Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1977332582', 'doi': 'https://doi.org/10.1016/j.nbd.2009.07.021', 'title': "Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Aβ assembly forms throughout life", 'display_name': "Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Aβ assembly forms throughout life", 'publication_year': 2009, 'publication_date': '2009-11-01', 'ids': {'openalex': 'https://openalex.org/W1977332582', 'doi': 'https://doi.org/10.1016/j.nbd.2009.07.021', 'mag': '1977332582', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19660551', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2782414'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.nbd.2009.07.021', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S35878148', 'display_name': 'Neurobiology of Disease', 'issn_l': '0969-9961', 'issn': ['0969-9961', '1095-953X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2782414?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103254943', 'display_name': 'Ganesh M. Shankar', 'orcid': 'https://orcid.org/0000-0003-4767-5470'}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I100930933', 'display_name': 'University College Dublin', 'ror': 'https://ror.org/05m7pjf47', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I100930933']}], 'countries': ['IE', 'US'], 'is_corresponding': False, 'raw_author_name': 'Ganesh M. Shankar', 'raw_affiliation_strings': ["Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA", 'Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Sciences, Conway Institute for Biomedical and Biomolecular Research, University College Dublin, Belfield, Dublin 4, Republic of Ireland'], 'affiliations': [{'raw_affiliation_string': "Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA", 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}, {'raw_affiliation_string': 'Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Sciences, Conway Institute for Biomedical and Biomolecular Research, University College Dublin, Belfield, Dublin 4, Republic of Ireland', 'institution_ids': ['https://openalex.org/I100930933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062137111', 'display_name': 'Malcolm A. Leissring', 'orcid': 'https://orcid.org/0000-0001-7185-4255'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Malcolm A. Leissring', 'raw_affiliation_strings': ["Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA"], 'affiliations': [{'raw_affiliation_string': "Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA", 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I1283280774']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024779060', 'display_name': 'Anthony Adame', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anthony Adame', 'raw_affiliation_strings': ['Department of Neurosciences, School of Medicine, University of California, La Jolla, San Diego, CA 92093, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosciences, School of Medicine, University of California, La Jolla, San Diego, CA 92093, USA', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069465815', 'display_name': 'Xiaoyan Sun', 'orcid': 'https://orcid.org/0000-0001-7978-292X'}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiaoyan Sun', 'raw_affiliation_strings': ["Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA"], 'affiliations': [{'raw_affiliation_string': "Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA", 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075598333', 'display_name': 'E. T. C. Spooner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Edward Spooner', 'raw_affiliation_strings': ["Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA"], 'affiliations': [{'raw_affiliation_string': "Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA", 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074775445', 'display_name': 'Eliezer Masliah', 'orcid': 'https://orcid.org/0000-0002-2117-5569'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eliezer Masliah', 'raw_affiliation_strings': ['Department of Neurosciences, School of Medicine, University of California, La Jolla, San Diego, CA 92093, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosciences, School of Medicine, University of California, La Jolla, San Diego, CA 92093, USA', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087935119', 'display_name': 'Dennis J. Selkoe', 'orcid': 'https://orcid.org/0000-0001-8846-9767'}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dennis J. Selkoe', 'raw_affiliation_strings': ["Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA"], 'affiliations': [{'raw_affiliation_string': "Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA", 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072719225', 'display_name': 'Cynthia A. Lemere', 'orcid': 'https://orcid.org/0000-0002-2983-7870'}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cynthia A. Lemere', 'raw_affiliation_strings': ["Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA"], 'affiliations': [{'raw_affiliation_string': "Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA", 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028988178', 'display_name': 