Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders

Name: Work Video:
Duration: 3 min 30 s
Thomas R. Insel; Bruce N. Cuthbert; Marjorie A. Garvey; Robert Heinssen; Daniel S. Pine; Kevin J. Quinn; Charles A. Sanislow; Philip Wang
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'mood': [1349, 2270, 2612, 3546], 'disorder': [1350, 2184, 2464, 2613, 2923, 3396], 'consistently': [1352], 'responds': [1353], 'lithium,': [1355], 'scheme': [1361], 'recognize': [1368, 1492, 1535], 'there': [1370], '"ifs"': [1373], 'stage.': [1376], 'We': [1377, 1491], 'still': [1379], 'way': [1382], 'knowing': [1384], 'succeed.NIMH': [1389], 'plans': [1390], 'maintain': [1392], 'liaison': [1393], 'American': [1396, 1679, 3739], 'Psychiatric': [1397, 1680, 3403], 'Association': [1398], 'World': [1401], 'Organization': [1403], 'regarding': [1404], 'mutual': [1405], 'interests': [1406], 'classification.': [1409, 1490], 'initial': [1412], 'step,': [1413], 'representatives': [1414], 'APA,': [1417], 'WHO,': [1418], 'met': [1421], 'July': [1423, 2341, 2651, 3481], '2009': [1424], 'map': [1426, 2756], 'out': [1427], 'common': [1428], 'ground.': [1429], 'These': [1430], 'organizations': [1431], 'articulated': [1434], 'importance': [1436, 1537], 'adding': [1438], 'systems,': [1446], 'our': [1449], 'state': [1451], 'knowledge': [1453, 2127], 'seems': [1456], 'immediate': [1463], 'use.': [1465], 'views': [1467, 3566], 'beginning': [1471], 'transformative': [1474], 'effort': [1475], 'needs': [1477], 'succeed': [1479], 'decade': [1483], 'beyond': [1485], 'implement': [1487], 'creation': [1495], 'daunting': [1503], 'task,': [1504], 'likely': [1507], 'require': [1508], 'mid-course': [1510], 'corrections': [1511], 'deliver': [1517], 'transformation': [1519], 'seek': [1521], 'care.': [1524], 'hopes': [1527], 'scientific': [1530], 'communities': [1533], 'joining': [1539], 'constructive': [1541], 'dialogue': [1542], 'efforts': [1544], 'aiming': [1545], 'accelerate': [1547], 'pace': [1549], 'outcomes.National': [1557], 'Health,': [1561, 1581, 3741], 'Bethesda,': [1562, 1587], 'Md.Commentary': [1563], 'accepted': [1564], 'publication': [1566], 'April': [1567, 2428, 2448, 2466], '2010.': [1568], 'Address': [1569], 'correspondence': [1570], 'reprint': [1572], 'requests': [1573], 'Dr.': [1575], '6001': [1582], 'Executive': [1583], 'Blvd.': [1584], '(MSC': [1585], '9632),': [1586], 'MD': [1588], '20892-9632;': [1589], '[email': [1590], 'protected]nih.gov': [1591], '(e-mail).All': [1592], 'authors': [1593], 'report': [1594], 'financial': [1596], 'commercial': [1599], 'interests.References1': [1600], 'Regier': [1601], 'DA': [1602, 2038], ',': [1603, 1606, 1609, 1646, 1649, 1689, 1736, 1739, 1742, 1745, 1772, 1775, 1778, 1781, 1784, 1787, 1790, 1793, 1796, 1799, 1802, 1805, 1808, 1811, 1814, 1817, 1820, 1823, 1826, 1829, 1832, 1835, 1838, 1841, 1844, 1847, 1850, 1853, 1856, 1859, 1862, 1865, 1868, 1871, 1874, 1877, 1880, 1883, 1886, 1889, 1892, 1895, 1898, 1901, 1904, 1907, 1910, 1913, 1923, 1926, 1929, 1932, 1935, 1938, 1942, 1945, 1948, 1951, 1954, 1957, 1960, 1963, 1966, 1969, 1972, 1975, 1978, 1981, 1984, 1987, 1990, 1993, 1996, 1999, 2002, 2005, 2008, 2011, 2014, 2017, 2020, 2023, 2026, 2030, 2033, 2036, 2055, 2058, 2061], 'Narrow': [1604], 'WE': [1605], 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[1851], 