Title: Evidence for a Pituitary Site of Action for the Acute Inhibition of LH Release by Estrogen in the Rat
Abstract: Intravenous administration of estradiol in doses of 20 ng or more was capable of inhibiting LH release in ovariectomized rats as indicated by a decrease in plasma LH determined by radioimmunoassay. The inhibition came on within 1 hr and could persist for up to 4 hr after a single injection. The decrease in plasma LH which followed the injection of estradiol was at least in part caused by a decreased sensitivity of the pituitary gland to LRF since the increment in plasma LH in response to injection of the synthetic decapeptide was significantly decreased in estradiol—treated animals. Endocrinology92: 1680, 1973)
Publication Year: 1973
Publication Date: 1973-06-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 53
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