'Dominic M. Walsh', 'orcid': 'https://orcid.org/0000-0002-0718-6261'}, 'institutions': [{'id': 'https://openalex.org/I100930933', 'display_name': 'University College Dublin', 'ror': 'https://ror.org/05m7pjf47', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I100930933']}], 'countries': ['IE'], 'is_corresponding': True, 'raw_author_name': 'Dominic M. Walsh', 'raw_affiliation_strings': ['Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Sciences, Conway Institute for Biomedical and Biomolecular Research, University College Dublin, Belfield, Dublin 4, Republic of Ireland'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Neurodegenerative Research, School of Biomolecular and Biomedical Sciences, Conway Institute for Biomedical and Biomolecular Research, University College Dublin, Belfield, Dublin 4, Republic of Ireland', 'institution_ids': ['https://openalex.org/I100930933']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5028988178'], 'corresponding_institution_ids': ['https://openalex.org/I100930933'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 7.224, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 113, 'citation_normalized_percentile': {'value': 0.99994, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '36', 'issue': '2', 'first_page': '293', 'last_page': '302'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11335', 'display_name': 'Prion Diseases: Causes and Molecular Basis', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12023', 'display_name': 'Cholinesterase Inhibitors in Neurodegenerative Diseases', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/synaptophysin', 'display_name': 'Synaptophysin', 'score': 0.80592936}, {'id': 'https://openalex.org/keywords/immunoprecipitation', 'display_name': 'Immunoprecipitation', 'score': 0.7263437}, {'id': "https://openalex.org/keywords/alzheimer's-disease", 'display_name': "Alzheimer's Disease", 'score': 0.503741}, {'id': 'https://openalex.org/keywords/amyloid', 'display_name': 'Amyloid (mycology)', 'score': 0.44814608}], 'concepts': [{'id': 'https://openalex.org/C2777209535', 'wikidata': 'https://www.wikidata.org/wiki/Q14864388', 'display_name': 'Synaptophysin', 'level': 3, 'score': 0.80592936}, {'id': 'https://openalex.org/C71829478', 'wikidata': 'https://www.wikidata.org/wiki/Q901305', 'display_name': 'Immunoprecipitation', 'level': 3, 'score': 0.7263437}, {'id': 'https://openalex.org/C141035611', 'wikidata': 'https://www.wikidata.org/wiki/Q5532934', 'display_name': 'Genetically modified mouse', 'level': 4, 'score': 0.632981}, {'id': 'https://openalex.org/C85265743', 'wikidata': 'https://www.wikidata.org/wiki/Q885458', 'display_name': 'Blot', 'level': 3, 'score': 0.575967}, {'id': 'https://openalex.org/C148762608', 'wikidata': 'https://www.wikidata.org/wiki/Q3748185', 'display_name': 'Hippocampal formation', 'level': 2, 'score': 0.56362236}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.55839235}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.46484393}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.44941458}, {'id': 'https://openalex.org/C2777633098', 'wikidata': 'https://www.wikidata.org/wiki/Q2736051', 'display_name': 'Amyloid (mycology)', 'level': 2, 'score': 0.44814608}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4428292}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.43267334}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.42735076}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.38576147}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.38434964}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.37407988}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.28068995}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.26397687}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.23676622}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.18006471}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.17230442}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.16809183}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1164867}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008136', 'descriptor_name': 'Longevity', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000367', 'descriptor_name': 'Age Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047468', 'descriptor_name': 'Immunoprecipitation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008136', 'descriptor_name': 'Longevity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008811', 'descriptor_name': 'Mice, Inbred DBA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.nbd.2009.07.021', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S35878148', 'display_name': 'Neurobiology of Disease', 'issn_l': '0969-9961', 'issn': ['0969-9961', '1095-953X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/ce5eee9fd7b14346a233029deb1313cb', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2782414', 'pdf_url': 'https://europepmc.org/articles/pmc2782414?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782414', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19660551', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2782414', 'pdf_url': 'https://europepmc.org/articles/pmc2782414?