'Möller': [1854], 'HJ': [1855], 'Giegling': [1857], 'I': [1858, 1870, 1925, 2007], 'Rasmussen': [1860], 'HB': [1861], 'Timm': [1863], 'Mattheisen': [1866], 'Bitter': [1869], 'Réthelyi': [1872], 'JM': [1873], 'Magnusdottir': [1875], 'BB': [1876], 'Sigmundsson': [1878], 'Olason': [1881], 'P': [1882, 2022, 2057], 'Masson': [1884], 'G': [1885, 1950], 'Gulcher': [1887], 'JR': [1888], 'Haraldsson': [1890], 'Fossdal': [1893], 'Thorgeirsson': [1896], 'TE': [1897], 'Thorsteinsdottir': [1899], 'U': [1900, 1953], 'Ruggeri': [1902], 'Tosato': [1905], 'Franke': [1908], 'Strengman': [1911], 'Kiemeney': [1914], 'LA': [1915], 'Genetic': [1916], 'Risk': [1917, 3105, 3297], 'Outcome': [1919], 'Psychosis': [1921, 3654], '(GROUP)': [1922], 'Melle': [1924], 'Djurovic': [1927], 'Abramova': [1930], 'L': [1931, 2004, 2025], 'Kaleda': [1933], 'V': [1934, 1989], 'Sanjuan': [1936], 'de': [1939], 'Frutos': [1940], 'Bramon': [1943], 'Vassos': [1946], 'Fraser': [1949], 'Ettinger': [1952], 'Picchioni': [1955], 'Walker': [1958], 'Toulopoulou': [1961], 'Need': [1964], 'AC': [1965], 'Ge': [1967], 'Yoon': [1970], 'JL': [1971], 'Shianna': [1973], 'KV': [1974], 'Freimer': [1976], 'NB': [1977], 'Cantor': [1979], 'RM': [1980], 'Murray': [1982], 'Kong': [1985], 'Golimbet': [1988], 'Carracedo': [1991], 'Arango': [1994], 'Costas': [1997], 'Jönsson': [2000], 'EG': [2001], 'Terenius': [2003], 'Agartz': [2006], 'Petursson': [2009], 'Nöthen': [2012], 'MM': [2013], 'Rietschel': [2015], 'Matthews': [2018], 'PM': [2019], 'Muglia': [2021], 'Peltonen': [2024], 'St': [2027], 'Clair': [2028], 'Goldstein': [2031], 'DB': [2032], 'Collier': [2037], 'Common': [2040], 'variants': [2041], 'conferring': [2042], 'risk': [2043, 2665, 3628], 'Nature': [2046, 3014], '460:744–747': [2048], 'Scholar8': [2052], 'Losh': [2053], 'Sullivan': [2056], 'Trembath': [2059], 'Piven': [2062], 'developments': [2066, 2320], 'autism:': [2071], 'phenome': [2073], 'genome.': [2075], 'Neuropathol': [2077], 'Exp': [2078], 'Neurol': [2079], '67:829–837': [2081], 'Scholar': [2085], 'FiguresReferencesCited': [2086], 'byDetailsCited': [2087], 'byPathobiology': [2088], 'CNS': [2090], 'immunodeficiency': [2092], 'virus': [2093], 'infectionDimensions': [2094], 'childhood': [2096, 2623], 'maltreatment': [2097], 'adult': [2099], 'risky': [2100], 'behaviors:': [2101], 'Differential': [2102], 'affective': [2103, 2420], 'inhibitory': [2105, 2205], 'control': [2106, 2206], 'mechanismsChild': [2107], 'Abuse': [2108], '&': [2109, 2912, 3363, 3529, 3585], 'Neglect,': [2110], 'Vol.': [2111, 2125, 2143, 2159, 2178, 2198, 2221, 2235, 2266, 2292, 2310, 2329, 2346, 2364, 2392, 2413, 2433, 2453, 2471, 2487, 2511, 2536, 2557, 2579, 2608, 2634, 2656, 2675, 2714, 2736, 2751, 2778, 2798, 2832, 2853, 2871, 2897, 2915, 2934, 2957, 2985, 3000, 3016, 3033, 3054, 3082, 3096, 3113, 3138, 3169, 3190, 3215, 3231, 3252, 3276, 3320, 3339, 3366, 3387, 3405, 3422, 3450, 3466, 3489, 3515, 3532, 3548, 3564, 3573, 3588, 3607, 3637, 3662, 3681, 3698, 3715, 3742, 3761, 3786, 3811], '134The': [2112], '(un)learning': [2113], 'functions': [2116], 'significance': [2119], 'healthClinical': [2122], 'Psychology': [2123, 3167], 'Review,': [2124, 3168], '98Psychopathological': [2126], 'methodically': [2129], 'sound': [2130], 'diagnostics': [2131], 'core': [2133, 2377], 'elements': [2134], 'forensic': [2136], 