], 'inhibition': [258], 'NF‐κB': [260], 'as': [261, 263], 'well': [262], 'catalytic': [265], 'activity.—Chung,': [266], 'T.‐W.,': [267], 'Moon,': [268], 'S.‐K.,': [269], 'Chang,': [270], 'Y.‐C.,': [271, 275], 'Ko,': [272], 'J.‐H.,': [273], 'Lee,': [274], 'Cho,': [276], 'G.,': [277], 'Kim,': [278, 280, 282], 'S.‐H.,': [279], 'J.‐G.,': [281], 'C.‐H.': [283], 'Novel': [284], 'effect': [287], 'phenyl': [294], 'hepatocarcinoma': [297], 'cells:': [298], 'complete': [299], 'hepatoma': [302], 'mechanism.': [308], 'FASEBJ': [309], '.': [310], '18,': [311], '1670–1681': [312], '(2004)': [313]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1978272694', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 17}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 22}, {'year': 2016, 'cited_by_count': 28}, {'year': 2015, 'cited_by_count': 24}, {'year': 2014, 'cited_by_count': 39}, {'year': 2013, 'cited_by_count': 35}, {'year': 2012, 'cited_by_count': 41}], 'updated_date': '2025-01-09T08:14:37.059753', 'created_date': '2016-06-24'}