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 70, 'referenced_works': ['https://openalex.org/W1261866575', 'https://openalex.org/W1481325978', 'https://openalex.org/W1584834830', 'https://openalex.org/W1605023308', 'https://openalex.org/W1648265574', 'https://openalex.org/W1870043354', 'https://openalex.org/W1886575365', 'https://openalex.org/W1963568158', 'https://openalex.org/W1970874743', 'https://openalex.org/W1972567838', 'https://openalex.org/W1976981142', 'https://openalex.org/W1979147525', 'https://openalex.org/W1979543098', 'https://openalex.org/W1981458288', 'https://openalex.org/W1982556153', 'https://openalex.org/W1985323612', 'https://openalex.org/W1990752558', 'https://openalex.org/W1993465897', 'https://openalex.org/W1997177821', 'https://openalex.org/W1999206064', 'https://openalex.org/W1999234381', 'https://openalex.org/W2001900724', 'https://openalex.org/W2003320905', 'https://openalex.org/W2004546493', 'https://openalex.org/W2004852048', 'https://openalex.org/W2004968757', 'https://openalex.org/W2008006047', 'https://openalex.org/W2009174342', 'https://openalex.org/W2012215271', 'https://openalex.org/W2015513282', 'https://openalex.org/W2019644389', 'https://openalex.org/W2031121623', 'https://openalex.org/W2036234078', 'https://openalex.org/W2036288989', 'https://openalex.org/W2050669612', 'https://openalex.org/W2057035225', 'https://openalex.org/W2058432632', 'https://openalex.org/W2060339401', 'https://openalex.org/W2063236931', 'https://openalex.org/W2070045579', 'https://openalex.org/W2074816156', 'https://openalex.org/W2075481535', 'https://openalex.org/W2078917784', 'https://openalex.org/W2084972185', 'https://openalex.org/W2088151512', 'https://openalex.org/W2088269376', 'https://openalex.org/W2093530590', 'https://openalex.org/W2095456987', 'https://openalex.org/W2096410114', 'https://openalex.org/W2099370040', 'https://openalex.org/W2100610042', 'https://openalex.org/W2109727228', 'https://openalex.org/W2118265926', 'https://openalex.org/W2121963977', 'https://openalex.org/W2122065036', 'https://openalex.org/W2123249770', 'https://openalex.org/W2126800086', 'https://openalex.org/W2134613265', 'https://openalex.org/W2135771073', 'https://openalex.org/W2136901555', 'https://openalex.org/W2138938985', 'https://openalex.org/W2146729934', 'https://openalex.org/W2148808954', 'https://openalex.org/W2150999725', 'https://openalex.org/W2152304945', 'https://openalex.org/W2165021720', 'https://openalex.org/W2169152986', 'https://openalex.org/W2169308121', 'https://openalex.org/W2185500845', 'https://openalex.org/W4296154147'], 'related_works': ['https://openalex.org/W4249924263', 'https://openalex.org/W4248154288', 'https://openalex.org/W4231695350', 'https://openalex.org/W4206430714', 'https://openalex.org/W3416380', 'https://openalex.org/W2384299429', 'https://openalex.org/W2381555473', 'https://openalex.org/W2023039255', 'https://openalex.org/W1540697074', 'https://openalex.org/W150314098'], 'abstract_inverted_index': {'The': [0], 'amyloid': [1], 'β-protein': [2], '(Aβ)': [3], 'is': [4], 'believed': [5], 'to': [6, 39, 43, 74, 143], 'play': [7], 'a': [8, 144], 'causal': [9], 'role': [10], 'in': [11, 66, 86, 140], "Alzheimer's": [12], 'disease,': [13], 'however,': [14], 'the': [15, 24, 53, 75, 115, 122, 131, 138], 'mechanism': [16], 'by': [17], 'which': [18], 'Aβ': [19, 28, 41, 67, 79, 112, 129, 146], 'mediates': [20], 'its': [21], 'effect': [22], 'and': [23, 42, 69, 96, 102, 109, 136], 'assembly': [25, 126], 'form(s)': [26], 'of': [27, 78, 107, 124, 128, 133], 'responsible': [29], 'remain': [30], 'unclear.': [31], 'Several': [32], 'APP': [33], 'transgenic': [34], 'mice': [35, 135], 'have': [36, 48], 'been': [37], 'shown': [38], 'accumulate': [40], 'develop': [44], 'cognitive': [45], 'deficits.': [46], 'We': [47], 'studied': [49], 'one': [50], 'such': [51], 'model,': [52], 'J20': [54, 134], 'mouse.': [55], 'Using': [56], 'an': [57, 63, 84], 'immunoprecipitation/Western': [58], 'blotting': [59], 'technique': [60], 'we': [61], 'find': [62], 'age-dependent': [64], 'increase': [65, 85], 'monomer': [68], 'SDS-stable': [70], 'dimer.': [71], 'But': [72], 'prior': [73], 'earliest': [76, 116], 'detection': [77], 'dimers,': [80], 'immunohistochemical': [81], 'analysis': [82, 104], 'revealed': [83, 105], 'oligomer': [87], 'immunoreactivity': [88], 'that': [89], 'was': [90], 'coincident': [91], 'with': [92], 'reduced': [93], 'hippocampal': [94], 'MAP2': [95], 'synaptophysin': [97], 'staining.': [98], 'Moreover,': [99], 'biochemical': [100], 'fractionation': [101], 'ELISA': [103], 'evidence': [106], 'TBS': [108], 'triton-insoluble': [110], 'sedimentable': [111], 'aggregates': [113], 'at': [114], 'ages': [117], 'studied.': [118], 'These': [119], 'data': [120], 'demonstrate': [121], 'presence': [123], 'multiple': [125], 'forms': [127], 'throughout': [130], 'life': [132], 'highlight': [137], 'difficulty': [139], 'attributing': [141], 'synaptotoxicity': [142], 'single': [145], 'species.': [147]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1977332582', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2024-08-31T11:48:56.863559', 'created_date': '2016-06-24'}