Title: Phospholipid degradation and signal translation for protein phosphorylation
Abstract: Phospholipid degradation, particularly phosphatidylinositol turnover provoked by a wide variety of extracellular messengers such as neurotransmitters, hormones, growth factors and many other biologically active substances, appears to be a sign for the transmembrane control of cellular functions and the proliferation through activation of a novel protein kinase (protein kinase C). In many tissues both cAMP and cGMP block the receptor-linked phospholipid degradation and thereby counteract this signal translation. Tumor-promoting phorbol esters intercalate into the membrane phospholipid bilayer and directly activate protein kinase C without inducing phosphatidylinositol turnover.
Publication Year: 1983
Publication Date: 1983-01-01
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
Cited By Count: 323
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