'psychiatryForensic': [2137], 'Science': [2138], 'International:': [2139], 'Mind': [2140, 3455], 'Law,': [2142], '3Examining': [2144], 'patterns': [2145], 'functioning': [2148, 2785, 3458, 3620, 3719], 'across': [2149, 2210, 3005], 'dimensions': [2150], 'psychopathologyJournal': [2152], 'Behavior': [2154, 3153], 'Therapy': [2155, 3062], 'Experimental': [2157], 'Psychiatry,': [2158, 2177, 2197, 2220, 2265, 2291, 2309, 2328, 2345, 2363, 2391, 2607, 2633, 2655, 2674, 2797, 2956, 3095, 3112, 3137, 3636, 3810], '77Molecular': [2160], 'N-methyl-d-aspartate': [2164], 'receptor': [2165], 'antagonists:': [2166], 'Highlighting': [2167], 'their': [2168], 'transdiagnostic': [2171, 2476, 2543, 3463], 'therapeuticsProgress': [2172], 'Neuro-Psychopharmacology': [2174, 2194, 2217], 'Biological': [2176, 2196, 2219], '119Effects': [2179], 'comorbid': [2181], 'posttraumatic': [2182], 'stress': [2183, 2601, 2922, 3395], 'Chinese': [2189], 'male': [2190], 'methamphetamine': [2191], 'patientsProgress': [2192], '119Charting': [2199], 'disruption': [2203], 'subcomponents': [2209], 'disorders:': [2212, 2763, 3461], 'meta-analysisProgress': [2215], '119Individualized': [2222], 'prediction': [2223], 'cognition': [2226, 3542], 'cortical': [2232, 2550, 3002], 'anatomyNeuroimage:': [2233], 'Reports,': [2234, 2412, 2432, 2452, 2470, 2486, 2510, 2535], '2,': [2236], 'No.': [2237, 2268, 2294, 2312, 2331, 2348, 2366, 2394, 2415, 2435, 2455, 2473, 2489, 2513, 2538, 2559, 2581, 2610, 2636, 2658, 2677, 2716, 2738, 2780, 2800, 2834, 2855, 2873, 2936, 2959, 2987, 3018, 3035, 3056, 3098, 3115, 3368, 3452, 3491, 3517, 3575, 3609], '4The': [2238], 'effects': [2239, 2544], 'lisdexamfetamine': [2241], 'dimesylate': [2242], 'eating': [2244, 3024], 'behaviour': [2245], 'homeostatic,': [2247], 'reward': [2248, 3469, 3788], 'processes': [2251], 'women': [2253, 3392], 'binge-eating': [2255], 'symptoms:': [2256], 'experimental': [2258], 'medicine': [2259, 2744], 'study10': [2260], 'January': [2261], '2022': [2262, 2288, 2306, 2325, 2342, 2360, 2388, 2409, 2429, 2449, 2467, 2483, 2507, 2532, 2553, 2573, 2604, 2630, 2652, 2671, 2709, 2729, 2772, 2794, 2824, 2848, 2928, 2953, 2976, 3012, 3027, 3050, 3161, 3180, 3208, 3227, 3247, 3273, 3290, 3312, 3334, 3357, 3442, 3482, 3599, 3632, 3658, 3673, 3693, 3711, 3735, 3757, 3783, 3806], '|': [2263, 2289, 2307, 2326, 2343, 2361, 2389, 2410, 2430, 2450, 2468, 2484, 2508, 2533, 2554, 2574, 2605, 2631, 2653, 2672, 2710, 2730, 2773, 2795, 2825, 2849, 2868, 2929, 2954, 2977, 3013, 3028, 3051, 3162, 3181, 3209, 3228, 3248, 3274, 3291, 3313, 3335, 3358, 3443, 3483, 3600, 3633, 3659, 3674, 3694, 3712, 3736, 3758, 3784, 3807], 'Translational': [2264, 2290, 2308, 2327, 2344, 2362, 2390, 2955], '12,': [2267, 2293, 2311, 2330, 2347, 2365, 2393, 2414, 2434, 2454, 2472, 2488, 2512, 2537, 2958], '1Characterizing': [2269], 'AFFECT': [2274], 'study:': [2275], 'large,': [2277], 'longitudinal,': [2278], 'phenotypically': [2280], 'rich': [2281], 'cohort': [2283], 'US25': [2286], 'March': [2287, 2305, 2603, 2629, 2771, 2847], '1Developing': [2295], 'clusters:': [2297], 'linking': [2298], 'inflammatory': [2299], 'depressive': [2302, 2463, 2907, 3133], 'profiles31': [2304], '1Application': [2313], 'positron': [2315], 'emission': [2316], 'tomography': [2317], 'psychiatry—methodological': [2319], 'directions14': [2323], 'June': [2324, 3049, 3441], '1Relating': [2332], 'self-regulation': [2336], 'during': [2337, 3047], 'COVID-19': [2339], 'crisis11': [2340], '1Transdiagnostic': [2349, 2582], 'connectome': [2350, 2458, 3041], 'signatures': [2351, 2562], 'resting-state': [2353], 'fMRI': [2354], 'individual-level': [2356], 'intellectual': [2357], 'capacity6': [2358], 'September': [2359, 2387, 2552, 2670], '1Quantitative': [2367], 'trait': [2368, 2879], 'locus': [2369], 'endophenotypes': [2372], 'reveals': [2373, 2493, 2842], 'substrates': [2375, 2591], 'neurocognitive': [2381, 2661], 'spectrum': [2385, 2614], 'disorder24': [2386], '1Depressive': [2395], 'reduce': [2397], 'cortex-precuneus': [2401], 'normalizes': [2403], 'after': [2404, 3397], 'neurofeedback16': [2407], 'February': [2408, 2708, 2793, 2823, 2952], 'Scientific': [2411, 2431, 2451, 2469, 2485, 2509, 2534, 3052], '1Grey': [2416], 'matter': [2417, 3536], 'correlates': [2418, 2767, 3701], 'somatic': [2422], 'premenstrual': [2425], 'dysphoric': [2426], 'disorder9': [2427], '1Self-esteem': [2436], 'beliefs': [2439], 'rate': [2442], 'change': [2444, 2888], 'approval22': [2447], '1An': [2456, 2514], 'electroencephalography': [2457], 'model': [2460, 3204], 'severity26': [2465], '1Establishing': [2474], 'contextual': [2477], 'pathways': [2478], 'emotional': [2480], 'outbursts6': [2481], 'May': [2482, 2506, 2531], '1EEG': [2490], 'time–frequency': [2491], 'blunted': [2494], 'tendency': [2495], 'increased': [2499], 'processing': [2500, 3378, 3789], 'unpleasant': [2502], 'stimuli': [2503, 3381], 'dysphoria17': [2505], 'Internet': [2517], 'searches': [2518], 'marker': [2521], 'trends': [2523], 'population': [2525], 'US27': [2530], '1Multiscale': [2539], 'gradients': [2541], 'reflect': [2542], 'conditions': [2548], 'morphology27': [2551], 'Communications': [2555], 'Biology,': [2556], '5,': [2558, 2854], '1Psychiatrically': [2560], 'domain-general': [2564], 'decision-making': [2565], 'metacognition': [2567], 'general': [2570], 'population30': [2571], 'August': [2572], 'npj': [2575, 2850], 'Research,': [2578, 3156, 3404], 'alterations': [2583, 3004], 'emotion': [2586], 'regulation': [2587], '–': [2589], 'reappraisal': [2594], 'depression': [2598, 2876, 3067, 3224], 'post-traumatic': [2600, 2921, 3394], 'disorder8': [2602], 'BMC': [2606, 2632, 2654, 2673, 2711, 2796], '22,': [2609, 2635, 2657, 2676, 2715, 2799], '1The': [2611, 2856, 3699], 'vs.': [2615], 'tree:': [2618], 'EDIPHAS': [2619], 'adolescence': [2625], '205': [2627], 'patients18': [2628], '1Feasibility': [2637], 'acceptability': [2639], 'novel': [2642], 'telepsychiatry-delivered': [2643], 'precision': [2644, 2743, 3571], 'prescribing': [2645], 'intervention': [2646, 2700], 'depression19': [2650], '1Building': [2659], 'profile': [2662], 'suicidal': [2664], 'severe': [2667], 'disorders26': [2669], '1Training': [2678], 'Awareness,': [2680], 'Resilience': [2681], 'Action': [2683], '(TARA)': [2684], 'medical': [2686], 'students:': [2687], 'single-arm': [2689], 'mixed': [2690], 'feasibility': [2692], 'evaluate': [2695], 'TARA': [2696], 'indicated': [2699], 'prevent': [2702], 'stress-related': [2706], 'symptoms28': [2707], 'Medical': [2712], 'Education,': [2713], '1Clinical': [2717], 'illness': [2723], '(CRDC-BP):': [2724], 'validity13': [2727], 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